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All Journal Journal of Physical Education Health and Sport Jurnal Penelitian Ekosistem Dipterokarpa Majalah Farmasetika ULIN: Jurnal Hutan Tropis Media Farmasi Camellia Jurnal Sains dan Kesehatan Indonesian Journal of Forestry Research
Andrian Fernandes, Andrian
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Pengaruh Perbedaan Konsentrasi Lipomulse luxe sebagai Emulgator pada Krim Aromaterapi Lavender Oil (Lavandula angustifolia oil) dan Peppermint Oil (Mentha piperitae aetheroleum) Butarbutar, Maria Elvina Tresia; Septa Ryant Agus, Adhe; Selvina, Selvina; Fernandes, Andrian
Majalah Farmasetika Vol 10, No 5 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v10i5.66544

Abstract

Krim merupakan sediaan topikal yang terdiri dari fase air, emulgator, dan fase minyak. Emulgator memegang peran penting dalam sediaan krim yang mempengaruhi homogenitas, viskositas, stabilitas, dan penampilan sediaan krim. Oleh sebab itu, pemilihan dan konsentrasi emulgator menjadi hal yang sangat penting. Pada penelilitian ini variasi konsentrasi Lipomulse luxe digunakan sebagai emulgator untuk mengetahui pengaruh Lipomulse luxe terhadap sediaan krim. Sediaan krim yang akan dibuat adalah krim aromaterapi dengan variasi Lipomulse luxe, yaitu F1 (3%), F2 (4%), F3 (5%), dan F4 (6%). Krim aromaterapi dievaluasi yang meliputi pengamatan organoleptis, uji homogenitas, uji viskositas, uji pH, uji daya tercuci, dan uji stabilitas menggunakan metode sentrifugasi. Pengamatan organoleptis selama 28 hari menunjukkan perbedaan konsentrasi Lipomulse luxe tidak mempengaruhi warna (putih), bau (campuran lavender oil dan peppermint oil), dan bentuk (semi solid). Hasil homogenitas F1 menunjukkan ukuran globul yang terdispersi lebih besar dan F4 menunjukkan ukuran globul yang lebih kecil. Hasil viskositas menunjukkan F1 (10,1804 cP), F2 (18,016 cP), F3 (20,004 cP), dan F4 (22,768 cP), semakin besar konsentrasi Lipomulse luxe, maka semakin besar viskositas. Hasil uji pH menunjukkan F1 (5,16), F2 (5,26), F3 (5,66), dan F4 (5,78), perbedaan konsentrasi Lipomulse luxe tidak mempengaruhi pH sediaan krim aromaterapi. Hasil uji daya tercuci menunjukkan F1 (9,2 mL), F2 (10,2 mL), F3 (12,4 mL), dan F4 (16,0 mL), Lipomulse luxe mempengaruhi volume air yang dibutuhkan untuk krim dapat tercuci. Hasil uji stabilitas menggunakan metode sentrifugasi menunjukkan F1, F2, F3, dan F4 tidak stabil karena terjadi pemisahan fase. Perbedaan konsentrasi Lipomulse luxe mempengaruhi homogenitas, viskositas, daya tercuci, dan stabilitas sediaan krim aromaterapi. Semakin besar konsentrasi Lipomulse luxe semakin kecil ukuran globul, semakin besar viskositas, dan semakin besar volume air yang diperlukan untuk mencuci krim, dan semakin kecil volume air yang terpisah.Kata kunci: Krim aromaterapi, Lavender oil, Peppermint Oil, Emulgator, Lipomulse luxe
Antidepressant Activity Study of Keruing (Dipterocarpus grandiflorus) Oleoresin Candle Aromatherapy on Male Mice (Mus musculus) Balb/C Strain Agus, Adhe Septa Ryant; Butar-Butar, Maria Elvina Tresia; Fernandes, Andrian; Maharani, Rizki; Awan, Kevin Imanuel; Luhat, Martin Gilbert
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 2 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i2.24665

Abstract

Depression represents a manifestation of prolonged stress, which, if left untreated, may lead to severe mental disorders. For depression treatment therapy, it can be carried out based on evidence-based treatment for depression and anxiety. Aromatherapy candles can be used as a non-pharmacological medium for depression therapy, where keruing has active compounds are phthalic acid di(3-methoxybenzyl) ester and phthalic acid, 5-ethyl-1,3-dioxan-5-yl octyl ester, causing keruing oleoresin to have a distinctive fragrance. This study aims to evaluate the pharmacological potential of keruing as an antidepressant for non-pharmacological therapy. Aromatherapy candles were formulated with keruing oleoresin at concentrations of 0%, 2.5%, 5%, 7.5%, and 10%, followed by testing their antidepressant activity using the Conditioned Place Preference (CPP) method. The results of the Paired T-test for groups F0, F2, and F4 or formulas containing 0%, 5%, and 10% of keruing oleoresin have a significant effect (sig. values <0.05) between pre and post-test being given aromatherapy and induction. In the One-way ANOVA test, between their groups, it can be seen there was no significant difference in test activity, namely for the pre-treatment test (sig. 0.445 > 0.05) and for the post-treatment test (sig. 0.065 > 0.05). Results indicated that while the candles met physical quality standards outlined by the Indonesian National Standard (SNI), no significant antidepressant effects were observed in mice. Further refinement in methodology, including the concentration of active compounds and delivery methods, is recommended to enhance the pharmacological potential of keruing oleoresin.
Formulation of Keruing (Dipterocarpus grandiflorus) Oleoresin Aromatherapy Candles Butar-Butar, Maria Elvina Tresia; Agus, Adhe Septa Ryant; Leswana, Nurillahi Febria; Fernandes, Andrian
Jurnal Sains dan Kesehatan Vol. 6 No. 4 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i4.2331

