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Uji Sediaan Krim Ekstrak Daun Kratom (Mitragyna Speciosa Korth.) yang Berpotensi sebagai Antinosiseptif pada Mencit Jantan Galur DDY Puspita Raras Anindita; Herni Setyawati; Khurin In Wahyuni; Dwi Oktavia Putri; Yani Ambari
Jurnal Pharmascience Vol 10, No 1 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.12146

Abstract

Penelitian ini bertujuan untuk mengevaluasi potensi antinosiseptif pada sediaan krim ekstrak daun kratom dan menentukan dosis efektifnya. Metode ekstraksi daun kratom yaitu dengan cara remaserasi menggunakan pelarut etanol 70%. Hasil ekstrak kental yang diperoleh dari proses maserasi dimasukkan ke dalam sediaan vanishing cream dengan dosis 0,26 gram; 0,56 gram; dan 0,86 gram. Pengujian antinosiseptif menggunakan metode hotplate test pada mencit jantan galur Deutschland Denken Yoken (DDY). Hasil pengamatan dianalisis menggunakan statistik nonparametrik Kruskal Wallis dan uji persamaan regresi linier. Hasil analisis menunjukkan bahwa ketiga dosis krim ekstrak daun kratom memiliki perbedaan dan pengaruh terhadap jumlah loncatan kaki pada hewan coba jika dibandingkan dengan kelompok kontrol negatif yang berpotensi sebagai antinosiseptif namun kurang bermakna, karena tidak menggunakan kontrol positif. Kata Kunci: Antinosiseptif, Krim,Uji Sediaan, Daun Kratom, Mitragyna speciosa Korth.This study aims to evaluate the antinociceptive potential of kratom leaf ekstract cream and determine its effective dose. The kratom leaf extraction method  used maceration using 70% ethanol solvent. The crude extract obtained from the maceration process is put in to the vanishing cream preparation at a dose of 0.26 grams, 0.56 grams, and 0.86 grams. Antinociceptive testing used the hot plate method on DDY strain male mice. The results of the observations were analyzed using nonparametric statistics “kruskal wallis” and linear regression equation test. The results of analysis showed that the three doses of kratom leaf extract cream had an effect on the number of jumps on the legs of experimental animals when compared to the negative control group which had the potential to be antinociceptive but less significant, because it did not use a positive control.
PEMBERDAYAAN WARGA RT. 02 RW. 04 DUSUN SUMBEREJO DESA KINTELAN DALAM PENYULUHAN BAHAYA DIARE DAN CARA MENCUCI TANGAN YANG BENAR Wahyu Ningsih, Arista Wahyu Ningsih; Wahyu Ningsih, Arista; Dinda Zulia Rahma; Ivan Charles; Dewi Rahmawati; Yani Ambari; Bella Fevi Aristia; Farida Anwari; Elis Anita Farida
Jurnal Bakti untuk Negeri Vol 4 No 1 (2024): JBN
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jbn.v4i1.1919

Abstract

Real Work Lecture activities are routine student activities as part of the educational process carried out by providing learning experiences for students to live in the midst of communities outside the campus and directly identify and deal with development problems faced. The Real Work Lecture activity for S1 Pharmacy students of Anwar Medika University was carried out in Kintelan Village, Sumberejo Hamlet, Rt.02 Rw.04, Puri District, Mojokerto Regency, East Java Province. The purpose of this service is to provide understanding to the local community about the importance of knowing the dangers of diarrhea and teach how to wash hands properly as one of the diarrhea prevention measures. The activity was carried out by educating residents of RT.02 RW.04 Kintelan Village using leaflet media. Pre-test and post-test are conducted to measure the understanding of residents before education compared to after education. The results and outcomes of the activity showed an increase in residents' understanding of diarrhea counseling from 72% to 94%.
Kajian Penggunaan Matriks Pada Formulasi Tablet Lepas Lambat: Artikel Review Tarizza Puspa Anggrelia; Amelia Saputri Ginting; Yeka Khafidz Illa Rosyidah; Maratul Istifadah; Faizal Agustino; Dewi Rahmawati; Yani Ambari; Marthy Meliana Ariyanti Jalmav; Muhammad Fithrul Mubarak
Jurnal Anestesi Vol. 2 No. 3 (2024): Juli : Jurnal Anestesi
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/anestesi.v2i3.1249

