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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Jurnal BALIRESO IJoASER (International Journal on Advanced Science, Education, and Religion) ad-Dawaa : Journal of Pharmaceutical Sciences Borneo Journal Of Pharmascientech Jurnal Al-Qiyam Jurnal Tana Mana Pharmaceutical Reports Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi Jurnal Inovasi dan Pengembangan Hasil Pengabdian Masyarakat Journal of Pharmaceuticals and Natural Sciences Jurnal Pengabdian Farmasi dan Sains MPSJ Jurnal Ilmiah Nusantara
Bayu Putra, Bayu
bayuputra.pharm@gmail.com
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Journal : Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

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Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH): Effect of Immunomodulator of Purslane Herb Ethanol (Portulaca oleracea L.) on Rat (Rattus norvegicus) with Delayed Type Hypersensitivity (DTH) Parameter Putra, Bayu; Azizah, Rizqi Nur; Nopriyanti, Eka Maryam
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.679 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14106

Abstract

Portulaca oleracea L. is one of the plants empirically used as medicine and contains flavonoid compounds assumed to have an immunomodulatory effect. The research aimed to determine the immunomodulatory effect of ethanol extract of Portulaca oleracea L by Delayed Type Hypersensitivity parameter. The research used 20 male rats (Rattus norvegicus) divided into 5 groups where each group consisted of 4. Group I as a normal group (without treatment), group II (NaCMC control), group III, IV and V (treatment groups) were given EEHK with doses of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW doses. The dosage form was orally given for 7 days. On day 3, the rats were induced with SDMD antigen 10% v/v by intraperitonial and intraplantar on day 7. The observations were conducted by measuring the volume change of the rat's feet at the 4th, 24th, and 48th hours using a pletismometer. The research data obtained were statistically processed using Paired Samples T Test, One-Way Anova and Post Hoc LSD tests. The results of the research showed that the ethanol extract of common purslane was effective as an immunomodulator.
Aktivitas Ekstrak Daun Salam (Syzygium polyanthum) sebagai Antirheumatoid Artritis pada Tikus yang Diinduksi Complete Freund’s Adjuvants (CFA): Antirheumatoid Arthritis Activity of Salam (Syzygium polyanthum) Leaf Extract to Mice Induced by Complete Freund’s Adjuvants (CFA) Amirah, Sitti; Wati, Aulia; Putra, Bayu; Alani, Fitri Wasto
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.259 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14581

Abstract

Rheumatoid arthritis is an chronic autoimmune disease, which is characterized by inflammation and degradation of the joints and cartilages. Rheumatoid therapy is currently using immunosuppressant drugs, nonsteroidal anti-inflammatory drugs and corticosteroids. Treatment of chronic rheumatoid can trigger side effects. Syzygium polyanthum leaves contain alkaloid compounds, flavonoids, saponins, tannins and essential oils consist of citral and eugenol which are thought to be potential as antirheumatoid. This study aims to determine the effect antirheumatoid arthritis and effective dose of ethanol extracts of Syzygium polyanthum leaf. This study used 15 male rats. Treatment started by measuring foot volume using a pletismometer and then inducting CFA intraplantary as much as 0,1 mL on day 1 and left until day 16th. On the day 17th a foot volume and arthritis index was measured and then treated until the day 30th. The animals were divided into 5 groups: negative control (Na. CMC 1%), positive control (methylprednisolone dose 1.646 mg / kg BW), ethanol extractof Syzygium polyanthum leaf at a dose of 75 mg / kg, 150 mg / kg and 300 mg / kg. On the day 31st, foot volume and arthritis index measurements were taken again. The results showed a decrease in foot volume and arthritis index after given of the extract. Foot volume difference data were analyzed using the One Way Anova test followed by the Post Hoc LSD test. The difference between the arthritis index data was analyzed using Kruskal-Wallis followed by the Mann-Whitney test. Statistical results show that positive control has the same effect as extract (P> 0.05). Based on the results of statistical analysis of inflammation of the foot volume and the arthritis index shows that the ethanol extract of Syzygium polyanthum leaf had an effect as an antirheumatoid arthritis
Co-Authors , Faradiba Abdul Malik Ahmad, Aktsar Roskiana Alani, Fitri Wasto Alda, Alda Alfani, Ajeng Khori Amara, Ressa Andi Emelda Andi Maulana Kamri Arini Arini Ashar, Muhammad Affan Asriani Suhaenah Aulia Wati, Aulia Awali, Muhammad Noer Dedi Setiawan Dewi Yuliana Ehwanudin Ehwanudin, Ehwanudin Fadlina Chany Saputri Fitriana Fitriana Fitriana Hasbullah, Nurhijjah Hativa, Hativa Irma Santi, Irma Iskandar , A. Nasyrah Isyanda, Kenanga Maghfiroh, Ummu Majid, Wahid Abdul Muarsih, Ahmad Juniardhy Multazania, Multazania Munir, Sahrul Mustakim, Putri Dwiyanti Adha Mustofa, Ahmad Ihzal Nirmala, Maiyuni Nopriyanti, Eka Maryam Nur Aisyah, Irna Nissa Nurul Afiah Nurung, Ayyub Harly Rachmat Kosman, Rachmat Rahman, Safriana Rakhmat, Syahgita Ramadhani, Fitrah Anggun ramadhani, novita annur Resvani, Syahyu Rizqi Nur Azizah Rosyid, Ahmad Sihabudin Rusli Safriani Rahman, Safriani sahab, Fitria SALIM, MUH.AGUS Saputra, Rizki Maulana Siska Nuryanti, Siska Sitti Amirah Sukmawati Sukmawati Syahrul, Andi Ahmad Yundari, Yundari Zuniati, Mai