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ANALISIS KAFEIN DAN ASAM KLOROGENAT DALAM KULIT BUAH KOPI ARABIKA DAN ROBUSTA MENGGUNAKAN SPEKTROFOTOMETER UV-Vis Mega Karina Putri; Beta Ria Erika Marita Dellima; Happy Elda Murdiana; Eni Kartika Sari
Jurnal Farmamedika (Pharmamedika Journal) Vol 9 No 1 (2024): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v9i1.279

Produksi jumlah kopi sebanding dengan jumlah limbah yang dihasilkan dari proses pemisahan biji dari buahnya. Salah satu limbah tersebut adalah kulit buah. Jumlah limbah yang sangat besar belum diikuti pengelolan dan pemanfaatan yang optimal, sehingga berdampak negatif pada lingkungan. Kulit kopi mengandung kafein dan asam klorogenat yang masih dapat dimanfaatkan. Penelitian ini bertujuan untuk menetukan kadar kafein dan asam klorogenat yang terkandung di dalam kulit buah kopi arabika dan robusta. Kulit buah kopi arabika dan robusta diekstraksi dengan akuades kemudian diekstraksi cair-cair dengan kloroform, fraksi kloroform yang diperoleh diuapkan sehingga terbentuk kristal yang mengandung kafein. Hasil tersebut dianalisis kuantitatif dengan spektrofotmetri UV. Fraksi akuades dianalisis kuantitatif asam klorogenat. Hasil absorbansi yang diperoleh dari pembacaan spektrofotmetri UV, kemudian dihitung kadar kafein dan asam klorogenat dalam sampel dan dianalisis menggunakan software SPSS. Kadar kafein kulit buah kopi arabika sebesar 4,89% dan robusta sebesar 0,88%. Kadar asam klorogenat kulit buah kopi arabika sebesar 0,82% dan robusta 1,03%. Berdasarkan hasil tersebut, dapat disimpulkan bahwa kadar kafein pada kulit buah kopi arabika lebih tinggi dibandingkan kulit buah kopi robusta dan kadar asam klorogenat kulit buah kopi arabika lebih rendah dibandingkan kulit buah kopi robusta. Uji T independent menghasilkan bahwa kadar kafein dan kadar asam klorogenat pada kedua jenis kulit kopi berbeda signifikan. Perbedaan tersebut dapat dipengaruhi oleh jenis/variestas tanaman, asal geografis, seperti tempat tumbuh pada ketinggian yang berbeda, jenis tanah, curah hujan, waktu panen, dan intensitas tanaman terkena sinar matahari. Produksi jumlah kopi sebanding dengan jumlah limbah yang dihasilkan dari proses pemisahan biji dari buahnya. Salah satu limbah tersebut adalah kulit buah. Jumlah limbah yang sangat besar belum diikuti pengelolan dan pemanfaatan yang optimal, sehingga berdampak negatif pada lingkungan. Kulit kopi mengandung kafein dan asam klorogenat yang masih dapat dimanfaatkan. Penelitian ini bertujuan untuk menetukan kadar kafein dan asam klorogenat yang terkandung di dalam kulit buah kopi arabika dan robusta. Kulit buah kopi arabika dan robusta diekstraksi dengan akuades kemudian diekstraksi cair-cair dengan kloroform, fraksi kloroform yang diperoleh diuapkan sehingga terbentuk kristal yang mengandung kafein. Hasil tersebut dianalisis kuantitatif dengan spektrofotmetri UV. Fraksi akuades dianalisis kuantitatif asam klorogenat. Hasil absorbansi yang diperoleh dari pembacaan spektrofotmetri UV, kemudian dihitung kadar kafein dan asam klorogenat dalam sampel dan dianalisis menggunakan software SPSS. Kadar kafein kulit buah kopi arabika sebesar 4,89% dan robusta sebesar 0,88%. Kadar asam klorogenat kulit buah kopi arabika sebesar 0,82% dan robusta 1,03%. Berdasarkan hasil tersebut, dapat disimpulkan bahwa kadar kafein pada kulit buah kopi arabika lebih tinggi dibandingkan kulit buah kopi robusta dan kadar asam klorogenat kulit buah kopi arabika lebih rendah dibandingkan kulit buah kopi robusta. Uji T independent menghasilkan bahwa kadar kafein dan kadar asam klorogenat pada kedua jenis kulit kopi berbeda signifikan. Perbedaan tersebut dapat dipengaruhi oleh jenis/variestas tanaman, asal geografis, seperti tempat tumbuh pada ketinggian yang berbeda, jenis tanah, curah hujan, waktu panen, dan intensitas tanaman terkena sinar matahari.

