Article Per Year (5 Year)
p-Index From 2020 - 2025
2.543
P-Index
This Author published in this journals
All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional The Indonesian Biomedical Journal Jurnal Biodjati JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Indonesian Journal of Chemistry JFIOnline Pharmaceutical Sciences and Research (PSR) Journal of Food and Pharmaceutical Sciences
Marlyn Dian Laksitorini, Marlyn Dian
Faculty of Pharmacy Gadjah Mada University, Sekip Utara Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

Published : 19 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search
Journal : Journal of Food and Pharmaceutical Science

 1 
The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet Nur Hidayah, Arifatu; Ardiana Wati, Anas; Yuniarti, Nunung; Laksitorini, Marlyn Dian
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.8284

Abstract

Creatine monohydrate has been developed as a neuroprotective agent and can penetrate in vitro model of the blood-brain barrier. However, its delivery is hampered by its limited capacity of creatine transporter. The floating system is known to increase the residence time of drugs in the stomach; thus, the active substances can be absorbed more optimally. Therefore, this study is aimed to develop creatine monohydrate floating tablets by optimizing the proportion of HPMC K100M and NaHCO2 and evaluating the quality of floating tablets. The formula was designed Simplex Lattice Design method. Tablets were prepared by the wet granulation method and evaluated for granule and tablet parameters. The results showed that HPMC K100M significantly increased flow time, absorption rate, hardness, floating time, swelling index; decreased index tap, fragility, and floating lag time. Meanwhile, an increase in NaHCO2 significantly affects an increase in floating lag time. The optimum formula obtained was 18.87% HPMC K100M and 21.12% NaHCO2. Verification of the optimum formula showed that tablet parameters were not significantly different from the predicted formula. The studies suggest that this prototype can be developed to increase creatine residence time in the stomach.
Porcine Derived Ingredients in Cosmetic Products and its Halal Authentication Method within Complex Matrices Nawwaruddin, Hazza' Hammam; Rohman, Abdul; Laksitorini, Marlyn Dian
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.17717

Abstract

Nowadays cosmetics are an important commodity and the market for halal cosmetics is seeing growth. Cosmetics that contain porcine-derived ingredients are typically the source of halal problems. Gelatin and collagen are porcine derivatives that are extensively used in cosmetics. Hence, verifying the presence of porcine derivatives in cosmetics by developing analytical methods is critical. Despite this urgency, determining porcine-derived components in cosmetics is challenging, since cosmetics are quite complex with variable matrix forms. Moreover, to the best of our knowledge, there are only a few papers on developing porcine derivatives analysis in cosmetic items. This mini-review objective is to depict the current understanding of determining porcine collagen and gelatin in cosmetic matrixes. The findings revealed that the LC-MS/MS method is superior for determining gelatin and collagen sources in complex matrixes due to its sensitivity and accuracy. PCR and ELISA methods have challenges with the marker degradation problem since the derivatives undergo extensive processing conditions, thus lowering the methods’ specificity and sensitivity, especially in complex matrixes. The SDS-PAGE method applications are limited and the method is suitable for a relatively simple matrix. This review highlights findings that support future advancements in cosmetic analysis for halal authentication.
Monoclonal Antibodies Aggregation during Administration to Patients and the Role of Pharmaceutical Excipients Almira, Deta; Nurcahya, Bekti Meilani; Rahmawati, Fita; Laksitorini, Marlyn Dian
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21391

Abstract

Monoclonal antibodies (mAbs) are powerful therapeutic agents known for their high specificity and effectiveness in treating complex diseases. Yet, one of their major challenges is their tendency to aggregate, which can reduce treatment efficacy and even trigger unwanted immune responses. This review focuses on how pharmaceutical excipients can help prevent antibody aggregation, particularly during the drug administration process, a phase often overlooked. We conducted a systematic literature search using Scopus, PubMed, and ScienceDirect, targeting studies on excipients and aggregation in therapeutic proteins. After applying the selection criteria, six original research articles were analyzed. The findings reveal that several excipients—such as L-arginine, polysorbates, trehalose derivatives, proline analogs, and cyclodextrins—can effectively stabilize mAbs. They work by reducing interfacial stress, minimizing protein–protein interactions, and preserving antibody structure during stress conditions like infusion or inhalation. These insights highlight the importance of choosing the right excipient based on the administration route to ensure antibody stability and therapeutic impact. By shifting the focus from formulation to administration, this review provides a practical perspective that can support the development of safer and more effective mAb therapies.
Co-Authors Abdul Karim Zulkarnain Abdul Rohman Afifah, Laelatul Akhmad Kharis Nugroho Alam, Lucky Prabowo Miftachul Almira, Deta Andyra, Vania Uly Ardiana Wati, Anas Ardiningtyas, Bondan cahyani, sulastari Cici Darsih Devi, Dwitya Devi Nurlistyo Dwi Umi Siswanti Endang Astuti Fatimi, Hana Anisa Fita Rahmawati Handayani, Sri Handoyo, Rumaisha Lale Hani Susanti, Hani Harsanti, Dian Dwi Harsanti, Dian Dwi Hidhayati, Noor Indrianingsih, Anastasia Wheni Isdwiani, Renita Isdwiani, Renita Larasati, Savira Wahyu Muhammad Thesa Ghozali Nawwaruddin, Hazza' Hammam Ni’maturrohmah, Dwi Nunung Yuniarti Nur Hidayah, Arifatu Nurcahya, Bekti Meilani Rahmasari, Firdaus Salvia Respati, Anindita Kresna Respati, Anindita Kresna Rizal Maulana Hasby, Rizal Maulana Sahid, Muhammad Novrizal Abdi Saifullah Sulaiman, Teuku Nanda Seftian, Muhammad Selalau, Waly Prakasa Sulaiman, Teuku Nanda Sulaiman, Teuku Nanda Saifullah Sumlang, Gavriel Hagai Paulus Supraptiyah, Cicilia Supraptiyah, Cicilia Suwarto, Tiekha Kencanasari Suwarto, Tiekha Kencanasari Tri Joko Raharjo Tri Rini Nuringtyas Utami, Indrawati Dian Utami, Nila Vidilia