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All Journal INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) YUSTISI FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Aisyah : Jurnal Ilmu Kesehatan Yustisi: Jurnal Hukum dan Hukum Islam BIOVALENTIA: Biological Research Journal Jurnal Locus Penelitian dan Pengabdian Journal of Applied Agricultural Science and Technology Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies
. Hayun
Faculty Of Pharmacy, Universitas Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : indonesian journal of pharmacy

 1 
Synthesis and Preliminary In Vitro Anti-inflammatory Evaluation of Mannich Bases Derivatives of 4’-Methoxy-substituted of Asymmetrical Cyclovalone Analogs Rahmawati, Nur; Hariyanti, Hariyanti; Saputri, Fadlina Chany; Hayun, Hayun
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp35

Abstract

Two of Mannich bases derivatives of 4’-methoxy-substituted of asymmetrical cyclovalone analog (ACA) (2a and 2b) were synthesized. The synthesized compounds and the other two Mannich bases derivatives of 4'-methoxy-substituted ACA (2c and 2d) were evaluated for their in-vitro anti-inflammatory activity preliminary by protein denaturation inhibition method using a final concentration of 1.57 μM. The study found that all the Mannich bases exhibited anti-inflammatory potential with inhibition ranging from 33.17- 42.47%. The activity of 2b (42,47%) and 2d (41.90%) was higher than that of diclofenac sodium (35.27%) and the parent compound 1 (38.16%). As a conclusion,  2b and 2d have a prospect as a potential candidate for an anti-inflammatory agent. Further study should be done using more specific methods.
Analysis of Derivate Compound Between Sodium Alendronat with Chloride by High Performance Liquid Chromatography Yahdiana Harahap; Hayun .; Meriska Sukandar
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.159 KB) | DOI: 10.14499/indonesianjpharm0iss0pp88-95

Abstract

Sodium alendronate is one of biphosphonate group drugs for the treatment of osteoporosis,. The aim of this research was to obtain the optimum condition for forming derivative of sodium alendronate with dansyl chloride. By adding 270 μL dansyl chloride to 0.1 M sodium carbonate buffer at pH 10.0 mixing with thermomixer at 50.oC for 50 minutes, resulted in a stable derivative within 30 minutes. The compound was analysed by high performance liquid chromatography method using C18 column acetonitrilemethanol-buffer (25 mM KH2PO4 and 25 mM citric acid) (20:15:65;v/v) as mobile phase at a flow rate of 1.0 mL/minute; (detected at wavelength of excitation 320 nm and emission 495 nm). The retention time of the derivative was 19.758 minutes, the calibration’s curve was linear at concentration range of 0.2-1 μg/mL with coefficient of correlation (r) 0.9995 and limit of quantitation 0.114 μg/mL.Key word : HPLC, sodium alendronat, dansyl chloride, fluorescence
DETERMINATION OF SIBUTRAMINE ADULTERATED IN HERBAL SLIMMING PRODUCTS USING TLC DENSITOMETRIC METHOD Hayun Hayun; Baitha P Maggadani; Nurul Amalina
Indonesian Journal of Pharmacy Vol 27 No 1, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (734.241 KB) | DOI: 10.14499/indonesianjpharm27iss1pp15

Abstract

Determination of sibutramine adulterated in herbal slimming product using thin layer chromatography (TLC) densitometric method with TLC silica gel 60 F254 aluminium plate as stationary phase and mixture of toluen-diethylamine (10:0.3) as mobile phase has been developed. The calibration curve in the concentration range of 0.50 to 5.00 µg/spot showed good linier relationship (r2 = 0.9986). The limit of detection and quantitation (LOD and LOQ) were 217.5 ng and 724.9 ng/spot, respectively. The method gave satisfactory specificity, linierity, precision and accuracy validation criteria and was applied for determination of sibutramine in herbal slimming products obtained from several drugstrores in Depok City, West Java, Indonesia. Results of the determination showed that six of seven samples analyzed were detected containing sibutramine HCl with the concentration of 2.45 - 26.24 mg in a single dosage of slimming herbal products
Co-Authors . Harianto . Harmita . Yenti A.A. Ketut Agung Cahyawan W Abdul Mun'im Abdul Mun'im Abdul Munim Abdul Munim Andika Purnomo Arif Arrahman Arry Yanuar Ayuningtyas N Putri Azminah Azminah Baitha P Maggadani Baitha Palanggatan Maggadani Baitha Palanggatan Maggadani, Baitha Palanggatan Berna Elya Camelia D.P Masrijal Catur Jatmika, Catur Citra Nur Azizah Citra Nur Azizah, Citra Nur Dini Hariria Dini Hariria, Dini Eva Siburian Fadlina Chany Saputri Fajriati, Annisa Febriyanti, Lilis Fready SIP Gadis Anggraini Harianto Harianto Hariyanti Hariyanti Hasan, Nahrul Hasri, Hasirudin Hendri, Rifki Anshory Herman Suryadi Inas Priasti Siwi Kadek Devi Arum Savitri Karim, La Ode Muhammad Kusmadi Kurmardi Kusmardi Lisa N Luh Putu Ratna Sundari Lutfhi Zarkasih Mashendra Masrijal, Camelia D.P. Meriska Sukandar Mohamad Rahmatullah Zakaria Mulia Ade Karina Mun'im, Abdul Nafi’ah, Nadya Ismi Nelly D Leswara Nelly D. Leswara Nelly Dhevita Leswara Novi Fajar Utami Nur Rahmawati Nurul Amalina Setiajid, Muhammad Aditya Setiajid, Muhammad Aditya Sherly Meilianti Sherly Meilianti, Sherly Sutriyo Syamsu Nur, Syamsu Taufiq Indra Rukmana Ulfah Aunillah Ulfah Aunillah, Ulfah Yahdiana Harahap Yenti, Yenti Zarkasih, Lutfhi