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All Journal Jurnal Bioterdidik: Wahana Ekspresi Ilmiah Journal of Health (JoH) JMM (Jurnal Masyarakat Mandiri) Jurnal Medika Malahayati BERDAYA: Jurnal Pendidikan dan Pengabdian Kepada Masyarakat Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal Kolaboratif Sains Journal of Health and Nutrition Research Jurnal PADE: Pengabdian & Edukasi Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Intania Riska Putrie, Intania Riska
Department Of Biochemistry, Faculty Of Medicine, Tadulako University, Palu , Sulawesi Tengah, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Representasi Kadar Methemoglobin (Methb) Akibat Paparan Pestisida pada Petani di Sigi Biromaru Intania Riska Putrie; Tri Setyawati; Devi Oktafiani; Ryka Marina Walanda; Listawati; Putrie, Intania Riska
Journal of Health Vol. 12 No. 2 (2025): Journal of Health (JoH) - July
Publisher : LPPM STIKES Guna Bangsa Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/joh.v12n2.11

Abstract

Pesticides can be toxic and disrupt the ecosystem if used for long periods in high doses. High toxicity due to intensive pesticide exposure will affect heme biosynthesis. Oxygen is carried by red blood cells that contain Fe2+ ions bound to hemoglobin. Exposure to toxic pesticides will cause Fe2+ ions to oxidize to Fe3+, resulting in hemoglobin changing into Methemoglobin (MetHb). This causes Hb to be unable to bind with oxygen, resulting in anemia. Methemoglobin measurement is important for farmers because they are at high risk. This measurement can also be used for early detection, prevention of complications, and evaluation of pesticide exposure. This study aims to determine MetHb levels in farmers intensively exposed to pesticides. This study used a cross-sectional design with a stratified sampling technique. This study used 50 farmers who were directly exposed to pesticides. The sample used was a 3cc venous blood sample taken using a syringe. The blood sample was then measured for MetHemoglobin levels using a spectrophotometer. This research was conducted in two villages, namely Kalukubula Village and Lolu Village. In Kalukubula Village, the average MetHemoglobin level was 6.53%, with the lowest level being 2.95% and the highest level being 9.95%. In Lolu Village, the average MetHemoglobin level was 5.72%, with the lowest level being 1.80% and the highest level being 9.60%. Normal MetHemoglobin levels in humans range from 0-3%. MetHemoglobin levels in farmers in Sigi Biromaru mostly showed Asymptomatic Methemoglobin results, meaning that most farmers suffer from MetHemoglobin but do not show clinical symptoms.
FENOMENA DIABETES MELITUS BERDASARKAN USIA DAN JENIS KELAMIN DI DESA WINOWANGA KABUPATEN POSO Putrie, Intania Riska; Putri, Isramita Cahyani; Devie, Devie; Rahmah, Fauziah; Violen, Syella Jesica; Hasanuddin, Bintang
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.45474

Abstract

Penyakit yang menjadi penyebab kematian cukup tinggi setiap tahunnya adalah Penyakit Tidak Menular (PTM), contohnya diabetes. Diabetes Melitus dapat menyerang siapa saja tanpa memandang usia atau gender. Namun, faktor penuaan mengakibatkan peningkatan resiko Diabetes Melitus akibat penurunan sensitivitas insulin yang menyebabkan kenaikan kadar gula darah. Tujuan penelitian ini untuk mengetahui fenomena penyakit Diabetes Melitus berdasarkan usia dan jenis kelamin di Desa Winowanga Kabupaten Poso Sulawesi Tengah. Penelitian ini melakukan pemeriksaan Gula Darah Sewaktu menggunakan Glukometer Easy Touch. Sampel penelitian ini berjumlah 50 orang. Hasil pemeriksaan didapatkan nilai Gula Darah Sewaktu (GDS) normal sebanyak 42 orang  (84%), dan pre-DM 8 orang (16%). Sampel pre-DM sebanyak 8 orang berjenis kelamin wanita dengan kategori usia Dewasa (1 orang), Pre-Lansia (4 orang) dan Lansia (3 orang). Diharapkan dapat memperbanyak sampel penelitian serta dapat dilakukan pula pengukuran Gula Darah Puasa (GDP) berbasis laboratorium.
Relevansi Kejadian Hipertensi Terhadap Tingkat Pemahaman Masyarakat Desa Winowanga Sulawesi Tengah Putrie, Intania Riska; Saleh, Andi Khofifah Indah; Nabila, Fidya Fika; Ikhsani, Nur Ilmi; Samitha, Vitti Metta; Sakti, Muhammad Iradat
Jurnal Medika Malahayati Vol 9, No 3 (2025): Volume 9 Nomor 3
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v9i3.19627

