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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Oto Rhino Laryngologica Indonesiana JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Asian Journal of Health Research eJournal Kedokteran Indonesia
Nyilo Purnami
Departement Of Otorhinolaryngology Head And Neck Surgery, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Knowledge, Attitude, and Perception of Youth Population in Indonesia toward COVID-19 Vaccination Alfian Nurfaizi; Lelyana Sih Afgriyuspita; Ni Made Adnya Suasti; Ummi Imamatal Muttaqin; Berliana Nur Azizah; Indira Syahraya; Baiq Dwi Hadiatul Azni; Ayuning Tetirah Ramadhani; Crysciando Jefryco Putra; Nyilo Purnami
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.63

Abstract

Introduction: COVID-19 vaccination acceptance by the youth population is still a major problem. Community vaccination programs are needed to immediately achieve immunity so that the goals of good health and well-being can be achieved. This study aims to identify the factors that influence vaccine acceptance in a group of youth non-health professionals. Methods: This cross-sectional, observational questionnaire-based study was conducted among 194 individuals in the age range of 18 to 25 years through online questionnaires. Data was collected using snowball sampling techniques collect data from respondents about their socio-demographics, knowledge, attitudes, and perceptions (KAP). Statistical used descriptive and analytical calculations (Chi-square and Mann-Whitney test). Results: There was a correlation between occupation, comorbid status, and history of COVID-19 with vaccination acceptance. The average score of knowledge among the non-vaccinated group versus the vaccinated group were 52.13 ± 14.556 and 53.68 ± 13.843 (out of 70), respectively (p= 0.509), while the average score for attitude was 6.76 ± 1.781 and 7.44 ± 1.220 (out of 8) respectively (p = 0.004). The occupation, comorbid status, history of COVID-19, perception of dangerous side effects, and willingness to pay were associated with COVID-19 vaccination acceptance. Conclusion:  The vaccinated group showed a more positive attitude, though their average knowledge score was not significantly different with the unvaccinated group. Massive health promotion regarding COVID-19 vaccine safety, reassuring the population, especially the unemployed population and COVID-19 survivors should be taken by policymakers to ensure adequate knowledge, positive attitudes, and perceptions against COVID-19 vaccination.
INCREASING SOCIETY AWARENESS REGARDING EARLY DETECTION OF HEARING DISTURBANCE IN TUBAN REGENCY, EAST JAVA Nyilo Purnami; Artono; Puguh Setyo Nugroho
Jurnal Layanan Masyarakat Vol. 7 No. 2 (2023): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v7i2.2023.236-244

Abstract

Hearing loss can interfere with communication, affecting social, school, and work environments. Hearing loss can be prevented by early detection and management of hearing loss. Tuban is one of the districts in East Java; the case data was obtained on the ear as a hearing organ, namely otitis externa (25.56%). acute otitis media (22.46%), cerumen obturation (16.15%), chronic suppurative otitis media (7.56%), and sensorineural deafness (5.72%). The early detection and management skills of hearing loss are mandatory for doctors working in primary health care, so a series of activities are needed to improve this knowledge and skills. Activities outside the network include lecture methods, question-and-answer discussions and training. The activity was attended by 52 participants with details of 48 doctors and four health workers. Most recent education is S1 or equivalent (96.1 most occupations are general practitioners (92.30%), and most workplace public health centers (69.23%). The pre-test score was 47, and the post-test value was 57.
Seropositivity of Anti-Rubella Antibodies as A Marker for Rubella Infection in Infants at High Risk of Congenital Deafness Nyilo Purnami; Risa Etika; Martono Martono; Puspa Wardhani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1479

