Article Per Year (5 Year)
p-Index From 2021 - 2026
2.906
P-Index
This Author published in this journals
All Journal Jurnal Sains dan Teknologi Farmasi JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Farmasi Higea Media Karya Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Journal of Nursing and Public Health (JNPH) Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Health Science JAFP (Jurnal Akademi Farmasi Prayoga) Jurnal Pharmacopoeia Riset Informasi Kesehatan Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Jurnal Ilmiah Farmasi Simplisia Proceeding of Bengkulu International Conference on Health Medicor : Journal of Health Informatics and Health Policy
Resva Meinisasti
Poltekkes Kemenkes Bengkulu
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

Published : 29 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 29 Documents
Search

 1   2   3 
Polymorphism E23K KCNJ11 Gen as a Risk Factor of Diabetes Mellitus in Serawai Tribe Of Bengkulu Raden Sunita; Sahidan Sahidan; Rachmat Hidayat; Resva Meinisasti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 1 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i1.105

Abstract

ABSTRACT Background: Type 2 diabetes mellitus (T2DM) is a multifactorial disease involving genetic and environmental factors. The E23K KCNJ11 gene polymorphism causes KATP canal overactivity, decreases cell membrane depolarization potential, and decreases insulin secretion. E23K polymorphism of the KCNJ11 gene as a risk factor for T2DM. Research Objective: This study aimed to analyze the E23K polymorphism of the KCNJ11 gene as a risk factor for T2DM in the Bengkulu Serawai. Method: This study is a case-control study. The subjects of the study were 100 people with T2DM patients as a case group (50 people) and Non-DM subjects with families who did not have a history of T2DM as a control group (50 people). Fasting blood glucose (GDP) was analyzed by spectrophotometry and E23K KCNJ11 gene by polymerase chain reaction fragment length polymorphism (PCR-RFLP). Data were analyzed by statistics. Results: The frequency of AA genotypes in cases was higher than the controls (12% and 8%) (p = 0.001). The frequency of A allele in the case was higher than the control (32% and 18%) (p = 0.017). The risk of T2DM on AA / GA genotypes was 4.75 times higher in cases than controls (p = 0,000, OR 4.75 95% CI 2.01-11.24). The risk of T2DM in A allele was 2.14 times higher in cases than in controls (p = 0.017, OR 2.14, 95% CI 1.11-4.15). Conclusion: E23K polymorphism of the KCNJ11 gene as a risk factor for T2DM in Bengkulu Serawai Tribe. Keywords: E23K gene KCNJ11, DMT2, Non-DMT2.
The Effectiveness Test of Betel Leaf Ethanol Extract Cream (Piper Betle Linn) Toward Propionibacterium acnes Bacterial Growth Resva Meinisasti; Zamharira Muslim; Krisyanella; Raden Sunita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 2 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i2.112

