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All Journal Jurnal Sain Veteriner Jurnal Pelita Pendidikan Jurnal Teknologi Pendidikan Jurnal Pendidikan Biologi Biosfer: Jurnal Pendidikan Biologi Jurnal Pembelajaran dan Biologi Nukleus Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) JURNAL BIOSHELL Bioscientist : Jurnal Ilmiah Biologi Jurnal Pengabdian Teknologi Tepat Guna Journal of Biology Education
Herbert Sipahutar, Herbert
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Nursing Public Health Social Sciences Veterinary

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Pengaruh Ekstrak Etanol Daun Bosibosi (Timonius flavescens) terhadap Jumlah dan Diameter Pulau Langerhans Tikus Putih (Rattus norvegicus) yang Diinduksi Bisphenol A Saragih, Juwanda Pranata; Sipahutar, Herbert
Jurnal Sain Veteriner Vol 43, No 3 (2025): Desember
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.107383

Abstract

Bisphenol A (BPA) merupakan senyawa kimia sintetis yang banyak digunakan dalam industri plastik dan diketahui bersifat toksik serta mengganggu sistem endokrin, termasuk memengaruhi fungsi pankreas. Daun bosibosi (Timonius flavescens (Jacq.) Baker) mengandung senyawa metabolit sekunder seperti flavonoid, fenolik, saponin, serta terpenoid/steroid. Flavonoid dalam bosibosi diketahui memiliki aktivitas biologis tinggi dan berpotensi sebagai antidiabetes. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun bosibosi terhadap jumlah dan diameter pulau Langerhans tikus putih (Rattus norvegicus) yang diinduksi BPA. Penelitian menggunakan rancangan acak lengkap (RAL) dengan enam perlakuan dan lima ulangan. Tikus diberi 0,5 ml minyak jagung, BPA dosis tunggal (50 mg/kg BB), dan kombinasi BPA + ekstrak etanol daun bosibosi (EEDB) dosis bertingkat (125, 250, dan 500 mg/kg BB) secara oral selama 30 hari. Kelompok normal hanya diberi pelet dan air. Pada hari ke-31, tikus dibedah dan pankreas diambil untuk ditimbang serta diproses histologinya. Hasil uji ANOVA menunjukkan bahwa pemberian EEDB tidak memberikan pengaruh yang signifikan (P > 0,05) terhadap berat badan, berat pankreas, rasio berat pankreas, dan jumlah pulau Langerhans. Namun, EEDB berpengaruh signifikan (P < 0,05) terhadap diameter pulau Langerhans. Disimpulkan bahwa ekstrak etanol daun bosibosi berpotensi melindungi struktur pulau Langerhans dari kerusakan akibat paparan BPA.Kata kunci : Bisphenol A; Rattus norvegicus; Timonius flavescens; pankreas; pulau Langerhans
Pengaruh Ekstrak Etanol Daun Bosibosi (Timonius flavescens (Jacq.) Baker) terhadap Jumlah Folikel Ovarium Tikus Putih (Rattus norvegicus) yang Diinduksi Bisphenol A Panjaitan, Melisa Lidwina; Sipahutar, Herbert
Jurnal Sain Veteriner Vol 43, No 3 (2025): Desember
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.107589

Abstract

Kehadiran BPA sebagai pengganggu endokrin dalam kehidupan manusia telah memberikan dampak negatif terutama pada kondisi kesehatan. Upaya untuk menemukan bahan alami yang murah, aman dan efektif untuk mengobati penyakit akibat toksisitas BPA menjadi semakin penting. Penelitian ini bertujuan untuk mengetahui potensi pemberian ekstrak etanol daun bosibosi ( Timonius flavescens (Jacq.) Baker) terhadap jumlah folikel ovarium tikus putih (Rattus norvegicus) yang menginduksi BPA. Adapun parameter yang diamati yaitu berat badan, berat organ ovarium, rasio berat ovarium, jumlah folikel primer dan folikel sekunder. Tikus dibagian menjadi menjadi 6 kelompok (1 kelompok terdiri dari 6 ekor tikus). Kelompok I tikus hanya diberi pakan dan minum. Kelompok II, diberi 0,5 ml minyak jagung. Kelompok III, diberi BPA 50 mg/kg/hari. Kelompok IV, diberi BPA 50 mg/kg/hari+EEDB 225 mg/kg/hari. Kelompok V, diberi BPA 50 mg/kg/hari+EEDB 250 mg/kg/hari. Kelompok VI, diberi BPA 50 mg/kg/hari+EEDB 500 mg/kg/hari. Pemberian perlakuan dilakukan secara lisan selama 30 hari. Hasil analisis Uji ANOVA menunjukkan perbedaan yang signifikan (p < 0,05) terhadap berat badan. Pada berat organ dan rasio berat organ tidak terdapat perbedaan yang signifikan (p > 0,05). Namun pemberian BPA dan esktrak etanol daun bosibosi berpengaruh signifikan (p < 0,05) terhadap jumlah folikel primer dan folikel sekunder. Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak etanol daun bosibosi memelihara jumlah folikel primer dan folikel sekunder pada ovarium.Kata kunci: Bisfenol A; ekstrak etanol daun bosibosi; folikel primer; folikel Sekunder
Pengaruh Model Pembelajaran TGT Berbantuan E-LKPD Berbasis Teka-Teki Silang terhadap Minat, Keaktifan, dan Hasil Belajar Siswa Panjaitan, Chatryn Joice Elisabet; Sipahutar, Herbert
Biosfer: Jurnal Pendidikan Biologi Vol. 19 No. 1 (2026): Biosfer: Jurnal Pendidikan Biologi
Publisher : Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/biosferjpb.60767

