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All Journal Jurnal Ilmiah Universitas Batanghari Jambi Martabe : Jurnal Pengabdian Kepada Masyarakat Manuju : Malahayati Nursing Journal JURNAL FARMASIMED (JFM) Jurnal Ilmiah Manusia dan Kesehatan Khazanah Intelektual Jurnal Kesehatan Tambusai Jurnal Endurance: Kajian Ilmiah Problema Kesehatan Journal of Education Technology Information Social Sciences and Health Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Jurnal Pengabdian Harapan Ibu (JPHI) Jurnal Ilmiah Farmasi Simplisia Radinka Journal of Health Science Jurnal Abdimas Kesehatan Journal of Natural Products and Drug Development
Aisa Dinda Mitra
Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Histopathology Test in Dyslipidemic Female White Rats (Rattus Norvegicus) Treated With Chitosan Nanoparticle Gel of Pineapple Peel Extract (Ananas Comosus (L.) Merr) as Anti-Cellulite Indri Merista; Aisa Dinda Mitra; Camila Putri Firira
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/ms60zx36

Abstract

Cellulite is considered a skin condition associated with aging appearance due to the accumulation of fat deposits beneath the skin. The use of natural-based skincare products, such as pineapple peel extract containing active compounds, offers an alternative solution for reducing cellulite. Pineapple peel contains beneficial bioactive compounds, including flavonoids, tannins, saponins, bromelain enzymes, and secondary metabolites such as quercetin, which act as lipolytic agents. This study aimed to determine the effect of varying concentrations of pineapple peel extract gel and chitosan nanoparticle–based pineapple peel extract gel on their anti-cellulite effectiveness and to identify the gel formulation that meets good physical quality requirements. The research employed an experimental method, beginning with sample collection, determination, simplicia preparation, extraction using maceration, phytochemical screening, nanoparticle solution formulation, and gel formulation with various concentrations (F0 0%, F1 2.5%, F2 5%, F3 2.5%, and F4 5%). The gel formulations were evaluated for their physical properties, including organoleptic characteristics, homogeneity, pH, spreadability, adhesiveness, and stability, followed by a histopathological test on the skin. The results show that all gel formulations exhibit physical characteristics that meet standard quality requirements. The variation in gel concentration influences the histopathological outcomes in female dyslipidemic white rats with cellulite, where an increased concentration of chitosan nanoparticle gel up to 5% significantly reduces the number of fat cells and improves skin tissue structure.
Effect of Acarbose on Blood Sugar Levels in Male White Rats (Rattus norvegicus) With Pathologies of Liver Dysfunction and Renal Dysfunction Sry Nur Admidha; aisa dinda mitra; Mohammad Qais Rezvani
Journal of Natural Products and Drug Development Vol. 1 No. 1 (2025): Journal of Natural Products and Drug Development
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/jnpdd.v1i1.50

Abstract

Background of study: Diabetes is caused by metabolic disorders that result in high blood glucose levels due to insulin deficiency and insulin resistance. This disease can trigger serious psychological, social, and physical problems and increase the risk of kidney and liver disease. Insulin resistance exacerbates liver damage through hyperinsulinemia and oxidative stress, which also affects kidney function. Research on acarbose suggests its potential to reduce diabetes complications, including liver and kidney dysfunction.Aims and scope of paper: This study aims to determine the effect of acarbose on blood glucose levels in diabetic rats with induced liver and kidney dysfunction using an in vivo experimental model.Methods: This study is an in vivo experiment using a male white rat (Rattus norvegicus) as a subject. The study began with acclimatization of mice, followed by induction with aloxan, CCl4, and gentamicin, and observation for 7 days. After that, the mice were given acarbose suspension according to the test group, and blood samples were analyzed.Result: The results showed that acarbose was effective in lowering blood sugar levels in diabetic and liver-dysfunction mice, but had no effect in kidney-dysfunction mice because there was no kidney damage.Conclusion: acarbose significantly lowered blood sugar levels in mice with diabetes and liver dysfunction, but not in those with kidney dysfunction.
The Effect of Video and Leaflet Media on Students’ Knowledge of Anthelmintic Drug Use at SMP Y, Merangin Regency Olivia Paramitha; Ruri Putri Mariska; Aisa Dinda Mitra
Journal of Education Technology Information Social Sciences and Health Vol. 5 No. 2 (2026): September 2026
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/jetish.v5i2.9248

Abstract

Helminthiasis remains one of the most common health problems among school-aged children in Indonesia. Limited knowledge regarding the proper use of anthelmintic drugs may reduce the effectiveness of helminthiasis prevention and control. This study aimed to determine the effect of video and leaflet media on students’ knowledge regarding the use of anthelmintic drugs and to compare the effectiveness of both educational media. A quasi-experimental study using a pretest-posttest two-group design was conducted among 60 seventh-grade students at SMP Y, Merangin Regency. Participants were divided into a video group (n=30) and a leaflet group (n=30) using total sampling. Knowledge was measured using a structured questionnaire before and after the educational intervention. Data were analyzed using the Wilcoxon Signed-Rank Test and Mann–Whitney Test. The mean knowledge score increased from 65.83 to 80.50 in the video group and from 72.00 to 88.17 in the leaflet group. The Wilcoxon test showed a significant increase in knowledge in both groups (p<0.001), whereas the Mann–Whitney test demonstrated no significant difference in knowledge improvement between the two educational media (p=0.799). Both video and leaflet media effectively improved students’ knowledge regarding the use of anthelmintic drugs; however, no significant difference in effectiveness was observed between the two interventions.
Co-Authors Achmad Noerkhaerin Putra Ahmad Rozan Dewansyah Aisyah, Andi AMANDA, REGINA Amelia Soyata Andriani, Medi Arfiani, Iffah Ayu Cahyani, Dian Camila Putri Firira Dewansyah, Ahmad Rozan Dewi, Rasmala Dian Ayu Cahyani Distia Nurhuda Diya Nurniati Putri Ediwan Nestawri Hutabarat Farah, Zahratul Fatihah, Anya Aulia Fitri Suprianti Ghina Nabilla Dwi Saputri Iffah Arfiani Indah Oktaviani, Resky Indra Gunawan Indri Meirista Indri Merista Jeihan Zahira Dianda Jelly Permatasari Lioni Regina Pradipta M. Henityo Agung As'adi Medi Andriani, Medi Andriani Meirina Silaban Melayusma Muchtar Miftahul Ilmi Miftahul Ilmi, Miftahul Mohammad Qais Rezvani Nanda Putri Chairunnisa Natari, Rifani Bhakti Novira, Tita Aulya Nurniati Putri, Diya Oktarani Nadila Olivia Paramitha Putri Chairunnisa, Nanda Raihana Salsabila Regina Amanda Regina Pradipta, Lioni Resky Indah Oktaviani Rezky Adinda Rizky Yulion Ruri Putri Mariska Sanuddin, Mukhlis Sepriani Septyawati, Marni Sry Nur Admidha Suharwinda Suharwinda Sutrisno , Deny Tita Aulya Novira Veni Asna Dewi Yulvi Anggriyani Zahira Dianda, Jeihan ‘Aliyah, Siti Hamidatul