Abstract

Hearing loss in newborns or congenital deafness can be caused by the development of several parts of the auditory system. Congenital deafness is often associated with infections, such as Toxoplasmosis, Rubella, Cytomegalovirus (CMV), and Herpes (TORCH). Deafness is very difficult to be early detected. Therefore, simple but fast methods are needed. Early detection is based on the Newborn Hearing Screening (NHS) program. Otoacoustic Emission (OAE) and Automated Auditory Brainstem Response (AABR) checks are raw materials for early detection. Congenital deafness often occurs with pregnancy infections with viruses such as Rubella. Rubella infection during pregnancy, especially during the first trimester, often causes Congenital Rubella Syndrome (CRS). Rubella infection often occurs with other causes, such as Toxoplasma, CMV, and Herpes. A Serological test can be used as one of the diagnostics of this infection. This study used single Rubella IgG and IgM antibodies and double antibodies test as a marker for the infection. The authors wanted to correlate the serological examination of this infection with the auditory function. Rubella infection was detected with single serological anti-Rubella IgG and IgM and double multiple Rubella and TORCH serological tests. Also, the auditory function was assessed using the OAE and AABR test in this research. The result showed 35 (77.7%) patients with positive Rubella serological tests among 45 NICU patients at Dr. Soetomo Hospital. There were number of patients was 12 (34.2%) patients with a single positive serological test and 23 (65.7%) patients with positive multiple TORCH serological tests. The number of patients with Rubella negative infection was 10 (22.2%). There were 11 (31.4%) patients of positive Rubella infections with positive hearing loss and 24 (68.6%) patients with negative hearing loss. From the results of the study, 35 patients were at high risk of disturbance and the statistical analysis showed that there were no significant serological differences in Rubella positive with hearing loss (p=0.087). Hearing loss in NICU infants has a high risk of factors causing Rubella infection and other related causes. In most Rubella positive serological tests IgG was found, which can be due to maternal factors. Serology tests need to be repeated for confirmation under the surveillance program. How to follow-up the patients and define the next laboratory test after six months remain a great challenge. The efforts need to be strengthened in surveillance programs.
Correlation of malondialdehyde and hearing threshold level at frequency 4000 Hz post gunshot exposure Nyilo Purnami; Fauzi Helmi; Sri Herawati
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.283

Abstract

Background: The incidence of acoustic trauma after gunshot exposure in students of the SekolahPolisi Negara (SPN) is quite high. Malondialdehyde (MDA) is a compound that can portray oxidativestress due to free radicals. The correlation between the levels of MDA and the hearing threshold frequencypost gunshot exposure could be used as the base for administering antioxidants to prevent acoustictrauma. Objective: To find out the correlation between the levels of MDA and the hearing thresholdfrequency post gunshot exposure, in East Java SPN students. Method: An observational analytic studywith a retrospective cross sectional approach using secondary data of medical records of the East JavaSPN students batch 2017/2018. The samples were selected by simple random sampling. Result: Out of50 students, the mean of age was 19.62 years. All samples were male with mean 559.17 and standarddeviation (SD) 959.86. The calculation of the 4000 Hz frequency threshold value obtained an averagevalue of 31.52 and SD of 13.4. Hearing loss complaint was found in 1 student (2%). No complaints oftinnitus and vertigo were found. Statistical tests with Pearson correlation between serum MDA levels and4000 Hz frequency threshold values showed a correlation coefficient (r) of 0.74 and p = 0.00 (p<0.05).Conclusion: There was a significant correlation between MDA levels and the hearing threshold at 4000Hz frequency after gunshot exposure in East Java SPN students.Keywords: acoustic trauma, malondialdehyde, hearing threshold level at frequency 4000 HzABSTRAKLatar belakang: Insiden trauma akustik pasca pajanan letusan senjata api pada siswa Sekolah PolisiNegara (SPN) cukup tinggi. Malondialdehid (MDA) merupakan senyawa yang dapat menggambarkanstres oksidatif akibat radikal bebas. Adanya hubungan antara kadar MDA dengan nilai ambang dengarfrekuensi 4000 Hertz (Hz) dapat menjadi dasar pemberian antioksidan untuk pencegahan traumaakustik. Tujuan: Membuktikan hubungan antara kadar MDA dengan nilai ambang dengar frekuensi4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur. Metode: Penelitian ini adalahobservasional analitik dengan pendekatan retrospektif cross sectional menggunakan data sekunderberupa rekam medik siswa SPN Jawa Timur angkatan 2017/2018. Sampel dipilih secara simple random sampling. Hasil: Dari 50 siswa, usia rerata adalah 19,62 tahun. Seluruh sampel penelitian adalah laki-laki, rerata=559,17 dan standar deviasi (SD)=959,86. Penghitungan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil nilai rerata=31,52 dan SD=13,4 Keluhan penurunan pendengaran hanya dijumpai pada 1 siswa (2%). Uji statistik dengan korelasi Pearson antara kadar MDA dalam serum dengan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil koefisien korelasi (r) sebesar 0,74 dan p = 0,00 (p<0,05). Kesimpulan: Terdapat hubungan yang signifikan antara kadar MDA dengan nilai ambang dengar frekuensi 4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur.Kata kunci: trauma akustik, malondialdehid, nilai ambang dengar frekuensi 4000 Hz
The correlation between plasma reactive oxygen species and hearing threshold levels in presbycusis patients Nyilo Purnami; Anita Nuraini; Bakti Surarso
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.291

