Article Per Year (5 Year)
p-Index From 2020 - 2025
1.733
P-Index
This Author published in this journals
All Journal JURNAL GIZI INDONESIA Journal of Nutrition College Cosmogov: Jurnal Ilmu Pemerintahan The Indonesian Biomedical Journal Universa Medicina SOEPRA Jurnal Hukum Kesehatan Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Telenursing (JOTING) Diponegoro International Medical Journal (DIMJ)
Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 13 Documents
Search

 1   2 
Prothrombine and activated partial thromboplastin time are prolonged in hepatic cirrhosis Limijadi, Edward Kurnia Setiawan; Suromo, Lisyani Budi; Budiwiyono, Imam
Universa Medicina Vol 35, No 1 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.26-32

Abstract

BackgroundChronic hepatitis and hepatic cirrhosis are chronic liver diseases that cause disorders of liver function, such as the formation of platelets and coagulation factors (prothrombin time/PT and activated partial thromboplastin time/APTT). Chronic hepatitis in the long term can develop into hepatic cirrhosis. The aim of this study was to determine platelet count, PT, and APTT as indicators in the progression of chronic hepatitis towards hepatic cirrhosis. MethodsA cross-sectional study was conducted on 50 patients with chronic hepatitis and hepatic cirrhosis in Semarang City Regional General Hospital, Telogorejo Hospital and Kariadi General Hospital. The platelet count was measured with a Sysmex XP-100, while PT and APTT was measured with a Sysmex CA-1500 coagulometer. The Mann Whitney test was applied to analyze the difference in platelet count, PT, and APTT between chronic hepatitis and hepatic cirrhosis. Results Median, minimum, and maximum values of platelet count, PT and APTT in chronic hepatitis were 284.000/µl, 210.000/µl, 390.000/µl; 10.6 sec, 9.5 sec, 13.6 sec; and 30.5 sec, 24.2 sec, 46.4 sec, respectively, and in hepatic cirrhosis they were 96.300/µl, 48.200/µl, 133.800/µl; 27.5 sec, 11.9 sec, 44.7 sec; and 55.6 sec, 31.3 sec, 72.0 sec, respectively. There was a significant difference the reduction of platelet count, and the prolongation of PT and APTT in chronic hepatitis compared to hepatic cirrhosis (p=0.000). ConclusionsProthrombine time and APTT were prolonged and platelet count was decreased in hepatic cirrhosis subjects. The three parameters may be used to evaluate the progression of chronic hepatitis towards hepatic cirrhosis.
Correlation between HbA1c level and monocyte percentage in obesity Limijadi, Edward Kurnia Setiawan; Hendrianingtyas, Meita
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.001 KB) | DOI: 10.14710/jgi.8.1.75-78

Abstract

Background : HbA1c is one of the parameters that can be useful for diagnosing diabetes mellitus that can occur in obesity. Monocyte as an inflammatory cell is widely studied in relation to diabetes mellitus and obesity. The purpose of this study is to analyze the correlation between HbA1c levels and monocyte percentage in obesity.Methods : A Cross-sectional study of 30 medical students at a private laboratory in Semarang on March – April 2017 was done. The monocyte percentage included incomplete blood count was examined with the Sysmex XS-800i hematology analyzer, while HbA1c level was examined with Hemocue HbA1c 501 System. Spearman test was done for analyzing data with p <0.05 was considered statistically significant. Result and discussion : Median of HbA1c level was 5.8 ± 0.23%. Medians of leukocyte count, lymphocyte percentage, neutrophil percentage, and monocyte percentage were 8,600 ± 339,77 /μl, lymphocyte percentage 33% ± 1.19%, neutrophil percentage 56% ± 1.35%, and monocyte percentage of 9.0% ± 0.26%, respectively. Spearman test showed that correlation value (r) was 0.131 (p = 0.489).Conclusion and suggestion : There was no correlation between HbA1c levels and monocyte percentage in obesity. The increased of monocyte percentage can be used as monitoring and evaluation parameters in obesity that can lead to diabetes mellitus. Further study can be done in an obese population with older age as well as other parameters related to obesity and diabetes mellitus.
HUBUNGAN HbA1c DENGAN CRP PADA PENDERITA DIABETES MELITUS TIPE-2 DENGAN OBESITAS DAN TANPA OBESITAS Permatasari, Narulita Dyah; Rachmawati, Banundari; Riansari, Anugrah; Limijadi, Edward Kurnia Setiawan
Journal of Nutrition College Vol 9, No 4 (2020): Oktober
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v9i4.29011

