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All Journal bionature As-syifaa Jurnal Farmasi Jurnal Mandala Pengabdian Masyarakat JOMPA ABDI: Jurnal Pengabdian Masyarakat Pharmaceutical Reports Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan

Safriani Rahman

Faculty Of Pharmacy, Universitas Muslim Indonesia, Makassar 90231, Indonesia

Author-ID : 512348

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L) PADA TIKUS PUTIH (Rattus norvegicus) DIABETES MELITUS YANG DIINDUKSI ALOKSAN DENGAN PARAMETER MALONDIALDEHID (MDA) Safriani Rahman; Rachmat Kosman; Inda Rahmaniar
As-Syifaa Jurnal Farmasi Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Hyperglycemia in Diabetes can caused the excessive production of Reactive Oxygen Species (ROS) in the body that will causes oxidative stress that tissue damage. Oxidative stress can indicated by increasing MDA levels. This research aims to know and determine the concentration ethanol extract of soursop leaves that have antioxidant activity to MDA levels in diabetic rats. 9 white rats were divided into 3 groups. All rats were induced by alloxan 110mg/Kg.BB intraperitoneally. Group I was administered with Na.CMC as a negative control, group II and III were administered with ethanol extract of soursop leaves 2,5% and 5%. Administration were given orally for 12 days orally. Examination of blood glucose and MDA levels conducted before and after the administration. MDA Assay performed with TBA method was based on reaction of MDA-TBA as measured on a spectrophotometer 532 nm wavelength. The results were analysized statistically by using randomized block design (RBD) method. Based on the research has been done, it was showed that the ethanol extract of soursop leaves can lower blood glucose levels of diabetic rats and extract with concentration of 5% has potential as an antioxidant activity that can reduce MDA levels in diabetic rat.

UJI EFEK HIPOGLIKEMIK EKSTRAK ETANOL BUAH SAWO MANILA (Manilkara zapota) PADA MENCIT JANTAN YANG DIINDUKSI ALOKSAN Aulia Wati; Safriani Rahman
As-Syifaa Jurnal Farmasi Vol 8, No 1 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Diabetes mellitus is a metabolic disorder of carbohydrate, fat and protein that is characterized of hyperglycemia. Manila sapodilla (Manilkara zapota) empirically has been used by people as a traditional medicine. This study aims to determine the hypoglycemic effects and an effective concentration of ethanol extract manila sapodilla fruit as hypoglycemic on male mice induced by alloxan. The group of test animals consisted of 25 mice balb / c males were divided into 5 groups. Negative control group Na.CMC suspension 1% w / v, the comparison group glibenclamide 0.65 mg/kgbw, and group 3, 4, and 5 are a group of ethanol extract manila sapodilla fruit (EBSM) at a doses of 250 mg/kgbw, 500 mg/kgbw, and 750 mg/kgbw. Before treatment all test animals alloxan induced a dose of 150 mg/kgbw intraperitoneally (i.p). Given the test preparation is done orally once daily for 21 days. Blood collection from tail vein of mice on day 1 (h- 3rd), -3, -7, -11, -14, -17 and days 21 during treatment. Measurement of blood glucose levels is done before induction as early glucose levels, glucose levels after induction as diabetes mellitus, and after the end of therapy as glucose levels. The results were analyzed statistically by t-test and one-way ANOVA. Results showed EBSM a dose of 250 mg/kgbw showed no significant different compared to glibenclamide suspension. From this study it can be concluded that manila sapodilla fruit extract has hypoglycemic effects with an effective dose of 250 mg/kgbw. Keywords : Hyperglycemia, Manilkara zapota, male mice, alloxan.

