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All Journal Eureka Herba Indonesia Proceedings of the International Conference on Nursing and Health Sciences Media Farmasi Indonesia International Journal of Medicine and Health Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) International Journal of Health, Engineering and Technology Usada Nusantara: Jurnal Kesehatan Tradisional Jurnal Pengabdian Masyarakat dan Riset Pendidikan Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan
Kharisma Jayak Pratama
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary Other

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Cost-Effectiveness Analysis Of The Use Of Ciprofloxacin And Levofloxacin Antibiotics For Urinary Tract Infections In BPJS Inpatients At RSUD Dr. Moewardi Surakarta Annisa Nurulita Dyah Savitri; Kharisma Jayak Pratama; Aprilia Puteri Santika
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.606

Abstract

Urinary tract infections (UTIs) are a significant health burden in Indonesia, with high antibiotic therapy costs in BPJS inpatients. This study aims to analyze the cost-effectiveness of ciprofloxacin versus levofloxacin in BPJS inpatient UTI patients at Dr. Moewardi Surakarta Hospital from January to June 2025. This study used retrospective quantitative descriptive research with secondary data from medical and financial records; the population of all cases met the criteria (n=127) using total sampling. Data extraction instruments were demographic variables, effectiveness (temperature, length of hospitalization), and direct medical costs; CEA analysis via ACER, ICER, and Mann-Whitney test (p<0.05). The results showed equivalent effectiveness (ciprofloxacin 36.78%; levofloxacin 35%), ACER of ciprofloxacin Rp470,910 lower than levofloxacin Rp621,220, negative ICER Rp-2,451,792, with no significant difference (p>0.05). Conclusion: Both therapies are economically equivalent, supporting the optimization of JKN.
The Effect Of Variations In The Concentration Of Ethanol Extract Of Green Okra Fruit (Abelmoschus Esculentus L. Moench) On The Antioxidant Activity Of Face Mist Preparations Using The DPPH Method Sirna Dzawil Kamala; Alfina Nurrahman; Kharisma Jayak Pratama
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.613

Abstract

Skin aging due to oxidative stress from free radicals from UV exposure and pollution requires natural antioxidants in topical products. Ethanol extract from green okra fruit (Abelmoschus esculentus L. Moench) rich in phenolics has strong potential to capture DPPH. This quantitative preclinical experimental study aims to test the effect of extract concentration (3%, 6%, 9%) on antioxidant activity and physical quality of face mist preparations. The population of face mist preparations; purposive samples include controls and three formulas with three replications. UV-Vis spectrophotometer instruments for IC50 DPPH at 516 nm (operating time 15 minutes), pH meter, Brookfield viscometer. Descriptive and inferential analysis One-Way ANOVA and Tukey HSD (SPSS, p <0.05). The results showed IC50: control 71.92 ppm (strong), Formula I 146.75 ppm (moderate), II 80.63 ppm (strong), III 78.72 ppm (strong); pH 4.57-5.15 (skin compatible); viscosity 1.22-3.75 mPa.s (meets <5 mPa.s); homogeneous. High concentrations significantly increase antioxidant activity (p<0.05). In conclusion, the 9% formula of optimized strong antioxidant face mist meets cosmetic standards, with anti-aging potential.
Cost-Effectiveness Analysis Of Pulmicort-Combivent And Pulmicort Single Use In Inpatients With Chronic Obstructive Pulmonary Disease At Dr. Moewardi Regional Hospital Yustina Esha Maunia Chantika; Kharisma Jayak Pratama; Vivin Marwiyati Rohmana
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.633

Abstract

Chronic Obstructive Pulmonary Disease (COPD) causes a high economic burden due to repeated hospitalizations, but the cost-effectiveness of Pulmicort-Combivent versus Pulmicort alone has not been evaluated at Dr. Moewardi Regional General Hospital. This study aims to determine ACER, ICER, and cost-effectiveness of therapy using CEA. This study was a retrospective, descriptive, cross-sectional observational study with a total sampling of 62 hospitalized COPD patients from January 2024 to November 2025. Medical record data instruments were analyzed using ACER, ICER, and the Mann-Whitney test. The results showed that the ACER of Pulmicort-Combivent Rp225,775 (40% effectiveness) was lower than that of Pulmicort alone Rp765,036 (14.03%), ICER Rp-65,554, with no significant difference (p>0.05). Both therapies were equivalent in terms of cost-effectiveness.
Evaluation Of The Rationality Of Antibiotic Use In Hospitalized Adult Patients With UTI Diagnosis On Clinical Outcome At Dr. Moewardi Regional Hospital Malinda Apriliani; Kharisma Jayak Pratama; Niken Luthfiyanti
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.651

