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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Folia Medica Indonesiana Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Ilmiah Kedokteran Wijaya Kusuma Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kesehatan Islam : Islamic Health Journal Indonesian Journal of Anesthesiology and Reanimation (IJAR) Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology International Islamic Medical Journal Idarotuna : Jurnal of Administrative Science Jurnal Widya Medika

Achmad Basori, Achmad

3Departement Pharmacology, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Author-ID : 627752

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Molecular Toxicology of Organophosphate Poisoning Fery Setiawan; Arif Rahman Nurdianto; Heribertus Agustinus B Tena; Ahmad Yudianto; Jenny Sunariani; Achmad Basori; Acrivida Mega Charisma
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v11i1.1596

The use of organophosphates (pesticides and other compounds to eradicate pests), currently, to increase the fulfillment of the population's consumption needs has a double-edged sword effect, on the one hand it can increase the need for food to be consumed by the population. The negative effect that can arise is the safety of organophosphate drugs which can contaminate the soil and water sources around the place where organophosphate drugs are used. The negative effects of organophosphates are associated with the effects of xenobiotics on humans who consume them. Xenobiotics are associated with toxicdynamic effects where organophosphates cause irreversible inhibition of the enzyme acetylcholinesterase (ACh). ACh is one of the main enzymes in the nervous system that terminates impulse conduction through the hydrolysis process of acetylcholine enzymes. Acetylcholinesterase is a specific molecular target of organophosphate pesticides. The inhibition of the Ach enzyme causes the inhibition of the acetylcholine enzyme which is normally always hydrolyzed by the Ach enzyme and is a specific biological marker of pesticide poisoning. Inhibition of ACh will cause the accumulation of the enzyme acetylcholine, resulting in negative effects of organophosphate poisoning which can lead to death. In this paper, the authors collect from various sources related to the study of molecular toxicology toxidynamic effects of drug safety and organophosphate poisoning. The results of this review article show that organophosphate poisoning is associated with irreversible inhibition of the acetylcholinesterase enzyme which results in death in the individual concerned.

Antibacterial Effect of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 ON Klebsiella pneumoniae Producting Extended-Spectrum β-Lactamase (ESBL) Setiawati, Yuani; Retnowati, Wiwin; Basori, Achmad
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1326

Klebsiella pneumoniae as an opportunistic pathogen can cause nosocomial infection. The main concern on this bacterium is directed on the extended-spectrum β-Lactamase (ESBL)-producing Klebsiella pneumoniae. The therapy of ESBL-producing Klebsiella pneumoniae infections is very limited because of its multidrug resistance. It had been found new local isolates Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 in mangrove East Coast of Surabaya. These isolates have potential to produce antibiotics (Retnowati, 2008). This study was aimed to prove these isolates may inhibit the growth of ESBL-producing Klebsiella pneumonia. The test of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 using the modification Agar print method against clinical isolates of ESBL-producing Klebsiella pneumoniae. The diameter of inhibition zone (mm) formed shows activity of these isolates. The profiles of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 were different in terms of periode required to reach peak activity, duration of activity and inhibition zone diameter produced during 10 days of observation. Streptomyces sp-MWS3 reached the peak activity most rapidly on day 3 with the largest inhibition zone diameter of 9 mm in ESBL-producing Klebsiella pneumoniae. There were significant differences in inhibition zone diameter between Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 against ESBL-producing Klebsiella pneumoniae.

Correlation between the Bacteriostatic and Bactericide Effect with Antibiofilm and Anticolony Spreading from Javanese Citronella Oil on Methicillin-Resistant Staphylococcus aureus (MRSA) Hidayah, Amaliyah Nurul; Wasito, Eddy Bagus; Debora, Kartuti; Basori, Achmad; Isnaeni, Isnaeni; Utomo, Budi
Folia Medica Indonesiana Vol. 55 No. 1 (2019): March
Publisher : Universitas Airlangga

Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium that has been resistant to various types of antibiotics, so it is not easy to be treated with antibiotics and needs other solutions. Javanese citronella oil distilled from the Cymbopogon nardus plant is proven to function as an antibacterial agent (bacteriostatic and bactericidal), fungicide and repellent. This study aimed to prove that there is a positive correlation between bacteriostatic and bactericidal effects with antibiofilm and anticolony spreading from Javanese citronella oil on MRSA. The intended antibiofilm is a barrier to biofilm formation and eradication. Bacteriostatic and antibiofilm effects were tested using microtiter plates assay, bactericidal effect test with subculture into the media and anticolony spreading effect test with spot inoculation in Tryptic Soy Broth media supplemented with 0.24% agar. The bacteriostatic effect test data were analyzed using paired t-test, bactericidal effect using the Friedman test, antibiofilm effect test using Kruskall-Wallis and the results of all the tests correlated using Pearson and Spearman correlation. The statistical significance used was p<0.05. The results showed that Javanese citronella oil had a bacteriostatic concentration of 0.02% (v/v) and bactericidal concentration of 0.78% (v/v). The Pearson correlation test showed that there was a negative correlation between bacteriostatic and bactericidal effects on biofilm formation with r = -0.956 (p = 0.000), but the correlation was positive for biofilm eradication with r = 0.918 (p = 0.000) and anticolony spreading with r = 1.000 (p = 0.000).