Analisa Kerasionalan Resep Pediatri Penderita Asma Martha Dillia Handayani; Happy Elda Murdiana
Jurnal Ilmu Kebidanan (Journal of Midwivery Science) Vol. 2 No. 1 (2014): Jurnal Ilmu Kebidanan (Journal of Midwifery Science)
Publisher : Jurnal Ilmu Kebidanan (Journal of Midwivery Science)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36307/pwpdjm27

Background: Asthma is an inflammatory disease characterized airways bronchoconstriction, inflammation, and excessive response to stimuli in addition, there are also inhibitory to air flow due to constriction of the bronchi. Resulting in hyperinflation distal lung mechanical changes, and increasing difficulty in breathing. Many factors that increase the severity of asthma include cigarette smoke, allergic rhinitis, sensitivity to aspirin.Objektive: to determine the classes of drugs and rational drug to patients who suffer from asthma in pediatric inpatient Panti Rapih Yogyakarta in January – December 2013.Methode: The method in this research is descriptive with cross sectional. Population in this study were all patient medical records in pediatric inpatient Panti Rapih Yogyakarta in January – December 2013. Samples in this study were all medical records of cases of asthma in pediatric inpatients aged 1 – 12 years in Panti rapih Yogyakarta in January – December 2013. Instrument used is the data collection sheet using non descriptive analytic classes of drugs include corticosteroids, β2 adrenergic, anticholinergic, rational drug with indication and appropriate mode of administration.Result: The treatment of most cases of asthma using β2 adrenergic much as 83 (79,8%), as many as 57 (54,8%) corticosteroids, anticolinergics as many as 8 (7,4%) and rationalization for indications and proper way of giving the results showed that all ratioal.Conclusion: The pattern of prescribing for pediatric asthma patients in inpatient Panti Rapih Yoyakarta is rationalKey words: Pediatric Asthma, Rational Prescription

PENDAMPINGAN PEMBUATAN SABUN BERBAHAN ECO ENZYM UNTUK KEBUTUHAN KESEHATAN MASYARAKAT Murdiana, Happy Elda; Nikasius Jonet Sinangjoyo; Dewi Rahmawati; Mega Karina Putri; Melia Eka Rosita; Mohammad Nurul Hasanudin
Diseminasi: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 2 (2024)
Publisher : Pusat Pengabdian kepada Masyarakat- LPPM Universitas Terbuka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33830/diseminasiabdimas.v6i2.8938

Hidup sehat dan sejahtera adalah salah satu sasaran pembangunan berkelanjutan Indonesia ditahun 2023. Pengolahan limbah organik rumah tangga menghasilkan produk eco-enzym yang dapat dimanfaatkan untuk kebutuhan kebersihan rumah tangga. Pembuatan sabun batangan berbahan eco-enzyme mempunyai kelebihan mudah digunakan, praktis dan penyimpanan yang tahan lama. Tujuan dari pengabdian ini adalah untuk memberi pemahaman dan pelatihan pembuatan sabun batangan berbahan limbah organik yang diolah menjadi eco-enzym. Audien yang merupakan ibu-ibu sangat antusias melakukan praktek pembuatan dan mengevaluasi keberhasilan produk, efikasi dan iritasi yang mungkin ditimbulkan. Akhirnya para ibu mengetahui pentingnya mengolah limbah menjadi bahan bermanfaat bagi kebersihan.

