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All Journal Public Health of Indonesia International Journal of Applied Biology Medical Laboratory Technology Journal Jurnal Endurance: Kajian Ilmiah Problema Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Health Information : Jurnal Penelitian Borneo Journal of Medical Laboratory Technology Jurnal Teknologi Kesehatan Molucca Medica Mestaka: Jurnal Pengabdian Kepada Masyarakat Jurnal Inovasi, Pemberdayaan dan Pengabdian Masyarakat Media Penelitian dan Pengembangan Kesehatan
Reni Yunus, Reni
Department Of Nursing, Polytechnic Of Health Kendari, Southeast Sulawesi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

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Immunomodulatory activity of kersen leaf extract (Muntingia calabura) on diabetic rats: analysis of immune response Hasan, Fonnie Esther; Yunus, Reni; Magdalena, Magdalena
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 6 No 2 (2024): Promising and valuable research towards diagnosis, prognosis and treatment of dis
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v6i2.5746

Abstract

The immune response to high blood glucose levels leads to an inflammatory response and also produces inflammation mediators. Immunomodulatory functions of Kersen (Muntingia calabura) need further enhancement to ensure that its benefits are more widely recognized by the public. This study aims to determine the immunomodulatory activity of Kersen leaf in inducing and modulating the immune response in diabetic rats. This study was an experimental laboratory with a pre-and post-test with a control group design. The subjects were 30 white rats (Rattus Novergicus Wistar Strain), were treated with extract M. calabura dose 1 (100 mg/kg bw/day), dose 2 (200 mg/kg bw/day), dose 3 (300 mg/kg bw/day). For clinical evaluation, three control groups were formed, including a Normal Control Group, a Diabetes Mellitus (DM) Positive Group, and a DM Positive Group treated with Anti-Diabetic Drugs. The highest amount of IFN-γ concentrations were found in the DM positive control group + antidiabetic drugs (710.3 ± 27.2 ng/mL).  The highest number of Nitrit Oxide (NO) concentration was found in the DM positive control group (103.7 ± 10.2 µmol/L). The highest average amount of pancreatic β cell regeneration was found in the normal control group.  The DM positive control group and the treatment group had a significant difference (p < 0.05) It means that there is a significant difference in the data of all treatment groups, or these three groups have anti-diabetic activity by repairing or preventing damage to the pancreas organ in DM rats. This study revealed that M. calabura possesses immunomodulatory activity, capable of inducing and modulating immune responses in diabetic rats.
Co-Authors Afrindayanti Afrindayanti Angriani Fusvita Anita Rosanty, Anita Askrening Askrening Askrening Citranti, Elvia Darmayani, Satya Darmayani, Satya Fauzi, Ahmad Zil Fina Astina Fonnie E. Hasan Fristiohady, Adryan Gobel, Sri Yunanci Van Hasan, Aswiro Hasan, Fonnie E Hasan, Fonnie Esther Hasnah, Nur Ihwan, Muh. Ikbal Ikbal Jumasran, Jumasran Kartini Kartini Magdalena Magdalena Muh. Ikhsan, Muh. Muhammad Hilam Munanto, Risman Naningsih, Hasmia Nurhayani, St. NURHAYU MALIK, NURHAYU Nurtimasiah, Wa Ode Orno, Theosobia Grace Petrus Nugroho DS Puspita, Sarlita Putra, Ahmat Rediansya Rafika Rafika Rahayu, Dian Yuniar Syanti Ruth Mongan Ruth Mongan, Ruth Sari, Julianti Isma Satya Darmayani Supiati Supiati Supryatno, Adi Susilawati Trees, Trees Triyaswati, Desty Tuty Yuniarty Tuty yuniarty, Tuty Wijayati, Fitri