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Kadar Kolesterol Total Tikus Hiperkolesterolemia dengan Pemberian Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas (L.) Lam) Siti Fatimah; Desto Arisandi; Meirina Sindi Saputri
Journal of Health (JoH) Vol 5 No 1 (2018): Journal of Health - Januari 2018
Publisher : LPPM STIKES Guna Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (991.809 KB) | DOI: 10.30590/vol5-no1-p33-39

Abstract

The increase in total cholesterol level increases the risk of cardiovascular disease. Sweet potato leaves are a food that contains polyphenols, flavonoids, quercetin, tannin, and fiber that effectively lower total cholesterol levels. This study aims to analyze the effect of ethanol extracts of leaf purple sweet potato on serum total cholesterol levels of rats fed a high-fat diet. An experimental study with design pre and posttest carried out on 10 male Wistar rats (Rattus norvegicus) fed a high-fat, which are 2 groups: 1 group the control hypercholesterolemia and 1 group ethanol extracts of leaf purple sweet potato. Dose based on leaves of quercetin that is equal to 2 mg/kgBB. The average content of quercetin ethanol extracts of leaf purple sweet potato was analyzed to obtain 14,08 mg/100g. Ethanol extracts of leaf purple sweet potato are given for 14 days by way of on the sonde. Serum total cholesterol was determined by the CHOD-PAP method. The data obtained were analyzed descriptively.The result of this study obtained the average total cholesterol level of white blood rats before giving ethanol extracts of leaf purple sweet potato that is 189,89 mg/dl, whereas after administration of ethanol extracts of leaf purple sweet potato dose 2 mg/kgBB that is 131,92 mg/dl. The decrease in total cholesterol level of white rats after giving ethanol extracts of leaf purple sweet potato with dose 2 mg/kgBB that is 30,52 %.
Edukasi Online Menurunkan Nyeri Dismenore di Masa Pandemi Covid-19 Chentia Misse Issabella; Febry Heldayasari Prabandari; Yustina Ananti; Desto Arisandi
Journal of Health (JoH) Vol 9 No 1 (2022): Journal of Health (JoH) - Januari 2022
Publisher : LPPM STIKES Guna Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/joh.v9n1.423

Abstract

During menstruation, young women sometimes experience menstrual pain which is called dysmenorrhea. Dysmenorrhea can be fatal if not handled properly because it can interfere with daily activities. With the Covid-19 outbreak, the prevalence of dysmenorrhea in female adolescents in Sleman Regency has increased, causing discomfort and anxiety. Based on the results of a survey that was conducted in June-August 2020 in Sleman Regency, as many as 254 young women had experienced menstruation and it was found 186 young women (73,22%) experienced dysmenorrhea. This study aims to determine the effect of online education on reducing dysmenorrhea pain in female adolescents in Sleman Regency in 2020. This study used a Quasy experimental method. The sample used 142 young women and was divided into 2 groups with a simple random sampling technique. Statistical test using the Mann-Whitney test. The results of this study showed a decrease in dysmenorrhea pain in young women who had been given online education by four-level, while those without education decreased by one level. The results of the study show the difference between providing online education with those without education on the reduction of dysmenorrhea pain on the first-month p-value 0,000 < α= 0,05 and on the second month p-value 0,000 < α= 0,05 in Sleman Regency in 2020. It is hoped that young women can provide treatment for dysmenorrhea pain reduction with online knowledge has been obtained.
Deteksi Filariasis Bancrofti dengan Filariasis Test Strip (FTS) dan Perilaku Pencegahan Gigitan Nyamuk di Desa Endemis Filariasis Amban Manokwari Papua Barat Nurlaili Farida Muhajir; Hieronymus Rayi Prasetya; Novyan Lusiyana; Desto Arisandi
BALABA: JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA Volume 16 Nomor 1 Juni 2020
Publisher : Balai Penelitian dan Pengembangan Kesehatan Banjarnegara Badan Litbangkes Kemenkes RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (367.452 KB) | DOI: 10.22435/blb.v16i1.2457

