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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UntukMu NegeRI JCES (Journal of Character Education Society) JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Kefarmasian Indonesia
Sholichah Rohmani, Sholichah
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Evaluation of Virgin Coconut Oil Concentration Variations in Emulgel Formulations of Garlic (Allium sativum L.) Extract as an Antibacterial Hand Sanitizer Rohmani, Sholichah; Fitria, Krismona Rizky Nur; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Ermawati, Dian Eka; Sasongko, Heru; Zulpadly, M. Fiqri; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Aratanti, Anif Nur; Untari, Meta Kartika
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

One of the effective ways to stay healthy is maintaining cleanliness, including hand hygiene. Various diseases can be easily transmitted through the hands. However, modern developments have changed the habit of handwashing with water to using hand antiseptics. Hand sanitizer is an alternative to overcome this problem. Unfortunately, some hand sanitizer gels on the market still contain alcohol as an antibacterial ingredient. It is necessary to innovate in making hand sanitizers using non-alcoholic ingredients as antibacterials, for example, natural ingredients like garlic. Garlic contains allicin that functions as an antibacterial. Meanwhile, VCO contains high lauric acid with antibiotic properties that function as antiviral, antibacterial, and antiprotozoal. It also contains capric acid, with antiviral and antibacterial functions. This study aims to examine the effect of concentration variation of VCO on the physical stability of garlic extract emulgel preparation and antibacterial effectiveness against the growth of Staphylococcus aureus. The concentration variation of VCO in this study was 3%, 5%, and 7% for 3 types of formulas. The results showed that the concentration variation of VCO in emulgel preparations gave differences in the physical properties of the gel, including pH, viscosity, adhesive strength, and spreadability. It can be concluded that the higher the VCO concentration, the higher the pH, viscosity, and adhesive power, and the lower the spreadability and antibacterial inhibition power against Staphylococcus aureus. The best result from the evaluation of physicochemical properties and antibacterial tests was Formula 1, although it was still in the weak inhibitory power category.
HPLC Analysis with Evaluation of Antioxidant and Antisenescence Activities of Parijoto (Medinilla speciosa Reinw. ex Bl.) Methanolic Extract in Vero Cells Artanti, Anif Nur; Rohmani, Sholichah; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Zulpadly, M. Fiqri; Meitasari, Annisa Diyan; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika; Sasongko, Heru; Ermawati, Dian Eka; Setyawan, Feri
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp44-56

Abstract

Parijoto (Medinilla speciosa Reinw. ex Bl.) is a traditional medicinal plant rich in polyphenolic compounds that are associated with antioxidant and cytoprotective activities. The present study aims to investigate the phytochemical profile, antioxidant capacity, cytotoxicity, and anti-senescence effects of parijoto methanolic extract. The methanolic extract of parijoto (MEP) was subjected to qualitative thin-layer chromatography (TLC) for the detection of flavonoids, quantitative high-performance liquid chromatography (HPLC) for the determination of quercetin and naringin, and antioxidant activity assessment using the DPPH method. The mobile phase for quercetin analysis was water: acetonitrile (45:55), while for naringin, it was acetonitrile:water: formic acid (21:78.8:0.2). Cytotoxicity was evaluated in Vero cells using the MTT assay, while senescence in normal kidney cells was assessed by senescence-associated β-galactosidase (SA-β-gal) staining. Results showed that the extract contained quercetin (5.76±0.11 ppm). The extract exhibited strong antioxidant activity with an IC₅₀ value of 40.46 ppm. Cytotoxicity testing of MEP on Vero cells revealed low toxicity (529±0.77 μM) at physiologically relevant concentrations, supporting its safety for normal kidney cells. Moreover, in normal kidney cells, the extract conferred cytoprotective effects by reducing oxidative stress–induced damage and attenuating senescence-associated β-galactosidase. Collectively, these findings suggest that MEP exhibits potent antioxidant, cytoprotective, and anti-senescence activity in vitro, warranting further in vivo studies to validate its potential effects on kidney health and age-related cellular damage.
Co-Authors Aditya, Shafira Nur Amaris Susanto, Nindita Clourisa Anif Nur Artanti, Anif Nur Aratanti, Anif Nur Darojati, Ulfa Afrinurfadhilah Darojati, Ulfa Afrinurfadhillah Daswati Daswati ERMAWATI, DIAN EKA Fea Prihapsara, Fea Fitria, Krismona Rizky Nur Heru Sasongko Husna, Hanna Miftahul Kuncoro, Muhammad A.A. Kundarto, Wisnu Mar’atushsholihah, Luthfia Meitasari, Annisa Diyah Meitasari, Annisa Diyan Ningrum, Sonia Karunia Setyawan, Feri Susanto, Bela Novita Amaris Susanto, Nindita Clourisa Amaris untari, meta kartika Utami, Diyah Tri Wardhani, Wening Dyah Zulpadly, M. Fiqri Zulpadly, Muhammad Fiqri Zulphadly, M.Fiqri