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All Journal Jurnal Anestesi Perioperatif Indonesian Journal of Cancer Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Cancer
Andi Kurniadi, Andi
Department Of Obstetrics And Gynaecology, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Gambaran Faktor Risiko Kanker Endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022 Erfiandi, Febia; Balqis, Shalma Alaika Aurel; Salima, Siti; Mantilidewi, Kemala Isnainiasih; Kurniadi, Andi; Wibowo, Viko Duvadilan
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.578

Abstract

Tujuan: Mengetahui faktor risiko pasien kanker endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022.Metode: Penelitian metode deskriptif dengan menggunakan data sekunder. Kriteria inklusi yaitu pasien dengan diagnosis utama kanker endometrium.Hasil: Mayoritas pasien kanker endometrium berusia 50 – 59 tahun (34,8%), multipara (40,9%), Indeks Masa Tubuh ≥25 kg/m2 (33,2%), usia menarche ≥12 tahun (68,8%), tidak memiliki riwayat infertilitas (49,0%), belum menopause (36,4%), tidak memiliki riwayat terapi hormon (74,1%), pasien tidak memiliki riwayat kanker/lynsch syndrome (71,7%), tidak memiliki riwayat keluarga dengan lynch syndrome (75,7%), tidak menggunakan kontrasepsi (42,5%), dan tidak memiliki riwayat hipertensi (72,9%).Kesimpulan: Pasien kanker endometrium di RSUP Dr. Hasan Sadikin Bandung periode tahun 2020 – 2022 ditemukan paling banyak pada rentang usia 50 – 59 tahun, status paritas yaitu multi para (≥2 kelahiran hidup), indeks massa tubuh ≥25 (obesitas), belum menopause, usia menarche ≥12 tahun, tidak memiliki riwayat terapi hormon, tidak terdapat riwayat infertilitas, pasien tanpa riwayat kanker, tidak memiliki riwayat keluarga dengan kanker, tidak menggunakan kontrasepsi, dan tidak memiliki riwayat hipertensi.Overview of Endometrial Cancer Risk Factors at RSUP Dr. Hasan Sadikin in 2020 - 2022AbstractObjective: Indentifying the risk factor of endometrial cancer patients at RSUP Dr. Hasan Sadikin in 2020 - 2022.Method: This research used descriptive method by collecting secondary data. The inclusion criteria was patients with primary diagnosis of endometrial cancerResults: In this research, the majority of endometrial cancer patients were aged 50 - 59 years (34,8%), multiparous (40,9%), with body mass index ≥25 kg/m² (33,2%), menarche age of ≥12 years (68,8%), no history of infertility (49,0%), not menopausal yet (36,4%), no history of hormone therapy (74,1%), no patient history of cancer/Lynch syndrome (71,7%), no family history of lynch syndrome (75,7%), no history of contraceptive use (42,55), and no history of hypertension (72,9%).Conclusion: In 2020 - 2022, endometrial cancer patient in Dr. Hasan Sadikin Central General Hospital Bandung were mostly foung in the aged range 50 - 59 years, multiparous, obesity, not menopausal yet, menarche age of ≥12 years, no history of hormone therapy, no patient and family history of cancer, no history of contraceptive use and hypertension.Key words: Endometrial cancer, risk factor, descriptive study
Atypical Findings of Suspect Twin to Twin Transfusion Syndrome Quintero V: a Rare Case Report Gusasih, Bahar Sangkur; Irianti, Setyorini; Aziz, Muhammad Alamsyah; Kurniadi, Andi
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 4 October 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i4.2352

Abstract

Introduction: Twin-to-twin transfusion syndrome (TTTS) is a serious complication in monochorionic multiple pregnancies. Case Illustration: A-38 years old woman with G3P2AO felt 8 months pregnant and came for polyclinic control with the diagnosis of G3P2A0 gravida 34-35 weeks; Gemelli; Baby I Breech position; Baby I Polyhydramnios, IUFD; Suspected Twin Twin Transfusion Syndrome (TTTS Quintero V). However, atypical findings of TTTS are rarely found and should be taken as special notes such in this case. We will report a rare finding of TTTS in which the SDP level of the donor fetus was normal (not oligohydramnios). The suspected diagnosis of TTTS Quintero V in this case was made clinically based on the maternal-fetal ultrasound findings of a diamniotic monochorionic gemelli pregnancy with IUFD in the 2nd fetus II. However, there were non-standard findings in this case where the SDP level of the donor fetus was normal (not oligohydramnios). No other sequele complications were found in this case based on other examinations. Conclusions: Several therapies are available for TTTS including amnioreduction, laser ablation of the vascular placental anastomosis, selective feticide, and septostomy. Timing of delivery after management of singleton fetal death in the late second or early third trimester is debatable. Delivery method is determined based on obstetric indications.
Urinary Bladder Injury Among Patients with Placenta Accreta Spectrum: Comparison Between Wedge Resection and Total Hysterectomy Ismayadi, Tedi; Pribadi, Adhi; Kurniadi, Andi
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.877

