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All Journal The Indonesian Biomedical Journal Paediatrica Indonesiana Acta Biochimica Indonesiana Jurnal Biomedika dan Kesehatan Majalah Kedokteran Neurosains World Nutrition Journal Muhammadiyah Journal of Geriatric Indonesian Journal of Medical Chemistry and Bioinformatics Neurona Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Ninik Mudjihartini
Department Of Biochemistry And Molecular Biology, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Peran reseptor nuklear pada implantasi dan perkembangan blastokista Endrico Xavierees; Ninik Mudjihartini
Jurnal Biomedika dan Kesehatan Vol 4 No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2021.v4.37-46

Abstract

Syarat penting untuk terjadinya kehamilan, yaitu blastokista pada fase tertentu siap melakukan implantasi dan proliferasi endometrium, sehingga menjadi reseptif terhadap embrio untuk melakukan implantasi. Pada tahap selanjutnya, masih terdapat proses molekular yang berkesinambungan sampai pada akhirnya terjadi hubungan langsung antara blastokista dan dinding endometrium dengan membentuk plasenta. Implantasi yang tidak efisien tentunya akan menyebabkan kegagalan implantasi, sehingga muncul masalah infertilitas. Sebanyak 30% kasus kegagalan kehamilan disebabkan oleh masalah kesehatan embrio. Pemahaman yang lebih mendalam mengenai sinyal-sinyal yang berperan pada kedua proses berkesinambungan tersebut diharapkan dapat memberikan metode terapi yang baru pada kasus infertilitas, sehingga meningkatkan jumlah kehamilan.
Nutrient Intake Profile Among Children Aged 6–24 Months in Indonesia: A Descriptive Analysis Nurdina, Nazlah; Chandra, Dian Novita; Mudjihartini, Ninik; Sekartini, Rini
World Nutrition Journal Vol. 9 No. S1 (2025): Vol. 9 No. S1 (2025): Selected conference proceedings of the Nutri Symposium 2
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V09.S1.0024

Abstract

Background: Adequate nutrient intake in early childhood is critical for growth, cognitive development, and immune function. The first two years of life are a sensitive period where nutritional deficiencies may lead to long-term consequences. However, many children in low- and middle-income countries fail to meet dietary needs due to limited diversity and poor feeding practices. Objectives: To describe the intake of energy, macronutrients, and key micronutrients among Indonesian children aged 6–24 months
Urinary PYD/Creatinine Ratio Has Negative Correlation to Serum 25(OH)D and Positive Correlation to Chronic Lead Exposure Index Hajar, Siti Sarah; Mudjihartini, Ninik; Manikam, Nurul Ratna Mutu; Mulyana, Mulyana; Mansyur, Muchtaruddin
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3174

Abstract

BACKGROUND: The burden of disease due to lead exposure continues to increase. Lead interferes with 25(OH)D hydroxylation and calcium transport, increasing osteoclastic activity and bone resorption. Pyridinoline crosslinks (PYD), as an indicator of bone damage, can be seen earlier compared to imaging changes. Therefore, it is necessary to determine the correlation between serum 25(OH)D levels and the urinary PYD/creatinine ratio in workers exposed to lead, since up to now, there are only limited studies related to it.METHODS: This cross-sectional study involved 104 workers exposed to lead, selected from parents whose children had blood lead levels above 10 µg/dL. Questionnaires and physical examination were performed to obtain characteristic data from subjects. Data regarding blood lead levels, serum 25(OH)D levels, urinary PYD levels, and urinary creatinine levels were also obtained from various laboratory methods.RESULTS: Most subjects (86.5%) had inadequate serum 25(OH)D. Median blood lead levels was 6.3 (1.2-35.5) µg/dL, chronic lead exposure index was 35.3 (1.2-535.8) years µg/dL, serum 25(OH)D levels was 22 (8-52) ng/mL, and urinary PYD/creatinine ratio was 5.3 (3.6-28.1)×10-6. There was a significant negative correlation between serum 25(OH)D levels and urinary PYD/creatinine ratio in workers exposed to lead. There was also a significant positive correlation between chronic lead exposure index and the urinary PYD/creatinine ratio.CONCLUSION: Since urinary PYD/creatinine ratio is correlated with serum chronic lead exposure index and serum 25(OH)D levels, it suggests that pyridinoline might be a potential biomarker to detect bone metabolism disorder due to the chronic lead exposure. Vitamin D adequacy is also an important factor in preventing bone metabolism disorder amidst chronic lead exposure.KEYWORDS: 25(OH)D, bone resorption, pyridinoline, lead, worker
Hyperbaric Oxygen Therapy for Traumatic Brain Injury: A Review Of History, Development, Current Techniques, and Future Directions Wiwoho, Yudi Yuwono; Sadikin, Abdul Halim; Jusuf, Ahmad Aulia; Mulyawan, Wawan; Mudjihartini, Ninik; Ibrahim, Nurhadi; Jusman, Sri Widia A.; Sadikin, Mohamad
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.321