Abstract

Latar belakang: Diabetes melitus merupakan penyakit inflamasi kronis yang ditandai dengan peningkatan kadar glukosa plasma. Kadar glukosa plasma yang tinggi dalam jangka waktu lama (hiperglikemia kronik), menstimulasi peningkatan kadar C-reactive protein (CRP). Penderita DMT2 dengan obesitas kemungkinan memiliki kadar CRP yang lebih tinggi karena penumpukan sel adiposa juga dapat memicu reaksi inflamasi di dalam tubuh. Mengetahui hubungan antara obesitas, DMT2, dan kadar CRP sangat diperlukan untuk tujuan klinis serta mencegah terjadinya komplikasi penyakit.Tujuan: Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara kadar HbA1c dan CRP pada penderita diabetes melitus tipe 2 dengan obesitas dan tanpa obesitasMetode: Penelitian observasional analitik dengan pendekatan belah lintang dilakukan di Rumah Sakit Nasional Diponegoro dan beberapa klinik pratama di Semarang pada Mei-Juli 2020. Subjek penelitian adalah 30 penderita diabetes melitus tipe 2 dengan obesitas dan 30 penderita diabetes melitus tipe 2 tanpa obesitas usia 35-60 tahun Pengukuran kadar HbA1c dan CRP dilakukan menggunakan alat ichroma metode fluorescence immunoassay (FIA). Analisis statistik untuk menguji normalitas data menggunakan Shapiro wilk test, Independent t test dilakukan untuk mengetahui perbedaan rerata karakteristik antara kelompok obesitas dan non-obesitas, dan Spearman Rank digunakan untuk melihat korelasi antara HbA1c dengan kadar CRP.Hasil:  Tidak ada korelasi antara kadar HbA1c dengan CRP pada penderita diabetes melitus tipe 2 dengan obesitas p = 0.420, r = 0,153 dan tanpa obesitas yaitu p= 0,182, r = 0,250.Simpulan: Kadar CRP yang terjadi pada pasien diabetes mellitus tipe 2 dimana inflamasi berjalan kronis tidak dipengaruhi oleh tingginya HbA1c baik pada kondisi obesitas maupun tidak obesitas.
Potensi Susu Fermentasi dalam Mempengaruhi Parameter Furkaniaty, Annisa; Anjani, Gemala; Limijadi, Edward Kurnia Setiawan; Legowo, Anang Mohamad; Syauqy, Ahmad
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.8372

Abstract

This study aims to explain the effect of milk on hematological parameters. The method used is a literature review made through a systematic approach, using the PICO method, by searching for articles in the Pubmed, Scopus, and EBSCOhost databases. The research results showed that 425 articles were found, and seven articles met the inclusion criteria; these articles were fermented milk containing lactic acid bacteria, which are probiotics. Fermented milk products such as yogurt, Yakult, kefir, active, fermented goat's milk, and dahi influence hematological parameters. Namely, they can increase hemoglobin, ferritin, and erythrocyte count and reduce MCV. Milk fermentation affects hematological parameters, namely increasing hemoglobin, ferritin, and erythrocyte count and reducing MCV. Keywords: Anemia, Probiotics, Fe Absorption, Fermented Milk, Iron Status
Perbedaan Jumlah Trombosit, Leukosit Dan Eritrosit Dengan Kecepatan Sentrifugasi Yang Berbeda Pada Pembuatan Platelet Rich Plasma Fajaryani, Dwi; Rahayu, Muji; Limijadi, Edward Kurnia Setiawan
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.957 KB) | DOI: 10.36408/mhjcm.v7i1.421

