Article Per Year (5 Year)
p-Index From 2021 - 2026
5.031
P-Index
This Author published in this journals
All Journal Damianus Journal of Medicine The Indonesian Biomedical Journal Paediatrica Indonesiana Acta Biochimica Indonesiana Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Biomedika dan Kesehatan Majalah Kedokteran Neurosains Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal SOSIOEDUKASI : JURNAL ILMIAH ILMU PENDIDIKAN DAN SOSIAL Eureka Herba Indonesia Journal SAGO Gizi dan Kesehatan Muhammadiyah Journal of Geriatric Indonesian Journal of Medical Chemistry and Bioinformatics Eduvest - Journal of Universal Studies Neurona Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Ninik Mudjihartini
Departemen Biokimia Dan Biologi Molekuler, Fakultas Kedokteran, Universitas Indonesia, Jakarta, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 36 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 36 Documents
Search

 1   2   3   4 
The mTOR and total protein levels of stunted children Andreinie, Ria; Mudjihartini, Ninik; Chandra, Dian Novita; Sekartini, Rini
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.26-36

Abstract

Background Malnutrition is still a major health problem for children, with stunting being one of its manifestations. Human growth is in part controlled by the mammalian target of rapamycin (mTOR) pathway. Studies reviewing mTOR level and growth disorders in children are still limited and no research has described mTOR levels in stunted children in Indonesia. Objective To assess for a relationship between mTOR and total protein levels in blood plasma in stunted children aged 6-24 months and compare these levels with those in non-stunted children. Methods This case-control study was conducted in South Sumatra Province, Indonesia. Subjects were children aged 6-24 months. The inclusion criteria for the case group are children who have a length-for-age of <-2SD and the control group are children who have a body length according to age of more than or equal to -2 SD from the WHO growth standard chart. Anthropometric measurements were plotted on the WHO Growth Standards chart, while mTOR and total protein levels were measured using an ELISA method and spectrophotometry, respectively. Results Of 142 subjects, 71 children were allocated into each case and control group. Child characteristics that were significantly different between the two groups were age (P=0.002), birth length (P=0.012), weight-for-age Z-score (WAZ) (P<0.001), and body mass index (BMI) (P=0.015). WAZ status with the categories underweight and severely underweight had a higher risk of stunting. The mTOR and total protein levels between the two groups were not significantly different. Conclusion Further research is needed to explain the mechanism of mTOR signal deviations in children's growth and development, as mTOR and protein levels are not significantly different in stunted and non-stunted children.
Peran reseptor nuklear pada implantasi dan perkembangan blastokista Endrico Xavierees; Ninik Mudjihartini
Jurnal Biomedika dan Kesehatan Vol 4 No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2021.v4.37-46

Abstract

Syarat penting untuk terjadinya kehamilan, yaitu blastokista pada fase tertentu siap melakukan implantasi dan proliferasi endometrium, sehingga menjadi reseptif terhadap embrio untuk melakukan implantasi. Pada tahap selanjutnya, masih terdapat proses molekular yang berkesinambungan sampai pada akhirnya terjadi hubungan langsung antara blastokista dan dinding endometrium dengan membentuk plasenta. Implantasi yang tidak efisien tentunya akan menyebabkan kegagalan implantasi, sehingga muncul masalah infertilitas. Sebanyak 30% kasus kegagalan kehamilan disebabkan oleh masalah kesehatan embrio. Pemahaman yang lebih mendalam mengenai sinyal-sinyal yang berperan pada kedua proses berkesinambungan tersebut diharapkan dapat memberikan metode terapi yang baru pada kasus infertilitas, sehingga meningkatkan jumlah kehamilan.
Review literatur: Pengaruh media booklet dalam edukasi gizi pada pasien malnutrisi Siska Amelia; Wina Sinaga; Ninik Mudjihartini
Jurnal SAGO Gizi dan Kesehatan Vol 5, No 3A (2024): Agustus
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v5i3A.1741