Abstract

Hyperbaric oxygen therapy (HBOT) has gained increasing attention as a potential adjunctive treatment for traumatic brain injury (TBI) patients. This narrative review discusses the historical background, current preclinical and clinical studies, and explores its underlying mechanisms from biomolecular, histological, and clinical perspectives. HBOT promotes neural recovery by improving oxygenation, preserving mitochondrial integrity, enhancing neurotrophic support and synaptic connectivity, mitigating secondary injury pathways (including oxidative stress, inflammation, and apoptosis), and promoting angiogenesis and vascular stability. These mechanisms have demonstrated improvements of motor, cognitive, and memory functions both in preclinical and clinical studies, although outcomes and treatment protocols vary. However, challenges remain regarding optimal protocols, patient selection, and adverse effects. Further high-quality clinical trials are required to define the optimal HBOT regimen are required.
Comparing the effect of Centella asiatica L. and Acalypha indica L. treatment to carbonyl and glutathione level in the brains of old rats Mudjihartini, Ninik; Paramita, Reni; Siregar, Astrid Mariam Khairani; Filzadiyanti, Estiana; Sarsanti, Pungguri Ayu Nega; Purwaningsih, Erni
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.79

Abstract

Background: Free radicals in excessive concentrations damages cells and accelerate the aging process. Antioxidants found in Centella asiatica (CA) and Acalypha indica (AI) have the potential to prevent oxidative cellular damage. Objective: This study aimed to determine the effect of CA and AI on carbonyl and glutathione levels in the brain of older rats. Methods: 18-month age rats were treated using either AI, CA, or vitamin E. In addition, 18-month age and 2-month age untreated rats were used as a negative control. The brain carbonyl and glutathione levels were measured by Agustyanak and the Elmann method, respectively. Results: Treatment with CA significantly decreased brain carbonyl levels (2.87 nmol/mL) than the control rats (4.54 nmol/mL). Furthermore, treating AI did not reduce the brain carbonyl and GSH levels in aged brain rats. Conclusion: Centella asiatica can reduce the protein destruction that occurs with increasing age.
Co-Authors Abd. Rasyid Syamsuri Achmad Mulawarman Jayusman Ahmad A. Jusuf Ahmad Aulia Almira Devina Gunawan Andriani Andriani Ani Retno Prijanti Chandra, Dian Novita claresta diella Diana Sunardi Diyah Eka Andayani Diyah Eka Andayani Ekawati, Maria Endrico Xavierees Febriana Catur Iswanti Filzadiyanti, Estiana Hadiyati Fudla Hajar, Siti Sarah Harmelia, Dwi Helena Fabiani Ika Superti Daruningrum Inge Permadhi Jusman, Sri Widia Azraki Karin Wiradarma Khusun, Helda Krisnamurti, Desak G.B. Livia Kurniati Saputra Mohamad Sadikin Mohamad Sadikin Mohamad Saekhu Muchtaruddin Mansyur Mulyana Mulyana Nani Dharmasetiawani Novi Dewi Tanjung Nurdina, Nazlah Nurhadi Ibrahim Nurul Ratna Mutu Manikam Pratiwi, Sandi Puspita Prawirohajo, Pukovisa Purwaningsih, Erni Purwaningsih, Erni H. Purwosunu, Yuditiya Rahmawaty Ridwan, Rahmawaty Raphael Kosasih Ray Sugianto, Ray Reni Paramita Ria Andreinie Rini Sekartini Rita Lahirin, Rita Sadikin, Abdul Halim Saptawati Bardosono Saptawati Bardosono Sarsanti, Pungguri Ayu Nega Sheira Taflah Putri Handana Sheira Taflah Putri Handana Sianipar, Imelda M. Siregar, Astrid Mariam Khairani Siti Farida Sri W.A. Jusman Sri Widia A Jusman Wawan Mulyawan Widia AJ, Sri Wiji Lestari Wiji Lestari Wiwoho, Yudi Yuwono Yulhasri Yulhasri