Abstract

Latar belakang : Platelet Rich Plasma (PRP) adalah plasma dalam jumlah sedikit dengan jumlah trombosit banyak, didapatkan melalui sentrifugasi. Trombosit dalam PRP penting untuk penyembuhan luka dan memperbaiki jaringan rusak. Kecepatan sentrifugasi berperan penting dalam memisahkan sel darah merah dengan plasma dan menghasilkan platelet konsentrat. Penelitian ini bertujuan untuk mengetahui perbedaan jumlah trombosit, leukosit dan eritrosit dengan kecepatan sentrifugasi yang berbeda pada pembuatan platelet rich plasma. Metode: Penelitian belah lintang pada orang sehat di laboratorium RSUP Dr. Kariadi Semarang bulan Juli 2018. Darah vena ditampung dalam tabung sitras dan Ethylenediaminetetraacetic acid (EDTA). Darah EDTA untuk pemeriksaan hematologi rutin dengan hematology analyzer, hasil normal dilanjutkan pembuatan PRP dari darah sitras 3,2 % dengan dua metode sentrifugasi, dengan kecepatan 100xg-400x selama 10 menit (metode PRP1) dan kecepatan 540xg-2270xg selama 10 menit (metode PRP2). Kedua produk PRP dilakukan pemeriksaan jumlah trombosit, leukosit dan eritrosit. Data dianalisis dengan uji Kruskall Wallis dan Mann Whitney, signifikan bila p< 0.05. Hasil : Sampel terdiri dari 35 orang responden. Terdapat perbedaan bermakna jumlah trombosit, leukosit dan eritrosit pada pembuatan PRP-1 dan PRP-2 (p<0.001) Simpulan : Terdapat perbedaan jumlah trombosit, leukosit dan eritrosit pada kecepatan sentrifugasi yang berbeda. Kecepatan sentrifugasi pada metode pembuatan PRP disarankan dalam pembuatan PRP. Kata kunci : PRP, trombosit, leukosit, eritrosit Background : Platelet Rich Plasma (PRP) consisting of small amounts plasma with many platelet, which was obtained by centrifugation process. The platelet in PRP are essential for wound healing and repair of damaged tissue. The centrifugation velocity plays an important role in separating red blood cells by plasma and producing concentrated-platelets. This study aims to determine differences the number of platelets, leukocytes and erythrocytes with different centrifugation rates on platelet rich plasma production. Methods: This cross sectional study was conducted on 35 healthy people in the laboratory of Kariadi Hospital Semarang in July 2018. The blood vein were collected in Citrate 3.2 % and Ethylenediaminetetraacetic acid (EDTA) tubes. Sample EDTA for complete blood counts, if the results were normal then continued with PRP preparation in 2 different methods centrifugation (PRP 1 at 100xg-400xg for 10 minutes and PRP 2 at 540xg-2270 xg for 10 minutes). Both of the PRP products were calculated the amounts of platelet, leukocytes, and erythrocytes. The data were analyzed by Kruskall Wallis and Mann Whitney, p < 0.05 was considered as significant. Results : There was a significant difference between PRP-1 and PRP-2 method in platelet counts, leukocytes count and erythrocytes count (p<0.001). Conclusion : There was differences in platelet count, leukocytes count and erythrocytes count with different centrifugation rate. Centrigugation rate on PRP-1 method is recommended in the production of PRP. Keyword PRP, platelets, leukocytes, erythrocytes
The Association between Obstructive Sleep Apnea and Glycated Haemoglobin A1c (Hba1c) Level in Diabetes Mellitus Type II Patient Dewi, Anna Mailasari Kusuma; Handayani, Peny; Rachma, Devi Elvina; Limijadi, Edward Kurnia Setiawan
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15191

