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Efek Iritasi Sabun Mandi Batang Mengandung Susu Produk Usaha Kecil Menengah di Kota Cimahi Vikasari, Suci Nar; Hermanto, Faizal; Simatupang, Elivas; Sutjiatmo, Afifah Bambang; Sutarna, Titta Hartyana; Puspadewi, Ririn; Rachmawan, Lucky; Haq, Fahmy Ahsanul
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2592

Abstract

One of the ways to increase profit in small and medium business (UKM) in Cimahi is by diversifying its products, through manufacturing of bar soap derived from cow's milk from UKM. The requirement of bath soap is proper acidity (pH) level, otherwise it will make the skin dry, itchy or even increase irritation. Therefore, this in vivo non-clinical irritation evaluation is conducted to evaluate the effects of bar soap produced by UKM in Cimahi according to the guidelines in rat test animals. The animals is divided into five groups and exposed to soap for four hours. Five soap samples is obtained from UKM in Cipageran area, Cimahi. Observations is made at the hours of 1, 4, 24, 48, and 72 hours after exposure and is continued for 14 days. The measured parameters is erythema and edema, and the primary irritation index. The results showed that bar soap containing cow milk produced by UKM in Cimahi did not cause erythema and edema. Primary irritation index of all bath soap samples was 0.0 . It can be concluded that soap bars containing cow's milk produced by Cimahi City UKM including into the category of very mild irritation (negligigle).
Aktivitas Antibakteri Minyak Biji Anggur terhadap Staphylococcus epidermidis dalam Sediaan Krim Puspadewi, Ririn; Anggreani, Wulan; Faradilla, Agny Vardha
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Grape seeds contain 75% unsaturated fats namely linoleic acid and vitamin E which contributes to its resistance to oxidation and is often chosen for use in the cosmetic, culinary, pharmaceutical, and health fields. The purpose of this study is to determine the activity of grape seed oil (Vitis vinifera L.) in inhibiting the growth of Staphylococcus epidermidis bacteria in cream preparations. The research was carried out through several stages, namely organoleptic examination of grape seed oil, making grape seed oil cream formula and its evaluation, testing antibacterial activity by disc diffusion method. Anti-acne cream preparations containing grape seed oil are made in 4 formulas, namely F0 (without grape seed oil), F1 (24%), F2 (30%), F3 (36%). All formulations during storage do not change shape, smell, and colour and homogeneity whereas pH and viscosity change during storage. The formulation of grape seed oil cream forms a stable cream from the results of freeze and thaw, showing no changes in globule size with globules <50μm. Based on the results of the antibacterial activity test, the best formula is F3, its provides the greatest inhibition against the growth of Staphylococcus epidermidis bacteria. Grape seed oil in cream preparations can inhibit the growth of Staphylococcus epidermidis.