Abstract

Penyakit menular menjadi penyebab kematian cukup tinggi atau setara 74% dari total kasus tercatat. Hipertensi merupakan contoh penyakit tidak menular yang menjadi penyakit dengan angka kematian tertinggi. Berdasarkan data Puskesmas Maholo menunjukkan bahwa hipertensi menempati urutan pertama tertinggi di Kecamatan Lore Timur sehingga penelitian ini bertujuan untuk mengetahui korelasi kejadian hipertensi terhadap tingkat pengetahuan masyarakat di Desa Winowanga, Kecamatan Lore Timur. Sampel dalam penelitian ini sebanyak 50 orang dengan menggunakan pendekatan cross sectional. Pengukuran tekanan darah menggunakan Sphygmomanometer digital OMRON HEM-8217 serta pengukuran tingkat pengetahuan menggunakan kuesioner. Data hasil pengukuran kemudian dianalisis menggunakan SPPS dengan uji analisis deskriptif dan uji korelasi somer'd. Hasil penelitian menunjukkan bahwa terdapat 25 orang mengalami Hipertensi (50%) dan 7 orang mengalami Pre-Hipertensi (14%). Kategori usia penderita hipertensi dan pre-hipertensi terbanyak pada usia lansia. Berdasarkan uji korelasi somers’d memperlihatkan hasil yang tidak terdapat korelasi antara tingkat pengetahuan dengan kejadian hipertensi di Desa Winowanga (p=0,795). Diharapkan penelitian selanjutnya dapat menggunaan alat tensi manual dan tensi digital serta pemberian pretest untuk pengukuran tingkat pengetahuan.
ABCC8 Gene Factors in Maturity-Onset Diabetes of The Young (MODY): Literature Review Setyawati, Tri; Walanda, Ryka Marina; Putrie, Intania Riska; Oktafiani, Devi; Sulisda, Sulisda
Journal of Health and Nutrition Research Vol. 4 No. 1 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i1.347

Abstract

Maturity-Onset Diabetes of the Young (MODY) is a monogenic form of diabetes caused by single-gene mutations affecting insulin secretion, often presenting in young individuals. Mutations in the ABCC8 gene (MODY12), encoding the SUR1 subunit of the pancreatic β-cell K-ATP channel, are a known cause, though relatively rare (1-3% prevalence). This literature review summarized cases of ABCC8-MODY, detailing genetic/clinical features, differentiating it from Type 1 (T1DM) and Type 2 (T2DM) diabetes, and outlining treatments. A Google Scholar search (2020-2024) using keywords "ABCC8 gene," "diabetes," and "young age," followed by screening based on specific inclusion/exclusion criteria, yielded 7 relevant articles from an initial 1,010. The ABCC8 gene is crucial for insulin secretion via the K-ATP channel; mutations cause β-cell dysfunction and MODY12 with variable phenotypes. Misdiagnosis as T1DM/T2DM is frequent. Key MODY features include young onset (<25-35 years), strong family history, absence of pancreatic autoantibodies, persistent endogenous insulin production (detectable C-peptide), and often, high sensitivity to sulfonylureas (SUs). Accurate diagnosis requires meticulous history, clinical assessment, and definitive molecular genetic testing (e.g., NGS). Notably, patients with ABCC8-MODY typically respond well to SU therapy, making early, correct diagnosis vital for appropriate management. Identifying these genetic defects is paramount for distinguishing MODY from other diabetes types and optimizing patient care based on specific underlying pathophysiology and therapeutic responsiveness
HUBUNGAN KADAR KREATININ DENGAN HEMOGLOBIN PADA PASIEN GAGAL GINJAL KRONIK (GGK) DI RSUD UNDATA PROVINSI SULAWESI TENGAH PADA TAHUN 2022 Muhammad Hilmi Falah; Setyawati, Tri; Walanda, Ryka Marina; Putrie, Intania Riska
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 9 No. 1 (2024): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v9i1.1255