Abstract

Mass Drug Administration (MDA) of filariasis in Amban, the endemic area of filariasis, was carried out since 2016. The treatment target of the filariasis area is the area with the microfilaria rate (Mf rate ≥ 1%). The purposes of this study were to detect Wuchereria bancrofti antigens after 3 years of mass treatment and to find out the environmental characteristic and preventive behavior from mosquito bites in Amban the endemic filariasis village Manokwari, West Papua. This observational analytic study was conducted in Amban by examining the subject with the AlereTM Filariasis Strip Test (FTS) and questionnaires collection on 56 research subjects. Respondents were taken capillary blood and followed by tracking environmental and behavioral data of questionnaires. The data obtained was performed by bivariate analysis. The result showed that 56 respondents were negative for W. bancrofti filarial antigen (Mf rate 0%). Research subjects were dominated by the age range of adults, moderate education, and unemployment. The subjects living environment 58.9% far from the garden and 57.1% far from standing water. Preventive behavior from mosquito bites showed that 44.1% use wire ventilation; 44.6% use repellent; 19.6% do not do an outdoor activity at the night; 39.3% use mosquito nets; 28.6% do not do habits of hanging clothes. The level of education was related to the behavior to use repellent (p = 0.025).
Efektivitas Infusa Daun Talok (Muntingia calabura) dalam Menghambat Pertumbuhan Bakteri Klebsiella pneumoniae Fitri Nadifah; Desto Arisandi; Siti Fatimah; Dani Setiawan
Jurnal Nasional Teknologi Terapan (JNTT) Vol 2, No 3 (2018): NOVEMBER
Publisher : Penelitian dan Pengabdian Kepada Masyarakat Sekolah Vokasi Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.005 KB) | DOI: 10.22146/jntt.44933

Abstract

Klebsiella pneumoniae is one of the most bacteria found in urine of Urinary Tract Infection (UTI) Patients. Study in many countries has found that this species become resistant to more than one antibiotics. This research goal is to know the effectiveness of talok (Muntingia calabura) infused water inhibiting the growth of K. pneumoniae. This was an experimental study using K. pneumoniae bacteria isolated from urine samples using diffuse agar method. The concentration of talok infused water was varied from 25-100% and the antibiotics used was cefotaxime, meropenem and chloramphenicol. The inhibition activity was measured by the diameter of inhibition zone. The results show that K. pneumoniae is still give sensitive response to antibiotic treatments. While the inhibition zone from talok infused water treatments can be categorized in middle and strong activity. From this study we can conclude that talok infused water potential in inhibiting the growth of K. pneumoniae. Future study still needed to develop this potential, especially for the bacteria that has been resistant to some antibiotics.
Potensi Ekstrak Kulit Buah Pisang Kepok (Musa Paradisiaca) sebagai Antihiperkolesterolemia Desto Arisandi; Siti Fatimah; Aldina Yunika; Larasati Adristya Damayanti; Muhammad Jumardi; Rahma Fadhilian Achmad
Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat 2022: Prosiding Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat (SNPPKM 2022)
Publisher : Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (78.112 KB) | DOI: 10.35960/snppkm.v2i1.1169

Abstract

Peningkatan kadar kolesterol di dalam darah (hiperkolesterolemia) merupakan salah satu faktor risiko yang paling utama terhadap kejadian penyakit jantung koroner (PJK). Ekstrak kulit pisang kepok kuning mentah mengandung senyawa antioksidan yaitu flavonoid, alkaloid, tanin, triterpenoid, dan saponin yang diketahui dapat menurunkan kadar kolesterol di dalam darah. Jenis penelitian menggunakan true experiment dengan rancangan pretest dan posttest with control group design. Subyek penelitian yaitu tikus putih (Rattus norvegicus) sebanyak 15 ekor yang dibagimenjadi 3 kelompok (kontrol negatif, kontrol positif, dan perlakuan). Dosis pemberian ekstrak kulit buah pisang kepok kuning mentah yaitu 600 mg/kgBB/hari selama 14 hari. Kadar kolesterol total diperiksa menggunakan metode CHOD-PAP pada spektrofotometer. Data penelitian dianalisis menggunakan paired t-Test dengan bantuan program STATA for Windows version 12.0. Hasil penelitian menunjukkan rata-rata kadar kolesterol total tikus putih sebelum pemberian ekstrak kulit buah pisang kepok kuning mentah dosis 600 mg/kgBB/hari yaitu 191 mg/dL dan setelah pemberian ekstrak selama 14 hari yaitu 119 mg/dL. Pemberian ekstrak kulit buah pisang kepok kuning mentah bermakna secara statistik (P < 0,001) dapat menurunkan kadar kolesterol total tikus sebesar 72 mg/dL (38%). Ekstrak kulit buah pisang kepok kuning mentah memiliki potensi sebagai kandidat obat atihiperkolesterolmia.
Potensi Ekstrak Serai Wangi (Cymbopogon nardus (L.) Rendl.) sebagai Larvasida Nyamuk Aedes aegypti Fitri Nadifah; Desto Arisandi; Siti Mahmuda
Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat 2022: Prosiding Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat (SNPPKM 2022)
Publisher : Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.455 KB) | DOI: 10.35960/snppkm.v2i1.1170