UJI AKTIVITAS IMUNOGLOBULIN M (IgM) EKSTRAK ETANOL HERBA RUMPUT MUTIARA (Hedyotis corymbosa) PADA MENCIT (Mus musculus) JANTAN DENGAN METODE HEMAGLUTINASI Safriani Rahman; Bayu Putra; Rachmat Kosman; Riska Mustika
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

A Research About Activity of Ethanol of Pearl Grass (Hedyotis corymbosa) On The Imunoglobulin M (IgM) by Hemaglutination Method Had Been Conducted of Male Mice. This research purpose to established of activity imunoglobulin M (IgM) from ethanol extract of pearl grass (Hedyotis corymbosa). Mice is animal that used for this research,The mice was divided into 4 treatment groups, where each group consisted of 3 mice. The first group as negative control, and each group was given Sheel Red Blood Cell (SRBC) 2 % as many 0,1 ml intraperitonially, after that negative control group was administrated with air sulingt, and other group was administrated with ethanol extract dose 26 mg, 78 mg, dan 130 mg for five days. The blood from all group was collected by intracardial after five days. The activity of imunoglobulin M (IgM) was measured by hemaglutination method based on titer of the imunoglobulin M (IgM) there was highest dilution of mice blood serum in which aglutination was showed. Research result showed Ethanol extract of Pearl Grass (Hedyotis corymbosa) at 26 mg, 78 mg, and 130 mg dose, can increased imunoglobulin M (IgM) activity.Key words : Imunoglobulin M, Hedyotis corymbosa, Hemaglutination Method

UJI EFEK EPITELISASI EKSTRAK BATANG WOLE WOE ASAL KABUPATEN HALMAHERA TENGAH TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS Safriani Rahman; Rachmat Kosman; Sitti Amirah
As-Syifaa Jurnal Farmasi Vol 14, No 1 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i1.792

Wole woe is a native plant of Indonesia which is widely used by the people of Central Halmahera as a medicinal plant. Empirically this plant is widely used for wound treatment. This study aims to determine the effect of epithelialization of wole woe stem extract and determine the effective concentration and duration of wound healing in rats after administration of wole woe stem extract. This research was conducted experimentally in a laboratory using 25 rats which were divided into 5 groups consisting of 1 control group, 1 comparison group, and 3 treatment groups of wole woe stem extract. Wound induction was carried out using a 100 0C hot plate measuring 2x2 cm and affixed to the surface of the rat's back skin for 2 seconds. After a burn is formed, the extract is applied 2 times a day for 21 days. Observations on wound healing were carried out macroscopically and measuring the surface area of the wound. The results showed that the administration of wole woe bark extract influenced healing second-degree burns in rats. The results of statistical analysis showed that there was no difference between the comparison group and the extract test group (p>0.05). Based on the percent reduction in wound, the most effective concentration in wound healing was 5% (99.75%). Wound healing time in rats was 21 days.

AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL BATANG WOLE WOE ASAL HALMAHERA TENGAH TERHADAP BAKTERI GRAM POSITIF Staphylococcus epidermidis DAN Staphylococcus aureus Fitriana Fitriana; Sitti Amirah; Safriani Rahman
As-Syifaa Jurnal Farmasi Vol 14, No 1 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i1.793

The wole woe plant is one of the plants empirically used by the Weda community in Central Halmahera district as a traditional medicine to treat various diseases such as breast cancer, cysts, vaginal discharge, diabetes mellitus, wounds, dysentery, cholesterol, and gout. Therefore, a study was conducted on the antimicrobial activity of the ethanolic extract of wole woe stems against gram-positive bacteria S. epidermidis and S. aureus with the aim of determining the concentration that provides antimicrobial activity of the ethanolic extract of wole woe stems by using the agar diffusion method. The results obtained in the screening test gave activity at a concentration of 0.1% and the results of the minimum inhibitory concentration test (MIC) and the minimum killing concentration test (MBC) obtained a MIC value of 1.6% for S. epidermidis bacteria and 0.8% for S. aureus bacteria, while the MBC value is 1.6% for both bacteria. The results of statistical tests on the diameter of the inhibition zone from the antimicrobial activity test against S. epidermidis and S. aureus, showed that there was a difference in the ability to inhibit bacterial growth between the positive control and the test concentration group of 2.5%, 5% and 10%. In the ratio of the inhibitory ability of bacteria at a spesific concentration, the test results showed that S. epidermidis bacteria had different bacterial growth inhibition abilities with S. aureus bacteria. Based on the results obtained, the ethanol extract of wole woe stems has potential as an antimicrobial.

