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All Journal Martabe : Jurnal Pengabdian Kepada Masyarakat Manuju : Malahayati Nursing Journal JURNAL FARMASIMED (JFM) Khazanah Intelektual Jurnal Endurance: Kajian Ilmiah Problema Kesehatan Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Jurnal Pengabdian Harapan Ibu (JPHI) Radinka Journal of Health Science Journal of Natural Products and Drug Development
Aisa Dinda Mitra
Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi
Agriculture, Biological Sciences & Forestry Arts Humanities Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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THE EFFECT OF GIVING KEDUDUK LEAF EXTRACT (Melastoma malabathricum L.) ON REDUCING BLOOD SUGAR LEVELS IN MALE WHITE RATS (Rattus norvegicus) WITH KIDNEY DYSFUNCTION COMPLICATIONS Aisa Dinda Mitra; Deny Sutrisno; Oktarani Nadila
Jurnal Endurance Vol. 10 No. 1 (2025): Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jen.v10i1.3249

Abstract

Diabetes mellitus is a multifactorial chronic metabolic disorder characterized by increased blood glucose levels due to insufficient insulin production. One of the plants that can be used to reduce blood sugar levels is keduduk leaves (Melastoma malabathricum L.). This study aims to determine the potential of keduduk leaf extract in reducing blood sugar levels in male white rats (Rattus norvegicus) with complications of kidney dysfunction. Methods This study is an experimental study in which rats were induced diabetes using alloxan dose 150 mg/kgBB for 3 days and kidney dysfunction with gentamicin dose 80 mg/kgBB for 7 days. Data were analyzed using Two Way Anova followed by Duncan test. The results showed that the administration of keduduk leaf extract at a dose of 400 mg/kgBB most significantly reduced blood sugar levels in male white rats with complications of kidney dysfunction. The results of creatinine examination after being given the extract showed that there was an effect of kidney complications on the decrease in blood sugar levels in rats, where the decrease in blood sugar levels in the diabetes group with kidney dysfunction complications was smaller than the diabetes group without complications. Keduduk leaf extract can potentially affect kidney function and has adverse side effects, especially on damaged kidney function. Keywords : Alloxan; keduduk leaf extract (Melastoma malabathricum L.); gentamicin; maceration; blood sugar level reduction
PEMANFAATAN TANAMAN JAHE,KUNYIT ,SERAI SERTA DAUN SALAM UNTUK PEMELIHARAAN KESEHATAN DI RT 01 KELURAHAN SOLOK SIPIN KECAMATAN DANAU SIPIN KOTA JAMBI Amelia Soyata; Aisa Dinda Mitra; Melayusma Muchtar; Ediwan Nestawri Hutabarat
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 5, No 4 (2022): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v5i4.1223-1228

Abstract

Kelurahan Solok Sipin merupakan salah satu kelurahan yang ada di Kecamatan Danau Sipin. Pada kegiatan pengabdian masyarakat yang dilakukan di RT. 01 diketahui sebagian besar warga masyarakat banyak mengalami penyakit hipertensi,warga RT 01 juga memanfaatkan pekarangan rumahnya untuk menanam tanaman herbal yang dapat digunakan untuk kebutuhan mereka sendiri, di antaranya adalah tanaman jahe,kunyit,serei dan daun salam.namun pemanfaatan tanaman tersebut hanya sebagai bumbu dalam masakan sehari sehari. Maka dari pengabdian masyarakat ini diharapkan dapat memberikan edukasi kepada warga bagaimana cara penggolahan jahe,kunyit ,serei menjadi minuman yang berkhasiat menjaga kesehatan dan daun salam,sebagai tanaman herbal berkhasiat untuk menurunkan penyakit hipertensi,sehingga setelah dilakukan kegiatan pengandian masyarakat ini dapat meningkatkan pengetahuan warga tentang hipertensi dan pengolahan minuman herbal sebagai minuman yang bermanfaat untuk kesehatan
Histopathology Test in Dyslipidemic Female White Rats (Rattus Norvegicus) Treated With Chitosan Nanoparticle Gel of Pineapple Peel Extract (Ananas Comosus (L.) Merr) as Anti-Cellulite Indri Merista; Aisa Dinda Mitra; Camila Putri Firira
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/ms60zx36

