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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL PHARMASCIENCE Chimica et Natura Acta Pharmacology and Clinical Pharmacy Research FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Current Research on Biosciences and Biotechnology Indonesian Journal of Biological Pharmacy
Ajeng Diantini, Ajeng
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Hypoglycaemic Properties of The Combination of Roselle Calyx (Hibiscus sabdariffa Linn.) and Stevia Leaves (Stevia rebaudiana B.) in Alloxan-Induced White Rats Febriyanti, Raden Maya; Putri, Refitha Nurul; Diantini, Ajeng; Levita, Jutti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59646

Abstract

Roselle (Hibiscus sabdariffa L.) and stevia (Stevia rebaudiana Bertoni) are known to contain phenolic compounds and flavonoids that act as antioxidants and are beneficial in lowering blood sugar levels. This study aimed to determine the phytochemical content and evaluate the hypoglycemic effects of a combined aqueous extract of H. sabdariffa and S. rebaudiana in a 3:1 ratio on diabetic rats. Aqueous extracts were prepared and analyzed for total phenolic and flavonoid contents using the Folin-Ciocalteu and aluminum chloride methods. Diabetes was induced in male Wistar rats by intraperitoneal injection of alloxan (235 mg/kgBW). Rats in the test groups received 500 or 1000 mg/kgBW of the combination, with blood glucose levels measured on the 0th, 7th, and 14th days post-treatment using a glucometer. H. sabdariffa, S. rebaudiana, and their combination contained total phenolic contents of 102.75, 188.053, and 118.856 mgGAE/g, respectively, and flavonoid contents of 3.099, 6.987, and 4.791 mgQE/g, subsequently. Administration of the combination extract at 1000 mg/kgBW showed the highest hypoglycemic effect, reducing blood glucose levels by 35.98% on the 14th day compared to the negative control (p<0.05). The combination of H. sabdariffa and S. rebaudiana extracts demonstrates significant hypoglycemic activity, attributed to their phenolic and flavonoid content.
Co-Authors Amalia, Riezki Anggraeni, Sra R. Anjabtsawa, Daffa Budhi Prihartanto Destiani, Dika P. Effendi, M. Fariz Euis Julaeha Fattah, Miswar Febrianti, Raden M. Febriyanti, Maya Hadad, Nur Diana HANIFAH, SYIFA Ibrahim, Susannia Ida Musfiroh, Ida Intan Barliana, Melisa Intania, Ruri Irma M. Puspitasari, Irma M. Jutti Levita Keri Lestari Listiani, Nita Melisa Intan Barliana, Melisa Intan Mirdayani, Eli Moelyono Moektiwardoyo, Moelyono Moelyono, M W Moelyono, M W Nadiya Nurul Afifah Nur Rahayuningsih, Nur Putri, Norisca A. Putri, Norisca A. Putri, Refitha Nurul Putu Dian, Putu Raden Maya Febriyanti Rahmayanti, Annisa N. Rindarwati, Asti Y. Rizky Abdulah Rochjana, Anna Uswatun Hasanah Rudi Supriyadi Sahidin, Idin Siagian, Bryan J. Sinuraya, Rano K. Sinuraya, Rano K. Sitepu, Rini Daud Sofa D. Alfian, Sofa D. Sri Adi Sumiwi Suwantika, Auliya A. Taofik Rusdiana Tati Herlina Taufik, Adit Tri Mayanti Wibisono, Aditya Seiza Yasmiwar Susilawati Yoppi Iskandar Yulisar, Riza