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All Journal Medicina E-Jurnal Medika Udayana Sari Pediatri Paediatrica Indonesiana ISM (Intisari Sains Medis) : Jurnal Kedokteran Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal Pediatric Sciences Journal Public Health and Preventive Medicine Archive Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Folia Medica Indonesiana
Ketut Dewi Kumara Wati
Department Of Pediatrics Faculty Of Medicine Udayana University
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Public Health

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Journal : World Nutrition Journal

 1 
Partially Hydrolyzed Whey Protein: A Review of Current Evidence, Implementation, and Further Directions Badriul Hegar; Zakiudin Munasir; Ahmad Suryawan; I gusti Lanang Sidhiarta; Ketut Dewi Kumara Wati; Erfi Prafiantini; Irene Irene; Yvan Vandenplas
World Nutrition Journal Vol. 5 No. 1 (2021)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.i1.0008

Abstract

Background: Human milk is known to be the best nutrition for infants as it provides many health benefits. For non-breastfed infants, cow's milk based infant formula is the most optimal option to provide the needed nutrition. However, approximately 2-5% of all formula-fed infants experience cow’s milk allergy during their first year of life. Partially hydrolyzed whey formula (pHF-W) have been widely recommended to prevent the development of allergic disease in infants. However, according to epidemiological data, approximately half of the infants developing allergy are not part of the at-risk group.Objectives and Methods: This article aims to review the effects of pHF-W in preventing allergy, especially atopic disease, in all non-breastfed infants, as well as the safety aspect of pHF-W if used as routine formula. The role of pHF-W in the management of functional gastro-intestinal (GI) disorders is also reviewed.Results: Several clinical studies showed that pHF-W decrease the number of infants with eczema. The strongest evidence is provided by the 15-year follow up of the German Infant Nutritional Intervention study which showed reduction in the cumulative incidence of eczema and allergic rhinitis in pHF-W (OR 0.75, 95% CI 0.59-0.96 for eczema; OR 0.67, 95% CI 0.47-0.95 for allergic rhinitis) and casein extensively hydrolysed formula  group (OR 0.60, 95% CI 0.46-0.77 for eczema; OR 0.59, 95% CI 0.41-0.84 for allergic rhinitis), compared to CMF as a control, after 15 years of follow-up. pHF-W was also found to be beneficial in the management of functional GI disorders such as regurgitation, constipation and colic.Conclusions: The use of pHF-W in allergic infants has been recommended in various guidelines across the countries, as a primary prevention of allergic disease. One pHF-W has been approved by the US FDA and the European Commission's European Food Safety Authority (EFSA) for its safety and suitability as a routine infant formula for all healthy infants. According to the data obtained in the management of functional GI disorders, pHF-W is better tolerated than formula with intact protein. Further studies assessing the effect of routine use of pHF-W in a larger population of non-breastfed infants should also be conducted, in order to observe any potential harm and to determine the benefit and cost-effectiveness ratio.
Co-Authors Adnyana, I Gusti Agung Ngurah Sugitha Ahmad Suryawan Anak Agung Ngurah Ketut Putra Widnyana Anak Agung Tri Yuliantini Anang Endaryanto Apsari, Putu Indah Budi Arini Setiawati Aryono Hendarto Ayu Setyorini Mestika Mayangsari Badriul Hegar Bagus Ngurah Putu Arhana BNP Arhana Budi Setiabudiawan Cempaka, Putu Mas Vina Paramitha Deborah Melati, Deborah Dewi Wulandari Dewi, Ni Luh Putu Mulia Laksmi Dina Muktiarti, Dina Dyah Kanya Wati Eka Gunawijaya Endy P. Prawirohartono Erfi Prafiantini Eva Jacomina Jemima Sapulete Gusti Ayu Putu Nilawati Hamid H A Haryadi Haryadi - Hendra Santoso Hendra Santoso Hendra Santoso Hindra Irawan Satari, Hindra Irawan I Gusti Agung Ngurah Sugitha Adnyana I Gusti Ayu Putu Eka Pratiwi I gusti Lanang Sidhiarta I Gusti Lanang Sidiartha I Gusti Ngurah Sanjaya Putra I Ketut Suarta I Made Kardana I N Sartika I Nyoman Budi Hartawan I Nyoman Supadma I Nyoman Supadma I Putu Gede Karyana I Wayan Dharma Artana I Wayan Dharma Artana, I Wayan Dharma I Wayan Eka Satriawibawa I Wayan Gede Artawan Eka Putra I Wayan Gede Artawan Eka Putra, I Wayan Gede Artawan Eka I Wayan Gustawan Ida Bagus Krisna Jaya Sutawan Ida Bagus Subanada Irene Irene Johannes Hudyono Juergens, Stefanie Kadek Surya Jayanti, Kadek Surya Ketut Suarta Ketut Tangking Ketut Tuti Parwati Merati Komang Ayu Witarini Luh Putu Ratna Sundari Made Ardinata Made Bandem Kenny Wijaya Nugraha Made lndah Nastiti Utami Budha Maria Priskila Melisa Anggraeni Melva Louisa Merati, Tuti Parwati Metriani Nesa, Ni Nyoman Mohammad Juffrie Nesa, Ni Nyoman Metriani Ni Made Ayu Agustini Ni Nyoman Metriani Nesa Ni Putu Siadi Purniti Ni Putu Veny Kartika Yantie, Ni Putu Veny Kartika NP Veny Kartika Yantie Pande Putu Yuli Anandasari Purwoko, Agus Putu Ayu Widyanti Putu Ayunda Trisnia Putu Diah Vedaswari Putu Indah Budi Apsari Retno Asti Werdhani Ronaldi, Melissa Roni Naning Sawitri, Anak Agung Sagung Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Stefanie Juergens Suandi IKG Sumadiono Sumadiono supadma, I nyoman Susanto, Yohanes Widiantari, Ni Made Widiastari, A.A Ayu Widiastari, A.A Ayu Yvan Vandenplas Zakiudin Munasir