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All Journal Buletin Veteriner Udayana Jurnal Kedokteran Brawijaya Journal of Nutrition College Jurnal Tumbuhan Obat Indonesia e-Journal Pustaka Kesehatan Althea Medical Journal Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Majalah Obstetri dan Ginekologi Jurnal Gizi Klinik Indonesia Medical and Health Science Journal Abdimasku : Jurnal Pengabdian Masyarakat Journal of Community Development Jember Medical Journal (JMJ) International Journal of Health and Information System (IJHIS) Indonesian Journal of Biomedicine and Clinical Sciences HARENA: Jurnal Gizi
Elly Nurus Sakinah, Elly Nurus
Departemen Farmakologi, Fakultas Kedokteran, Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : UNEJ e-Proceeding

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The Effect Of Cholecalciferol On Fasting Blood Glucose In Streptozotocin-induced Hyperglycemia Mice Sakinah, Elly Nurus
UNEJ e-Proceeding Indonesian Protein Society (IPS), International Seminar and Workshop 2014
Publisher : UNEJ e-Proceeding

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Abstract

Glucose uptake into skeletal muscle cells require insulin-dependent and insulin independent signaling pathways, both leading to the translocation of glucose transporter-4 (GLUT4) to the plasma membrane. Insulin resistance occurs due to failure of insulin signaling to translocate GLUT4 resulting in the failure of glucose uptake and causing hyperglycemia. Cholecalciferol is known to have a function in regulating calcium homeostasis was shown to increase the synthesis of insulin and increasing insulin sensitivity. The purpose of this study is to explain the role of cholecalciferol to decreased fasting blood glucose in streptozotocin-induced hyperglyemia mice. 30 mice adapted for one week and then induced using 150mg/kgBW streptozotocin (STZ) intraperitoneally, After experiencing hyperglycemia mice were divided into 5 groups (n=6 each), Group I (hyperglycemic control), group II (25ng cholecalciferol), group III (50ng cholecalciferol), group IV (100ng cholecalciferol), and group V (metformin 300mg/kgBBB). Cholecalciferol given orally for 14th days. On day 15th the examination of fasting blood sugar levels were taken and the mice. Fasting blood sugar levels measured using a glucometer. Based on statistical analysis showed that there were significant differences in fasting blood sugar levels between treatment groups (p<0,001). Based on univariate regression analyses there was negative correlation of cholecalciferol with fasting blood glucose (p<0,001). Cholecalciferol may lower fasting blood sugar levels in hyperglycemia mice models. Keywords: cholecalciferol, fasting blood glucose, STZ.
The Effect Of Cholecalciferol On Fasting Blood Glucose In Streptozotocin-induced Hyperglycemia Mice Elly Nurus Sakinah
UNEJ e-Proceeding Indonesian Protein Society (IPS), International Seminar and Workshop 2014
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Glucose uptake into skeletal muscle cells require insulin-dependent and insulin independent signaling pathways, both leading to the translocation of glucose transporter-4 (GLUT4) to the plasma membrane. Insulin resistance occurs due to failure of insulin signaling to translocate GLUT4 resulting in the failure of glucose uptake and causing hyperglycemia. Cholecalciferol is known to have a function in regulating calcium homeostasis was shown to increase the synthesis of insulin and increasing insulin sensitivity. The purpose of this study is to explain the role of cholecalciferol to decreased fasting blood glucose in streptozotocin-induced hyperglyemia mice. 30 mice adapted for one week and then induced using 150mg/kgBW streptozotocin (STZ) intraperitoneally, After experiencing hyperglycemia mice were divided into 5 groups (n=6 each), Group I (hyperglycemic control), group II (25ng cholecalciferol), group III (50ng cholecalciferol), group IV (100ng cholecalciferol), and group V (metformin 300mg/kgBBB). Cholecalciferol given orally for 14th days. On day 15th the examination of fasting blood sugar levels were taken and the mice. Fasting blood sugar levels measured using a glucometer. Based on statistical analysis showed that there were significant differences in fasting blood sugar levels between treatment groups (p<0,001). Based on univariate regression analyses there was negative correlation of cholecalciferol with fasting blood glucose (p<0,001). Cholecalciferol may lower fasting blood sugar levels in hyperglycemia mice models. Keywords: cholecalciferol, fasting blood glucose, STZ.
Co-Authors Abu Khoiri Achmad Ilham Tohari Ain Yuanita Insani Akhmad Makhmudi Ali Santosa Alvin Faizin Lisar Amalia Nur Zahra Ancah Caesarina Novi Marchianti Andi Muhammad, Andi Angga Mardro Rahardjo Apryanita, Hudayah Arifa Mustika Aris Prasetyo Arista Prima Nugrahani Athoillah, Nabil Azham Purwandhono Azka Darajat Azka Darajat Bagus Wahyu Mulyono Barus, Marsha Zahra Adyanda Cahyana, Nugraha Wahyu Candra Agung Wibisana Cholis Abrori, Cholis Cicih Komariah Cindy Meylania Pradana Darajat, Azka Dear Farah Sielma Desie Dwi Wisudanti Dewantari, Septiarina Putri Dimes Atika Permanasari Dita Diana Parti Dwike Rachma Maydaniar Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati ENNY SUSWATI Erma Sulistyaningsih Erma Sulistyaningsih Fawziyah Putri Maulida Febrina Sylva Fridayanti Febrina Sylva Fridayanti, Febrina Sylva Gusfita Trisna Ayu Putri Hairrudin Hairrudin Heni Fatmawati Hilda Nur Achfidawati Inreswari, Laksmi Jauhar Firdaus Khana Nurfadhila Lubis, Arinie Awindya Maria Ulfa Mega Citra Prameswari Mochammad Amrun Hidayat Muhammad Rijal Fahrudin Hidayat Muhammad Yuda Nugraha Muhtar Ady Kusuma Nadzir Ansharullah Akbar Niki Niki Rahmawati Nistiandani, Ana Novail Alif Muharrom Nurud Diniyah Pattipeilohy, Florence Pattipeilohy, Florence Marianty Prasetyo, Aris Ramadhani, Alfiyah Ranindya Putri Cipta Indraswari Ricky Roosdiana Dewi Rini Riyanti Rizka Nuzula Wardani Rosita Dewi Rumastika, Nindya Shinta septa surya wahyudi, septa surya Sheilla Rachmania, Sheilla Shinta Madyaning Wuri Shiwi Linggarjati Siswoyo Siswoyo Sudarmanto, Yohanes Sugiyanta Sugiyanta Supangat Supangat Supangat Supangat T Ariani Widiastini Tegar Syaiful Qodar Tira Anjeli Rahmah Toyibatul Hidayati Ulfa Elfiah Vidya Muqsita Wibsono, Sony Yudha Nurdian Yuli Hermansyah Zahrah Febianti