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Hubungan Diabetes Melitus Tipe 2 dengan Kadar Profil Lipid Pasien di RSUD Undata Provinsi Sulawesi Tengah Tahun 2023 Saladin Ardhya Prawira AS; Wahyuni, Rosa Dwi; Sumarni; Putrie, Intania Riska
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 10 No. 1 (2025): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar

Diabetes Melitus Tipe 2 (DMT2) merupakan masalah kesehatan global yang terus meningkat, terutama di negara berkembang seperti Indonesia. Salah satu faktor risiko yang berperan adalah profil lipid, termasuk kolesterol total, LDL, HDL, dan trigliserida. Penelitian ini bertujuan untuk mengeksplorasi hubungan antara DMT2 dan kadar profil lipid pada pasien di RSUD Undata Provinsi Sulawesi Tengah Tahun 2023. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara Diabetes Melitus Tipe 2 dengan Kadar Profil Lipid pada Pasien di RSUD Undata Provinsi Sulawesi Tengah Tahun 2023. Penelitian menggunakan desain cross-sectional dengan sampel sebanyak 37 pasien yang memenuhi kriteria inklusi dan eksklusi. Data sekunder dari rekam medis pasien digunakan untuk analisis. Uji statistik yang diterapkan meliputi analisis univariat dan bivariat menggunakan Uji Chi-Square untuk menentukan hubungan antarvariabel. Analisis menunjukkan bahwa tidak terdapat hubungan yang signifikan antara Diabetes Melitus Tipe 2 dengan kadar kolesterol total (p = 0,418), LDL (p = 1,000), HDL (p = 1,000), maupun trigliserida (p = 0,454). Penelitian ini tidak menemukan hubungan signifikan antara Diabetes Melitus Tipe 2 dengan kadar profil lipid pasien. Hasil ini menunjukkan bahwa faktor lain seperti genetika, metabolisme, dan gaya hidup mungkin lebih berperan dalam pengaruh profil lipid pada pasien Diabetes Melitus Tipe 2 di RSUD Undata Provinsi Sulawesi Tengah Tahun 2023.

Representasi Kadar Methemoglobin (Methb) Akibat Paparan Pestisida pada Petani di Sigi Biromaru Intania Riska Putrie; Tri Setyawati; Devi Oktafiani; Ryka Marina Walanda; Listawati; Putrie, Intania Riska
Journal of Health Vol. 12 No. 2 (2025): Journal of Health (JoH) - July
Publisher : LPPM STIKES Guna Bangsa Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/joh.v12n2.11

Pesticides can be toxic and disrupt the ecosystem if used for long periods in high doses. High toxicity due to intensive pesticide exposure will affect heme biosynthesis. Oxygen is carried by red blood cells that contain Fe2+ ions bound to hemoglobin. Exposure to toxic pesticides will cause Fe2+ ions to oxidize to Fe3+, resulting in hemoglobin changing into Methemoglobin (MetHb). This causes Hb to be unable to bind with oxygen, resulting in anemia. Methemoglobin measurement is important for farmers because they are at high risk. This measurement can also be used for early detection, prevention of complications, and evaluation of pesticide exposure. This study aims to determine MetHb levels in farmers intensively exposed to pesticides. This study used a cross-sectional design with a stratified sampling technique. This study used 50 farmers who were directly exposed to pesticides. The sample used was a 3cc venous blood sample taken using a syringe. The blood sample was then measured for MetHemoglobin levels using a spectrophotometer. This research was conducted in two villages, namely Kalukubula Village and Lolu Village. In Kalukubula Village, the average MetHemoglobin level was 6.53%, with the lowest level being 2.95% and the highest level being 9.95%. In Lolu Village, the average MetHemoglobin level was 5.72%, with the lowest level being 1.80% and the highest level being 9.60%. Normal MetHemoglobin levels in humans range from 0-3%. MetHemoglobin levels in farmers in Sigi Biromaru mostly showed Asymptomatic Methemoglobin results, meaning that most farmers suffer from MetHemoglobin but do not show clinical symptoms.