Abstract

Background: Presbycusis is a hearing loss due to the degeneration process in elderly people of 65 years old and beyond, characterized by a decrease in hearing sensitivity in both ears. Reactive oxygen species (ROS) are assumed to have an important role in the pathogenesis of presbycusis. Purpose: To find out the correlation between ROS levels in plasma and hearing threshold levels in presbycusis patients. Method: The design was cross sectional and conducted at the Outpatient Clinic of Neurotology Division, Geriatric Clinic, Clinical Pathology Installation, and Central Installation of Biomaterials Network Bank of Dr. Soetomo Hospital. Samples were taken by consecutive sampling for audiometric examination and measurement of ROS levels in plasma. Results: Fifty samples were collected, ROS levels in plasma were found with mean (SD) of 2.46 ng/ml (0.84). The mean hearing threshold level was 47.70 dB (12.42). The Pearson statistical test revealed a significant correlation between ROS levels in plasma and hearing threshold levels, with p=0.003 (p<0.05), and the correlation coefficient (r) 0.41. Conclusion: There was a correlation between ROS in plasma and hearing threshold levels in presbycusis patients, with a significant moderate-positive correlation pattern. It indicated that the higher the ROS levels in plasma, the higher the hearing threshold levels in presbycusis patients. Latar belakang: Presbikusis adalah gangguan pendengaran akibat proses degenerasi yang dijumpai pada usia 65 tahun atau lebih, ditandai oleh penurunan kepekaan pendengaran pada kedua telinga. Reactive oxygen species (ROS) diduga mempunyai peran penting pada patogenesis  presbikusis. Tujuan: Untuk mengetahui hubungan antara kadar ROS dalam plasma dengan nilai ambang dengar pada penderita presbikusis. Metode: Penelitian ini adalah cross sectional, dilakukan di Unit Rawat Jalan (URJ) THT-KL Divisi Neurotologi, URJ Geriatri, Instalasi Patologi Klinik, dan Instalasi Pusat Biomaterial Bank Jaringan RSUD Dr. Soetomo. Sampel diambil secara consecutive sampling. Diperoleh 50 sampel untuk dilakukan pemeriksaan audiometri dan pengukuran kadar ROS dalam plasma. Hasil: Kadar ROS dalam plasma didapatkan hasil rerata (SD) 2,46 ng/ml (0,84). Nilai ambang dengar didapatkan hasil rerata (SD) 47,70 dB (12,42). Hasil uji statistik dengan korelasi Pearson terhadap kadar ROS dalam plasma dan nilai ambang dengar didapatkan hasil koefisien korelasi (r) sebesar 0,41 dan p=0,003 (p<0,05). Kesimpulan: Terdapat hubungan antara kadar ROS dalam plasma dengan nilai ambang dengar pada penderita presbikusis dengan pola hubungan bersifat positif-sedang yang signifikan, yang berarti semakin tinggi kadar ROS dalam plasma, semakin tinggi nilai ambang dengar.
Hearing impairment in hemodyalisis patients with hypertension and diabetes mellitus type-2 Nyilo Purnami; Nunuk Mardiana; Sabrina Izzattisselim; Alfarika Rosmalia; Makhmudyah Indri Cahyani
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.396

