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All Journal The Indonesian Biomedical Journal Paediatrica Indonesiana Acta Biochimica Indonesiana Jurnal Biomedika dan Kesehatan Majalah Kedokteran Neurosains Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal SOSIOEDUKASI : JURNAL ILMIAH ILMU PENDIDIKAN DAN SOSIAL Muhammadiyah Journal of Geriatric Indonesian Journal of Medical Chemistry and Bioinformatics Neurona Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Ninik Mudjihartini
Department Of Biochemistry And Molecular Biology, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : World Nutrition Journal

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Serum Lactate Dehydrogenase Activity and Its Corellation with Carbohydrate Intake in Advanced Lung Cancer Patients claresta diella; Ninik Mudjihartini; Diana Sunardi; Dian Novita Chandra; Yulhasri Yulhasri; Achmad Mulawarman Jayusman
World Nutrition Journal Vol. 2 No. 2 (2019)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V02.i2.0002

Abstract

Introduction : The aim of this study was to determine serum lactate dehydrogenase activity and its correlation with carbohydrate intake in advanced lung cancer patients at Dharmais National Cancer Hospital Jakarta. Cancer Cells are characterized by increase anaerobic glycolysis termed the Warburg effect with lactate as an end product, catalyzed by LDH enzyme. Activities of lactate in cancer influences on tumor growth initiation, survival, proliferation, angiogenesis and metastasis. Serum LDH activity can be used as a diagnostic, prognostic, and predictive marker for tumor sensitivity and resistancy to therapy.Methods :56 subjects of advanced lung cancer from Dharmais National Cancer Hospital Jakarta were included in this cross sectional study. Subjects were recruited by consecutive sampling. Food intake of total carbohydrate was obtained by utilizing 24 hours food recall method. The activity of  serum LDH (IU/L) was measured by using enzymatic spectrophotometry method on automated analyzer.Results :The mean of age subjects was 56,98 ± 10,36 years old and 55,4% were male. Carbohydrate intake based on 24 hours food recall was 57,64 ± 10,85%. The median of LDH activity was 541,5 (164–6539) IU/L, 60,7% was increase.Conclusion :This study showed medium negative significant correlation (p = 0,017, r = - 0,317) between total carbohydrate intake per day in grams with LDH serum activity. If carbohydrate source is reduced, the LDH enzyme will increase to keep the glycolysis process going. The results of this study indicate that an adequate carbohydrate needed in patients with cancer.
Correlation Between Docosahexaenoic Acid Intake and It’s Content in Breast Milk of Lactating Mothers in Jakarta Raphael Kosasih; Ninik Ninik Mudjihartini; Saptawati Bardosono
World Nutrition Journal Vol. 3 No. 1 (2019): Volume 03 Issue 1 Include Supplements Oral Presentation Abstracts of 14th Sympo
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V03.i1.0005

Abstract

Objective: Docosahexaenoic acid (DHA) is the predominant structural fatty acid in the brain and one of the most important nutrient for cognitive development in early life. During early life, there is very limited metabolic capability to convert omega-3 fatty acids to DHA. Therefore, newborn intake of DHA completely depends on preformed DHA in mother’s breast milk. This study aims to determine DHA intake among lactating mothers and their association with breast milk’s DHA.Method: This cross-sectional study was conducted in Grogol Petamburan and Cilincing Public Health Centre in Jakarta. Eighty healthy lactating mothers aged 20–35 years old in 1–6 months postpartum was taken using consecutive sampling method. Mother’s DHA intake was assessed with a semiquantitative food frequency questionnaire. Post-feed breast milk specimens were collected in the morning, transported with cool boxes, and stored in the laboratory at -70° C before the analyses. Breast milk DHA content was analysed using Gas Chromatography with Mass Spectrometry. Descriptive analyses and Spearman rho test was used with a 95% confidence level.Result: This study showed the median of subjects’ DHA intake was 158.5(13.9–719.7) mg/day, i.e. 67.5% of the subjects was below Food and Agriculture Organization (FAO) recommendation (200 mg/day). The median of breast milk DHA was 51.7(19–184.7) mg/day, only 42.5 % of the subjects had breast milk DHA to meet the minimal requirement of their infant based on FAO recommendation (0.1% of total energy requirement). There was a moderate correlation between subject DHA intake with breast milk’s DHA content (r = 0.478, p < 0.001).  Conclusion:  More than half of the subjects had DHA intake below FAO recommendation. Our finding showed a positive moderate correlation between DHA intake and breast milk DHA among lactating mothers.
Correlation between Serum Hugh Sensitivity C-Reactive Protein With Dietary Intake of Indonesian Lactating Mothers Karin Wiradarma; Diana Sunardi; Ninik Mudjihartini
World Nutrition Journal Vol. 3 No. 1 (2019): Volume 03 Issue 1 Include Supplements Oral Presentation Abstracts of 14th Sympo
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V03.i1.0008