Abstract

Demam Berdarah Dengue (DBD) merupakan salah satu permasalahan kesehatan masyarakat utama di seluruh daerah tropis, termasuk Indonesia. Nyamuk Aedes aegypti merupakan perantara utama penularan penyakit DBD. Salah satu cara untuk mengendalikan jumLah nyamuk adalah menggunakan larvasida. Serai wangi (Cymbopogon nardus (L.) Rendle) merupakan tanaman yang tersebar di banyak wilayah di Indonesia dan berpotensi sebagai larvasida alami karena mengandung sejumLah zat aktif, terutama sitronela dan geraniol. Tujuan penelitian ini adalah untuk mengetahui kematian larva nyamuk Ae. aegypti dengan perlakuan berbagai konsentrasi ekstrak batang serai wangi. Penelitian ini bersifat deskriptif menggunakan ekstrak serai wangi dengan konsentrasi 4%, 8%, 12%, 16% dan 20%. Sebagai kontrol negatif, digunakan air keran. Dua puluh larva nyamuk Ae. aegypti digunakan sebagai subyek penelitian pada masing-masing perlakuan. Pengamatan kematian larva dilakukan setiap 30 menit sekali selama 2 jam. Kontrol negatif dan konsentrasi terendah ekstrak tidak mengakibatkan kematian larva (0%), sedangkan konsentrasi 8% menghasilkan 40% kematian larva. Pada konsentrasi ekstrak 12%, 16% dan 100%, seluruh larva mati setelah perlakuan 2 jam. Konsentrasi ekstrak minimum yang efektif dapat mengakibatkan 50% kematian larva adalah 12%. Dari penelitian ini dapat disimpulkan bahwa ekstrak batang serai wangi memiliki potensi sebagai larvasida dan menggantikan larvasida konvensional dengan mengikuti standar etika yang telah ditetapkan.
IDENTIFIKASI IMMUNOGLOBULIN MIU (IgM) IMMUNOGLOBULIN GAMMA (IgG) ANTI SALMONELA PADA SERUM PASIEN DEMAM TIFOID DI PUSKESMAS GODEAN II, SLEMAN, YOGYAKARTA Yuliana Prasetyaningsih; Fitri Nadifah; Desto Arisandi; Dieta Dieon Saputri
GEMA KESEHATAN Vol. 12 No. 2 (2020): Desember 2020
Publisher : POLTEKKES KEMENKES JAYAPURA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47539/gk.v12i2.134