Abstract

Background: Management of malnourished patients involves a process of nutritional counseling and education with the aim of increasing knowledge, food intake and nutritional status to help improve the patient's health.  As a form of non-video media, booklets contain educational material accompanied by graphic illustrations to help understand malnutrition patients.Objectives: This article aims to conduct literature reviews that explains the influence of booklets as a communication medium in the process of nutritional counseling and education and its impact on malnourished patients.Methods: The research design is of literature review on English language articles between 2013-2023, which were published in the most reputable journals in the field of nutrition (Nutrition Science) with the highest H-5 index. Search for articles via the internet from the PubMed database using the keywords malnutrition OR nutrition counseling OR nutrition education OR nutrition communications OR nutrition media OR nutrition booklet. To complete the results data, a search was also carried out for relevant Indonesian language literature to support elaboration and analysis.Results: 26 articles have been obtained discussing topics in the scope of malnutrition, nutritional counseling and education as well as related to the use of booklets as a media for nutritional education. Various previous research results state that selecting communication media and understanding the theory of changing individual health attitudes and behavior is an important part of the nutritional education and counseling process, where medical personnel must be able to build effective communication with malnourished patients. Booklets are a concise and practical communication medium for patients to read again, so they are proven to increase the effectiveness of patients' learning experiences and understandingConclusion: Booklets are an effective non-video media option and have a positive impact on improving the nutritional status of malnourished patients. It is recommended that stakeholders in health sector maximize the use of booklet media in nutritional counseling and education activities to help reduce the problem of malnutrition in Indonesia. 
Nutrient Intake Profile Among Children Aged 6–24 Months in Indonesia: A Descriptive Analysis Nurdina, Nazlah; Chandra, Dian Novita; Mudjihartini, Ninik; Sekartini, Rini
World Nutrition Journal Vol. 9 No. S1 (2025): Vol. 9 No. S1 (2025): Selected conference proceedings of the Nutri Symposium 2
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V09.S1.0024

Abstract

Background: Adequate nutrient intake in early childhood is critical for growth, cognitive development, and immune function. The first two years of life are a sensitive period where nutritional deficiencies may lead to long-term consequences. However, many children in low- and middle-income countries fail to meet dietary needs due to limited diversity and poor feeding practices. Objectives: To describe the intake of energy, macronutrients, and key micronutrients among Indonesian children aged 6–24 months
Urinary PYD/Creatinine Ratio Has Negative Correlation to Serum 25(OH)D and Positive Correlation to Chronic Lead Exposure Index Hajar, Siti Sarah; Mudjihartini, Ninik; Manikam, Nurul Ratna Mutu; Mulyana, Mulyana; Mansyur, Muchtaruddin
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3174

Abstract

BACKGROUND: The burden of disease due to lead exposure continues to increase. Lead interferes with 25(OH)D hydroxylation and calcium transport, increasing osteoclastic activity and bone resorption. Pyridinoline crosslinks (PYD), as an indicator of bone damage, can be seen earlier compared to imaging changes. Therefore, it is necessary to determine the correlation between serum 25(OH)D levels and the urinary PYD/creatinine ratio in workers exposed to lead, since up to now, there are only limited studies related to it.METHODS: This cross-sectional study involved 104 workers exposed to lead, selected from parents whose children had blood lead levels above 10 µg/dL. Questionnaires and physical examination were performed to obtain characteristic data from subjects. Data regarding blood lead levels, serum 25(OH)D levels, urinary PYD levels, and urinary creatinine levels were also obtained from various laboratory methods.RESULTS: Most subjects (86.5%) had inadequate serum 25(OH)D. Median blood lead levels was 6.3 (1.2-35.5) µg/dL, chronic lead exposure index was 35.3 (1.2-535.8) years µg/dL, serum 25(OH)D levels was 22 (8-52) ng/mL, and urinary PYD/creatinine ratio was 5.3 (3.6-28.1)×10-6. There was a significant negative correlation between serum 25(OH)D levels and urinary PYD/creatinine ratio in workers exposed to lead. There was also a significant positive correlation between chronic lead exposure index and the urinary PYD/creatinine ratio.CONCLUSION: Since urinary PYD/creatinine ratio is correlated with serum chronic lead exposure index and serum 25(OH)D levels, it suggests that pyridinoline might be a potential biomarker to detect bone metabolism disorder due to the chronic lead exposure. Vitamin D adequacy is also an important factor in preventing bone metabolism disorder amidst chronic lead exposure.KEYWORDS: 25(OH)D, bone resorption, pyridinoline, lead, worker
Intermittent Exposure to Hypobaric Hypoxia Increases VEGF, HIF-1α, and Nrf-2 Expressions in Brain Tissue Wardaya Wardaya; Dewi Sukmawati; Nurhadi Ibrahim; Frans Ferdinal; Ninik Mudjihartini; Mohamad Sadikin; Sri Widia A. Jusman; Irawan Satriotomo; Wawan Mulyawan
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3519