Abstract

This study aims to determine the effect of the Team Games Tournament (TGT) learning with crossword puzzles-based E-student worksheet on students’ learning interest, activity, and cognitive outcomes on the ecosystem material. This research is a quasi-experimental study using a pretest-posttest control group design. The subjects consisted of two classes: class X-2 (experimental) taught using the TGT model with crossword puzzles-based E-student worksheet, and class X-3 (control) taught using the Direct Instruction model. The TGT syntax included class presentation, team formation, games, tournament, and team recognition, while the Direct Instruction syntax included presentation of objectives and motivation, material delivery, guided practice, feedback, and independent practice. Data were collected using questionnaires (learning interest), observation sheets (learning activity), and tests (learning outcomes). The data obtained were analyzed using an independent sample t-test, which showed a significance value lower than 0.05. Students in the experimental class showed higher learning interest (71.2% > 58.9%), greater learning activity (81.15% > 59.04%), and higher cognitive outcomes (83.06 > 70.56) compared to the control class. It can be concluded that the TGT model with crossword puzzles-based E-student worksheet has a significant effect on improving students’ learning interest, activity, and cognitive outcomes. Teachers are encouraged to apply this model as a student-centered strategy to improve the quality of biology learning and to use similar interactive media to create more engaging and collaborative learning experiences.
Gamification-assisted project-based learning in biology education: Critical thinking and collaboration among students in urban Medan, Indonesia Situmorang, Damayanti; Sipahutar, Herbert
Biosfer: Jurnal Pendidikan Biologi Vol. 19 No. 1 (2026): Biosfer: Jurnal Pendidikan Biologi
Publisher : Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/biosferjpb.62892

Abstract

In 21st-century learning, students are required to develop critical thinking and collaboration skills. Project-Based Learning (PjBL) integrated with gamification is considered a potential approach to support these competencies. This study aimed to examine the effect of gamification-assisted PjBL on Grade X students’ critical thinking and collaboration skills in the biodiversity topic at SMAN 21 Medan. The study employed a quasi-experimental method using a Non-Equivalent Control Group design, involving class X5 as the experimental group and class X7 as the control group selected through random sampling. Critical thinking skills were measured using ten essay questions representing five indicators, while collaboration skills were assessed through an observation sheet based on four indicators. The results showed a significant difference between the experimental and control groups. The t-test analysis of critical thinking skills yielded a significance value of 0.016 (< 0.05), with the experimental group achieving a higher posttest mean score (75.25) than the control group (61.60). Similarly, collaboration skills showed a significant difference with a significance value of < 0.001. These findings indicate that gamification-assisted PjBL has a positive effect on improving students’ critical thinking and collaboration skills compared to PjBL without gamification. Therefore, it is recommended that biology teachers integrate gamification elements such as points, badges, and challenges into project-based learning to enhance students’ critical thinking and collaboration skills.
Co-Authors A.A. Ketut Agung Cahyawan W Agustina, Rezeki Sri Azimar Rusdi, Azimar Cristanty, Rina Dedy Husrizal Syah, Dedy Husrizal Deo Demonta Panggabean Diningrat, Diky Setya Doloksaribu, Maryati Evivani Ely Djulia Fauziyah Harahap Istiqomah, Khazanah Jonny Haratua Panggabean, Jonny Haratua Lestari, Sri Ratna Limbong, Forentina Mukti Hamjah Harahap, Mukti Hamjah Nasution, Marina Azzahra Natalia Kristiani Lase, Natalia Kristiani Panjaitan, Chatryn Joice Elisabet Panjaitan, Melisa Lidwina Renny Agustina, Renny Sapitri, Alfi Saragih, Juwanda Pranata Sembiring, Rinawati Sembiring, Surya Karinanta Sinambela, Aslinda Sipahutar, Melati Sri Agnes Sipayung, Yariski Sitanggang, Lawren Siti Khadizah Harahap, Siti Khadizah Situmorang, Damayanti Susanty, Revi Ruth Syahmi Edi Syarifuddin Syarifuddin Tarigan, Lola Zeramenda Tobing, Priskila Uli Arta Lumban Tri Effiyanti Tri Harsono Turnip, Ayu Monita