Abstract

Background: One of skin diseases that is frequently taking attention among teenagers and young adults is acne or in medical term called acne vulgaris. Acne treatment can be treated by repairing follicular abnormalities, decreasing sebum production, decreasing the number of Propionibacterium acnes colonies and reducing inflammation of the skin. The bacterial population of Propionibacterium acnes can be reduced by giving an antibacterial substance such as erythromycin, clindamycin and benzoyl peroxide. In the treatment of acne we can get antibacterial originating from nature, one of which can be obtained in the secondary metabolism of plants. The extracts and essential oils of betel leaf contain antibacterial and antifungal activities. The effectiveness of the use of betel leaf ethanol extract (Piper betle Linn) in acne treatment can be improved by creating formulations in form of cream preparations. Formulations in cream preparations will affect the amount and speed of active substances that can be absorbed. Objectives: To determine the effectiveness of the ethanol extract cream of betel leaf (piper betle linn) cream in formulas with what percentage of active substance has the most-inhibitory effect on the growth of Propionibacterium acnes. Methods:The study used experimental research. Propionibacterium acnes samples were diluted in 0.9% physiological NaCl sterile and embedded in Nutrient Agar (NA) media. The media was inserted into an incubator at 37 ° C for 24 hours. The test of antibacterial activity used the disk diffusion method. The antibacterial activity test results were statistically analyzed using the Statistical Product Services Solution (SPSS 17) program with a confidence level of 95% (α = 0.05). Results: The three creams containing betel leaf ethanol extracts at percentages of 5%, 10% and 15% for each had inhibitory zones: 9.8 mm, 15.85 mm, 17.35 mm. Conclusion: Cream that contains 15% active substance has the strongest inhibition.
ANALISA PRAKTIK SWAMEDIKASI DI KOTA BENGKULU AVRILYA IQORANNY SUSILO; RESVA MEINISASTI
Journal of Nursing and Public Health Vol 10 No 2 (2022)
Publisher : UNIVED Press, Universitas Dehasen Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Praktik swamedikasi merupakan praktik penggunaan obat-obatan pada seseorang untuk mengobati gejala atau gangguan kesehatan yang didiagnosis sendiri atau berdasarkan keluhan gejala yang pernah dirasakan di masa lampau. Badan Pusat Statistik menunjukkan bahwa lebih dari 60% masyarakat di Indonesia melakukan pengobatan sendiri. Praktik swamedikasi ini jika dilakukan dengan benar dapat mengurangi beban pemerintah dalam pelayanan kesehatan di sarana pelayanan kesehatan. Akan tetapi, praktik swamedikasi yang dilakukan tidak tepat dapat menimbulkan resiko tidak tercapainya efek kesembuhan yang diinginkan pasien. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang melatarbelakangi pelaksanaan praktik swamedikasi di masyarakat Kota Bengkulu. Penelitian deskriptif ini menggunakan desain cross sectional dengan teknik pengambilan sampel secara purposive sampling. Berdasarkan perhitungan jumlah sampel, diperoleh sebanyak 200 responden di Kota Bengkulu yang memenuhi kriteria inklusi. Analisis data dilakukan dengan analisa univariat dan bivariat dengan menggunakan uji Chi Square dengan taraf signifikasi (0,05). Dari hasil analisa univariat diperoleh distribusi demografi responden berusia antara 20-39 tahun (54,5%), berjenis kelamin wanita (64%) dan sudah menikah (77,5%). Dalam aspek pelayanan kesehatan, kepemilikan asuransi kesehatan (83%). Praktik swamedikasi dilakukan untuk mengatasi keluhan nyeri (22%), alasan melakukan swamedikasi karena penyakit yang dialami kategori ringan (41,5%), jangka waktu keluhan sakit yang dirasakan yaitu kurang dari 3 hari (77,5%), tingkat keparahan sakit yang dirasakan ringan (76%), jangka waktu penggunaan obat 1-3 hari (77%), sumber informasi obat yang digunakan adalah dari resep dokter (38,5), sumber informasi pemakaian obat adalah tenaga farmasi di apotik (68,5), rata-rata kunjungan ke apotek dalam 1 bulan adalah 1 kali (43%) dan tempat memperoleh obat selain di apotek adalah toko obat (63%). Hasil analisis hubungan antara variabel dependen dan variabel independen diperoleh hasil bahwa ada hubungan variabel umur (p=0,03), jenis kelamin (p=0,043) dan keparahan penyakit (p=0,014) dengan praktek swamedikasi di Kota Bengkulu. Sedangkan variabel Status Pernikahan, pendidikan, pekerjaan, jarak rumah, lama sakit, kepemilikan BPJS, lama penggunaan obat menunjukkan tidak ada hubungan dengan praktek swamedikasi di Kota Bengkulu.
Aktivitas Perlindungan Sinar UV Ekstrak Etanol Daun Kopi Robusta (Coffea canephora Pierre ex.A. Froehner) Secara In Vitro Krisyanella Krisyanella; Resva Meinisasti
Jurnal Farmasi Higea Vol 14, No 2 (2022)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kopi merupakan tanaman komoditas utama di Curup Kabupaten Rejang Lebong, Bengkulu. Pemanfaatan spesies kopi  umumnya masih terfokus pada biji kopi, sedangkan daun kopi hasil pemangkasan biasanya terbuang. Menurut literatur Daun kopi robusta (Coffea canephora) mengandung senyawa flavonoid dan tanin yang berpotensi memberikan aktifitas tabir surya. Tujuan Penelitian : menentukan nilai SPF dan aktifitas tabir surya dari ekstrak etanol daun kopi robusta. Metodologi penelitian adalah eksperimental laboratorium. Metoda ekstraksi yang digunakan adalah maserasi dengan etanol 70%. Pengukuran nilai SPF dilakukan secara in vitro menggunakan Spektrofotometer UV-Vis. Dari hasil pemeriksaan kandungan metaboblit sekunder, sampel mengandung senyawa Alkaloid, Flavonoid, Saponin, Tanin, Dan Steroid. Senyawa metabolit sekunder golongan flavonoid mempunyai potensi sebagai tabir surya karena adanya gugus kromofor yang mampu menyerap sinar UV sehingga mengurangi intensitasnya pada kulit Tanin juga  bermanfaat sebagai tabir surya. Tanin terkondensasi memiliki aktivitas sebagai antioksidan dan dapat melindungi kulit dari kerusakan yang ditimbulkan radiasi ultraviolet. Nilai SPF dari ekstrak dengan konsentrasi 50 ppm, 100 ppm dan 150 ppm  yaitu berurut-turut 6,911 (Proteksi sedang); 8,093 (Proteksi maksimum dan 12,989 (Proteksi maksimum). Berdasarkan hasil penelitian terlihat bahwa ekstrak etanol daun kopi robusta memiliki aktifitas tabir surya, dimana peningkatan aktifitas tabir surya berbanding lurus dengan kenaikan konsentrasi ekstrak. Daun kopi robusta berpotensi untuk dikembangkan menjadi sediaan tabir surya
FORMULATION OF HAIR GEL FROM CELERY ETHANOL EXTRACT (APIUM GRAVEOLENS .L) Resva Meinisasti; Krisyanella Krisyanella; Dewi Oktasari
Proceeding B-ICON Vol. 1 No. 1 (2022): Proceeding of The 2nd Bengkulu International Conference on Health (B-ICON 2022)
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/bicon.v1i1.15