Abstract

Background: Sensorineural hearing loss could occur in chronic kidney disease (CKD) patients undergoing hemodyalisis. In general, the frequency of hearing impairment in CKD is connected with age and gender, and with associated disorders such as hypertension and diabetes mellitus. Purpose: To find out the incidence of hearing loss (HL) in CKD patients with hypertension and diabetes mellitus who were undergoing hemodialysis, in Dr. Soetomo General Hospital. Method: This was an observational descriptive study. Subjects were all CKD patients who were undergoing hemodialysis from June until December 2019 in Dr. Soetomo General Hospital. Subjects were categorized demographically and the hearing impairment was examined with audiometric examination and otoacoutic emission test. Result: From 52 samples, there were 31 female and 21 male, with the ratio 1.5:1. The highest age group was in 31-40 years old, and the average was 47 years old. Hemodialysis CKD patients with hypertension were 46 subjects, 14 patients with normal hearing and 32 patients had hearing impairment: mild HL 25 patients, moderate HL 5 patients and moderate-severe 2 patients. Hemodialysis CKD patients with DM type-2 were 12 subjects, 3 patients with normal hearing, and 9 patients had hearing impairment: mild HL 4 patients, moderate HL 4 patients, and moderate-severe HL 1 patient. Conclusion: In this study, female hemodyalisis patients were more than male, and the highest age group was between 31-40 years old. Hearing impairment in CKD subjects with hypertension were mostly mild HL, while in CKD subjects with DM type-2 were mostly mild and moderate HL.ABSTRAK Latar belakang: Tindakan hemodialysis yang dilakukan pada penderita penyakit ginjal kronis (PGK) dapat menyebabkan gangguan pendengaran tipe sensorineural. Perlu dikembangkan penatalaksanaan gangguan pendengaran terkait hemodialisis. PGK dan gangguan pendengaran secara umum berhubungan dengan usia dan jenis kelamin, serta penyakit yang sering menyertai PGK seperti hipertensi dan diabetes mellitus. Tujuan: Mendapatkan angka kejadian gangguan pendengaran pada penderita PGK yang menjalani hemodialisis, dengan disertai hipertensi dan diabetes mellitus (DM) di RSUD. Dr. Soetomo. Metode: Disain penelitian ini adalah deskriptif observasional dengan sampel semua penderita PGK yang dilakukan hemodialisis di RSUD Dr Soetomo yang memenuhi kriteria inklusi. Sampel yang diambil berdasarkan data demografi kemudian dilakukan pemeriksaan audiometri dan otoacoustic emission. Hasil: Didapati penderita PGK perempuan sebanyak 31 orang dan laki-laki 21 orang, dengan rasio 1,5:1. Kelompok usia terbanyak adalah 31-40 tahun, dan rerata usia penderita 47 tahun. Pasien PGK yang dihemodialsis dengan disertai hipertensi ada 46 subjek, 14 orang tanpa gangguan pendengaran dan 32 orang mengalami gangguan pendengaran: derajat ringan 25 penderita, derajat sedang 5 penderita, dan derajat sedang-berat 2 penderita. Pasien PGK yang dihemodialisis dengan DM type-2 ada 12 orang: tanpa ganguan pendengaran 3 orang, gangguan pendengaran derajat ringan 4 penderita, derajat sedang 4 penderita,dan derajat sedang-berat 1 penderita. Kesimpulan: Penderita PGK jenis kelamin perempuan lebih banyak daripada laki-laki. Kelompok usia terbanyak adalah 31-40 tahun. Sebagian besar pasien PGK dengan HD mengalami gangguan pendengaran derajat ringan. PGK yang disertai hipertensi terbanyak mengalami gangguan pendengaran derajat ringan, sedangkan yang disertai DM yaitu derajat ringan dan derajat sedang.Kata kunci: gangguan pendengaran, hipertensi, diabetes mellitus tipe 2, penyakit ginjal kronis,hemodialisis
A survey of Indonesian otolaryngologist behavior in medical service during the CoVid-19 pandemic Indra Zachreini; Jenny Bashiruddin; Susyana Tamin; Harim Priyono; Ika Dewi Mayangsari; Respati Ranakusuma; Natasha Supartono; Fikri Mirza Putranto; Dewo Aksoro; Selfiyanti Bimantara; Yussy Afriana Dewi; Kote Noordhianta; Bintang Napitupulu; Sagung Rai Indrasari; Nyilo Purnami; Tengku Siti Hajar Haryuna; Juliandi Harahap; Eka Savitri; Tjandra Manukbua
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.444

