Garuda - Garba Rujukan Digital

p-Index From 2021 - 2026

2.572

P-Index

This Author published in this journals

All Journal INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) YUSTISI FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Aisyah : Jurnal Ilmu Kesehatan Yustisi: Jurnal Hukum dan Hukum Islam BIOVALENTIA: Biological Research Journal Jurnal Locus Penelitian dan Pengabdian Journal of Applied Agricultural Science and Technology Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies

Hayun Hayun

Departemen Farmasi FMIPA-UI

Author-ID : 553473

Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 28 Documents Claim Missing Document

Claim Missing Document

Articles

Title

Analisis Penambatan dan Simulasi Dinamika Molekular Komplex Siklookgesinenase-2 dengan Beberapa Senyawa Turunan Kuinazolinon Yanuar, Arry; Setiajid, Muhammad Aditya; Hayun, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 1 (2014)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (559.87 KB)

The aims of this research is to observe the inhibition activity of sulfonamides or sulfacetamides substituted of 3-Phenyl-2-styril-4(3H)-quinazolinones with COX-2. The study of COX-2, binding inhibition and dynamics interaction was done with in silico method by molecular docking with Auto Dock 4.0 and molecular dynamics in 2 nanoseconds with Amber 11. Those compound could be divided into 3 groups, based on ΔG scores of docking result: very selective group (-10.92 to -11.33 kcal/mol) compared to SC-558 (-10.90 kcal/mol); selective group compound (-9.22 to -10.68 kcal/mol) compared to celecoxib (-10.63 kcal/mol); non selective group, compound (-6.48 to -6.98 kcal/mol) compared to aspirin (-4.82 kcal/mol). Molecular dynamics simulation of 6COX complex with several quinazolinon derivates showed number and stability of hydrogen bond.Keywords : COX-2, anti-inflammatory, molecular docking, molecular dynamics.

SINTESIS ANALOG UK-3A : 6-HIDROKSI-N-FENILNIKOTINAMIDA DAN 6-HIDROKSI-N- FENILPIKOLINAMIDA DAN UJI SITOTOKSISITAS SECARA IN VITRO TERHADAPSEL KANKER MURINE LEUKEMIA P388 Febriyanti, Lilis; Hanafi, Muhammad; Hayun, Hayun
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.583

The Novel compound of analog UK-3A defined as HF-1 (6-hydroxy-N-phenylnicotinamide) and HF-2 (6-hydroxy-N-phenylpicolinamide)was successfully synthesized by amidation reaction of aromatic carboxilyc acids and primary amine by adding the activator of DCC (dicyclohexylcarbodiimide), catalyst DMAP (4-dimethyl aminopyridine, and DMSO (dimethyl sulfoxide) as the solvent. Reaction run for 24 hours in 55oC. Result shows yield of HF-1 as much as 52%, and for HF-2 is 16%. The analogue compounds structure of UK-3A were characterized by spectrophotometer FT-IR, LCMS, and NMR. Citotoxicity assay against Murine Leukemia cells of HF-1 and HF-2 by MTT (3-(4,5-dimethylltiazo-2-yl-) 2,5-diphenyltetrazolium bromide) assay. The result of bioassay showed IC50(inhibitory concentration)value 71 µg/mL and 63 µg/mL for HF-1 and HF-2 respectively. It informed that the analogue compounds have lower activity than UK-3A compound which has IC50 value 38 µg/mL.

The Novel compound of analog UK-3A defined as HF-1 (6-hydroxy-N-phenylnicotinamide) and HF-2 (6-hydroxy-N-phenylpicolinamide)was successfully synthesized by amidation reaction of aromatic carboxilyc acids and primary amine by adding the activator of DCC (dicyclohexylcarbodiimide), catalyst DMAP (4-dimethyl aminopyridine, and DMSO (dimethyl sulfoxide) as the solvent. Reaction run for 24 hours in 55oC. Result shows yield of HF-1 as much as 52%, and for HF-2 is 16%. The analogue compounds structure of UK-3A were characterized by spectrophotometer FT-IR, LCMS, and NMR. Citotoxicity assay against Murine Leukemia cells of HF-1 and HF-2 by MTT (3-(4,5-dimethylltiazo-2-yl-) 2,5-diphenyltetrazolium bromide) assay. The result of bioassay showed IC50(inhibitory concentration)value 71 Âµg/mL and 63 Âµg/mL for HF-1 and HF-2 respectively. It informed that the analogue compounds have lower activity than UK-3A compound which has IC50 value 38 Âµg/mL.

Analisis Penambatan dan Simulasi Dinamika Molekular Komplex Siklookgesinenase-2 dengan Beberapa Senyawa Turunan Kuinazolinon Yanuar, Arry; Setiajid, Muhammad Aditya; Hayun, .
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

The aims of this research is to observe the inhibition activity of sulfonamides or sulfacetamides substituted of 3-Phenyl-2-styril-4(3H)-quinazolinones with COX-2. The study of COX-2, binding inhibition and dynamics interaction was done with in silico method by molecular docking with Auto Dock 4.0 and molecular dynamics in 2 nanoseconds with Amber 11. Those compound could be divided into 3 groups, based on Î?G scores of docking result: very selective group (-10.92 to -11.33 kcal/mol) compared to SC-558 (-10.90 kcal/mol); selective group compound (-9.22 to -10.68 kcal/mol) compared to celecoxib (-10.63 kcal/mol); non selective group, compound (-6.48 to -6.98 kcal/mol) compared to aspirin (-4.82 kcal/mol). Molecular dynamics simulation of 6COX complex with several quinazolinon derivates showed number and stability of hydrogen bond.Keywords : COX-2, anti-inflammatory, molecular docking, molecular dynamics.

Co-Authors . Harmita A.A. Ketut Agung Cahyawan W Abdul Mun'im Abdul Munim Andika Purnomo Arif Arrahman, Arif Arry Yanuar Ayuningtyas N Putri Azminah Azminah Baitha P Maggadani Baitha Palanggatan Maggadani, Baitha Palanggatan Berna Elya Catur Jatmika, Catur Citra Nur Azizah, Citra Nur Dini Hariria, Dini Fajriati, Annisa Febriyanti, Lilis Fready SIP Gadis Anggraini Harianto Harianto Hariyanti Hariyanti Hasan, Nahrul Hasri, Hasirudin Hendri, Rifki Anshory Herman Suryadi Karim, La Ode Muhammad Kusmadi Kurmardi Kusmardi Kusmardi Lisa N Luh Putu Ratna Sundari mashendra, Mashendra Masrijal, Camelia D.P. Meriska Sukandar Mulia Ade Karina Mun'im, Abdul Nafi’ah, Nadya Ismi Nelly D. Leswara Novi Fajar Utami Nurul Amalina Rukmana, Taufiq Indra Setiajid, Muhammad Aditya Setiajid, Muhammad Aditya Sherly Meilianti, Sherly Siburian, Eva Sutriyo Sutriyo, Sutriyo Syamsu Nur, Syamsu Ulfah Aunillah, Ulfah Yahdiana Harahap Yahdiana Harahap Yenti, Yenti Zakaria, Mohamad Rahmatullah Zarkasih, Lutfhi

Title Search

Found 4 Documents Search Journal : JFIOnline

Abstract

Abstract

Abstract

Abstract

Title

Found 4 Documents
Search
Journal : JFIOnline