Representasi Kadar Methemoglobin (Methb) Akibat Paparan Pestisida pada Petani di Sigi Biromaru Intania Riska Putrie; Tri Setyawati; Devi Oktafiani; Ryka Marina Walanda; Listawati; Putrie, Intania Riska
Journal of Health Vol. 12 No. 2 (2025): Journal of Health (JoH) - July
Publisher : LPPM STIKES Guna Bangsa Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/joh.v12n2.11

Pesticides can be toxic and disrupt the ecosystem if used for long periods in high doses. High toxicity due to intensive pesticide exposure will affect heme biosynthesis. Oxygen is carried by red blood cells that contain Fe2+ ions bound to hemoglobin. Exposure to toxic pesticides will cause Fe2+ ions to oxidize to Fe3+, resulting in hemoglobin changing into Methemoglobin (MetHb). This causes Hb to be unable to bind with oxygen, resulting in anemia. Methemoglobin measurement is important for farmers because they are at high risk. This measurement can also be used for early detection, prevention of complications, and evaluation of pesticide exposure. This study aims to determine MetHb levels in farmers intensively exposed to pesticides. This study used a cross-sectional design with a stratified sampling technique. This study used 50 farmers who were directly exposed to pesticides. The sample used was a 3cc venous blood sample taken using a syringe. The blood sample was then measured for MetHemoglobin levels using a spectrophotometer. This research was conducted in two villages, namely Kalukubula Village and Lolu Village. In Kalukubula Village, the average MetHemoglobin level was 6.53%, with the lowest level being 2.95% and the highest level being 9.95%. In Lolu Village, the average MetHemoglobin level was 5.72%, with the lowest level being 1.80% and the highest level being 9.60%. Normal MetHemoglobin levels in humans range from 0-3%. MetHemoglobin levels in farmers in Sigi Biromaru mostly showed Asymptomatic Methemoglobin results, meaning that most farmers suffer from MetHemoglobin but do not show clinical symptoms.

FENOMENA DIABETES MELITUS BERDASARKAN USIA DAN JENIS KELAMIN DI DESA WINOWANGA KABUPATEN POSO Putrie, Intania Riska; Putri, Isramita Cahyani; Devie, Devie; Rahmah, Fauziah; Violen, Syella Jesica; Hasanuddin, Bintang
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.45474

Penyakit yang menjadi penyebab kematian cukup tinggi setiap tahunnya adalah Penyakit Tidak Menular (PTM), contohnya diabetes. Diabetes Melitus dapat menyerang siapa saja tanpa memandang usia atau gender. Namun, faktor penuaan mengakibatkan peningkatan resiko Diabetes Melitus akibat penurunan sensitivitas insulin yang menyebabkan kenaikan kadar gula darah. Tujuan penelitian ini untuk mengetahui fenomena penyakit Diabetes Melitus berdasarkan usia dan jenis kelamin di Desa Winowanga Kabupaten Poso Sulawesi Tengah. Penelitian ini melakukan pemeriksaan Gula Darah Sewaktu menggunakan Glukometer Easy Touch. Sampel penelitian ini berjumlah 50 orang. Hasil pemeriksaan didapatkan nilai Gula Darah Sewaktu (GDS) normal sebanyak 42 orang (84%), dan pre-DM 8 orang (16%). Sampel pre-DM sebanyak 8 orang berjenis kelamin wanita dengan kategori usia Dewasa (1 orang), Pre-Lansia (4 orang) dan Lansia (3 orang). Diharapkan dapat memperbanyak sampel penelitian serta dapat dilakukan pula pengukuran Gula Darah Puasa (GDP) berbasis laboratorium.