Abstract

Objective: This study aims to assess the incidence of urinary bladder injury among pregnant women with placenta accreta spectrum (PAS) who underwent total hysterectomy and wedge resection.Methods: This study employed a cross-sectional design by reviewing secondary data of all pregnant women with PAS who underwent total hysterectomy or wedge resection at Hasan Sadikin General Hospital from January 2021 to December 2023. Statistical analysis for categorical data used the Chi-square test or Fisher’s exact test, and numerical data were analyzed using the unpaired T-test or Mann-Whitney test.Results: The sample consists of 116 patients. A total of 84 patients underwent total hysterectomy, and 32 patients underwent wedge resection. There was no significant difference in mean age between the two groups (p = 0.129). The results showed a significant difference between the two groups for birth weight (p = 0.007) and the incidence of urinary bladder injury (p = 0.018). No urinary bladder injury occurred in the wedge resection group, while 13 (15.50%) patients experienced urinary bladder injury in the total hysterectomy group.Conclusion: Total hysterectomy is associated with a higher incidence of urinary bladder injury compared to wedge resection.Cedera Vesika Urinaria pada Pasien dengan Spektrum Plasenta Akreta:Perbandingan antara Wedge Resection dan Total HisterektomiAbstrak Tujuan: Penelitian ini bertujuan untuk menilai angka kejadian cedera vesika urinaria antara wanita hamil dengan spektrum plasenta akreta (SPA) yang menjalani histerektomi totalis dan wedge resection.Metode: Metode yang digunakan dalam penelitian ini adalah metode potong lintang dengan meninjau data sekunder semua ibu hamil dengan SPA yang menjalani histerektomi totalis atau wedge resection di Rumah Sakit Umum Pusat Hasan Sadikin periode Januari 2021 - Desember 2023. Analisis statistik untuk data kategorik menggunakan uji Chi-square atau uji Fisher dan data numerik diuji menggunakan uji T-tidak berpasangan atau uji Mann-Whitney.Hasil: Sampel penelitian ini terdiri atas 116 pasien. Sebanyak 84 pasien menjalani histerektomi totalis dan 32 pasien menjalani wedge resection. Tidak ada perbedaan rata-rata usia yang bermakna antar kedua kelompok (p = 0,129). Hasil penelitian menunjukkan perbedaan yang signifikan antara kedua kelompok untuk berat badan lahir (p = 0,007) dan kejadian cedera vesika urinaria (p = 0,018). Tidak ada yang mengalami cedera vesika urinaria pada kelompok wedge resection, sedangkan 13 (15,50%) pasien mengalami cedera vesika urinaria pada kelompok histerektomi totalis.Kesimpulan: Histerektomi totalis berhubungan dengan tingkat kejadian cedera vesika urinaria yang lebih tinggi dibandingkan dengan wedge resection.
HALP and SII: Innovative Biomarkers for Diagnosing Ovarian Cancer in Both Epithelial and Non-Epithelial Subtypes Ridwan, Steven; Mantilidewi, Kemala Isnainiasih; A.W., Gatot Nyarumenteng; Kurniadi, Andi; Suardi, Dodi; Salima, Siti; Rauf, Syahrul; Hidayat, Yudi Mulyana
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.882