Hubungan Ketercapaian Kadar Gula Darah Dengan Aturan Pakai Obat Gula Darah Pada Pasien Diabetes Dengan Hipertensi Murdiana, Happy Elda; Mediastuti, Fitriani; Rosita , Melia Eka; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p180-185

Diabetes mellitus (DM) is a chronic metabolic disease that causes death in the world. The government’s effort to help patients with DM slow down to meet complications with the integrated health service system, namely Prolanis. This study aims to determine the relationship between the achievement of ideal blood glucose levels with the accuracy of the rules for using Antidiabetic Oral (ADO), and compliance with coming to health facilities, as well as the relationship between achieving ideal blood pressure with the accuracy of rules for using antihypertension drug and compliance with coming to health facilities. The research was conducted at the Darmarini Public Health Center, Temanggung with the research subject of DM patients with comorbid hypertension, the number of prolanis participants was 47 people. Data processing is analyzed by chi-square. There is a relationship if p<0,05 and expected count >5. This study showed that there was a significant relationship between the achievement of ideal blood glucose levels with the rules for using ADO, but there was no relationship between the achievement of ideal blood glucose levels with compliance with visits to health facilities, achieving ideal blood pressure level with the accuracy of the rules of use and compliance with visits to health facilities

Vitamins Sales Before and During the COVID-19 Pandemic at Network Online Pharmacies in Indonesia Murdiana, Happy Elda; Putri, Mega Karina; Widayati, Aris; Rahmawati, Dewi; Rosita, Melia Eka
JURNAL INFO KESEHATAN Vol 23 No 2 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss2.1518

The use of vitamins and micronutrients as an immunity enhancer during the COVID-19 pandemic is needed. The use of vitamins and micronutrients as immunity boosters during the COVID-19 pandemic is very much needed. The description of vitamin needs can be predicted from vitamin sales carried out by network online pharmacies in Indonesia. Vitamins C and E are antioxidants that indirectly have a role as an antiviral. Vitamin D can increase immunity, so its availability is important during the COVID-19 pandemic. This study compares vitamin sales before and during the COVID-19 pandemic at online pharmacies in Indonesia as a description of vitamin use in the community, and their availability by the pharmaceutical industry so that the government can take policies to accelerate this period. The study began by taking master data of all vitamin sales from January 2019 to December 2020 at one of the online pharmacies in Indonesia. Data on all sales each year were grouped based on vitamin content, namely single vitamins, containing two vitamins, and multivitamins (more than two vitamins) and then compared them. Data analysis used the independent t-test, and if the data was not normal and homogeneous, it was processed using the Mann-Whitney test by SPSS version 26 software. The results showed that there was a significant difference between sales of vitamin C (p<0.05), vitamin E (p<0.01), a combination of vitamins B and C (p<0.05), vitamins B and E (p<0.05), and multivitamins (p<0.001) in online pharmacy networks in Indonesia before and during the COVID-19 pandemic. Interestingly, sales of vitamin D did not increase significantly during the COVID-19 pandemic due to limited supplies from pharmaceutical companies even though vitamin D is very important for increasing immunity, thus giving rise to the policy of the Indonesian Ministry of Health to utilize sunlight as the main source of vitamin D.

Evaluasi Drug Related Problems (DRPS) Pada Pasien Diabetes Melitus Tipe II dengan Komplikasi Penyakit Ginjal Kronik di RS X Yogyakarta Kusumiati, Marna; Atmaja, Sarah Puspita; Murdiana, Happy Elda
MAHESA : Malahayati Health Student Journal Vol 4, No 2 (2024): Volume 4 Nomor 2 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i2.13381