Abstract

BACKGROUND: Hypoxia inducible factor-1α (HIF-1α), nuclear factor erythroid 2-related factor 2 (Nrf-2), and vascular endothelial growth factor (VEGF), play a crucial role as neuroprotective factors. Currently, there is a lack of studies examining the biomolecular responses of the brain to intermittent hypoxia resulting from various pressures. This study was conducted to investigate the physiological responses, histopathological features, and cellular adaptive responses in the brains of rats that were intermittently exposed to hypobaric hypoxic conditions.METHODS: Thirty male Sprague Dawley rats were divided into six groups: a control group and five treatment groups exposed to hypobaric hypoxia. The treatment groups were placed in a hypobaric chamber simulating an altitude of 3,048 meters for 1 hour/day for 1, 7, 14, 21, and 28 days. After exposure, brain tissue was collected for histopathological analysis and protein quantification of HIF-1α, Nrf-2, cytoglobin (Cygb), neuroglobin (Ngb), VEGF, malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT).RESULTS: In the brain, intermittent hypobaric hypoxia significantly increased HIF-1α expression (p=0.000) and its downstream proteins Cygb (p=0.000), and VEGF (p=0.001), with a peak at 14x IHH exposure compared to control. This was followed by a significant increase in Nrf-2 expression (p=0.000), SOD (p=0.000), Gpx (p=0.000), and CAT activity (p=0.000), indicating an adaptive antioxidant response. Conversely, MDA levels was decreased with prolonged exposure, suggesting reduced oxidative damage.CONCLUSION: IHH elevates HIF-1α, Nrf-2, and oxidative stress markers, triggering an adaptive antioxidant response in the rat’s brains.KEYWORDS: HIF-1α, intermittent hypobaric hypoxia, Nrf-2, oxidative stress
Hyperbaric Oxygen Therapy for Traumatic Brain Injury: A Review Of History, Development, Current Techniques, and Future Directions Wiwoho, Yudi Yuwono; Sadikin, Abdul Halim; Jusuf, Ahmad Aulia; Mulyawan, Wawan; Mudjihartini, Ninik; Ibrahim, Nurhadi; Jusman, Sri Widia A.; Sadikin, Mohamad
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.321

Abstract

Hyperbaric oxygen therapy (HBOT) has gained increasing attention as a potential adjunctive treatment for traumatic brain injury (TBI) patients. This narrative review discusses the historical background, current preclinical and clinical studies, and explores its underlying mechanisms from biomolecular, histological, and clinical perspectives. HBOT promotes neural recovery by improving oxygenation, preserving mitochondrial integrity, enhancing neurotrophic support and synaptic connectivity, mitigating secondary injury pathways (including oxidative stress, inflammation, and apoptosis), and promoting angiogenesis and vascular stability. These mechanisms have demonstrated improvements of motor, cognitive, and memory functions both in preclinical and clinical studies, although outcomes and treatment protocols vary. However, challenges remain regarding optimal protocols, patient selection, and adverse effects. Further high-quality clinical trials are required to define the optimal HBOT regimen are required.
Vitamin D and COVID-19: Insight on Mechanism and Implementation in Equatorial Countries Indah Bachti Setyarini; Nurul Ratna; Ninik Mudjihartini
Majalah Kedokteran Indonesia Vol 71 No 2 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.2-2021-354

Abstract

Coronavirus disease 2019 (COVID-19) is a global pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection, affecting millions of people worldwide due to its ease of transmission. Despite limited information on effective therapeutic options, vitamin D has been regularly reported to exert beneficial immunomodulatory effects affecting both innate and adaptive immune systems. As it is synthesized in the skin under ultraviolet radiation, population living in equatorial countries are presumed to have adequate vitamin D, however several studies have shown otherwise. This article is aimed to give an insight on the different mechanisms by which vitamin D affects our immune system in COVID-19, as well as discussing correlation of having sunlight all year round by being near the equator towards vitamin D adequacy.
Peptida Antimikrobial Cathelicidin dan Hubungannya terhadap Vitamin D dalam Masa Pandemi COVID-19 Natasha Dianasari Devana; Ninik Mudjihartini
Majalah Kedokteran Indonesia Vol 72 No 6 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.6-2022-923