Abstract

Background: Uncontrolled hair loss will cause baldness. Celery (Apium graveolens L.) contains compounds apiin, apigenin, mannitol, inositol, asparagine, glutamine, choline, linamarose potassium and sodium. Apigenin is the main chemical content in celery which is known to have activity as a vasodilator that can stimulate hair growth. The purpose of the study was to determine the hair gel formula that had the best characteristics. The concentration variations used were 5%, 7.5% and 10%. This study uses experimental research methods. The activity starts from the preparation of the ethanol extract of dried celery, gel formualtion, and then evaluation of the preparation. The evaluation of the preparations included organoleptic tests, homogeneity, spreadability, pH, irritation, freeze thraw and the preference of the preparations by the respondents. The results showed that Formulas 1 (5%) and 2 (7.5%) met the standard parameters of hair gel preparations, while formula 3 (10%) did not standardize the spreadability test. In the organoleptic test, it was seen that the higher the concentration of the extract used, the more concentrated the color of the preparation. However, the increase in extract concentration did not significantly affect the dispersion of the preparation. Based on the results obtained, it can be concluded that Formula 1 (5%) has the best hair gel preparation characteristics compared to other formulas.
FORMULATION OF LOTION OF GERGA ORANGE PEEL ETHANOL EXTRACT WITH VARIATION OF EXTRACT CONCENTRATION Krisyanella Krisyanella; Resva Meinisasti; Silvi Elvianita
Proceeding B-ICON Vol. 1 No. 1 (2022): Proceeding of The 2nd Bengkulu International Conference on Health (B-ICON 2022)
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/bicon.v1i1.41