Abstract

Abstract Background: Obstructive sleep apnea (OSA) is a chronic condition characterized by repetitive episodes of upper airway collapse, apnea, and arousal during sleep. OSA and type 2 diabetes mellitus (T2DM) are common comorbid conditions. Haemoglobin A1c (HbA1c) is an approximation of an individual’s average blood glucose level for the prior two to three months, and therefore is considered to be a major index for monitoring glycaemic control in diabetic patientsObjective: This study aimed to examine the association between OSA and HbA1c levels in T2DM patients.Methods: This was a cross-sectional study. The study assesses the association between OSA and HbA1c levels in 75 T2DM patients. OSA in the patient was asses with Epworth Sleepiness Scale (ESS) questionnaire. HbA1c values were obtained from the patient’s records. Data presented in mean ± SD, max, and min. Correlations analyses using Pearson correlation coefficient with p < 0.05 were considered statistically significant.Results: A total of 75 T2DM has a mean BMI were 25.26 ± 48.31 kg/m2 with mean HbA1c levels of about 7.1 ± 0.19%. The mean ESS score was 5 ± 0.429. The very weak correlation between OSA and BMI was statistically significant, r = 0.213; p = 0.047. Meanwhile, a very weak correlation between OSA and HbA1c levels was not statistically significant, r = 0.137; p = 0.242Conclusion: Among adults with T2DM, the correlation between OSA with HbA1c was not statistically significant
Diagnosing Urinary Tract Infection: Bacterial Count and Gram Identification Using Flow Cytometry Hayati, Mardiyah; Darmawati, Sri; Santosa, Budi; Lestari, Anak Agung Wiradewi; Limijadi, Edward Kurnia Setiawan; Felim, Jethro
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2309

Abstract

Urine culture is still the gold standard for Urinary Tract Infection (UTI) diagnostics, but it takes a long time and expensive. The flow cytometry is a more practical, fast, and reliable test for diagnosing UTI. The study was conducted to determine the validity of the bacterial count with UF 5000 flow cytometry compared to urine culture and to evaluate the coherence between Gram identification (BACT-INFO) results and the manual Gram stain.  This was a cross-sectional study aimed to determine the sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) of bacterial count compared to urine culture and to evaluate the coherence between BACT-INFO results with manual Gram stain. Urine from 60 patients diagnosed with suspected UTI was assessed for the ability to diagnose UTI using bacterial count from UF 5000 flow cytometry compared to urine culture and to determine the correlation between BACT-INFO with manual Gram staining results. This study was conducted from January to April 2022. Statistical analysis using the ROC curve showed that the Area Under the Curve (AUC) of the urine bacterial count was 0.856 and by setting a cut-off of 961.8/µL, the sensitivity was 84.0%, specificity 88.9%, PPV 97.7%, NPV 50.0%. The concordance of BACT-INFO compared to manual Gram staining is moderate (obtained from Cohen's Kappa coefficient value 0.3269) with a p-value of 0.0000. The most common bacterial species include Escherichia coli (40.67%), Klebsiella pneumoniae ss pneumoniae (20.33%), Proteus mirabilis (10.17%), Pseudomonas aeruginosa (8.47%), and Acinetobacter baumannii (6.78%). Urine bacterial count based on the flow cytometry method with a cut-off of 961.8/µL has sensitivity and specificity > 80% in diagnosing UTI. There is moderate concordance between BACT-INFO and manual Gram staining. The most common bacteria as the cause of UTI include Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Acinetobacter baumannii.
The Difference between Coagulation Profile and Fibrinolysis in Acute and Chronic Leukemia Patients Limijadi, Edward Kurnia Setiawan; Devi, Wivina Riza; Tjitradinata, Cynthia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2331

Abstract

The incidence of acute and chronic leukemia has been increasing for years resulting in many complications, one of them being hypercoagulability. Evaluation can be conducted using coagulation testing, including PT, aPTT, and fibrinogen levels, as well as fibrinolysis assays, such as D-dimer levels. Studies about these parameters between acute and chronic leukemia in the first diagnosis of leukemia need to be evaluated. This study aimed to evaluate the difference in coagulation and fibrinolysis profiles between acute and chronic leukemia. This study was a cross-sectional observational analysis of 34 acute and chronic leukemia patients in Ulin Government Hospital, Banjarmasin from October 2019 to February 2020. PT, aPTT, fibrinogen level, and D-dimer were analyzed on COA Lab 1000. Independent T-test and Mann-Whitney test were used to analyze data. The test results of PT, aPTT, fibrinogen, and D-dimer levels, for acute and chronic leukemia, were 13.96±1.86 vs. 16.73±4.74 seconds (p=0.029); 39.63±2.43 vs. 45.87±13.98 seconds (p=0.154); 286,18±180,58 vs. 328,81±150,63 mg/dL (p=0.459); and 746±3.392 vs. 1,466.56±445,86 µg/L (p=0.731), respectively. Significant differences were found in Prothrombin Time (PT) between acute and chronic leukemia patients, while no notable distinctions were observed in activated Partial Thromboplastin Time (aPTT), fibrinogen levels, or D-dimer levels.
Calcium and CA 15-3 Level in Breast Cancer Patients Pre- and Post-Mastectomy Surgery Kirom, Umi Aminotul; Santosa, Budi; Limijadi, Edward Kurnia Setiawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2343

