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All Journal Health Science Journal of Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Urology The Indonesian Biomedical Journal Padjadjaran Journal of Dentistry Molecular and Cellular Biomedical Sciences (MCBS) Smart Medical Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Indonesian Journal of Biomedicine and Clinical Sciences
Didik Setyo Heriyanto
Department Of Anatomical Pathology, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Smart Medical Journal

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Association of CXCR4 mRNA Expression with Clinicopathological Aspects of Invasive Breast Carcinoma Novan Adi Setyawan; Didik Setyo Heriyanto; Naomi Yoshuantari; Irianiwati Irianiwati
Smart Medical Journal Vol 4, No 1 (2021): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v4i1.46870

Abstract

ABSTRACT BackgroundBreast cancer is the most common malignancy in women of which majority histological type is Invasive (Ductal) Carcinoma of No Special Type (NST). The prognosis in breast carcinoma is influenced by many factors such as age, tumor size, degree of histology, and lymph node metastasis. Another factor in the development and metastasis of breast cancer is the chemokine receptor CXCR4 and its ligand, CXCL12. Studies state that the expression of CXCR4 in Breast Invasive Carcinoma associated with clinicopathologic aspects remain unclear. This study aims to determine differences in the level of CXCR4 mRNA expression between clinicopathologic aspects in breast carcinoma..MethodA total of 50 samples of formalin-fixed paraffin-embedded (FFPE) tissues diagnosed as invasive breast carcinoma (NST) are used in this study. Samples are divided into groups, namely with and without lymph node metastasis, age <45 years and> 45 years, small and large size, low grade and high grade. CXCR4 mRNA expression is quantitatively examined by qRT-PCR. CXCR4 mRNA expression differences between various clinicopathologic aspects were analyzed by One-Way ANOVAResultOf the 50 samples, 26 samples (52%) revealed increased expression of CXCR4 mRNA compared to normal tissue. There were no significant differences in mRNA expression of  CXCR4 between various prognostic factors (p> 0.05) such as the status of lymph node metastasis, histologic grading, size, and age. However, the expression of CXCR4 mRNA is increased in breast carcinoma when compared to normal breast tissue. Nonetheless the level of CXCR4 expression alone is not associated to clinicopathologic aspects in invasive breast carcinoma.ConclusionCXCR4 mRNA expression did not differ significantly between the various clinicopathological aspects of invasive breast carcinoma. Keyword: invasive breast carcinoma, mRNA of CXCR4, Clinicopathologic aspects 
Co-Authors . Suharno Adeodatus Yuda Handaya Aditya Rifqi Fauzi Agus Supartoto Ahmad Hamim Sadewa Ahmad Zulfan Ahmad Zulfan Ajeng Viska Icanervilia Alberta Vania Handoko Alfasunu, Serafim Alharsya Franklyn Ruckle Alva Sinung Anindita Andreas Pramudito Andrew Nobiantoro Gunawan Anwar, Sumadi Lukman Aria Danurdoro Auliya Suluk Brilliant Sumpono Azriel Farrel Kresna Aditya Bening Rahimi Titisari Brigitta Natasya Halim Bustanul Ardianto Camelia Herdini Danarto Danarto Danarto Danarto Danarto Danarto Datu Respatika Dhimas Hari Sakti Diah Rumekti Hadiati Dibyo Pramono Endang Soetristi Ery Kus Dwianingsih Ferronika, Paranita Frannata, Lucky Hanafi, Arif Riswahyudi Hendra Susanto Ida Ayu Setyawati Sri Krisna Dewi idha safitri Imelda, Priscillia Indra Tri Mahayana Indrawarman Soeroharjo Indrawati Indwiani Astuti Indwiani Astuti Indwiani Astuti Irianiwati Widodo Isadora Gracia, Isadora Jayusman, Achmad Mulawarman Joshua Andrew Junaedy Yunus Juwita Raditya Kamal Agung Yudayana Kevin Radinal Lina Choridah Mauny, Muhammad Puteh Melita Suwan Djaja Muhammad Bayu Sasongko Muhammad Javedh Iqbal Muhammad Puteh Mauny Muhammad Puteh Mauny Mustofa Mustofa Nanda Qoriansas Naomi Yoshuantari Neneng Ratnasari Novan Adi Setyawan Nur Arfian Nur Arfian Nur Signa Gumilas Nurlaila, Prima Sugesty Pawiroranu, Suhardjo Puji Lestari Rachma Greta Perdana Putri Rachma Greta Putri Raden Danarto Rengganis, Anggraeni Ayu Renovaldi, Dede Rita Cempaka Ryan Feraldy Haroen Sabirin, Rahmaningsih Mara Sagung Rai Indrasari Sakti Ronggowardhana Brodjonegoro Sangundo, Muhammad Faham Sari Eka Pratiwi Sasongko, Muhammad Bayu Setyo Purwono Siti Boedina Kresno Sofia Mubarika Haryana Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Sumoro, William Supartoto, Agus Supriatno Totok Utoro Vincent Laiman Vincent Lau Wahyu Tri Widayati Widhasari, Idhayu Anggit Yudi Susanto Yuliani, Fara Silvia