Abstract

Background and Objectives:Chronic low-grade inflammation has emerged as important pathophysiology of non-communicable diseases, which can cause negative effects to mother and baby. Dietary intake has been known as important factor to affect inflammation, which can be measured by high-sensitivity C-reactive protein (hs-CRP). This study aimed to examine the correlation between serum hs-CRP with dietary intake in lactating mothers.Methods:A cross-sectional study was conducted by consecutively enrolling 71 lactating mothers, 3-6 months post-partum, age 20-35 years old, visiting Grogol Petamburan and Cilincing community health center between February and April 2019. Dietary assessment was conducted using semi-quantitative food frequency questionnaire. Anthropometric measurements included were pre-pregnancy weight, post-partum weight, and body height. Serum hs-CRP was measured by immunoturbidimetry method. Spearman correlation was used, with p<0.05 considered significant.Results:Correlation was found between serum hs-CRP and energy (r = 0.372, p = 0.001), carbohydrate (r = 0.295, p = 0.013), and vitamin B6 (r = -0.285, p = 0.016) intake. We also found that serum hs-CRP was correlated with pre-pregnancy (r = 0.296, p = 0.012) and post-partum BMI (r = 0.430, p<0.001).Conclusion:Energy, carbohydrate, and vitamin B6 intakes are positively correlated with serum hs-CRP level.
Vitamin E and Vitamin C Intake Among Lactating Mothers In Jakarta Sheira Taflah Putri Handana; Diyah Eka Andayani; Ninik Mudjihartini
World Nutrition Journal Vol. 3 No. 1 (2019): Volume 03 Issue 1 Include Supplements Oral Presentation Abstracts of 14th Sympo
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V03.i1.0009

Abstract

Background and ObjectivesVitamin E is a lipid soluble vitamin which obtain only through diet. Vitamin E has many functions including antioxidant and well known to prevent lipid peroxidation in membrane cell. Vitamin C helps to regenerate vitamin E back into non radical. Vitamin E and C intake among vulnerable group such as lactating mother still uncleared especially in Jakarta. The aim of this study to determine level of vitamin E and C intake among lactating mothers in JakartaMethods60 lactating mothers aged 20–40 years old in 1–6 months postpartum were recruited on Grogol Petamburan and Cilincing Public Health Centre in Jakarta. This cross sectional study held from March 2019 until April 2019. Vitamin E and C dietary intake were collected with semi quantitative food frequency questionnaire. Descriptive analysis was used in this study.ResultsThis study showed that median value  of vitamin E intake was 6.50 (1.20-43.10) gram/day with 91.7% subjects does not meet vitamin E recommended daily intake (RDA) recommendation (19 gram/day), otherwise 70% vitamin C intake was above RDA recommendation (100 gram/day) with median value is 120.05 (23.0-479.2) gram/day.ConclusionVitamin E intake among lactating mothers in Jakarta was not adequate and far below RDA recommendation but vitamin C intake among lactating mothers in Jakarta was adequate and met RDA recommendation.
Correlation Between Docosahexaenoic Acid Intake and It’s Content in Breast Milk of Lactating Mothers in Jakarta Raphael Kosasih; Ninik Mudjihartini; Saptawati Bardosono
World Nutrition Journal Vol. 3 No. 2 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V03.i2.0006

Abstract

Objective: Docosahexaenoic acid (DHA) is the predominant structural fatty acid in the brain and crucial for cognitive development in early life. Newborn DHA intake completely depends on preformed DHA in mother’s breast milk. In advancing years, globalization has been declining the fish intake of Asian countries. This study aims to determine DHA intake among lactating mothers in Jakarta and its association with breast milk’s DHA.Method: This cross-sectional study was conducted in Grogol Petamburan and Cilincing Public Health Centers, Jakarta. Eighty healthy lactating mothers aged 20–35 years old in 1–6 months postpartum were taken using consecutive sampling method. Characteristics data were taken by interviews and DHA intake was assessed with the semiquantitative food frequency questionnaire. Breast milk specimens were collected in the morning and its DHA content was analyzed using Gas Chromatography with Mass Spectrometry. Descriptive analyses and Spearman rho test were used with a 95% confidence level.Result: This study showed the median of subjects’ DHA intake was 158.5(13.9–719.7) mg/day, i.e., 67.5% of the subjects was below Food and Agriculture Organization (FAO) recommendation. The median of breast milk DHA was 51.7(19–184.7) mg/day, only 42.5 % of the subjects had breast milk DHA to meet the minimal requirement of their infant. A moderate positive correlation was found between maternal DHA intake with breast milk DHA (r = 0.478, p < 0.001). Conclusion:  Maternal DHA intake has moderate positive correlation with breast milk DHA, more than half of the subject had DHA intake below FAO recommendation.
Low Dietary Omega-6 to Omega-3 Fatty Acid Intake Ratio Enhances Adiponectin Level in Obesity Helena Fabiani; Ninik Mudjihartini; Wiji Lestari
World Nutrition Journal Vol. 5 No. 1 (2021)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.i1.0005