Abstract

Background: World Health Organization (WHO) announced a newly discovered virus that first identified in Wuhan, China on December 2019, namely SARS-CoV-2 as the cause of corona virus disease (COVID-19) which had become global pandemic. Doctors as medical practitioners are categorized as vulnerable group to be infected by corona virus, and many otorhinolaryngologists had been infected and even died in performing medical services. Among the causative factors why otorhinolaryngologists could get infected by corona virus is their behavior. Purpose: To assess the behavioral level of otorhinolaryngologists in medical services during Covid-19 pandemic. Method: Descriptive study with a cross sectional design. Research samples were otorhinolaryngologists in Indonesia who met the inclusions criteria. The samples were selected by consecutive sampling method, and obtained 1299 subjects. Behavioral level was assessed from 3 aspects: knowledge, attitude, and practice, which comprised of 12 questions. Result: It was found that 461 respondents had a good behavioral level (35.5%), 677 respondents had moderate levels (52.1%) and 161 respondents had low level (12.4%). There was a statistically significant correlation between knowledge with behavioral level, attitude with behavioral level, and practice with behavioral level (p=0.001). Conclusion: The study of behavioral level of otorhinolaryngologists in medical service during Covid-19 pandemic obtained the highest number was moderate level 677 respondents (57.2%), and there was a statistically significant correlations between the variable of knowledge with behavioral level, the variable of attitude with behavioral level, and the variable of practice with behavioral level (p=0.001).ABSTRAK Latar belakang: Organisasi kesehatan dunia (WHO) mengumumkan virus baru yang pertama kali muncul di Wuhan China, pada Desember 2019, yaitu SARS-CoV-2 sebagai penyebab corona virus disease 19 (Covid 19) dan menyatakan sebagai pandemi. Dokter sebagai tenaga kesehatan merupakan kelompok yang rentan terinfeksi virus corona dan berdasarkan laporan, sudah banyak dokter Telinga Hidung Tenggorok - Bedah Kepala Leher (THT-KL) yang terinfeksi bahkan meninggal dunia dalam pelayanan medis. Salah satu faktor penyebab dokter THT-KL terinfeksi oleh virus corona adalah tingkat perilaku dokter THT-KL. Tujuan: Mengetahui tingkat perilaku dokter THT-KL dalam melakukan pelayanan medis saat pandemi Covid 19. Metode: Penelitian deskriptif dengan rancangan studi potong lintang. Sampel penelitian adalah dokter THT-KL di Indonesia yang memenuhi kriteria inklusi. Teknik pengambilan sampel secara berurutan, dan mendapatkan 1299 sampel. Tingkat perilaku dinilai dari 3 aspek yaitu dimulai dari pengetahuan, sikap dan tindakan yang terdiri dari 12 pertanyaan. Hasil: Didapatkan tingkat perilaku responden dokter THT-KL dalam pelayanan medis pada pandemi Covid 19, tingkat perilaku baik sebanyak 461 responden (35,4%), tingkat sedang 677 responden (52,1%), dan tingkat kurang 161 responden (12.4%). Terdapat hubungan yang signifikan antara pengetahuan dan tingkat perilaku, sikap dengan tingkat perilaku dan tindakan dengan sikap perilaku (p=0,001). Kesimpulan: Didapatkan tingkat perilaku dokter THT-KL dalam pelayanan medis pada pandemi covid 19, terbanyak adalah tingkat perilaku sedang sebanyak 677 responden (57,2%), dan terdapat hubungan yang bermakna antara variabel pengetahuan dengan tingkat perilaku, variabel sikap dengan tingkat perilaku dan variabel tindakan dengan tingkat perilaku dokter THT-KL dalam pelayanan medis pada pandemi Covid 19, dimana nilai p = 0,001. Kata kunci: perilaku, dokter THT-KL, pandemic, Covid-19
Differences in the Development of Language and Social Independence in Children with Speech Delay and Sensorineural Hearing Loss based on the Age for Early Intervention and the Duration of Auditory-Verbal Therapy Zamrotu Iva Purwanti; Achmad Chusnu Romdhoni; Ahmad Suryawan; Nyilo Purnami; Ninuk Dwi Ariningtyas
Folia Medica Indonesiana Vol. 59 No. 4 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v59i4.51495

