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All Journal Pharmacon Indonesian Journal of Science and Technology UNEJ e-Proceeding Majalah Farmasetika Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Inkofar JPEMAS: Jurnal Pengabdian Kepada Masyarakat
Fauzia Azzahra, Fauzia
Program Studi D3 Farmasi, Politeknik Meta Industri, Jln. Inti 1 Blok C1 No 7 Lippo Cikarang, Jawa Barat, Indonesia
Humanities Computer Science & IT Control & Systems Engineering Education Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Transportation

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Physical Characterization of Chitosan-based Syzygium polyanthum Leaves Extract Nanoparticles Hidayati, Evi Nurul; Rahayyu, Annisa Maulidia; Azzahra, Fauzia
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23296

Abstract

Indonesia is one of the most abundant in natural resources countries in the world. The bay leaves are well- known among the locals and have various pharmacological properties, including anti dyslipidemia. Currently, the use of nanoparticle technologies in dyslipidemia treatment is quite popular. These treatments have numerous advantages such as enhancing the potency of dyslipidemia agents. The purpose of this study is to develop chitosan-based nanoparticles made from Syzygium polyanthum leaves extract using crosslink method. Chitosan is used as the polymer and STPP as the crosslinker with the ratio of chitosan:STPP is 5:1. Two formula is generated, F1 is chitosan-based nanoparticle extract and F2 is chitosan-base nanoparticle blank. Syzygium polyanthum extract contains alkaloid, flavonoid, saponin, quinone, and tannin, as determined by secondary metabolites screening. The total flavonoid content of Syzygium polyanthum leaves extract determined as quercetin is 0.04%. Physical properties of generated nanoparticles such as size, polydispersity index (PI) and zeta potential are investigated. Particle sizes of nanoparticles F1 and F2 are 180.1 ± 0.5 nm and 464.3 ± 25.98 nm with the PI values of F1 and F2 are 0.220 ± 0.02 and 0.563 ± 0.112 respectively. Zeta potential value for F1 is 21.8 ± 1.74 mV and F2 is 17.8 ± 0.21 mV. The entrapment efficiency is evaluated to determine the extract content of the nanoparticle, and the result is 47.13%. From this research, the chitosan-based nanoparticles containing Syzygium polyanthum formula have good physical properties. Further investigation is needed to evaluate its potential as anti-dyslipidemia. 
Co-Authors Adryan Fristiohady Agung W.M. Yodha Aisyiah, Aisyiah Anas Subarnas Andini Sundowo Asfin, Aulia Mutiara Dewi Dewi Kinanti, Cahya Dewi Melani Hariyadi DIANTINI, AJENG - Eni Masruriati Euis Julaeha Fitriani, Rima Haifa, Ayu Izzatin Haifa, Ayu ꞌIzzatin Hidayati, Evi Nurul I. Sahidin Idha Kusumawati Joko Santoso Marliana, Elsa Maulidia Rahayyu, Annisa Mayuri, Nindya Sekar Ma’rifah, Bahriyatul Mohammad Ghozali Pratiwi, Maharani Dwi Raden Maya Febrianti Rahayyu, Annisa Maulidia Ramadhani, Intan Puspita Riezki Amalia Setyahadi , Siswa Sofa Fajriah SRI RAHAYU Stanly William Emmanuel Taurhesia , Shelly Tisa Amalia, Tisa Vina Fauziah W. Wahyuni Wahyu Pratama Wartini Nurfajriah Yuni Elsa Hadisaputri