Abstract

Aromatherapy is an alternative treatment method that utilizes essential oils and volatile components, such as terpenes and aromatic compounds. The active compounds of keruing oleoresin are phthalic acid, namely phthalic acid di(3-methoxybenzyl) ester and phthalic acid, 5-ethyl-1,3-dioxan-5-yl octyl ester causing keruing oleoresin to have a distinctive fragrance. The purpose of this study was to formulate keruing oleoresin in aromatherapy candle preparations. This research method includes base optimization, formulation of keruing oleoresin aromatherapy candles with concentrations of 0%; 2.5%; 5%; 7.5%; and 10%, and evaluation of aromatherapy candles including organoleptic testing, melting point, and burning time. The results of organoleptic testing of aromatherapy candles in shape, aroma, and color showed that F4 with 10% oleoresin concentration had a more dominant aroma and color. Melting point and burning time tests showed F1 with a concentration of 2.5% had a higher melting point of 54.6°C and a longer burning time of 144 minutes. Keywords:          Dipterocarpus grandiflorus, oleoresin, aromatherapy candle
CHEMICAL AND ORGANOLEPTIC PROPERTIES OF BEKAI (Pycnarrhena tumefacta Miers) LEAVES FOR FLAVOURING AGENT (BIO-VETSIN) Maharani, Rizki; Fernandes, Andrian; Turjaman, Maman; Kuspradini, Harlinda; Lukmandaru, Ganis
Indonesian Journal of Forestry Research Vol. 7 No. 2 (2020): Indonesian Journal of Forestry Research
Publisher : Association of Indonesian Forestry and Environment Researchers and Technicians

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59465/ijfr.2020.7.2.121-133

Abstract

The "tasty" cuisine tends to use chemical flavour agent containing monosodium glutamate (M.S.G.). M.S.G. utilizations, in long-term, may cause health problems, especially triggering cancer cells. Therefore necessary to introducing and increasing a natural flavouring agent to eliminate those health problem, such as bekai leaf. Bekai (Pycnarrhena tumefacta Miers) is familiar as a natural flavour agent (bio-vetsin) in cuisine for forest communities in Nyapa Indah Village, Berau, East Kalimantan, Indonesia. However, until now there has been no proper analysis support for widespread utilization of bekai leaf. This paper studies the presence of phytochemicals, antioxidant and GC MS analysis from bekai leaf extracts, as well as five hedonic classifications of organoleptic test, to reinforce the need for a better understanding of consumers reaction in terms of possible acceptance of additional bekai leaves applied in soup as bio-vetsin. Present study showed that the qualitative screening of phytochemical compounds in bekai leaves ethanolic extracts revealed presence of alkaloids, flavonoids, tannins and steroids. Antioxidants of bekai leaves using 2,2-diphenyl-1-picrylhydrazy (DPPH) method showed that concentrated extract has 80.1%, which predicted can improve immune for inhibitory action of cancer cells. GC MS analysis suspected that bekai leaf extract contained 5 (five) major compounds, i.e. oxirane dodecyl, gamma sitosterol, vitamin E (α tokoferol), 9.12-Octadecadienoic acid (Z,Z)- (natural linoleic acid), and 3-Tetradecanynoic acid (myristic acid). These chemical compound in related with their phytochemical were predicted to contained strong antioxidant activities and some of them commonly used as flavour agent in cuisine for some food industries.
Co-Authors Agus, Adhe Agus, Adhe Septa Ryant Amiril Saridan, Amiril Awan, Kevin Imanuel Butar-Butar, Maria Butar-Butar, Maria Elvina Tresia Ganis Lukmandaru Luhat, Martin Gilbert M. Fajri, M. Maman Turjaman Maria Elvina Tresia Butar-Butar Nurillahi Febria Leswana Prehatin, Chrisbaningrum Rizki Maharani Rohmatus Rizqy Kisna Yunanta, Rohmatus Rizqy Kisna Rosamah, Enih Selvina, Selvina Septa Ryant Agus, Adhe Sister Sianturi Siswandono, Siswandono Syamsul Arifin