Relevansi Kejadian Hipertensi Terhadap Tingkat Pemahaman Masyarakat Desa Winowanga Sulawesi Tengah Putrie, Intania Riska; Saleh, Andi Khofifah Indah; Nabila, Fidya Fika; Ikhsani, Nur Ilmi; Samitha, Vitti Metta; Sakti, Muhammad Iradat
Jurnal Medika Malahayati Vol 9, No 3 (2025): Volume 9 Nomor 3
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v9i3.19627

Penyakit menular menjadi penyebab kematian cukup tinggi atau setara 74% dari total kasus tercatat. Hipertensi merupakan contoh penyakit tidak menular yang menjadi penyakit dengan angka kematian tertinggi. Berdasarkan data Puskesmas Maholo menunjukkan bahwa hipertensi menempati urutan pertama tertinggi di Kecamatan Lore Timur sehingga penelitian ini bertujuan untuk mengetahui korelasi kejadian hipertensi terhadap tingkat pengetahuan masyarakat di Desa Winowanga, Kecamatan Lore Timur. Sampel dalam penelitian ini sebanyak 50 orang dengan menggunakan pendekatan cross sectional. Pengukuran tekanan darah menggunakan Sphygmomanometer digital OMRON HEM-8217 serta pengukuran tingkat pengetahuan menggunakan kuesioner. Data hasil pengukuran kemudian dianalisis menggunakan SPPS dengan uji analisis deskriptif dan uji korelasi somer'd. Hasil penelitian menunjukkan bahwa terdapat 25 orang mengalami Hipertensi (50%) dan 7 orang mengalami Pre-Hipertensi (14%). Kategori usia penderita hipertensi dan pre-hipertensi terbanyak pada usia lansia. Berdasarkan uji korelasi somers’d memperlihatkan hasil yang tidak terdapat korelasi antara tingkat pengetahuan dengan kejadian hipertensi di Desa Winowanga (p=0,795). Diharapkan penelitian selanjutnya dapat menggunaan alat tensi manual dan tensi digital serta pemberian pretest untuk pengukuran tingkat pengetahuan.

ABCC8 Gene Factors in Maturity-Onset Diabetes of The Young (MODY): Literature Review Setyawati, Tri; Walanda, Ryka Marina; Putrie, Intania Riska; Oktafiani, Devi; Sulisda, Sulisda
Journal of Health and Nutrition Research Vol. 4 No. 1 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i1.347

Maturity-Onset Diabetes of the Young (MODY) is a monogenic form of diabetes caused by single-gene mutations affecting insulin secretion, often presenting in young individuals. Mutations in the ABCC8 gene (MODY12), encoding the SUR1 subunit of the pancreatic β-cell K-ATP channel, are a known cause, though relatively rare (1-3% prevalence). This literature review summarized cases of ABCC8-MODY, detailing genetic/clinical features, differentiating it from Type 1 (T1DM) and Type 2 (T2DM) diabetes, and outlining treatments. A Google Scholar search (2020-2024) using keywords "ABCC8 gene," "diabetes," and "young age," followed by screening based on specific inclusion/exclusion criteria, yielded 7 relevant articles from an initial 1,010. The ABCC8 gene is crucial for insulin secretion via the K-ATP channel; mutations cause β-cell dysfunction and MODY12 with variable phenotypes. Misdiagnosis as T1DM/T2DM is frequent. Key MODY features include young onset (<25-35 years), strong family history, absence of pancreatic autoantibodies, persistent endogenous insulin production (detectable C-peptide), and often, high sensitivity to sulfonylureas (SUs). Accurate diagnosis requires meticulous history, clinical assessment, and definitive molecular genetic testing (e.g., NGS). Notably, patients with ABCC8-MODY typically respond well to SU therapy, making early, correct diagnosis vital for appropriate management. Identifying these genetic defects is paramount for distinguishing MODY from other diabetes types and optimizing patient care based on specific underlying pathophysiology and therapeutic responsiveness

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