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All Journal Jurnal Kreativitas PKM Adi Husada Nursing Journal JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Peduli Masyarakat EDUNursing Avicenna : Journal of Health Research Jurnal Kesehatan Kusuma Husada PENA ABDIMAS : Jurnal Pengabdian Masyarakat Indonesian Nursing Journal of Education and Clinic (Jurnal Pendidikan dan Praktik Keperawatan Indonesia) Jurnal Keperawatan dan Kesehatan (JKK) Jurnal Medika: Medika Journal of Advanced Nursing and Health Sciences Jurnal Riset Keperawatan dan Kesehatan
Wahyuningsih Safitri, Wahyuningsih
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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THE EFFECTIVENESS OF GALENIC CREAM OF DURIAN PEEL EXTRACT AND CHITOSAN FOR TREATMENT OF DIABETIC ULCERS Agustin, Wahyu Rima; Harti, Agnes Sri; Crisdian S, Hanugrah Ardya; Safitri, Wahyuningsih; Saputro, Sutiyo Dani; Saelan, Saelan
INDONESIAN NURSING JOURNAL OF EDUCATION AND CLINIC (INJEC) Vol 11, No 1 (2026): INJEC
Publisher : Asosiasi Institusi Pendidikan Ners Indonesia (AIPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24990/injec.v11i1.594

Abstract

Introduction: The chemical substance of durian peel (Durio zibethinus L.) is a polysaccharide polymer of D-galacturonic acid which is polar and anti-microbial. Chitosan is a derivative of chitin from the peels of Crustaceae animals, which is polycationic and antimicrobial; biodegradable, and biocompatible with animal tissues. Diabetic ulcers are chronic wounds due to neurological disorders and vascular disorders in the legs, causing tissue damage. The purpose of the study was to analyze the effectiveness of galenic preparations of durian peel extract and chitosan for the treatment of diabetic ulcers.Method: This research is experimental including testing the quality of 5% durian peel extract cream preparations; 2% chitosan, a mixture of both ratio = 1:1; 1:2 physically, chemically, microbiologically, and the rate of wound healing in test animals. Statistical data analysis of One Way Anova parametric test.Results:  The results showed that the preparation of galenic durian peel extract cream and chitosan and their combination ratio (1:1), (1:2) could be formulated and met the quality test of cream preparations physically, chemically, and microbiologically according to the requirements of BPOM No. 32 of 2019 and is effective for healing diabetic ulcers on the 8th day.Conclusions: The preparation of galenic durian peel extract cream and chitosan and their combination ratio (1:1), (1:2) can potentially be developed as a cream preparation for healing diabetic ulcers.
Co-Authors Agnes Sri Harti Ani Noor, Frieda Atiek Murharyati Crisdian S, Hanugrah Ardya Damayanti, Tetania Evi Diani, Nova Okta Ediyono, Suryo Erliawan, Iwan Fredy Chandra Fadillah, Siti Frieda Ani Noor Gita, Anggi Putri Aria Hutari Puji Astuti Ika Subekti Wulandari, Ika Subekti Kusumawati, Mira wahyu Maria Wisnu Kanita Meta Meriza, Tiara Nurul Devi Ardiani, Nurul Devi Nurul Izzati, Wavi Oktavianus, O Pinto, Sufina Prastyoningsih, Aris Pratiwi, Ajeng Maharani Puspitaningrum, Mita Rahayu, Retnaning Tyas Ratih Dwilestari Puji Utami, Ratih Dwilestari Puji Rosalina, Sylvia S. Dwi Sulisetyawati Saelan, Saelan Saputro, Sutiyo Dani Setiyawan Siwi Indra Sari, Siwi Indra Sulisetyowati, Dwi Suryandari, Dewi Utami, Ratih Dwi Lestari Puji Wahyu Rima Agustin Yusup Subagio Sutanto