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All Journal Media Ilmu Keolahragaan Indonesia The Indonesian Biomedical Journal Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Medicine Sumatera Medical Journal Jurnal Keperawatan Priority Journal of Telenursing (JOTING) Indonesian Journal of Global Health research Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED) Jurnal Penyakit Dalam Indonesia
Santi Syafril, Santi
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Majalah Kedokteran Nusantara The Journal Of Medical School

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Efektifitas Kombinasi Ekstrak Sambiloto (Andrographis paniculata (burm.f.) nees) dan Daun Salam (Syzygium polyanthum (wight) walp) terhadap Kadar hs-CRP pada Pasien Dislipidemia Yulindaa, Wina; Lindarto, Dharma; Syafril, Santi
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 3 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Introduction Dyslipidemia is risk factor of cardiovascular disease and significantly correlated with increased hs-CRP concentration. Simvastatin, a sintetic antidyslipidemic drug, decreases hs- CRP concentration. But long term use of sintetic drug may cause side effects, so that phytopharmaca is preferably to be consumed. Combination sambiloto extract and salam could decrease proinflammatory cytokines, cholesterol, and triglyceride. Aim of this study was to compare the effect of combination sambiloto extract and salam with simvastatin on hs-CRP concentration in dyslipidemic patientsMethods This clinical trial use prospective design. Treated group (n = 15) and control group (n = 15) were selected by double blind random sampling. Before and after 30 days therapy, blood sample was taken. Data was analysed with SPSS, p < 0.05 was considered significant.Results There was significant decrease of hs-CRP before and after 30 days therapy in treated group ((3.02 ± 3.13 vs 1.67 + 1.37) mg/dL; p = 0.005); meanwhile insignificant decrease was there in control group ((2.78 ± 1.97 vs 2.25 ± 2.32) mg/dL; p = 0.285). hs-CRP decrease of treated group was bigger than in control group, but statistically insignificant ((1.35 ± 2.37 vs 0.53 ± 1.96) mg/dL; p = 0.089 mg/dL).Conclusion Combination sambiloto extract (Andrographis paniculata) and salam (Syzygium polyanthum) 2 x 150 mg for 30 days decreased hs-CRP concentration lower than simvastatin 1 x 20 mg, but statistically insignificant.Keywords : hs-CRP, Andrographis paniculata and Syzygium polyanthum, dyslipidemia
Co-Authors Awaluddin Saragih Aznan Lelo Bernando, Andri Dairion Gatot, Dairion dharma Lindarto, dharma ELMAN BOY Ginting, Almaycano Handayani, Savina Harahap, Juliandi Ihsan, Brama Imelda Rey Irawaty, Noni Kembaren, Tambar Lubis, Dian Anindita Mardia, Andri Iskandar Merlin, Asri Pangaribuan, Jessica Patricia Prianwari, Catur Rahma, Hadiyatur Rahmad Isnanta, Rahmad Ratna Akbari Ganie, Ratna Akbari Ricke Loesnihari Sanusi, Muhammad Arif Sembiring, Rosita Juwita Sholat, Alfi Dewi Siregar, Dewi Indah Sari Siregar, Jelita Situmorang, Immanuel Sri Sumartiningsih Sugeng, Santoso Sylvana, Dhini Tarigan, Amira Permatasari Theresia, Lydia Yetty Machrina Yulindaa, Wina Yusni Yusni