Abstract

Highlights : This study explored the significance of auditory-verbal therapy as an early intervention for children with speech delay and sensorineural hearing loss, a topic that deserves further research in developing countries such as Indonesia. The findings highlight the significance of age and therapy duration on the language development of children with speech delay and sensorineural hearing loss. AbstractSpeech delay is primarily attributed to sensorineural hearing loss, which may significantly impact a child's language development and social independence. Consistent and periodic auditory-verbal therapy as an early intervention has the potential to positively influence language development, thereby fostering independence in children. The objective of the research was to examine the differences in the development of language and social independence among children who have speech delay and sensorineural hearing loss at the children's age for early intervention and with the duration of auditory-verbal therapy taken into consideration. The research employed an analytical-observational design with a cross-sectional approach and total sampling. The sample comprised 29 children who were undergoing the weekly routine of auditory-verbal therapy at Yayasan Aurica, Surabaya, Indonesia. The tool utilized in this study was the Pre-Screening Developmental Questionnaire. The data underwent bivariate analysis, specifically using the Chi-squared test with a significance level set at a p-value of <0.05. The language development analysis resulted in a p-value of 0.013 for the age variable and a p-value of 0.019 for the therapy duration variable. Meanwhile, the social independence analysis yielded a p-value of 0.229 for the age variable and a p-value of 0.111 for the therapy duration variable. In conclusion, the influence of age on early intervention had a significant difference from that of the duration of auditory-verbal therapy on the language development of children with speech delay and sensorineural hearing loss. Conversely, age and therapy duration did not exert any meaningful difference in terms of their influence on the children's social independence development.
RECCURENT LARYNGEAL PAPILLOMA Purnami, Nyilo; Fathoni, Rizka
Indonesian Journal of Tropical and Infectious Disease Vol. 3 No. 1 (2012)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (963.253 KB) | DOI: 10.20473/ijtid.v3i1.196

Abstract

A case of respiratory papillomatosis was reported. The patient suffered from the disease since eight months old with chief complaint progressive hoarseness and dyspnea. It was diagnosed with respiratory papillomatosis and scheduled for performing tracheotomy and continued with the first microlaryngeal surgery (MLS). Decanulation was taken after 2nd surgery of removing papillomas. Finally was reported she got serial of surgery for 22 times during 18 years of age. It was costly and deteriorating quality of life. The problem remains persisted because of frequent recurrences and need for repetitive surgeries. Specimen biopsy for histologic examination was shown the signs of HPV infection, papilomatic coated squamous epithel with mild dysplasia and coilocytosis. The threatening of upper airway obstruction is the main important reason for patient's coming. The patency of airway assessed by Direct Laryngoscopy then the next treatment was decided with schedule of Micro Laryngeal Surgery (MLS). Finally the MLS treatment is just only for temporarilyrecovery. A further research to define the proper treatment in the future is required, especially for prevention of the diseases related to the viral causes of infection.
POLYMERASE CHAIN REACTION AND SEROLOGY TEST TO DETECT RUBELLA VIRUS IN CONGENITAL RUBELLA SYNDROME PATIENTS WITH HEARING LOSS Izzattisselim, Sabrina; Purnami, Nyilo
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 1 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i1.8735

