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All Journal Jurnal Farmasi Udayana Jurnal Kedokteran Brawijaya BIOTROPIA - The Southeast Asian Journal of Tropical Biology Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea Cendekia Journal of Pharmacy Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Sains dan Praktis Jurnal Farmasetis Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Borneo Journal of Pharmacy Indonesian Journal of Pharmacology and Therapy
Dita Maria Virginia
Sanata Dharma University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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THE EFFECT OF PHARMACIST INTERVENTION THROUGH TELEPHARMACY SERVICES ON COMPLIANCE AND FASTING BLOOD SUGAR LEVELS IN DIABETES MELLITUS TYPE 2 PATIENTS AT NATALIA FARMA PHARMACY Dharmawan, Nancy Natalia; Virginia, Dita Maria; Priyatni, Nunung
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.13120

Abstract

Diabetes Mellitus is a disease that cannot be cured; thus, it requires high compliance to control blood sugar levels and prevent complications. Telepharmacy can help improve Type 2 Diabetes Mellitus Patients (T2DM) compliance by providing information and education about the disease, medications, and how to use the medication appropriately. The purpose of this study is to analyze the level of compliance and the fasting blood sugar levels of T2DM patients after receiving telepharmacy services by pharmacists at Natalia Farma Pharmacy. This study uses a cohort design with a purposive sampling technique. The research population is the diabetic patients at Natalia Farma Pharmacy in Ende Regency, with a sample size of 60 subjects. In this study, there were two groups observed, namely the intervention and control groups. The intervention group received additional telepharmacy services through WhatsApp for 3 months, including education, drug therapy monitoring, and reminders to take medication. Patient compliance and blood sugar measurement were carried out before and after administering the intervention. The data obtained were then analyzed using SPSS with the t-test. The results showed that telepharmacy affected both patient compliance and fasting blood sugar level, with p-values of 0.002 and 0.009, respectively. Therefore, the existence of telepharmacy intervention can significantly enhance patient compliance and help to control fasting blood sugar levels in T2DM patients at Natalia Farma Ende Pharmacy
Association of glutathione S-transferase M1 (GSTM1) null genotype polymorphism with the effectiveness of metformin monotherapy in type 2 diabetes mellitus (T2DM) patients Ni Luh Made Noviana Dewi; Dwi Aris Agung Nugrahaningsih; Dita Maria Virginia
Indonesian Journal of Pharmacology and Therapy Vol 7 No 1 (2026)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.17812

Abstract

Genetic variations may contribute to the development of diabetes and influence individual susceptibility to the disease. One of the relevant genes is glutathione S-transferase M1 (GSTM1). Alterations in the expression of GST enzymes can lead to inefficient detoxification processes. Such genetic variations are believed to contribute to interindividual variability in metformin response, potentially affecting therapeutic outcomes. This study aimed to evaluate the effect of the GSTM1 null genotype on the effectiveness of metformin monotherapy in patients with type 2 diabetes mellitus (T2DM). This was an observational study with a case–control design. The case group consisted of T2DM patients who failed to achieve the target HbA1c level. Detection of the GSTM1 null genotype was performed using polymerase chain reaction (PCR). The association between GSTM1 genotype and the effectiveness of metformin was analyzed using the Chi-square test. Disease risk associated with the genetic polymorphism was assessed by calculating the odds ratio (OR) and 95% confidence interval (CI). There was no significant association between GSTM1 genotype groups and the effectiveness of metformin monotherapy (OR = 0.487; p = 0.318). In conclusion, the GSTM1 null genotype does not significantly influence the therapeutic effectiveness of metformin monotherapy in patients with T2DM.
The Analysis of Medicine-taking Compliance Towards Therapy Outcome in Hypertension Patients at Community Health Centers in Yogyakarta Municipality Fortinasari, Rimanita; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008656

Abstract

Compliance to medication has a significant role in regulating the blood pressure and the risk for Atherosclerosis Vascular Disease (ASCVD) in Diabetes Mellitus Type 2 (DMT2) patients with hypertension as comorbidity. This study (n=523) aimed to analyzed this relationship at community health centers Yogyakarta municipality. We conducted an observational study with a cross-sectional design to analyze the medical record data collected during January-December 2023 among patients categorized under the inclusion criteria. Compliance was measured using the Medication Possession Ratio (MPR) then descriptively and correlatively with Chi-square analyses. No significant relationship is showed between the compliance of antihypertensive therapy to blood pressure (p=0.8670.05) and ASCVD risk (p=0.0800.05; OR=0.662; 95%CI:0.416-1.052). Age (p=0.001), gender (p=0.001) and BMI (p=0.0014) had a highly significant relationship with ASCVD risk, but only BMI (p=0.0070.005; OR 1.812) showed significant relationship with controlled blood pressure. The research findings reveal that compliance to antihypertensive therapy does not have a significant relationship with blood pressure control or ASCVD risk in patients with DMT2 and hypertension as comorbidities in Yogyakarta municipality. Highlighting the need for further investigation, it is vital to include other factors into blood pressure management.
Co-Authors Agustina Setiawati Albertus I. Brilian Aris Widayati Aris Widayati Ariyanti, Ni Kadek Nining Arwinda, Prili Asri, Ni Komang Intan Prima Brilian, Albertus I. Christianus Heru Setiawan Christine Patramurti Co’o, Maria Dolorosa Dewita, Aquina Nino Rama Dhanti Dharmawan, Nancy Natalia Dina Christin Ayuning Putri Distya Pratiwi, Luh Anggi Djaswadi Dasuki Djunaedi, Jeniffer Kalyana Paramita Dwi Aris Agung Nugrahaningsih Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty, Fenty Florentinus Dika Octa Riswanto fortinasari, rimanita Gollumawo, Serly Sofia D. Gregorius Bhaskara Wikanendra Gregorius Bhaskara Wikanendra Gregorius Bhaskara Wikanendra Handika Immanuel Jago Uko, Maria Anjeline Jannah, Widyatul Leonardo Susanto Utomo Linawati Yunita Lisa Kurnia Sari, Lisa Kurnia Ni Luh Made Noviana Dewi Nur, Lisa Febriana Pero, Veronika Giuliany Phebe Hendra Phebe Hendra Phebe Hendra Phebe Hendra, Phebe Pinaryanto, Kartono Pramono, Zita Dhirani Pratiwi, Vera Dwi Priyatni, Nunung Putu Dyana Christasani Rita Suhadi Rohmahtika, Amanda Roni Permana Saputra Sari, Theresia Maria Fioretty Ine Sri Hartati Yuliani Sugiastana, Bagus N. Travita, Anggi Silva Tunjung Wibowo Wakitha, Stephanus Satria Wira Wiracana, I Made Yunita Linawati