UJI TOKSISITAS EKSTRAK ETANOL BATANG KAYU WOLE WOE TERHADAP LARVA Artemia salina Leach MENGGUNAKAN METODE Brine Shrimp Lethality Test (BSLT) Virsa Handayani; Safriani Rahman; Andi Nur Alam Amaliah
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.901

The Wole Woe plant is one of the plants that is empirically used as traditional medicine by the Weda community in Central Halmahera Regency. The stem part of the Wole Woe plant is used to treat various diseases. This study aims to determine the toxicity of Wole Woe logs using the Brine Shrimp Lethality Test (BSLT) method. This research was started by extracting Wole Woe logs using ethanol 70% solvent with the reflux method and then carried out phytochemical screening which showed that Wole Woe logs contained alkaloids, flavonoids, saponins, triterpenoids, and tannins compounds. Toxicity testing of Wole Woe wood stem ethanol extract against Artemia salina Leach larvae was divided into 5 test groups, namely 4 treatment groups (concentrations of 250 ppm, 500 ppm, 750 ppm, and 1000 ppm) and 1 control or comparison group (sea water). Each concentration was made in 3 vials containing 10 larvae of Artemia salina Leach. Observations were made by looking at the mortality of Artemia salina Leach larvae after 24 hours of treatment. The results of the study can be seen through probit analysis by calculating the LC50 value. The LC50 of the ethanol extract of Wole Woe logs is 453.942 ± 59.564 g/mL. This indicated that the ethanolic extract of Wole Woe logs had a toxic effect on Artemia salina Leach larvae because the LC50 value was< 1000 ppm

POTENSI ANTIBAKTERI EKSTRAK ETANOL BATANG WOLE WOE ASAL HALMAHERAH TENGAH TERHADAP BAKTERI Pseudomonas aeruginosa dan Bacillus subtilis MENGGUNAKAN METODE DIFUSI AGAR Fitriana Fitriana; Sitti Amirah; Safriani Rahman; Bayu Putra
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.904

The wole woe plant empirically in the community in Central Halmaherah district is used to treat various diseases, such as breast anticancer, cysts, vaginal discharge, diabetes mellitus, wounds, dysentery, cholesterol, and uric acid, which is thought to have bioactive compounds, that is antibacterial compounds. Therefore, a study was conducted to determine the antibacterial potential of the ethanol extract of wole woe stems against Pseudomonas aeruginosa and Bacillus subtilis bacteria using the agar diffusion method. The results of the screening test showed activity at a concentration of 0.1% and the results of the minimum inhibitory concentration test (MIC) and the minimum killing concentration test (MBC) obtained 1.6% for Pseudomonas aeruginosa bacteria. For Bacillus subtilis bacteria, the MIC value is 0.2% and the MBC value is 3.2%. The statistical test results of the inhibition zone diameter data from the antibacterial activity test against Pseudomonas aeruginosa and Bacillus subtilis bacteria showed that there was a difference in the ability to inhibit bacterial growth between the positive control and the test concentration group of 2.5%, 5% and 10%. The results obtained from the ethanol extract of wole woe stems have potential as antibacterial.

AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL BATANG WOLE WOE TERHADAP MIKROBA PATOGEN MENGGUNAKAN DIFUSI AGAR Fitriana Fitriana; Sitti Amirah; Safriani Rahman; Sukmawati Sukmawati
As-Syifaa Jurnal Farmasi Vol 15, No 1 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i1.967

Infectious diseases can be caused by the entry of microorganisms such as bacteria, fungi, parasites, and viruses that can cause diseases in humans. One of the plants used empirically by the Weda community in Central Halmahera is the stem part of the wole woe plant. The aim of this study was to determine the antimicrobial activity of the ethanol extract of wole woe stems against pathogenic microbes such as Propionibacterium acnes, Escherichia coli, Salmonella thypi, Shigella dysentriae, Vibrio cholerae, and Candida albicans. This study used the agar diffusion method with various concentrations of 2.5%, 5%, and 10%, and positive controls for bacteria with chloramphenicol, positive controls for fungi with nystatin, and DMSO as a negative control. Based on the average diameter of the inhibition zone obtained, the test microbes were classified into the medium-strong category because they had an inhibition zone diameter ranging from 9 mm to 13 mm. The positive control for chloramphenicol for bacteria was classified into the very strong category because it had an inhibition zone diameter of >20 mm, while the positive control for nystatin for fungi was classified into the strong category because it had an inhibition zone diameter of >10 mm. Based on these tests, it can be concluded that the ethanol extract of wole woe stems has antimicrobial activity

AKTIVITAS ANTIINFLAMASII EKSTRAK ETANOL BATANG WOLE WOE PADA TIKUS DENGAN METODE RAT HIND PAW EDEMA Safriani Rahman; Sitti Amirah; Fitriana Fitriana; Bayu Putra
As-Syifaa Jurnal Farmasi Vol 15, No 1 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i1.961

Inflammation is the natural protective response of the body to tissue damage brought on by toxic chemicals, microbiological organisms, or physical trauma. The purpose of this investigation is to find out how active the ethanol extract of Wole woe stem is and how much of it is needed to get results. This anti-inflammatory study was conducted on 15 rats using the rat hind paw edema method. The rats were divided into 5 groups: group I served as a negative control (Na.CMC), group II served as a positive control (diclofenac sodium 0.9 mg/kgBW), groups III, IV, V received doses of Wole woe stem ethanol extract ranging from 100 mg/kgBW to 400 mg/kgBW, respectively. Oral administration was used for all the test materials, and after an hour, each test animal received a subplantar injection of 0.1 milliliters of 1% carrageenan solution. A plethysmometer was used to take readings every hour for a period of eight hours to get an accurate reading of the volume of the rat’s foot. The collected test results were subjected to statistical analysis, in which a one-way ANOVA and a post hoc LSD test were used. According to the findings of the research that was carried out, it was discovered that an ethanol extract of Wole woe stems possessed anti-inflammatory action, and the most effective dose was found to be 400 milligrams per kilogram of body weight (mg/kgBW).

PEMBUATAN COOKIES SEHAT UNTUK PENDERITA KOLESTEROL DI DESA PADDINGING KECAMATAN SANROBONE KABUPATEN TAKALAR Fitriana Fitriana; Safriani Rahman; Sitti Amirah; Ayyub Harly Nurung
Jurnal Mandala Pengabdian Masyarakat Vol. 4 No. 1 (2023): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v4i1.150

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Co-Authors A Hasrawati Anak Agung Istri Sri Wiadnyani Andi Cassia Siamea Andi Emelda Andi Maulana Kamri Andi Nur Alam Amaliah Andi Salmah Rahmah Annisa Amaliah Aulia Wati Aulia Wati Ayyub Harly Nurung Aztriana Aztriana, Aztriana Bayu Putra Bayu Putra Bayu Putra Eka Mega Asariningtyas Ema Sukmawati Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Franita Achmad Hardianti Hardianti Inda Rahmaniar Kosman Rachmat, Kosman Mukrima Iva, Mukrima Mustari Mustari Rachmat Kosman Rachmat Kosman Rachmat Kosman Rahmatia S Hi Amin Ririn Ririn Riska Mustika Riyan Wulansari Puspa Seruni Sitti Amirah Vina Purnamasari M Virsa Handayani

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