Abstract

Urinary Tract Infection (UTI) is a common infection with high antibiotic resistance due to irrational use.  To assess the rationality of antibiotics in adult inpatients with UTI at Dr. Moewardi Regional General Hospital using the Gyssens method, ATC/DDD patterns, and their relationship with clinical outcomes. A retrospective descriptive observational study of medical records of 50 acute pyelonephritis patients (population 270, Slovin sample e=10%, consecutive sampling), collected in December 2025. LPD medical records; analysis: Gyssens (qualitative Permenkes 28/2021), ATC/DDD (quantitative), Fisher's Exact (p<0.05). 64% female, 52% >60 years; ciprofloxacin 90%; rationality 46% (Gyssens category 0), 54% irrational (mainly short duration 44%); ATC/DDD: ciprofloxacin 47.2%, ceftriaxone 52.8%; outcome improved 94%; p=0.090 (not significant). Rationale was low, especially for duration, with no significant association with outcome; stewardship is recommended to prevent resistance.
Analysis Of The Relationship Between Pharmacists' Knowledge, Attitude, And Perception Levels Towards Telepharmy Implementation In Sukoharjo Regency Fiska Febriani Fikri; Kharisma Jayak Pratama; Hidayah Apriliawan
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.660

Abstract

The Covid-19 pandemic has accelerated the adoption of technology in healthcare services, including the implementation of telepharmacy. The success of telepharmacy implementation depends on the readiness of pharmacists in terms of their knowledge, attitudes, and perceptions. This study aims to analyze the relationship between the level of knowledge, attitudes, and perceptions of pharmacists towards the implementation of telepharmacy in the Sukoharjo Regency. This study is a qualitative descriptive study with a cross-sectional approach. The study sample consisted of 30 pharmacists working in pharmacies and community health centers in Sukoharjo Regency, selected using purposive sampling. Data were collected using a questionnaire that had been tested for validity and reliability, as well as in-depth interviews. Data analysis included univariate and bivariate analysis with chi-square. The results showed that the majority of pharmacists had a good level of knowledge (mean 76.7%), indicating that pharmacists had a good understanding. Pharmacists' attitudes were in the adequate category (mean 60%), and pharmacists' perceptions were in the adequate category (mean 70%). Statistical analysis using chi-square indicated that there was a significant relationship between pharmacists' knowledge and perceptions, with a p-value of 0.014 (p <0.05). There was a significant relationship between the variables of attitude and perception, as indicated by a p-value of 0.001 (p <0.05). The conclusion of the implementation of tele-pharmacy is not only in terms of knowledge, but also in strengthening positive attitudes through supportive infrastructure, technical training, and clear regulations.
Troponin Profile Of Clopidogrel And Ticagrelor With Old Generation PPIs In Myocardial Infarction Patients Erlisa Ika Yuni Pramesti; Kharisma Jayak Pratama; Hidayah Apriliawan
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.664

Abstract

Myocardial infarction is a leading cause of cardiovascular death in Indonesia with an increasing prevalence. The interaction of clopidogrel-ticagrelor with older-generation PPIs can affect antiplatelet efficacy and troponin levels. This study aims to describe troponin levels in the use of clopidogrel and ticagrelor with older-generation PPIs and their relationship to patient characteristics and lipid profiles. A retrospective descriptive observational method was conducted on 76 myocardial infarction patients at March eleventh University Hospital (November 2024-November 2025) using medical record data. Univariate (frequency, mean) and bivariate (Chi-Square, p<0.05) analyses were processed using SPSS. The results showed that the majority of patients were male (66%), aged 46-65 years (64%). There was no significant association between gender (p=0.542), age (p=0.415), clopidogrel-PPI (p=0.346), ticagrelor-PPI (p=0.368), and LDL (p=0.100) with troponin, but triglycerides were significantly associated (p=0.040). The average troponin of clopidogrel was 9.465 ng/L, higher than that of ticagrelor (3.879 ng/L). It was concluded that triglycerides significantly influenced troponin, while patient characteristics and the combination of antiplatelet-PPI did not.
Co-Authors Afina Rachmalia Artha Aryasuta Alfina Nurrahman Annisa Nurulita Dyah Savitri Annora Rizky Amalia Aprilia Puteri Santika Ardi Setyawan Bangkit Riska Permata Danang Raharjo Desy Ayu Irma Permatasari Dewi Weni Sari Erlisa Ika Yuni Pramesti Fiska Febriani Fikri Hidayah Apriliawan Isna Nur Khasanah Malinda Apriliani Meli Oktavia Mutia Della Citra Nabilah Hanim Mohd Sabri Niken Luthfiyanti Nurchaina Aprilia Dewi Rohmana, Vivin Marwiyati Sari, Dewi Weni Shela Novita Devi Sirna Dzawil Kamala Siti Nur Indriyah Tiara Ajeng L Wardani, Tatiana Siska Yustina Esha Maunia Chantika