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All Journal PENA SAINS Indonesian Journal of Pure and Applied Chemistry JKPK (Jurnal Kimia dan Pendidikan Kimia) Fullerene Journal of Chemistry Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya SOSCIED Oxygenius Journal Of Chemistry Education Stannum : Jurnal Sains dan Terapan Kimia Jurnal Inovasi Pendidikan dan Sains Jurnal Anugerah: Jurnal Pengabdian Kepada Masyarakat Bidang Keguruan dan Ilmu Pendidikan Sciening : Science Learning Journal Hydrogen: Jurnal Kependidikan Kimia Jurnal Pengabdian Kepada Masyarakat JUPADAI : Jurnal Pengabdian Kepada Masyarakat Entalpi Pendidikan Kimia Jurnal Pengabdian Kepada Masyarakat JIPI (Jurnal IPA dan Pembelajaran IPA) Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Akademika Kimia Jurnal Abdimas Mahakam
Stefan Marco Rumengan
Universitas Negeri Manado
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Nursing Physics Public Health Social Sciences Veterinary Other

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Total Synthesis and Molecular Docking study of Peptide AWVDY as an Anti-inflamation Agent Anderson Arnold Aloanis; Jessika Maya Jovanka Najoan; Vlagia Indira Paat; Stefan Marco Rumengan; Rymond Jusuf Rumampuk
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 10, No 2 (2025): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v10i2.103623

Abstract

Bioactive peptides are known for their diverse biological functions, many of which support health and well-being. In this study, we synthesized and evaluated the anti-inflammatory potential of the peptide AWVDY, derived from oyster (Crassostrea rivularis). The synthesis was performed using the solid-phase peptide synthesis (SPPS) method, applying the Fmoc strategy on 2-chlorotrityl chloride (2-CTC) resin, and achieved a high yield of 95.83%. The resulting peptide was characterized using Time-of-Flight Mass Spectrometry (TOF-MS), which detected a peak at m/z [M+H⁺] 653.1418, consistent with the expected molecular formula C₃₂H₄₀N₆O₉. This was further validated by analytical HPLC, showing a retention time of 22.596 minutes. Molecular docking studies indicated that AWVDY binds favorably to the pro-inflammatory cytokines TNF-α and Interleukin-6, with binding affinities of -10.360, -10.430, and -8.960 kcal/mol, respectively. These findings suggest that AWVDY may act as a dual-target peptide capable of modulating inflammatory pathways, highlighting its potential as a promising candidate for the development of new anti-inflammatory therapeutics. 
CHEMLIT: Development and Feasibility of a Sensor-Based Chemistry Practicum Tool for Electrolyte Solutions Lorry Enjlina Br Surbakti; Maria Murniyanti Parhusip; Natasya Patulak; Septiany Ch. Palilingan; Stefan Marco Rumengan; Jakub Saddam Akbar
Hydrogen: Jurnal Kependidikan Kimia Vol. 14 No. 2 (2026): April 2026
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v14i2.19512

Abstract

Chemistry learning requires the integration of macroscopic, submicroscopic, and symbolic representations. However, limited availability of practicum tools in senior high schools often hinders students’ comprehensive understanding of chemical concepts, particularly in electrolyte and nonelectrolyte solutions. This study aimed to develop and implement CHEMLIT, a sensor-based chemistry practicum tool designed to support learning on solution electrical conductivity. The study employed a Research and Development (R&D) approach using the ADDIE model, consisting of analysis, design, development, implementation, and evaluation stages. Needs analysis was conducted through classroom observations and teacher interviews, followed by prototype design, assembly, calibration, and functional testing to ensure stability and safety. The implementation involved two senior high schools in the Minahasa region, with chemistry teachers serving as reviewers and students as trial users. Feasibility was evaluated by media experts, material experts, teachers, and students using five-point Likert-scale questionnaires, and the data were analyzed by converting scores into percentage-based feasibility criteria. Product feasibility was evaluated through validation by media experts, subject matter experts, chemistry teachers, and students using questionnaire instruments. The validation results indicated a very high level of feasibility, with scores of 91.7% from media experts, 96% from material experts, 92% from teachers, and student responses exceeding 93.99%, categorized as very good. These findings indicate that CHEMLIT meets technical, visual, and content feasibility standards and can serve as an alternative practicum tool for teaching electrolyte and non-electrolyte solutions, especially in schools with limited laboratory facilities. Its novelty lies in a portable sensor-based design that integrates quantitative conductivity measurement into conventional testing without complex digital systems.
Co-Authors Abdon Saiya Abdon Saiya Aisyiah R. P. Utami Aisyiah Restutiningsih Putri Utami Ajeng Triane Syawila Ana Mardliyah Anderson Arnold Aloanis Arsad, Regina Ayu Febrianti Akbar Bangun, Janneta Br Batu, Rumintang Lumban Chaleb P. Maanari Chaleb Paul Maanari Desire Atna Sridanty Rumondor Dian H O Howan Dian Herlinda Octorina Howan, Dian Herlinda Octorina Djakariah Djakariah Djakariah, Djakariah Djefri Tani Djois Sugiaty Rintjap Elsa Sangian Febrindah Ester Tambalean Feti Fatimah Feti Fatimah Freetje Waworuntu Indah U. Br. Sidabukke Jakub Saddam Akbar Jakub Saddam Akbar Jeanne M. Tuerah Jefry Wijaya Jefry Wijaya Jessika Maya Jovanka Najoan Joice Dorsila Susana Caroles Kartyka Nababan Khoirotul Ummah Kolompoy, Stevani Rosadelima Lorry Enjlina Br Surbakti Maria Murniyanti Parhusip Mariam Ulfah Marlina Karundeng Meike Paat Miftahul Jannah Miftahul Jannah Musma Rukmana Mustapa Mustapa Natasya Patulak Paat, Vlagia Indira Pongoh*, Emma Julien Pratiwi, Ananta Dian Robby Gus Mahardika Rymond Jusuf Rumampuk Sahabang, Neybi Sanusi Gugule Septiany Ch. Palilingan Soputan, Julieta Tambalean, Febrindah Ester Tengker, Soenandar M Tengker, Soenandar Milian Tengker, Soenandar Millian Tompunu Tuerah, Jeanne Maria Ulundeda, Efelien Ummah, Khoirotul Varisky Abraham Dumanaw Yana Sambeka Yohanes Bery Mokalu