Abstract

Objective: To evaluate the diagnostic utility of PHAL (Platelet, Hemoglobin, Albumin, and Lymphocyte), SII (Systemic Immune Inflammation Index), and SIRI (Systemic Inflammatory Response Index) for both epithelial and non-epithelial ovarian cancer.Methods: A cross-sectional study of 156 patients with ovarian masses was conducted using preoperative laboratory data to calculate PHAL, SII, and SIRI scores. Histopathology confirmed diagnoses. Population I included all ovarian cancer types and benign tumors, while Population II included only non-epithelial ovarian cancer and benign tumors. Statistical analysis using SPSS 25.0, involved ROC curve and validity testing to assess diagnostic performance.Result: SII showed the best performance in the overall population (AUC 0.738; sensitivity 71.25%; specificity 72.37%; accuracy 71.79%; LR+ 2.58; LR– 0.40). In the subgroup of non-epithelial ovarian cancer versus benign tumors, PHAL had the highest diagnostic accuracy (AUC 0.819; sensitivity 81.81%; specificity 73.68%; accuracy 75.51%; LR+ 3.11; LR– 0.25).Conclusion: PHAL and SII are effective, accessible, and low-cost biomarkers that can support ovarian cancer diagnosis through routine blood tests.PHAL dan SII: Biomarker Inovatif untuk Diagnosis Kanker Ovarium Subtipe Epitel dan Non-Epitel Abstrak Tujuan: Penelitian ini bertujuan untuk mengevaluasi nilai diagnostik dari PHAL (Platelet, Haemoglobin, Albumin, dan Limfosit), SII (Systemic Immune Inflammation Index), dan SIRI (Systemic Inflammatory Response Index) pada kanker ovarium epitelial dan non-epitelial. Metode: Penelitian dengan metode potong lintang ini melibatkan 156 pasien dengan massa ovarium. Data laboratorium pra-operatif digunakan untuk menghitung skor PHAL, SII, dan SIRI. Diagnosis ditegakkan melalui pemeriksaan histopatologi. Populasi I mencakup semua jenis kanker ovarium dan tumor jinak, sedangkan Populasi II hanya mencakup kanker ovarium non-epitelial dan tumor jinak. Analisis statistik dilakukan menggunakan SPSS 25.0, termasuk analisis kurva ROC dan uji validitas untuk menilai kinerja diagnostik. Hasil: Hasil penelitian menyimpulkan bahwa SII memiliki performa terbaik pada seluruh populasi (AUC 0,738; sensitivitas 71,25%; spesifisitas 72,37%; akurasi 71,79%; LR+ 2,58; LR– 0,40). Pada subkelompok kanker ovarium non-epitelial dibandingkan dengan tumor jinak, PHAL menunjukkan akurasi diagnostik tertinggi (AUC 0,819; sensitivitas 81,81%; spesifisitas 73,68%; akurasi 75,51%; LR+ 3,11; LR– 0,25). Kesimpulan: PHAL dan SII merupakan biomarker yang efektif, mudah diakses, dan berbiaya rendah yang dapat mendukung diagnosis kanker ovarium melalui pemeriksaan darah rutin. Kata kunci: Kanker ovarium, Skor PHAL (Platelet-Hemoglobin-Albumin-Limfosit), Systemic Immune-Inflammation Index, Systemic Inflammatory Response Index
Comparison of Chondroitin Sulfate-E Expression in Benign and Malignant Epithelial Type Ovarian Tumors Mantilidewi, Kemala Isnainiasih; A.W., Gatot Nyarumenteng; Kurniadi, Andi; Suardi, Dodi; Harsono, Ali Budi; Salima, Siti; A, Aditiyono; Hapsari, Kartika; Yantisetiasti, Anglita
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.861