Abstract

Rubella infections in pregnant women, especially during the first trimester, often lead to manifest as congenital rubella syndrome (CRS). This syndrome consists of several inherited disorders such as deafness, cataracts, and cardiac abnormalities. Deafness is the most common manifestation of CRS, 70-90% of all cases with deafness type are sensory neural deafness. The mechanism of hearing loss due to rubella virus is caused by hypoxia resulting from endothelial vascular damage in cochlea, followed by cell death in the organ of Corti and stria vascularis.Cochlea's stria damage makes alterations in the composition of endolymph. This study aimed to confirm rubella infection using PCR and serological tests in patients with CRS who were clinically deaf. A suspected CRS reported was a 2-month-old patient with an unclear response to surround sound. The patient had been already diagnosed with congenital cataracts before. Prenatal, perinatal and postnatal history was evaluated. Hearing screening was done by OAE (Biological), and AABR (Beraphone). Anti-rubella IgM and IgG was obtained from blood serum. PCR was carried out from a throat swab and the eye-lens specimen. OAE and AABR results ‘refer' to both sides of the ear indicated a sensorineural hearing loss. The serological examination of IgM was positive with an index of 15.00 and IgG rubella positive with a titer> 500 IU / ml. Positive results from the rubella virus were identified from the throat swab and lens specimens using the PCR method. Detection of rubella virus in CRS sufferers with clinical deafness of both ears gives positive results using PCR and serology methods. In the future PCR can be potential for prenatal diagnosis of rubella virus aimed at the provision of early prevention.
Co-Authors A Ratna Kartika M, A Ratna Ahmad Suryawan Ahyandi, Syarif Syamsi Airina, Andi Alda, Rieza Rizqy Aldri Frinaldi Alfarika Rosmalia Alfian nurfaizi Alfian Nurfaizi Alfian Nurfaizi Aminuyati Anggina Diksita Anita Nuraini Aristya, Meutia Putri Artono Artono Artono, Artono Asmaradianti, Aryunidya Aulia Sakinah Awalia, Awalia Ayuning Tetirah Ramadhani Baiq Dwi Hadiatul Azni Belanny Dwi Desihartati Berliana Nur Azizah Bintang Napitupulu Brahmono, Aditya Budi Utomo Budi Utomo Cahyani, Makhmudyah Indri Chriscelia Valery So Chriscelia Valery So Cintya Dipta Crysciando Jefryco Putra Dewo Aksoro Eddy Bagus Wasito Edith Frederika, Edith Eka Savitri Eka Savitri Falerina, Rosa Fauzi Helmi Fikri Mirza Putranto Firdha, Azizah Amimathul Fis Citra Ariyanto Galih, Antonius Ghaus, Akbar Hamam, Kusumagani Haryuna, Tengku Siti Hajar Hendra Kurnia Rakhma Hendra Kurnia Rakhma I'tishom, Reny Ika Dewi Mayangsari Ilmi, Avida Marisa Inayasari, Syahwina Indira Syahraya Indra Zachreini Indra Zachreini Izzattisselim, Sabrina Jenny Bashiruddin Jenny Bashiruddin Juliandi Harahap Juliandi Harahap Kote Noordhianta Lelyana Sih Afgriyuspita Mahesya, Alvian Wahyu Mahrus A Rahman, Mahrus A Makhmudyah Indri Cahyani Makhmudyah Indri Cahyani Martono Martono Mayangsari, Ika Dewi Myrna Adianti Narottama, Kadek Rama Natasha Supartono Natasha Supartono Ni Made Adnya Suasti Nico Probosutejo Ninuk Dwi Ariningtyas Nugroho, Puguh Setyo Nuniek Nugraheni Nunuk Mardiana, Nunuk Nuraini, Anita Nuramalia, Lady Sherly Nurdiansyah, Achmad Fajar Putra Nurvita, Rani Nurwasis Nurwasis Paulus Liben, Paulus Perdana, Rizka Fathoni Prabowo, Gwenny Ichsan Pralampito, Fajrinka Priyono, Harim Probosutejo, Nico Pudji Lestari Puspa Wardhani Puspita, Dwi Indah Rahma, Safira Respati Ranakusuma Respati Ranakusuma Retno Handajani Risa Etika, Risa Rizka Fathoni Perdana Rizka Fathoni, Rizka Romdhoni, Achmad Chusnu Rosydiah Rahmawati, Rosydiah S.Pd. M Kes I Ketut Sudiana . Sabrina Izzattisselim Sagung Rai Indrasari Sagung Rai Indrasari Salsabila, Aisyah Nur Saputri, Faradila Budi Selfiyanti Bimantara Septriana, Maya Sholehen, Alif Sofia Tiarini Sri Herawati Sriati Sriati Suhariningsih Sulistiawati Sumarman Sumarman Surarso, Bakti Susyana Tamin Susyana Tamin Tiarini, Sofia Tjandra Manukbua Tjandra Manukbua Ummi Imamatal Muttaqin WINARTO Wungu, Citrawati Dyah Kencono Yoga Rahmadiyanto Yoga Rahmadiyanto Yoga Rahmadiyanto Yussy Afriana Dewi Yussy Afriana Dewi Zamrotu Iva Purwanti Zuhria, Ismi