Abstract

Every year around the world, the prevalence of obesity is increasing. Obesity and its associated diseases have become some of the most pressing health problems in developed and developing countries. In its development, adipocytes dysfunction and chronic low-grade inflammation occur in obesity will stimulate diseases at higher risk including type 2 diabetes mellitus (T2DM), atherosclerosis, hypertension, and metabolic syndrome. Western diet and sedentary lifestyle are thought to have significantly contributed to the increase in obesity recently. Diet modification is a sound method to prevent obesity and its complications. Nevertheless, the concern lies in the ratio of omega-6 towards omega-3 fatty acids intake, which in its current state indicates an imparity. Omega-3 and omega-6 are two essential fatty acids that emerge as dominant factors in obesity through adiponectin. Adiponectin refers to a protein hormone conceived by adipocytes to prevent obesity and its subsequent complications by increasing insulin sensitivity, fatty acid oxidation, anti-inflammatory, and antiaterogenic. This study aims to determine the mechanism and the role of fatty acids in omega-6 towards those within omega-3 by using adiponectin as the indicator of advancement to obesity and its underlying diseases.
Dietary Fiber's Effect on High Sensitivity C-reactive Protein Serum in Sedentary Workers Livia Kurniati Saputra; Dian Novita Chandra; Ninik Mudjihartini
World Nutrition Journal Vol. 5 No. 1 (2021)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.i1.0006

Abstract

Low grade inflammation has been recognized of being involved in the pathogenesis of chronic disease pandemic. Individual lifestyle plays a major role in the development of low grade inflammation. Sedentary workers are at risk of low grade inflammation due to the nature of their work. Dietary habit also contributes to inflammatory status in the body. Dietary fiber intake indirectly affects the immune system. It has been hypothesized that fiber has anti-inflammatory effects, both body weight-related and body weight-unrelated This review will focus more on body weight-unrelated anti-inflammatory effect of fiber, especially through fiber’s fermentation metabolites, the short chain fatty acid (SCFA). Its anti-inflammatory effect can be seen by monitoring a biomarker of inflammation in the body, the high sensitivity C-reactive protein (hsCRP). This review’s objective is to cover the mechanisms and role of dietary fiber intake on serum hsCRP level as a marker of low grade inflammation on sedentary workers. 
Association between apolipoprotein B and dietary fibers Almira Devina Gunawan; Saptawati Bardosono; Ninik Mudjihartini
World Nutrition Journal Vol. 4 No. 2 (2021): Volume 04 Issue 2, August 2021
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.i2.0010

Abstract

Introduction Global awareness to the importance of natural fibers in vegetables and fruits are still generally very low. Indonesian people consume less fibers, which has been associated with the development of heart disease. Heart disease has been known as the leading cause of morbidity and mortality. Apolipoprotein B (ApoB) is a component of atherogenic particles that can be used as a marker for an increased risk of cardiovascular disease. Researches on apoB profile and its relationship with fiber intake has provided inconsistent results. This is an article review of the current literatures on the relationship between dietary fiber and serum apoB levels. Methods: This is an article review of the current literatures on the relationship between dietary fiber and apoB. We searched PubMed and Google Scholar using keyword “dietary fibers” and “ApoB” to capture meta-analyses, observational and experimental studies. A total of 97 publication and abstracts were screened for this review. After careful screening, nine studies were finally included. Results: Two studies did not find associations between dietary fiber and serum apoB, while other seven found the association. Dietary fiber has been reported to be involved in the metabolism of serum cholesterol and blood pressure; hence, the deficiency of dietary fiber intake is believed to contribute to the epidemic of cardiovascular diseases. Several factors including nutritional status, dietary diet pattern, age, gender, physical activity, and smoking habits might influence the relationship between dietary fiber and serum apoB. Conclusion: More studies are required in the future for better understanding on the effect of dietary fiber on the apoB; hence, the risk of cardiovascular diseases.
Effect of intermittent fasting on fat mass and fat free mass among obese adult: A literature review Hadiyati Fudla; Ninik Mudjihartini; Helda Khusun
World Nutrition Journal Vol. 4 No. 2 (2021): Volume 04 Issue 2, August 2021
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.i2.0008