Abstract

Objective: Ovarian cancer is the fifth leading cause of cancer-related death in women, due to late diagnosis and limited screening methods. Chondroitin Sulfate-E (CS-E) has shown potential as biomarkers. This study aims to evaluate CS-E expression in epithelial-type benign and malignant ovarian tumors and its potential as a biomarker using QuPath software.Methods: This observational analytic study used a cross-sectional design. Samples were selected based on histopathology of patients with epithelial-type benign and malignant ovarian tumors from surgeries in 2023. Immunohistochemistry using the GD3G7 antibody was performed to detect CS-E expression in tumor tissues preserved in paraffin blocks at Dr. Hasan Sadikin General Hospital Bandung. Expression was quantified using QuPath software. Statistical analysis used the Mann-Whitney and t-test. Result: No significant difference in CS-E expression was found between malignant and benign tumors (p = 0.492). Demographic factors (age, BMI, menopausal status, and parity) showed no significant differences between groups. Conclusion: CS-E expression has not yet demonstrated potential as a biomarker to distinguish between benign and malignant ovarian tumors.Perbandingan Ekspresi Chondroitin Sulfate-E pada Tumor Ovarium Jinak dan Ganas Tipe Epitel Abstrak Tujuan: Kanker ovarium merupakan penyebab kematian kelima terbanyak terkait kanker pada wanita yang disebabkan oleh keterlambatan diagnosis dan keterbatasan metode skrining. Chondroitin Sulfate-E (CS-E) menunjukkan potensi sebagai biomarker. Penelitian ini bertujuan mengevaluasi ekspresi CS-E pada tumor ovarium jinak dan ganas tipe epitelial serta menilai potensinya sebagai biomarker menggunakan perangkat lunak QuPath. Metode: Penelitian analitik observasional ini menggunakan desain potong lintang. Sampel dipilih berdasarkan hasil histopatologi pasien dengan tumor ovarium jinak dan ganas tipe epitelial dari operasi tahun 2023. Pemeriksaan imunohistokimia dengan antibodi GD3G7 dilakukan untuk mendeteksi ekspresi CS-E pada jaringan tumor yang diawetkan dalam blok parafin di RSUP Dr. Hasan Sadikin Bandung. Ekspresi dianalisis secara kuantitatif menggunakan perangkat lunak QuPath. Uji statistik yang digunakan adalah Mann-Whitney dan uji t. Hasil: Tidak ditemukan perbedaan bermakna dalam ekspresi CS-E antara tumor ganas dan jinak (p = 0,492). Faktor demografis (usia, indeks massa tubuh, status menopause, dan paritas) juga tidak menunjukkan perbedaan bermakna antar kelompok.Kesimpulan: Ekspresi CS-E belum menunjukkan potensi sebagai biomarker untuk membedakan antara tumor ovarium jinak dan ganas. Kata kunci: Biomarker, GD3G7, Glikosaminoglikan, Kanker Ovarium, Kondroitin sulfat 
Multiple Congenital Anomalies with Breech Presentation: Dilemma in Diagnostic Procedures, Delivery Management, and Counseling in Developing Country Gusasih, Bahar Sangkur; Pramatirta, Akhmad Yogi; Aziz, Muhammad Alamsyah; Kurniadi, Andi
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 3 July 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i3.2380

Abstract

Objective: Multiple congenital anomalies present significant diagnostic and management dilemmas, particularly in resource-limited settings. Globally, these conditions affect approximately 1 in 33 infants and are a major contributor to perinatal mortality. We report a rare case of a term pregnancy with severe, undiagnosed multiple congenital anomalies, highlighting the challenges in diagnosis, delivery management, and counseling in a developing country.Case Illustration: A 22-year-old primigravida presented at 35-36 weeks of gestation in active labor with a fetus in breech presentation. Antenatal ultrasonography at 27 weeks had revealed a single live fetus with severe fetal growth restriction, polyhydramnios, and multiple structural anomalies suspicious for an underlying trisomy. Amniocentesis was offered for a definitive diagnosis but was declined by the family. A female neonate was delivered via spontaneous vaginal breech delivery, with low APGAR scores. The infant was admitted to the High Care Unit for respiratory support but passed away the following day due to respiratory failure. The family had opted for a Do Not Resuscitate (DNR) status.Conclusions: In cases of severe fetal anomalies detected by ultrasound, advanced genetic testing like NIPT followed by diagnostic testing should be offered to facilitate definitive diagnosis and counseling. Delivery decisions in such cases should be individualized, prioritizing maternal safety while considering the fetal prognosis. This case underscores the urgent need for improved access to and awareness of genetic counseling and diagnostic services in developing countries to optimize perinatal outcomes.Keywords: breech presentatoin, developing countries, genetic counceling, multiple congenital anomalies, prenatal diagnosis.
Neutrophil-lymphocyte Ration Difference in Squamous Cell Carcinoma and Adenocarcinoma of Cervical Cancer Sinaga, Rislefia Amadina; Aditiyono, Aditiyono; Kurniadi, Andi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.732

