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All Journal Jurnal Kedokteran Brawijaya Journal of Nutrition College Jurnal Tumbuhan Obat Indonesia e-Journal Pustaka Kesehatan Althea Medical Journal Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Jurnal Gizi Klinik Indonesia Medical and Health Science Journal Abdimasku : Jurnal Pengabdian Masyarakat Journal of Community Development Jember Medical Journal (JMJ) International Journal of Health and Information System (IJHIS) Indonesian Journal of Biomedicine and Clinical Sciences HARENA: Jurnal Gizi
Elly Nurus Sakinah, Elly Nurus
Departemen Farmakologi, Fakultas Kedokteran, Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Althea Medical Journal

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Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Rat Sakinah, Elly Nurus; Supangat, Supangat; Wisudanti, Desie Dwi; Abrori, Cholis; Mustika, Arifa; Wibsono, Sony; Athoillah, Nabil
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3133

Abstract

Background: Indonesia as an agricultural country has more than 33 million workers in the agriculture. Pesticides have an important role in agriculture because they function as powerful plant pest exterminators. However, its use is considered to cause various toxic effects, one of which is on the nervous system. This study aimed to evaluate the impact of pesticide exposure on cognitive impairment by assessing the butyrylcholinesterase biomarker in the blood of rats as experimental animals.Methods: This was a true experimental study conducted during September–November 2022 at the Pharmacology and Biochemistry Laboratory, Faculty of Medicine, University of Jember with a post-test only approach using Wistar rats which were divided into 1 control group and 4 treatment groups treated with chlorpyrifos 5 mg/kg orally. Serum butyrylcholinesterase enzyme levels were measured using the kinetic photometric method and then analyzed with a regression test in IBM SPSS® Statistics software.Results: The average value of butyrylcholinesterase was 920.23±145.27 (Control group); 904.48±91.6 (7 days after chlorpyrifos administration); 889.81±95.2 (14 days after chlorpyrifos administration); 457.84±69.5 (28 days after chlorpyrifos administration); 575.82±194.25 (56 days after chlorpyrifos administration). The results of the One-Way ANOVA test showed significant differences between groups as indicated by a significance test of 0.024 (p <0.05).Conclusions: There is a relationship between the duration of exposure to chlorpyrifos and butyrylcholinesterase levels in Wistar rats. This fact shows that the longer an organism is exposed to low doses of chlorpyrifos pesticides, the higher the level of neurological system toxicity that occurs in that organism.
Co-Authors Abu Khoiri Achmad Ilham Tohari Ain Yuanita Insani Akhmad Makhmudi Ali Santosa Alvin Faizin Lisar Amalia Nur Zahra Ancah Caesarina Novi Marchianti Andi Muhammad, Andi Angga Mardro Rahardjo Apryanita, Hudayah Arifa Mustika Aris Prasetyo Arista Prima Nugrahani Athoillah, Nabil Azham Purwandhono Azka Darajat Azka Darajat Bagus Wahyu Mulyono Barus, Marsha Zahra Adyanda Cahyana, Nugraha Wahyu Candra Agung Wibisana Cholis Abrori, Cholis Cicih Komariah Cindy Meylania Pradana Darajat, Azka Dear Farah Sielma Desie Dwi Wisudanti Dewantari, Septiarina Putri Dimes Atika Permanasari Dita Diana Parti Dwike Rachma Maydaniar Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati ENNY SUSWATI Erma Sulistyaningsih Erma Sulistyaningsih Fawziyah Putri Maulida Febrina Sylva Fridayanti Febrina Sylva Fridayanti, Febrina Sylva Gusfita Trisna Ayu Putri Hairrudin Hairrudin Heni Fatmawati Hilda Nur Achfidawati Inreswari, Laksmi Jauhar Firdaus Khana Nurfadhila Lubis, Arinie Awindya Maria Ulfa Mega Citra Prameswari Mochammad Amrun Hidayat Muhammad Hanif Ar Robbani Muhammad Rijal Fahrudin Hidayat Muhammad Yuda Nugraha Muhtar Ady Kusuma Nadzir Ansharullah Akbar Niki Niki Rahmawati Nistiandani, Ana Novail Alif Muharrom Nurud Diniyah Pattipeilohy, Florence Pattipeilohy, Florence Marianty Pipiet Wulandari Prasetyo, Aris Ramadhani, Alfiyah Ranindya Putri Cipta Indraswari Ricky Roosdiana Dewi Rini Riyanti Rizka Nuzula Wardani Rosita Dewi Rumastika, Nindya Shinta septa surya wahyudi, septa surya Sheilla Rachmania, Sheilla Shinta Madyaning Wuri Shiwi Linggarjati Siswoyo Siswoyo Sudarmanto, Yohanes Sugiyanta Sugiyanta Supangat Supangat Supangat Supangat Supangat T Ariani Widiastini Tegar Syaiful Qodar Tira Anjeli Rahmah Toyibatul Hidayati Ulfa Elfiah Vidya Muqsita Wibsono, Sony Yudha Nurdian Yuli Hermansyah Yuli Hermansyah Zahrah Febianti