ABSTRACT The prevalence of Diabetes Mellitus (DM) sufferers increases every year, especially type 2 DM, because this often causes complications and even death. Type 2 diabetes mellitus has a major impact on the development of chronic kidney disease (CKD), based on uncontrolled type 2 diabetes over a long period of time. Achieving maximum therapeutic effects with minimal side effects is one of the responsibilities of pharmaceutical care, one of which is identifying the occurrence of Drug Related Problems (DRPs). The aim of this study was to evaluate DRPs in Type 2 DM patients with CKD complications at RS x Yogyakarta as evaluation material in handling the incidence of DRPs in type 2 DM patients with CKD complications. The method in this research is descriptive quantitative with data collection using a total sampling technique on retrospective data from medical record documents at the inpatient installation of Hospital The conclusion in this study is that the characteristics of type 2 DM sufferers with CKD are mostly women (51.35%), with age > 60 (67.56%), and the highest CKD stage is G5. The most common cause of DRP cases is inappropriate drug selection (64%), giving rise to the problem of unsafe drug events in patients (56%). Keywords: Diabetes Mellitus Type 2, Chronic Kidneys Disease (CKD), Drug Related Problems (Drps), Hospitalization. ABSTRAK Prevalensi penderita Diabetes Melitus (DM) setiap tahun mengalami peningkatan khususnya DM tipe 2, sehingga tidak sedikit yang menyebabkan komplikasi hingga kematian. DM tipe 2 berdampak besar pada pengembangan Penyakit Ginjal Kronis (PGK), akibat tidak terkontrolnya penyakit DM tipe 2 dalam jangka waktu lama. Pencapaian efek terapi maksimal dengan efek samping minimal adalah salah satu tanggungjawab farmasi salah satunya mengidentifikasi terjadinya Drug Related Problems (DRPs). Tujuan penelitian ini adalah melakukan Evaluasi DRPs pada Pasien DM Tipe 2 dengan komplikasi PGK di RS x Yogyakarta sebagai bahan evaluasi dalam penanganan kejadian DRPs pada pasien DM tipe 2 dengan komplikasi PGK. Metode dalam penelitian ini adalah deskriptif kuantitatif dengan pengambilan data menggunakan teknik total sampling pada data retrospektif dokumen rekam medis diinstalasi rawat inap RS X Yogyakarta Januari 2019 – Mei 2023. Hasil penelitian didapat penyebab Kasus DRP terjadi karena pemilihan obat yang tidak tepat (64%) dan pemilihan dosis obat kurang tepat (36%), dan potensi masalah yang terjadi adalah kejadian obat yang tidak aman pada pasien sebesar (56%) dan Kejadian pengobatan yang tidak efektif (44%). Kesimpulannya adalah, Penyebab Kasus DRPs paling banyak terjadi adalah pemilihan obat yang tidak tepat (64%), sehingga menimbulkan potensi masalah yakni kejadian obat yang tidak aman pada pasien sebesar (56%). Kata Kunci: Diabetes Melitus Tipe 2, Penyakit Ginjal Kronik (PGK), Drug Releted Problems (Drps), Rawat Inap.

Analisa Kerasionalan Resep Pediatri Penderita Asma Martha Dillia Handayani; Happy Elda Murdiana
Jurnal Ilmu Kebidanan (Journal of Midwivery Science) Vol. 2 No. 1 (2014): Jurnal Ilmu Kebidanan (Journal of Midwifery Science)
Publisher : Jurnal Ilmu Kebidanan (Journal of Midwivery Science)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36307/pwpdjm27

Background: Asthma is an inflammatory disease characterized airways bronchoconstriction, inflammation, and excessive response to stimuli in addition, there are also inhibitory to air flow due to constriction of the bronchi. Resulting in hyperinflation distal lung mechanical changes, and increasing difficulty in breathing. Many factors that increase the severity of asthma include cigarette smoke, allergic rhinitis, sensitivity to aspirin.Objektive: to determine the classes of drugs and rational drug to patients who suffer from asthma in pediatric inpatient Panti Rapih Yogyakarta in January – December 2013.Methode: The method in this research is descriptive with cross sectional. Population in this study were all patient medical records in pediatric inpatient Panti Rapih Yogyakarta in January – December 2013. Samples in this study were all medical records of cases of asthma in pediatric inpatients aged 1 – 12 years in Panti rapih Yogyakarta in January – December 2013. Instrument used is the data collection sheet using non descriptive analytic classes of drugs include corticosteroids, β2 adrenergic, anticholinergic, rational drug with indication and appropriate mode of administration.Result: The treatment of most cases of asthma using β2 adrenergic much as 83 (79,8%), as many as 57 (54,8%) corticosteroids, anticolinergics as many as 8 (7,4%) and rationalization for indications and proper way of giving the results showed that all ratioal.Conclusion: The pattern of prescribing for pediatric asthma patients in inpatient Panti Rapih Yoyakarta is rationalKey words: Pediatric Asthma, Rational Prescription

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