Abstract

Widal examination is a serological method to diagnose typhoid fever used by Godean II Public Health Center, Sleman Regency, Yogyakarta Special Region (DIY). However, this method is difficult to hold onto because there is no agreement on agglutination standards. A positive Widal test result is not necessarily typhoid fever. Therefore, the results really need to be confirmed by other supporting examinations. IgM anti Salmonella IgG rapid test is one of the serological tests to support the diagnosis of typhoid fever which has better sensitivity and specificity to handle specific antibodies against Salmonella typhi in serum. This study aims to examine the results of the serological test of Immunoglobulin Miu (IgM) Anti Salmonella gamma immunoglobulin (IgG) on positive widal samples at Godean II Public Health Center and to see the lowest positive widal titers IgM antisalmonella in the sample. This research is a descriptive study with accidental sampling technique. The method of examination used a rapid test immunochromatography to examine IgM IgG anti Salmonella typhi on positive widal serum samples at Puskesmas Godean II, Sleman, DIY. The results showed that 21.7% of the samples were positive IgG negative IgM; 8.7% of IgM samples were positive IgG positive, and 69.6% IgM negative IgG negative. Anti Salmonella IgM in widal positive samples appeared at titer 320. Anti Salmonella typhi IgM and IgG were detected in positive widal samples at Godean II Public Health Center. Immunoglobulin Miu (IgM) appears at titer 320.
Karakteristik Penderita Tuberkulosis Paru di Kabupaten Sleman, D.I.Yogyakarta Desto Arisandi; Wiwit Sugiarti; Rista Islamarida
Jurnal Formil (Forum Ilmiah) Kesmas Respati Vol 8, No 1 (2023)
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35842/formil.v8i1.470

Abstract

Indonesia merupakan negara yang menyumbang jumlah penderita TB tertinggi di dunia setelah India dan China.  Prevalensi TB secara regional terhadap penemuan kasus baru TB di DIY sejak tahun 2017 hingga 2019 mengalami peningkatan.  Penelitian ini bertujuan untuk mengetahui gambaran distribusi karakteristik penderita TB paru wilayah kerja puskesmas Kabupaten Sleman, D.I.Yogyakarta tahun 2021.Jenis penelitian deskriptif observsional dengan pendekatan cross sectional. Populasi penelitian yaitu penderita TB paru berusia ³ 15 tahun yang berada di 25 wilayah kerja puskesmas Kabupaten, Sleman, D.I.Yogyakarta pada periode Januari-Desember 2021.Hasil penelitian yaitu jumlah penderita TB paru di wilayah kerja puskesmas yang ada di Kabupaten Sleman, D.I.Yogyakarta tahun 2021 sebanyak 261 orang dengan karakteristik lebih banyak pada laki-laki (58,62%), usia 15-25 (24,14%), bekerja sebagai Non PNS/Swasta (32,18%), tipe TB dengan kategori kasus baru (81,23%), dan hasil pengobatan akhir dengan kategori sembuh sebanyak 127 orang (48,66%).
AKTIVITAS ANTIBAKTERI EKSTRAK DAUN LIDAH MERTUA (Sansivieria tirfasciata var.laurentii) TERHADAP BAKTERI Klebsilla pneumonia Fitriani, Audiah; Sawitri, Nining Eka; Khatrina, Syahdapuan Dara; Nadifah, Fitri; Arisandi, Desto
Journal of Indonesian Medical Laboratory and Science Vol 5 No 2 (2024): In Progress
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v5i2.217

Abstract

Background: Pneumonia is an acute infection of the lower respiratory tract characterized by coughing and shortness of breath caused by Klebsiella pneumoniae bacteria. Sansevieria contains flavonoids, saponins, alkaloids, and steroids known to have antibacterial properties that can destroy the bacterial cell walls.  Objectives: This study aimed to determine the antibacterial activity of Sansevieria leaf extract against the growth of K. pneumoniae.  Materials and Methods: Detection of antibacterial activity of Sansevieria was conducted with disc-diffusion test. The presence of antibacterial activity is indicated by the appearance of inhibition (clear) zone after applying the extract at a concentration of 60-100% to the culture medium. As a positive control, the antibiotic chloramphenicol was used.  Results: The higher the extract concentration, the higher the inhibition zone formed. The inhibition zone formed from extract concentrations of 60%, 70%, 80% is classified as medium (d = 8; 8.5; 9 mm). Meanwhile, the inhibition zones at concentrations of 90% and 100% are 10.5 and 13.5 mm and are classified as strong. The clear zone of the positive control was 29 mm (very strong). Conclusions: Sansevieria leaf extract has the potential to inhibit the growth of K. pneumoniae bacteria.
Efektivitas Ekstrak Kulit Rambutan (Nephelium lappaceum) Terhadap Penurunan Kadar Low Density Lipoprotein Nindhea Ferliza, Yoan; Katarina, Shinta; Dody Wibowo, Aldinol; Farida Muhajir, Nurlaili; Arisandi, Desto
Jurnal Medisains Kesehatan Vol. 5 No. 2 (2024): Jurnal Medisains Kesehatan
Publisher : Universitas Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59963/jmk.v5i2.333