Abstract

Gerga Orange (Citrus nobilis L. Var. RGL) are the main commodity in Lebong Regency, Bengkulu Province. These oranges have been processed by the community into syrup preparations and from this activity produce waste in the form of fruit peels. Based on previous research, the peel of this citrus fruit is known to have antioxidant and antibacterial activity, so it can be used as a raw material in the manufacture of lotion preparations. The purpose of this study was to determine the characteristics of the three lotion formulations from the ethanolic extract of the gerga orange peel (Citrus nobilis L. Var. RGL) with various concentrations of 8% (F1), 10% (F2), 12% (F3). The method used is the experimental method. The results showed that the three formulations of lotion met the standard of good lotion. In the organoleptic test, there were differences in the color of the preparation, where the color became more concentrated as the concentration of the extract increased. In the homogeneity test, the three formulas showed good homogeneity until the 14th day of testing. The pH of the three formulas was also in accordance with the SNI 16-4399-1996 standard, namely 4.5-8. The three formulas also did not cause allergic reactions to 10 respondents. Based on the results of the research that has been done, it can be concluded that all formulas of the ethanol extract of the gerga orange peel (Citrus nobilis L. Var. RGL) with varying concentrations can be formulated as lotion preparations that are physically and organoleptically stable, as well as the standard of SNI 16-4399-1996 in terms of pH of the preparation and irritation test. Of the three formulas, formula 1 has an advantage over the other formulas because it has a less intense color, which makes it superior in appearance.
Increasing Self-Medication Knowledge of Administrators in the Child Social Welfare Institution Muslim, Zamharira; Susilo, Avrilya Iqoranny; Pudiarifanti, Nadia; Meinisasti, Resva; Krisyanella, Krisyanella; Khasanah, Heti Rais; Irnameria, Dira
Media Karya Kesehatan Vol 6, No 2 (2023): Media Karya Kesehatan
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mkk.v6i2.44731

Abstract

Child Welfare Institution (CWI) managers often provide self-treatment or self-medication when foster children experience mild symptoms of illness. In its implementation, self-medication often results in inaccuracies. For this reason, it is necessary to increase the self-medication knowledge capacity of CWI managers in Bengkulu City. The aim of this activity is to increase knowledge about self-medication by CWI managers. This activity provides knowledge about how to manage medicines properly and correctly. The training was given using the Active Human Learning Method which was attended by 30 people. Based on the pretest results, the average score was 5.73, while the posttest results showed an increase in the average score to 7.27 and was tested by an independent t-test (p=0.000). Increasing this knowledge is important in supporting rational drug use programs. Keywords: Child Welfare Institutions, knowledge, self-medication.
Optimasi Formulasi Sediaan Masker Wajah Gel Peel-Off Dari Ekstrak Etanol Kulit Jeruk Nipis (Citrus Aurantiifolia Cortice) Berdasarkan Variasi Konsentrasi PVA Krisyanella, Krisyanella; Nadeak, Bella Nadeak; Meinisasti, Resva; Irnameria, Dira
Jurnal Akademi Farmasi Prayoga Vol 9 No 2 (2024): JURNAL AKADEMI FARMASI PRAYOGA
Publisher : Jurnal Akademi Farmasi Prayoga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

PVA pada formula sediaan masker gel Peel-off berfungsi sebagai basis pembentuk lapisan film, sehingga sediaanmudah dikelupas saat telah mengering . Menurut teori, Konsentrasi PVA pada sediaan masker gel peel of akanberpengaruh pada pH, viskositas, daya lekat, daya sebar dan waktu mengering. Berdasarkan literatur rangekonsentrasi PVA yaitu 7-10%.Namun pada penelitian yang telah dilakukan oleh Rian Karnelo (2012), sediaan maskergel peel of dari ekstrak etanol kulit jeruk nipis menunjukkan karakteristik sediaan yang baik pada konsentrasi PVA15%. Tujuan penelitian : Untuk mengetahui Masker Wajah Gel Peel-off Ekstrak Etanol Kulit Jeruk Nipis (C.aurantifolia) yang memiliki karakteristik terbaik berdasarkan variasi konsentasi PVA 7%, 10%, 15%. MetodePenelitian : Metode Eksperimental Laboratorium. Hasil Penelitian : Semakin tinggi konsentrasi PVA yang digunakanakan menghasilkan sediaan masker yang lebih kental sehingga daya sebar semakin kecil dan waktu sediaan mengeringsemakin cepat. Seluruh formula memenuhi standar sediaan masker gel peel of. Tidak ada pengaruh konsentrasi PVAterhadap organoleptis, homogentias dan nilai pH. Namun semakin tinggi konsentrasi PVA, menyebabkab sediaansemakin cepat mengering. Berdasarkan uji hedonik 100% responden lebih menyukai tekstur dari Formula 3 (PVA15%). Kesimpulan : Ketiga formula memenuhi syarat masker gel Peel-off , namun Formula 3 (PVA 15%) memilikikarakteristik terbaik pada uji daya sebar, uji waktu mengering dan uji hedonik
Formulasi Sediaan Krim Dari Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Lorenza; Meinisasti, Resva; Pradifta, Reysa
Jurnal Pharmacopoeia Vol 4 No 1 (2025): Maret 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i1.709