Effectiveness of Antidiarrheal Unripe Wooden Banana (Musa paradisiaca L.) in Male Balb-C/Mice Induced with Escherichia coli Ningsih, Arista Wahyu; Rochmanti, Maftuchah; Basori, Achmad
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

The survey results in Indonesia in 2017 showed that the diarrhea morbidity rate for all age groups was 6.897.463. In Indonesia, unripe wooden banana has been used empirically as an antidiarrheal by the people in Senduro village, Lumajang, East Java. The study aimed to prove the antidiarrheal effect of ethanol extract of unripe wooden banana (Musa paradisiaca L) in male Balb-C/mice induced by Escherichia coli bacteria.This study was a laboratory experimental study with post-test only control group design that used 40 micedivided into 8 groups, namely 1group without treatment (normal mice) and 7 groups induced by Escherichia coli(1negative controlgroup given CMC-Na, 3 groups positive controls were given Loperamid HCL 0,5 mg/kgBB, 1 mg/kgBB and 2 mg/kgBB and 3 treatment groups were given extracts 100 mg/kgBB, 200 mg/kgBB and 400 mg/kgBB). Observation of animals in this study was carried out for 4 hours. Data were analyzed of frequency of diarrhea, fecal weight and fecal consistency used Kruskal Wallis and the results showed significant differences between treatment groups (p <0.05). From the results of the Mann-Whitney test, the ethanol extract of unripe wooden banana with a dose of 100 mg/kgBB was notsignificantly different (p> 0.05) with the control group of Loperamid HCL dose of 0.5 mg/kgBB. Unripe wooden banana had been shown to have antidiarrheal activity at an extract dose of 100 mg/kg BB in terms of the parameters of fecal consistency, frequency of diarrhea, and fecal weight. The results showed that the higher the dose, the better antidiarrheal activity

Pemakaian Nitroglycerin Intravena Invivo Sebagai Antidotum Efek Heparin Dhihintia Jiwangga; Paul L. Tahalele; Achmad Basori
JURNAL WIDYA MEDIKA Vol. 4 No. 2 (2018)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v4i2.1813

Introduction: intravenous nitroglycerin, if given simultaneously with heparin, can obstruct the heparin's anticoagulant effect, but it still remains controversy. This statement underlies researcher to authenticate whether intravenous nitroglycerin can neutralize heparin Aim: to find out if intravenous nitroglycerin can neutralize heparin Method: this research is an in vivo experiment with a rabbit as the experimental subject at The Pharmacology Department of The Medical Faculty of The Airlangga University. The experimental subjects are divided into a control group and a treatment. The control group is only given a dose of heparin, while the treatment is given a dose of heparin and some doses of intravenous nitroglycerin. Each of this experimental subjects will be examined its activated clotting time (ACT) score with a hemochrone. The statistical test that will be used is the normality test with one sample kolmogorov smirnov test Result: the administration of 3 mg/kg dose of intravenous glyceryl trinitrate after the administration of 3 mg/kg heparin can reduce the ACT value or neutralize the heparin's anticoagulant effect significantly with the value p= 0,001 (pc0,005). The group that receives 6 mg/kg glyceryl trinitrate, if compared to the prior ACT before the administration of 6 mg/kg glyceryl trinitrate, has a change with the value p= 0,001 (PO, 05). The group that receives 9 mg/kg glyceryl trinitrate, if compared to the prior ACT before the administration of 9 mg/kg glyceryl trinitrate, has a significant change with p=0,010 (P

Co-Authors Acrivida Mega Charisma Ahmad Yudianto Ainur Rahmah Arif Rahman Nurdianto Arista Wahyu Ningsih Bilqis Inayatillah Budi Utomo David S Perdanakusuma Devyani Diah Wulansari Dhihintia Jiwangga Eddy Bagus Wasito Fery Setiawan Florence Pribadi Heribertus Agustinus B Tena Isnaeni Isnaeni Jenny Sunariani Kartuti Debora, Kartuti Maftuchah Maftuchah Meles, Dewa Ketut Mokhamad Saiful Hasan Nenny Triastuti Nova Primadina Nugroho Wibisono Nurina Hasanatuludhiyah Paul L Tahalele Rochmanti, Maftuchah Rochmanti Suhartati Suhartati Suhartati Suhartati Suhartati Sunarni Zakaria Sunarni Zakaria Tamam Jauhar Utariani, Arie Wiwin Retnowati Wurlina, W Yuani Setiawati Zeplin Jiwa Husada Tarigan Ziaulhaq Fathulloh

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