Abstract

Dyslipidemia is a lipid component disorder characterized by increased levels of total cholesterol, Low-Density Lipoprotein (LDL), and triglycerides, as well as decreased levels of High-Density Lipoprotein (HDL). Rambutan is known to contain flavonoids, tannins, saponins, quercetin and alkaloids, which have the ability to lower blood cholesterol levels. The aim of the research was to determine the effect of giving rambutan peel extract to rats on reducing low density lipoprotein (LDL) cholesterol levels. This is a true experiment research with a pretest-posttest and control group design approach.  The research samples were 15 male rats aged 8-10 weeks and weighing 150-250 grams. The dose of rambutan fruit peel was given at 180 mg/kgBW/day for 14 days. LDL cholesterol levels were measured by a spectrophotometer using an enzymatic method. Data analysis used the paired t-test on STATA for Windows software version 12.0 with a confidence level of 95%. Average LDL cholesterol levels in rats before and after administration were 53 and 35 mg/dl, respectively. Giving rambutan skin extract at a dose of 180 mg/dl can reduce LDL cholesterol levels significantly (p < 0.001) by 18 mg/dl (33.9%) in rats
Co-Authors Aan Devianto Agustina Pangala Aldina Yunika Amelda Oktavianti Putri Anita Devi Iriyani Ardina Nugrahani Arif Tirtana Arum Nuryati Bolosan, Fabio Andre Bulu, Martinus Tagu Chentia Misse Issabella Clara Pattirane, Evelin Dani Setiawan Dapa Ole, Ericson Umbu Robaka De Jesus, Maria Carolina Denisa Hamam Dewi Rahadian, Titah Dieta Dieon Saputri Dody Wibowo, Aldinol Ellen Engelina Eltanina Ulfameytalia Dewi Famela Adelena, Fitria Farida Muhajir, Nurlaili Farindira Vesti Rahmasari Fatya Nurul Hanifa Febry Heldayasari Prabandari Fitri Nadifah Fitri Nadifah Fitri Nadifah Fitri Nadifah Fitriani, Audiah Fransisca Jean Clarine Rettob Fuadah Hidayat, Tsamrotul Hidayat, Tsamrotul Fuadah Hieronymus Rayi Prasetya I Ketut Swarjana Ivana Elga Yunia Katarina, Shinta Khatrina, Syahdapuan Dara Larasati Adristya Damayanti Lesmono, Inez Melani Lista Dwi Indriyani Maloko, Seprianto Maria Asih Triyanti Maria D. Owa Lobo Maria Theresia Doe Bay, Maria Theresia Doe Meirina Sindi Saputri Melani Lesmono, Inez Mosa, Rambu Pedi Muhammad Jumardi Nindhea Ferliza, Yoan Nono, Arianto Novita Sari Novyan Lusiyana Nurlaili Farida Muhajir Nurlaili Farida Muhajir Nurlaili Farida Muhajir, Nurlaili Farida Octiria, Nessa Puspita Dewi, Novita Rahma Fadhilian Achmad Rista Islamarida Rista Islamarida, Rista Saraswati, Farikhatun Nisaa Sawitri, Nining Eka Setyonugroho, Winny Simon Sanga Lamanepa Sismawati Sismawati Siti Fatimah SITI FATIMAH Siti Mahmuda Sofvirah R. Sohy Sofvirah R. Sohy, Sofvirah R. Subrata Tri Widada Subrata Tri Widada, Subrata Tri Susliyanti, Maria Syahrul Junianto Lintin Syeun Nurochman Syeun Nurochman, Syeun Tri Wulandari Kesetyaningsih Uswatun Chasanah, Siti Velisshia, Velisshia Wiwit Sugiarti Yesi Apriliasari Yesi Apriliasari, Yesi Yuliana Prasetyaningsih Yuliana Prasetyaningsih Yuliana Prasetyaningsih Yustina Ananti