Abstract

Krim adalah salah satu sediaan yang digunakan untuk perawatan kulit wajah. Salah satu bahan alam yang dapat dijadikan sediaan krim adalah ekstrak etanol daun sirsak (Annona Muricata L.) yang berkhasiat untuk melembabkan kulit, serta mencegah penuaan dini. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik Formulasi Sediaan Krim Ekstrak Etanol Daun Sirsak (Annona Muricata L) dengan konsentrasi 1%, 2%, dan 3%”. Hasil penelitian yang telah dilakukan, pada sediaan krim berdasarkan konsentrasi ekstrak daun sirsak (Annona Muricata L.) semua memenuhi standar evaluasi sediaan dan berdasarkan evaluasi uji hedonik formula krim yang paling digemari responden adalah F1 (1%). Semua formula krim telah memenuhi kriteria standar krim yang baik dari semua segi pengujian yang telah dilakukan namun yang paling disukai adalah F1 (1%).
Pengujian Stabilitas Dipercepat dan Kandungan SPF pada Kombinasi Ekstrak Etanol Daun Sirih (Piper betle L.) dan Kopi Robusta (Coffe canephora) sebagai Formulasi Krim Wajah Meinisasti, Resva; Krisyanella, Krisyanella; Okfrianti, Yenni; Sastri Utami, Mardhah
JURNAL ILMIAH FARMASI SIMPLISIA Vol. 5 No. 1 (2025): Juni 2025
Publisher : Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/jifs.v5i1.852

Abstract

Penggunaan tabir surya diluar ruangan telah terbukti efektif untuk mengurangi paparan sinar ultraviolet (UV). Daun sirih (Piper betle Linn) dan biji kopi robusta (Coffea canephora) mengandung senyawa antioksidan untuk melindungi kulit dari paparan sinar UV yang berlebih. Kombinasi kedua bahan alam ini dapat digunakan sebagai tabir surya untuk membantu memperbaiki permeabilitas kulit, mencegah radikal bebas, dan sebagai antiaging. Penelitian ini bertujuan untuk mengetahui stabilitas dan Sun Protection Factor (SPF) krim ekstrak etanol daun sirih dan kopi robusta sebagai krim wajah. Penelitian dilakukan dalam lima tahapan yaitu ekstraksi, formulasi krim, uji stabilitas dipercepat dan kandungan SPF. Hasil uji stabilitas dipercepat sediaan krim konsentrasi 2,5% dan 5% tidak mengalami perubahan dari pengamatan organoleptis pada hari ke-0 sampai hari ke-90.  Nilai SPF krim pada konsentrasi 2,5% dan 5% masing-masing 38,202 dan 53,848. Krim wajah berbahan aktif ekstrak daun sirih dan kopi robusta memiliki potensi sebagai tabir surya alami yang stabil dan efektif dalam memberikan perlindungan tinggi terhadap sinar UV.
Co-Authors Atipah Charunisa Auzal Halim Avrilya Iqoranny Susilo Baharyati , Delta Baharyati, Delta Destiawan, Nanda Dewi Oktasari Diajeng Dea Resya Mawardi Erizal Zaini Febriyanto, Tedy Halimatussadiah, Halimatussadiah Irawan, Putra Adi Irnameria, Dira Iskandar, Fadhillah Jon Farizal, Jon Khasanah, Heti Rais Krisyanella Krisyanella Lanas, Azziyadatul Fadilah Lorenza Muslim, Zamharira Nadeak, Bella Nadeak Patroni, Rini Pradifta, Reysa Pudiarifanti, Nadia RACHMAT HIDAYAT Raden Sunita Raden Sunita Riyadi, Sunita Rizki Amalia Sari, Rizki Amalia Sagita, Pittri Andriani Sahidan Sahidan Salasa, Alfrida Monica Sastri Utami, Mardhah Silvi Elvianita Sunita, Raden Sunita, Raden TUTUT, ADES RELIJEN Utami, Mardhah Sastri Yenni Okfrianti Zamharira Muslim Zamharira Muslim