Abstract

Cellulite is considered a skin condition associated with aging appearance due to the accumulation of fat deposits beneath the skin. The use of natural-based skincare products, such as pineapple peel extract containing active compounds, offers an alternative solution for reducing cellulite. Pineapple peel contains beneficial bioactive compounds, including flavonoids, tannins, saponins, bromelain enzymes, and secondary metabolites such as quercetin, which act as lipolytic agents. This study aimed to determine the effect of varying concentrations of pineapple peel extract gel and chitosan nanoparticle–based pineapple peel extract gel on their anti-cellulite effectiveness and to identify the gel formulation that meets good physical quality requirements. The research employed an experimental method, beginning with sample collection, determination, simplicia preparation, extraction using maceration, phytochemical screening, nanoparticle solution formulation, and gel formulation with various concentrations (F0 0%, F1 2.5%, F2 5%, F3 2.5%, and F4 5%). The gel formulations were evaluated for their physical properties, including organoleptic characteristics, homogeneity, pH, spreadability, adhesiveness, and stability, followed by a histopathological test on the skin. The results show that all gel formulations exhibit physical characteristics that meet standard quality requirements. The variation in gel concentration influences the histopathological outcomes in female dyslipidemic white rats with cellulite, where an increased concentration of chitosan nanoparticle gel up to 5% significantly reduces the number of fat cells and improves skin tissue structure.
Effect of Acarbose on Blood Sugar Levels in Male White Rats (Rattus norvegicus) With Pathologies of Liver Dysfunction and Renal Dysfunction Sry Nur Admidha; aisa dinda mitra; Mohammad Qais Rezvani
Journal of Natural Products and Drug Development Vol. 1 No. 1 (2025): Journal of Natural Products and Drug Development
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/jnpdd.v1i1.50

Abstract

Background of study: Diabetes is caused by metabolic disorders that result in high blood glucose levels due to insulin deficiency and insulin resistance. This disease can trigger serious psychological, social, and physical problems and increase the risk of kidney and liver disease. Insulin resistance exacerbates liver damage through hyperinsulinemia and oxidative stress, which also affects kidney function. Research on acarbose suggests its potential to reduce diabetes complications, including liver and kidney dysfunction.Aims and scope of paper: This study aims to determine the effect of acarbose on blood glucose levels in diabetic rats with induced liver and kidney dysfunction using an in vivo experimental model.Methods: This study is an in vivo experiment using a male white rat (Rattus norvegicus) as a subject. The study began with acclimatization of mice, followed by induction with aloxan, CCl4, and gentamicin, and observation for 7 days. After that, the mice were given acarbose suspension according to the test group, and blood samples were analyzed.Result: The results showed that acarbose was effective in lowering blood sugar levels in diabetic and liver-dysfunction mice, but had no effect in kidney-dysfunction mice because there was no kidney damage.Conclusion: acarbose significantly lowered blood sugar levels in mice with diabetes and liver dysfunction, but not in those with kidney dysfunction.
Co-Authors Achmad Noerkhaerin Putra Ahmad Rozan Dewansyah Amelia Soyata Andriani, Medi Camila Putri Firira Dewi, Rasmala Dian Ayu Cahyani Distia Nurhuda Diya Nurniati Putri Ediwan Nestawri Hutabarat Fitri Suprianti Ghina Nabilla Dwi Saputri Iffah Arfiani Indri Meirista Indri Merista Jeihan Zahira Dianda Lioni Regina Pradipta M. Henityo Agung As'adi Meirina Silaban Melayusma Muchtar Miftahul Ilmi Mohammad Qais Rezvani Nanda Putri Chairunnisa Oktarani Nadila Raihana Salsabila Regina Amanda Resky Indah Oktaviani Rezky Adinda Rizky Yulion Sanuddin, Mukhlis Sepriani Sry Nur Admidha Suharwinda Suharwinda Sutrisno , Deny Tita Aulya Novira Veni Asna Dewi Yulvi Anggriyani ‘Aliyah, Siti Hamidatul