Abstract

This research discusses the use of matrices in sustained-release tablet formulations to optimize the active substance release profile. Extended-release tablets are a type of tablet formulation designed to release the active substance gradually in the body over a certain period of time. The main purpose of sustained-release tablets is to maintain drug levels in the blood or target area over a longer period of time, compared to conventional tablets which release the active substance quickly after ingestion. The method used in this research is a qualitative approach which aims to deepen an in-depth understanding of the phenomenon being studied. As a result, selecting the right type of matrix proves to be crucial in achieving the expected therapeutic effectiveness. Polymer matrices, both natural and synthetic, play an important role in controlling the stability and efficiency of tablets and their ability to gradually release active substances.
Analisis Formulasi Dan Evaluasi Tablet Effervescent Herta Meidya Nurhalita; Alfi Dwi Seviah; Miftakhul Jannah; Vina Aprilia Safari; Natalia Abuk Bria; Ria Lestari Herawati; Ramadhan Maulana Putra; Yani Ambari; Dewi Rahmawati; Marthy Meliana Ariyanti Jalmav; Muhammad Fithrul Mubarak
Observasi : Jurnal Publikasi Ilmu Psikologi Vol. 2 No. 2 (2024): May : Observasi: Jurnal Publikasi Ilmu Psikologi
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/observasi.v2i3.420

Abstract

The purpose of writing this review article is to determine the formulation analysis and evaluation of the use of various additional ingredients in effervescent tablets. The method used is a literature review originating from journals and other research results from various references regarding the formulation and evaluation of additional ingredients in various types of effervescent tablets. This aims to provide a summary of relevant publications and increase current understanding. Formulation and evaluation of additional ingredients in effervescents are important aspects that need to be considered in product development. Decisions regarding the use of additives should be based on the desired purpose, desired physical characteristics, stability, and consumer acceptability. With a good understanding of the formulation and evaluation, high quality effervescent tablets can be produced. The use of a variety of additional ingredients can provide different taste and texture characteristics to effervescent, which can affect consumer acceptability.
Review Artikel : Pembuatan Tablet Dengan Metode Granulasi Kering Dewi Rahmawati; Marthy Meliana; Yani Ambari; Ismatun Maulidiyah; Rizki Amalia Putri; Safanda Tiara; Miya Hartini Nur Wakhid; Marselinus Seran; Oktafia Damayanti; Isna Wulan; Brelianty Nevy
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 1 (2024): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i1.1205

Abstract

Dry granulation is a method that is carried out by making granules mechanically without the help of a binder. This method has several advantages, including using less equipment, being suitable for active ingredients that are not resistant to heat and humidity and speeding up the tablet disintegration time. The aim of this research is to find out how to make tablet preparations using the dry granulation method. The method used is by reviewing journals from Google Scholar, Pubmed, etc. from 2012-2024. The result of this research is to get the best formulation with various kinds of tests, then we can compare dry granulation and wet granulation, we can optimize the existing formulas.
The Making of TOGA (Family Medicinal Plants) and Its Utilization in Improving Public Health in Sumbergede Village Arista, Arista Wahyu Ningsih; Elis Anita Farida; Farida Anwari; Bella Fevi Aristia; Yani Ambari; Dewi Rahmawati; Ivan Charles; Ramadhan Maulana Putra; Oktafia Damayanti; Nungky Taniasari
⁠International Journal of Asia Pacific Community Service Vol. 1 No. 2 (2024)
Publisher : Universitas Kristen Cipta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71131/s57r8m88

Abstract

Family Medicinal Plants (TOGA) are plants that are grown in the yard and are efficacious as medicine. The plants planted in the mini garden are telang flowers, red binahong, and kumis kucing. The manufacture of TOGA serves as a means to bring medicinal plants closer to public health efforts, which include preventive efforts (prevention), promotive efforts (improving health degrees), and curative efforts (curing diseases). Based on the problems and potentials owned by Sumbergede village, Wringinanom District, Gresik Regency, several stages are carried out, namely coordinating the creation of a mini toga garden with the head of Sumbergede village, conducting a survey of the location where the TOGA mini park will be made, Preparing tools and materials to create a TOGA mini garden, Making a TOGA mini garden. The educational participants seemed enthusiastic about participating in this activity. Some participants were able to identify the types of TOGA around their homes and were motivated to add other kinds of TOGA. The use of TOGA is considered safer, more practical, and does not require much cost than the use of drugs from pharmacies. Through this activity, it is hoped that the community can be motivated to plant TOGA around their homes and increase the use of TOGA in the treatment of diseases with mild symptoms in the community. Family medicinal plants are very important because they concern the health aspect of the community of Sumbergede village.  
Artikel Riview: Pengaruh Penggunaan Matriks Pada Tablet Lepas Lambat Maulina Apriani; Dian Ayu Oktavia; Isnaini Sukmaning M; Dila Alvia Rahmasari; Zahwa Natasya Novita P; Alvito Syawal Z; Dewi Rahmawati; Dzakiya Zhihrotulwida; Yani Ambari; M. Fithrul Mubarak
Inovasi Kesehatan Global Vol. 2 No. 2 (2025): Mei : Inovasi Kesehatan Global
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ikg.v2i2.1580