Abstract

A peptide known as antimicrobial peptide (AMP) possesses antimicrobial effects against bacteria, fungus and viruses. AMP, also known as Host Defense Protein (HDP), is one of the body's defense mechanisms since it has the capacity to actively kill viruses. When it comes to respiratory cells, which are the major target of the SARS CoV-2 virus that produces COVID-19, cathelicidin, a kind of AMP in humans, is known to have protective properties. Cathelicidin AMP performance represents the first-line action of the natural immune system, with cathelicidin synthesis linked to appropriate vitamin D levels. Numerous earlier studies have discovered a connection between low cathelicidin levels and low vitamin D levels; this underlines the significance of vitamin D levels in strengthening the immune system. Naturally, particularly for the production of cathelicidin, which serves as the body's primary line of defense during the COVID-19 pandemic.
THE RELATIONSHIP BETWEEN VITAMIN D INTAKE AND PLASMA C-REACTIVE PROTEIN LEVELS AND APPENDICULAR SKELETAL MUSCLE INDEX IN ADULTS WITH OBESITY Issabella Nisrina Pratiwi; Ninik Mudjihartini; Wahyu Ika Wardhani
SOSIOEDUKASI Vol 15 No 1 (2026): SOSIOEDUKASI : JURNAL ILMIAH ILMU PENDIDIKAN DAN SOSIAL
Publisher : Fakultas Keguruan Dan Ilmu Pendidikan Universaitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/sosioedukasi.v15i1.7148

Abstract

Obesity is commonly associated with chronic low-grade inflammation and alterations in skeletal muscle mass, increasing the risk of sarcopenic obesity. Vitamin D deficiency and elevated C-reactive protein (CRP) levels are frequently observed in individuals with obesity and may contribute to impaired muscle metabolism. This study aimed to examine the relationship between vitamin D intake, plasma C-reactive protein (CRP) levels, and the Appendicular Skeletal Muscle Index (ASMI) among obese adults at Universitas Indonesia Hospital (RSUI). An analytical cross-sectional design was employed involving 70 obese adults aged 18–59 years. Vitamin D intake was assessed using a semi-quantitative food frequency questionnaire, plasma CRP levels were measured using enzyme-linked immunosorbent assay (ELISA), and ASMI was determined using bioelectrical impedance analysis. Data were analyzed using univariate, bivariate, and multivariate statistical methods. The results showed that most participants had inadequate vitamin D intake and elevated plasma CRP levels, indicating the presence of systemic inflammation. No significant association was found between vitamin D intake and CRP levels or between vitamin D intake and ASMI. However, plasma CRP levels demonstrated a weak but statistically significant association with ASMI. These findings suggest that inflammation plays a more prominent role than vitamin D intake in influencing skeletal muscle mass among obese adults, highlighting the multifactorial nature of sarcopenic obesity.
Co-Authors Abd. Rasyid Syamsuri Achmad Mulawarman Jayusman Ahmad A. Jusuf Ahmad Aulia Almira Devina Gunawan Andriani Andriani Ani Retno Prijanti Astrid Mariam Khairani Siregar Atikah Chalida Barasila Chandra, Dian Novita claresta diella Defli Yuandika Ruso Dewi Sukmawati Diana Sunardi Diyah Eka Andayani Diyah Eka Andayani Ekawati, Maria Endrico Xavierees Erlina, Linda Erni Purwaningsih Estiana Filzadiyanti Fadilah Fadilah Febriana Catur Iswanti Frans Ferdinal Hadiyati Fudla Hajar, Siti Sarah Harmelia, Dwi Helena Fabiani Ika Superti Daruningrum Immanuelle Kezia Indah Bachti Setyarini Inge Permadhi Irawan Satriotomo Issabella Nisrina Pratiwi Karin Wiradarma Karlina Lestari Khusun, Helda Krisadelfa Sutanto Krisnamurti, Desak G.B. Livia Kurniati Saputra Marsella Dervina Amisi Mohamad Sadikin Mohamad Saekhu Muchtaruddin Mansyur Mulyana Mulyana Nani Dharmasetiawani Natasha Dianasari Devana Nieka Adhara Wahono Novi Dewi Tanjung Novi Dewi Tanjung Nurdina, Nazlah Nurhadi Ibrahim Nurhadi Ibrahim Nurul Ratna Nurul Ratna Mutu Manikam Pratiwi, Sandi Puspita Prawirohajo, Pukovisa Pungguri Ayu Nega Sarsanti Purwaningsih, Erni H. Rahmawaty Ridwan, Rahmawaty Raphael Kosasih Ray Sugianto, Ray Reni Paramita Ria Andreinie Rini Sekartini Rita Lahirin, Rita Sadikin, Abdul Halim Saptawati Bardosono Saptawati Bardosono Sheira Taflah Putri Handana Sheira Taflah Putri Handana Sianipar, Imelda M. Siska Amelia Siti Farida Sri W.A. Jusman Sri Widia A.Jusman Wahyu Ika Wardhani Wardaya Wardaya Wawan Mulyawan Widia AJ, Sri Wiji Lestari Wiji Lestari Wina Sinaga Wiwoho, Yudi Yuwono Yuditiya Purwosunu Yulhasri Yulhasri Yulhasri