Abstract

Breast cancer has a potentially affect the calcium levels because of its role in regulating cell proliferation, differentiation, migration, invasion, metabolism, and apoptosis. Analysis related to changes in calcium levels in breast cancer patients can contribute to developing patient treatment plans. CA 15-3 is a protein made primarily by breast cancer cells and is an epitope of the transmembrane glycoprotein (MUC1). High concentrations of calcium and CA 15-3 levels are associated with tumor burden and prognostic factors for breast cancer. This study aims to prove that there are differences in the results of an examination of calcium levels and CA 15-3 in breast cancer patients before and after mastectomy surgery. In this study, 50 female patients who were diagnosed with stage I, II, and III breast cancer had their serum CA 15-3 levels and calcium levels checked before and 10 days after surgery. The research analysis used for this difference test is the paired T-test and the Wilcoxon test. In this study, it was found that CA 15-3 levels decreased after breast surgery. Mean calcium levels before surgery were (10.092+1.2762 mg/dL). Mean calcium levels after surgery were (8.489+1.0204 mg/dL). CA 15-3 levels before surgery were 26.895+18.4914 UI/mL and after surgery were 21.678+11.9711 UI/mL. It can be concluded that there was a decrease in calcium levels of 1.603 mg/dL, and CA 15-3 levels decreased by 5.217 UI/mL between before and after mastectomy surgery.
THE ROLE OF PUBLIC POLICY IN MITIGATING CORRUPTION: A COMPARATIVE ANALYSIS OF ANTI-CORRUPTION STRATEGIES IN ASIAN DEMOCRACIES Z. A., Safrizal; Sari, Avid Leonardo; Limijadi, Edward Kurnia Setiawan; Saliman, Abdul Rasyid; Taufiqurrachman, Taufiqurrachman
CosmoGov: Jurnal Ilmu Pemerintahan Vol 11, No 1 (2025)
Publisher : Department of Government, FISIP, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cosmogov.v11i1.60532

Abstract

Corruption is one of the major challenges faced by democracies in Asia, threatening government transparency and accountability. Effective public policies are essential to prevent corrupt practices and strengthen institutional integrity. Various anti-corruption strategies have been implemented, but their effectiveness varies depending on the political, social, and economic contexts of each country. This study aims to analyze the role of public policy in mitigating corruption in democracies in Asia through a qualitative approach. The research method involves collecting data from various relevant sources and comparative analysis of the strategies implemented. The results show that countries with strong legal systems and independent institutions are more successful in tackling corruption. In addition, civil society and media participation also contribute significantly to the effectiveness of anti-corruption policies. On the other hand, developing democracies face various challenges, including elite political influence and resource constraints, which hinder the implementation of anti-corruption policies. Comprehensive reforms are needed to create a more supportive environment for eradicating corruption.
Co-Authors Ahmad Syauqy Anak Agung Wiradewi Lestari Anang M Legowo Anjani, Gemala Ariosta Ariosta Banundari Rachmawati Budi Santosa Budi Santosa Devi, Wivina Riza Dewi, Anna Mailasari Kusuma Endang Wahyati Yustina, Endang Wahyati Fajaryani, Dwi Felim, Jethro Furkaniaty, Annisa Handayani, Peny Imam Budiwiyono, Imam Kirom, Umi Aminotul Leonardo Sari, Avid Lisyani Budi Suromo, Lisyani Budi Mardiyah Hayati Massa, Jaya Meita Hendrianingtyas Muji Rahayu Nyoman Suci Widyastiti Permatasari, Narulita Dyah Rachma, Devi Elvina Retnoningrum, Dwi Riansari, Anugrah Saliman Saliman Sri Darmawati Taufiqurrachman Tjitradinata, Cynthia Widodo, Sabar Yetty Movieta Nency, Yetty Movieta Z. A., Safrizal