Abstract

Introduction: Cervical cancer is the most commonly found malignancy in female reproductive system. There are two most found types of this cancer based on histopathologic finding, adenocarcinoma and squamous cell carcinoma (SCC). Each type has different outcome, especially in later stages. Neutrophil-lymphocyte ratio (NLR) is an indicator that can pinpoint the inflammation severity level, hence able to predict outcome and prognosis in malignancy, including cervical cancer.Objective: This study aimed to determine the difference of NLR in both types of cervical cancer Methods: This study used retrospective analytic observational with cross-sectional design. Data was sampled from Prof. dr. Margono Soekarjo General Regional Hospital medical record from patients diagnosed with cervical cancer of both types during January to December 2022. Mann-Whitney test was performed to determine the difference of NLR value between both types of cervical cancer. Result: Between January and December 2022, 68 patients were diagnosed with cervical cancer. Of these, 37 (54.41%) had squamous cell carcinoma (SCC) and 31 (45.59%) had adenocarcinoma. The neutrophil-to-lymphocyte ratio (NLR) ranged from 1.55 to 25.99 in SCC patients, with a mean value of [insert mean value here]. For adenocarcinoma patients, the NLR ranged from 1.32 to 11.99. Conclusion: Neutrophil-lymphocyte ratio can’t differentiate squamous cell carcinoma and adenocarcinoma of cervival cancer.Perbedaan Rasio Neutrofil Limfosit pada Kanker Serviks Tipe Karsinoma Sel Skuamosa dan Tipe AdenokarsinomaAbstrakPendahuluan: Kanker serviks merupakan keganasan yang paling banyak ditemukan pada sistem reproduksi wanita. Berdasarkan temuan histopatologi, terdapat dua jenis kanker serviks yang paling banyak ditemukan, yaitu adenokarsinoma dan karsinoma sel skuamosa (SCC). Setiap jenis memiliki hasil yang berbeda, terutama pada tahap selanjutnya. Rasio neutrofil-limfosit (NLR) merupakan salah satu indikator yang dapat digunakan untuk mengetahui tingkat keparahan inflamasi sehingga dapat memprediksi outcome dan prognosis pada suatu keganasan, termasuk kanker serviks.Tujuan: Penelitian ini bertujuan untuk mengetahui perbedaan NLR pada kedua jenis kanker serviks Metode: Penelitian ini menggunakan metode observasional analitik retrospektif dengan desain cross-sectional. Data diambil dari rekam medis RSUD Prof. dr. Margono Soekarjo mengenai pasien yang terdiagnosis kanker serviks kedua jenis tersebut selama bulan Januari hingga Desember 2022. Uji Mann-Whitney dilakukan untuk mengetahui perbedaan nilai NLR antara kedua jenis kanker serviks tersebut. Hasil: Antara Januari dan Desember 2022, terdapat 68 pasien yang terdiagnosis kanker serviks. Dari jumlah tersebut, 37 (54,41%) menderita karsinoma sel skuamosa (SCC) dan 31 (45,59%) menderita adenokarsinoma. Rasio neutrofil terhadap limfosit (NLR) berkisar antara 1,55 hingga 25,99 pada pasien SCC, dengan nilai rata-rata [masukkan nilai rata-rata di sini]. Untuk pasien adenokarsinoma, NLR berkisar antara 1,32 hingga 11,99. Kesimpulan: Rasio neutrofil-limfosit tidak dapat membedakan karsinoma sel skuamosa dan adenokarsinoma kanker serviks.Kata kunci: Adenokarsinoma, Kanker Serviks, Rasio Neutrofil-Limfosit,
Wound Dehiscence Following Obstetrics and Gynecology Surgeries: An Observational Study at a Tertiary Hospital in Bandung Mantilidewi, Kemala Isnainiasih; Firdaus, Nur’adilah; Kurniadi, Andi; Erfiandi, Febia; Kireina, Jessica; Natasya, Windy; Harsono, Ali Budi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.658