Abstract

Sustained-release tablets are pharmaceutical preparations designed to gradually release the active substance over a specific period, thereby maintaining a constant concentration of the drug in the circulatory system and enhancing therapeutic effectiveness.The development of sustained-release tablets aims to extend the duration of drug action, reduce the frequency of dose administration, and minimize fluctuations in drug levels in the plasma, which ultimately enhances patient compliance and treatment effectiveness, especially in chronic diseases.The purpose of this review is to identify various formulation methods and innovations in the production of sustained-release tablets, as well as to examine the factors that influence the success of these formulations.The method used in this study is a literature review that collects data from various scientific publications over the past five years through online platforms such as Google Scholar, using keywords related to matrix sustained-release tablets and pharmaceutical formulations.The results of the review indicate that various techniques, such as formulating polymer matrices, coating, and encapsulation, have been applied with varying degrees of success depending on the type of active ingredients and excipients used. Some formulation innovations, such as the use of natural polymer matrices and matrix modifications, have proven effective in achieving controlled, stable, and quality-standard-compliant drug release.
Review Artikel: Analisis Formulasi dan Evaluasi Tablet Effervescent Dewi Rahmawati; Dzakiya Zhihrotulwida; M. Fithrul Mubarak; Yani Ambari; Allyssia Salma; Siti Nur Rohmania; Siti Khoiriyah; Achmad Saichoni Arthaganda; Winda Wulandari; Salsabila Firdausi Hernila Putri; Silfi Maslicha
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1404

Abstract

The purpose of writing this review article is to analyze the formulation and evaluation of the use of various additives in effervescent tablets. The method used is a literature review taken from journals and other relevant research results regarding the formulation and evaluation of additives in various types of effervescent tablets. The purpose of this analysis is to provide a summary of relevant publications and to improve current understanding in this field. The importance of the formulation and evaluation of additives in effervescent tablets cannot be ignored, because it is a crucial aspect in product development. Decisions in the use of additives must consider the objectives to be achieved, the desired physical characteristics, product stability, and the level of consumer acceptance. With a deep understanding of this formulation and evaluation, we have the potential to produce high-quality effervescent tablets. Variations in additives can also provide different taste and texture characteristics, which of course can affect consumer acceptance.  
Artikel Review: Formulasi dan Evaluasi Sediaan Tablet Lepas Lambat Az Zahra, Maulidya Rachma; Viola Putri Andini; Maharani Intan Rusita; Tiara Anisa Maharani; Eva Putri Wulandari; Farid Rahmandani; Aisyah Adellina Santyas; Dewi Rahmawati; Dzakiya Zhihrotulwirda; Yani Ambari; Fitrul Mubarak
An-Najat Vol. 3 No. 2 (2025): Mei : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i2.2719

Abstract

Zat aktif yang berbentuk padat bisa diberikan kepada pasien dalam bentuk serbuk, tetapi umumnya zat aktif diformulasikan menjadi sediaan padat yang disebut tablet. Tablet lepas lambat adalah jenis tablet yang dirancang untuk melepaskan zat aktif secara perlahan-lahan ke dalam tubuh selama waktu tertentu. Tujuan penelitian ini untuk mengetahui formulasi dan evaluasi yang terdapat  pada sediaan tablet lepas lambat. Metode yang diterapkan dalam review artikel ini adalah dengan mengumpulkan dan memilah dari beberapa jurnal dengan tema yang sesuai dan sama, kemudian kami review menjadi 7 jurnal yang tepat. Pemilihan jurnal didasarkan pada kriteria tertentu, seperti relevansi topik, kualitas publikasi, dan tahun terbit yang terbaru untuk memastikan keakuratan dan kekinian data. Hasil menunjukkan bahwa formulasi dan evaluasi memegang peranan penting dalam pengembangan tablet lepas lambat. Pemilihan eksipien (HPMC, xanthan gum, gelatin, pati alami modifikasi) dan metode formulasi (granulasi basah, kempa langsung, Simplex Lattice Design) mempengaruhi profil pelepasan obat, sifat fisik, dan stabilitas tablet. Kesimpulan: Pemilihan eksipien dan metode formulasi sangat penting dalam menentukan karakteristik tablet lepas lambat. Eksipien dan metode yang tepat dapat mengoptimalkan pelepasan zat aktif sesuai standar farmakope.