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All Journal Jurnal Kedokteran Brawijaya Alami Journal (Alauddin Islamic Medical) Journal Sasambo Journal of Pharmacy Jurnal Ilmiah Sains Jurnal Yoga Dan Kesehatan Jurnal Novem Medika Farmasi
Nur Alim
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Islam Makassar, Makassar
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Evaluasi Toksisitas Teratogenik Buah Beligo (Benincasa hispida (Thunb.) Cogn.) Terhadap Fetus Mencit Bunting Nur; Mustaina; Jumrah Sudirman; Emilina Jafar
Alami Journal (Alauddin Islamic Medical) Journal Vol 8 No 2 (2024): JULY
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/alami.v8i2.45132

Abstract

The use of drugs during pregnancy can cause problems for the fetus. Prolonged use of synthetic drugs and herbal products risks causing accumulation in the fetus, while the fetus does not yet have a perfectly functioning metabolic system, which has the potential to cause teratogenic effects. Beligo (Benincasa hispida (Thunb.) Cogn.) is a plant that has the potential to be developed as a herbal medicine. This study aims to determine the teratogenic effect of ethanol extract of beligo fruit on the fetuses of female mice. The method included extraction by maceration and teratogenic effect testing using 16 mice, which were divided into four treatment groups—group I was given Sodium Carboxymethyl Cellulose (Na-CMC) 1% and groups II, III, and IV were given ethanol extract of beligo fruit flesh at doses of 140 mg, 280 mg, and 560 mg/kg BW, respectively, orally. The results showed that the ethanol extract of beligo fruit flesh at 140 mg, 280 mg and 560 mg/kgBW in mouse fetuses was 100% complete same with Na-CMC 1% as a negative control. In conclusion, the ethanol extract of beligo fruit at 140 mg, 280 and 560 mg/kgBW had no teratogenic effect.
Co-Authors A. Ihdinal Hagg Abidin, Araf Asraf Afirah, Nur Agus Sangka Pratama Ahmad Fauzan Emilina Jafar Fajrianti, Siti Hasanuddin, Rusman Indrawaty Kadir , Ira Jasmiadi Jasmiadi Jumrah Sudirman Karnidayanti Karnidayanti Muhammad Ihsan Musdalifah Musdalifah Musdalifah Mustaina Nadillah, Nadia Ni Ketut Sinarsih Nur Alfiah Irfayanti Nur Linda Nurdiyanti Nurdiyanti Nurul Jummah Pratama, Agus Sangka raudatul jannah Sri Sulistyawati Anton Suarni Suarni Sulastri, Dewi Tahirah Hasan Zulfitri Zulfitri