Abstract

Introduction: Wound dehiscence is a severe postoperative complication that disrupts an abdominal wound closure which can be caused by endogenous or exogenous flora that infect a surgical wound. Many factors are responsible for surgical site infection in obstetric and gynecology patients considering all the basic standards are ideally maintained in tertiary care hospitals. To identify the characteristics of surgical wound dehiscence (SWD) patients who underwent obstetric and gynecological surgeries at Dr. Hasan Sadikin Hospital from 2021 to 2022.Methods: This study utilized a quantitative descriptive approach with a retrospective design. Results: A total of 43 subjects were included in the study and were divided into three groups based on their surgery type: obstetrics (n=11), gynecology (n=7), and gynecological oncology (n=25). The majority of SWD cases were associated with gynecological oncology surgeries. The patients were predominantly aged 18-65 years (88%), had superficial SWD (65%), normal BMI (37%), were non-smokers (67%), had a history of steroid medication usage (63%), received prophylactic antibiotics (63%), underwent elective surgery (58%), had laparotomy surgeries (100%), with a duration of ≥180 minutes (35%), and intraoperative bleeding of ≤1500 cc (63%). The surgical wounds were primarily classified as clean type (47%), and therapeutic antibiotics were administered to the majority of patients (74%).Conclusion: Most of our findings were consistent with existing theories. However, the discrepancies observed in some outcomes can serve as an evaluative tool to assess the adherence of current practices to established guidelines. It is crucial to consider the risk factors for SWD when developing preventive strategies.Dehisensi Luka Pascaoperasi Obstetri dan Ginekologi: Sebuah Studi Observasi di Rumah Sakit Tersier Di BandungAbstrakPendahuluan: Dehisensi luka pascaoperasi merupakan komplikasi serius yang dapat mengganggu penutupan luka di perut yang disebabkan oleh adanya flora bersumber secara endogen atau eksogen yang menginfeksi luka operasi. Banyak faktor yang berperan dalam infeksi daerah operasi walaupun sudah dilakukannya semua standar operasional yang selalu dipertahankan di rumah sakit perawatan tersier. Untuk mengetahui karakteristik pasien dehisensi luka pascaoperasi obstetri dan ginekologi di RSUP Dr. Hasan Sadikin.Metode: Penelitian ini merupakan penelitian deskriptif retrospektif yang menganalisis faktor praoperatif, intraoperatif, dan pascaoperatif dari subjek penelitian. Hasil: Pada studi ini, terdapat 43 subjek yang selanjutnya dikategorikan menjadi tiga kelompok berdasarkan jenis operasinya: obstetri (n=11), ginekologi (n=7), dan onkologi ginekologi (n=25). Sebagian besar kasus berhubungan dengan operasi onkologi ginekologi, berusia 18 - 65 tahun (88%), memiliki dehisensi luka superfisial (65%), indeks massa tubuh normal (37%), bukan perokok. (67%), memiliki riwayat penggunaan obat steroid (63%), menerima antibiotik profilaksis (63%), menjalani operasi elektif (58%), menjalani operasi melalui laparotomi (100%), dengan durasi ≥180 menit (35%), memiliki luka operasi tipe bersih (47%), mengalami perdarahan intraoperative ≤1500 cc (63%), dan mendapatkan antibiotik terapeutik (74%).Kesimpulan: Sebagian besar hasil studi didapatkan sesuai dengan teori yang telah ada. Kesenjangan yang ditemukan pada luaran studi dapat menjadi alat evaluasi untuk menilai ketaatan pada praktik yang dilakukan untuk kemudian dijadikan pedoman praktik. Penting juga untuk mempertimbangkan faktor risiko dari dehisensi luka pascaoperasi ketika akan mengembangkan strategi preventif.Kata kunci: dehisensi luka pasca operasi, faktor risiko, praoperasi, intraoperasi, pascaoperasi
Survival Outcomes at Three Years After Primary vs Interval Debulking in Advanced Ovarian Cancer: A Retrospective Study from Hasan Sadikin Hospital (2021) Everdien, Alce; Kurniadi, Andi; Pusianawati, Dini; Nisa, Aisyah Shofiatun; Subhan, Dadang Hawari
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.1003