Abstract

Introduction Obesity is a serious hurdle facing by the world nowadays. Even though so many efforts have been done, yet the prevalence is keep rising. Intermittent fasting is seen as an effective and optimal approach for improving nutrition status without undesirable side effect. Objective to identify the effect of intermittent fasting on fat mass and fat free mass among obese adult. Methods: a literature exploration was conducted from January to October 2020 by searching the relevant studies from several databases. Results: many human clinical trials recommended that IF affects beneficial on body composition and body weight. Consuming calorie only in a certain time frame per day for 4-12 months put the body into a fast metabolism which influence the reduction of fat mass from 0.03–16.4% intervention and increasing of fat free mass for around 0.64 to 0.86%. Conclusion: intermittent fasting may reduce fat mass and increase fat free mass in obese adult through the reduction of energy intake (fasting) and the benefit to adipose tissue, liver, pancreas, skeletal muscle, and the brain.
Zinc as an inhibitor of NMDA receptor can exhibit antidepressant effect Novi Dewi Tanjung; Ninik Mudjihartini
World Nutrition Journal Vol. 6 No. 2 (2023): Volume 06 Issue 2, February 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.i2.0006

Abstract

Background : New antidepressant strategies are needed, due to unsatisfactory clinical efficacy and many side effects of commonly used drugs. Recent studies linking the pathophysiology of depression with glutamatergic imbalance. There is hyperactivity of the main excitatory system (glutamatergic) to its inhibition (GABAergic). N-methyl D-aspartate (NMDA) receptors as a part of glutamatergic synapses are potential targets for intervention. Antagonist administration for glutamatergic systems, such as zinc, can exhibit antidepressant effects. Objective : To observe the effect of zinc administration on NMDA receptors in depressed subjects Methods : In this paper, we provide a literature review. The method to achieve the objective consists of using literature exploration, which was conducted from February to June 2022 by searching the relevant studies from several databases. Results : Study trials both in human and animal subjects reveal that depression is associated with a lower concentration of zinc. Comparison between the lowest zinc intake with the highest zinc intake had significantly lower incidence of developing depression. Dietary zinc deficiency induces depression along with upregulation of the NMDA receptor complexes. Zinc’s antidepressant effects might be mediated through its action reducing NMDA channel-opening frequency. Conclusions : The presence of zinc may downregulate the glutamate response in binding to NMDA receptors. Because of numerous studies about the connection between zinc and depression, it seems that zinc may have the potency to develop new antidepressants. Since the capability of zinc administration to reduce depressive symptoms, it is expected leading to increased medication adherence, lower costs and better outcomes.
Co-Authors Abd. Rasyid Syamsuri Achmad Mulawarman Jayusman Ahmad A. Jusuf Ahmad Aulia Almira Devina Gunawan Andriani Andriani Ani Retno Prijanti Astrid Mariam Khairani Siregar Chandra, Dian Novita claresta diella Devana, Natasha Dianasari Diana Sunardi Diyah Eka Andayani Diyah Eka Andayani Ekawati, Maria Endrico Xavierees Erni Purwaningsih Estiana Filzadiyanti Febriana Catur Iswanti Hadiyati Fudla Hajar, Siti Sarah Harmelia, Dwi Helena Fabiani Ika Superti Daruningrum Inge Permadhi Jusman, Sri Widia Azraki Karin Wiradarma Khusun, Helda Krisnamurti, Desak G.B. Livia Kurniati Saputra Mohamad Sadikin Mohamad Sadikin Mohamad Saekhu Muchtaruddin Mansyur Mulyana Mulyana Nani Dharmasetiawani Novi Dewi Tanjung Nurdina, Nazlah Nurhadi Ibrahim Nurul Ratna Mutu Manikam Pratiwi, Issabella Nisrina Pratiwi, Sandi Puspita Prawirohajo, Pukovisa Pungguri Ayu Nega Sarsanti Purwaningsih, Erni H. Purwosunu, Yuditiya Rahmawaty Ridwan, Rahmawaty Raphael Kosasih Ratna, Nurul Ray Sugianto, Ray Reni Paramita Reni Paramita Ria Andreinie Rini Sekartini Rita Lahirin, Rita Sadikin, Abdul Halim Saptawati Bardosono Saptawati Bardosono Setyarini, Indah Bachti Sheira Taflah Putri Handana Sheira Taflah Putri Handana Sianipar, Imelda M. Siti Farida Sri W.A. Jusman Sri Widia A Jusman Wahyu Ika Wardhani Wawan Mulyawan Widia AJ, Sri Wiji Lestari Wiji Lestari Wiwoho, Yudi Yuwono Yulhasri Yulhasri