Abstract

Latar belakang: Gagal Ginjal Kronik (GGK) adalah keadaan kerusakan pada ginjal secara struktural ataupun fungsional yang telah terjadi selama tiga bulan atau lebih. Gagal ginjal kronik (GGK) ditandai gejala penurunan laju filtrasi glomerulus (LFG) mencapai kurang dari 60 ml/menit /1,73m2. Pada pasien GGK umumnya akan ditandai dengan hemoglobin yang rendah dan kadar kreatinin yang tinggi. Tujuan: Untuk mengetahui hubungan kadar kreatinin dengan hemoglobin pada pasien gagal ginjal kronik (GGK) di RSUD Undata Provinsi Sulawesi Tengah pada Tahun 2022. Metode: Penelitian ini dilakukan dengan metode deskriptif analitik melalui pendekatan cross sectional, data penelitian menggunakan rekam medis yang berisi hasil laboratorium dari kadar kreatinin dan hemoglobin pada pasien GGK. Sampel didapatkan menggunakan teknik Randoming sampling yang diambil secara acak dari total populasi 586 pasien. Sejumlah 100 pasien GGK stadium 5 didapatkan dari total populasi menggunakan rumus slovin yang disertai dengan kriteria inklusi dan eksklusi. Hasil: Berdasarkan uji analisis yang telah dilakukan, uji analisis menggunakan uji Spearman diperoleh p=0,023 dengan nilai (p<0,05).Kesimpulan: Terdapat hubungan antara kadar kreatinin dengan hemoglobin di RSUD Undata Provinsi Sulawesi Tengah pada Tahun 2022.
Analysis of dengue virus vector control causing dengue hemorrhagic fever (DHF) in high and low case Oktafiani, Devi; Intania Riska Putrie; Fakhriah M. Samiun
Jurnal EduHealth Vol. 15 No. 01 (2024): Jurnal eduHealt, Edition January - March, 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dengue Hemorrhagic Fever is still a global public health problem, especially in tropical and subtropical regions, including Indonesia as one of the dengue-endemic countries. Central Sulawesi is one of the endemic areas of dengue fever in Indonesia. DHF cases in Central Sulawesi Province are recorded to fluctuate every year and the morbidity rate tends to increase. In the Palu city area, Birobuli Selatan Village is the area with the highest cases, while in the Nunu Village, no dengue cases were detected. This research method is to use a questionnaire to look at the habits of people in areas with low cases and high cases in controlling disease vectors. Data analysis used the chi-square test. The research results showed that in the group of areas with high cases, there were differences in 3M habits (p=0.021), use of mosquito nets (p=0.000), plants around the house (p=0.000), and residential density (p<0.05). Meanwhile, there is no difference in the use of mosquito repellent and abate in the two regions. This research concludes that there are differences in people's habits regarding activities or activities in controlling mosquito vectors that cause dengue fever in areas with high cases and low cases
Co-Authors Andi Khofifah Indah Saleh Arwin Achmad Astuty, Eka Berti Yolida Devi Oktafian Devi Oktafiani Devi Oktafiani Devie Devie Dylan Tamalsir Dylan Tamalsir Elpira Asmin Esmeraldine, Genevieva Fakhriah M. Samiun Hasanuddin, Bintang Ikhsani, Nur Ilmi listawati Listawati, Listawati Mailoa, Joice Melda Yunita Muba'its Baldan Esa Muhammad Hilmi Falah Mus, Rosdiana Mutmainnah Abbas Nabila, Fidya Fika Oktafiani, Devi Presly G. Siahaya Putri, Isramita Cahyani Rahmah, Fauziah Rosa Dwi Wahyuni Ryka Marina Walanda Sakti, Muhammad Iradat Saladin Ardhya Prawira AS Saleh, Andi Khofifah Indah Samitha, Vitti Metta Siti Rabia'ah Zahid Sulisda, Sulisda SUMARNI Titin Agustina Titin Agustina Tri Juni Wijatmiko Tri Setyawati Violen, Syella Jesica