Abstract

Objective: Ovarian cancer is the third most prevalent malignancy among women in Indonesia. The 5-year survival rate is approximately 49%, with 68% of patients diagnosed at an advanced stage. Standard treatment involves debulking surgery, which is categorized into primary debulking surgery (PDS) and interval debulking surgery (IDS). This study aims to compare the survival outcomes of ovarian cancer patients treated with PDS versus IDS at Dr. Hasan Sadikin General Hospital (RSHS) during 2021.Methods: A retrospective review of medical records was performed for ovarian cancer patients who underwent surgery at RSHS in 2021. Patients were classified according to the type of surgical management (PDS or IDS), and survival data were analyzed accordingly.Result: A total of 46 patients were included, with 38 undergoing PDS and 8 undergoing IDS. The mean overall survival was 34.1 months for the PDS group and 27.5 months for the IDS group. Bivariate analysis showed no significant difference in survival between the two groups (HR: 1.810, p = 0.341; 95% CI: 0.53–6.13). However, age (HR: 0.950, p = 0.014; 95% CI: 0.91–0.99) and progression-free survival duration (HR: 0.788, p = 0.0001; 95% CI: 0.71–0.86) were identified as significant prognostic factors for overall survival.Conclusion: The mean overall survival for patients undergoing primary debulking surgery (PDS) was higher than for those undergoing interval debulking surgery (IDS), although this difference was not statistically significant.Angka Kelangsungan Hidup Tiga Tahun Setelah Debulking Primer vs Interval pada Kanker Ovarium Stadium Lanjut: Sebuah Studi Retrospektif di RSUP Hasan Sadikin (2021)AbstrakTujuan: Kanker ovarium merupakan keganasan ketiga terbanyak pada wanita di Indonesia. Angka kelangsungan hidup 5 tahun sekira 49%, dengan 68% pasien datang pada stadium lanjut. Tatalaksana standar melibatkan operasi debulking yang diklasifikasikan menjadi operasi debulking primer (PDS) dan operasi debulking interval (IDS). Penelitian ini bertujuan untuk membandingkan hasil kelangsungan hidup pasien kanker ovarium yang diobati dengan PDS versus IDS di RSUP Dr. Hasan Sadikin (RSHS) selama tahun 2021.Metode: Sebuah studi retrospektif dilakukan melalui tinjauan rekam medis pasien kanker ovarium yang menjalani tatalaksana bedah di RSHS pada tahun 2021. Pasien dikategorikan berdasarkan jenis tatalaksana bedah (PDS atau IDS), dan data kelangsungan hidup dianalisis.Hasil: Sebanyak 46 subjek diikutsertakan, dengan 38 pasien menjalani PDS dan 8 pasien menjalani IDS. Rerata kelangsungan hidup keseluruhan adalah 34,1 bulan pada kelompok PDS dan 27,5 bulan pada kelompok IDS. Analisis bivariat tidak menunjukkan perbedaan signifikan dalam kelangsungan hidup antara kedua kelompok (HR: 1,810, p = 0,341; 95% CI: 0,53–6,13). Namun, usia (HR: 0,950, p = 0,014; 95% CI: 0,91–0,99) dan durasi kelangsungan hidup bebas progresi (HR: 0,788, p = 0,0001; 95% CI: 0,71–0,86) diidentifikasi sebagai faktor prognostik yang signifikan terhadap kelangsungan hidup keseluruhan.Kesimpulan: Rata-rata kelangsungan hidup keseluruhan pasien yang menjalani operasi debulking primer (PDS) lebih tinggi daripada rata-rata kelangsungan hidup keseluruhan pasien yang menjalani operasi debulking interval (IDS), meskipun tidak signifikan secara statistik.Kata kunci: Angka kelangsungan hidup; kanker ovarium; pembedahan debulking interval; pembedahan debulking primer
Co-Authors A, Aditiyono A.W., Gatot Nyarumenteng Adhi Pribadi Aditiyono, Aditiyono Akhmad Yogi Pramatirta, Akhmad Yogi Ali Budi Harsono Anglita Yantisetiasti Arieff Kustiandi Aviscena Fahmi Ali Aziz, Muhammad Alamsyah Balqis, Shalma Alaika Aurel Budi Handono Dini Pusianawati Dodi Suardi Erfiandi, Febia Euis Maryani Eunike Febe Febriani Everdien, Alce Firdaus, Fery Muhamad Firdaus, Nur’adilah Gatot N. A. Winarno Gatot N.A. Winarno GATOT N.A.W Gatot Nyarumenteng Adhipurnawan Winarno Gezy Wita Giwangkancana Gusasih, Bahar Sangkur Hanifah Nurisa Putri Harsono, Ali Budi HARSONO, ALI BUDI Herman Susanto Hermin Aminah Usman Herry Aktyar Matondang HERU PRAYITNO Heru Prayitno HIDAYAT, YUDI M Ismayadi, Tedi Jusuf Sulaeman Effendi Kartika Hapsari Kemala Isnainiasih Mantilidewi Kireina, Jessica Kusuma, Aria Yusti Muhamad Bagja Ramadhan N.A.W, GATOT Natasya, Windy Nisa, Aisyah Shofiatun R. M. Sonny Sasotya Salima, Siti Setyorini Irianti Sinaga, Rislefia Amadina Siti Salima Steven Ridwan, Steven Subhan, Dadang Hawari Syahrul Rauf Wibowo, Viko Duvadilan Wiryawan Permadi YUDI M HIDAYAT Yudi Mulyana Hidayat Yunita Susanto Putri