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All Journal Nurani: Jurnal Kajian Syariah dan Masyarakat Al-Wijdan : Journal of Islamic Education Studies JEPAL (Journal of English Pedagogy and Applied Linguistics) Jurnal Pengabdian Masyarakat Bhinneka The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Social Empowerment SOSIO YUSTISIA Jurnal Hukum dan Perubahan Sosial Jurnal el-Huda: Jurnal Pendidikan, Sosial, dan Keagamaan Narra X Al-Zayn: Jurnal Ilmu Sosial & Hukum INTERACTION Communication Studies Journal EJI (English Journal of Indragiri) : Studies in Education, Literature, and Linguistics Jurnal Penelitian Pendidikan Samara: Journal of Islamic Law and Family Studies Comprehensive Journal of Islamic Studies
Muhammad Habiburrahman, Muhammad
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Transportation Other

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The Plausible Use of Mango (Mangifera indica) Peel Isoquercitrin as Adjuvant Therapy for Colorectal Cancer: Translating Research from Bench to Bedside Habiburrahman, Muhammad; Sutopo, Stefanus; Rahadiani, Nur
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202354-62

Abstract

A deadly and debilitating disease, colorectal cancer (CRC), is rapidly becoming a significant threat to public health. However, current therapeutic approaches are still hampered by various side effects. Due to its benefits and remarkable apoptotic impact on cancer cells, plant-derived flavonoids now garner interest as candidates for cancer therapy. Isoquercitrin, a flavonoid commonly found in fruit plants, especially mangoes, is notable due to its ability to inhibit cancer development through various mechanisms. This review aims to highlight the use of isoquercitrin extracted from mango peels in inhibiting CRC carcinogenesis. A literature search was done on Pubmed, Proquest, and Google Scholar using inclusion and exclusion criteria, and a narrative review was synthesised using the evidence gathered. Validity assessment was done through the the Office of Health Assessment and Translation (OHAT) and Oxford Center for Evidence-Based Medicine (CEBM) critical assessment tools. Evidence suggested that isoquercitrin is promising as adjuvant therapy in CRC. It may inhibit overaccumulation of cytoplasmic β-catenin and its translocation into the nucleus, thus downregulating the expression of target proto-oncogenes leading to carcinogenesis of colon crypts. Isoquercitrin concentration in mango peel is abundant, 557.7 mg/kg in dried mango peel and 31.0 mg/kg in pure extracts. A pharmacology study approved that a daily intake of 5.4 mg/kgBW of isoquercitrin has an effective anticancer effect. This substance has good oral bioavailability and is well-tolerated but inhibits the metabolising enzymes CYP1A1 and CYP1B1. In conclusion, isoquercitrin is a potential adjuvant in inhibiting CRC growth with minimum costs and side effects.
Problematika Surat Edaran Mahkamah Agung Nomor 2 Tahun 2023 Tentang Pelarangan Pencatatan Nikah Beda Agama Dalam Perspektif Hak Asasi Manusia Habiburrahman, Muhammad; Maskur, Moh.; Shalihah, Aini
Sosio Yustisia: Jurnal Hukum dan Perubahan Sosial Vol. 3 No. 2 (2023): November
Publisher : Magister Hukum Tata Negara Pascasarjana UIN Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15642/sosyus.v3i2.550

Abstract

The Supreme Court of the Republic of Indonesia issued a Supreme Court Circular Letter (SEMA) Number 2 of 2023 concerning the Prohibition of Registration of Interfaith Marriages. However, the rules reap the pros and cons. Various international agreements on civil, political, economic, social and cultural rights as well as conventions on the elimination of discrimination against women have given men and women the right and freedom to marry without any religious restrictions. The purpose of this writing will be to answer the formulation of the problem, namely to find out the complexity of recording interfaith marriages from a human rights perspective with material for analysis of the Supreme Court Circular Letter Number 2 of 2023. The research method in this paper uses normative law with a statutory and conceptual approach. The results of the research show that there is SEMA No. 2 of 2023 guided by the Marriage Law No. 1 of 1974 (Marriage Law) which has a standard that regulates the complete rejection of the legality of marriage for all religions and beliefs. Even though these various international conventions are contradictory, it needs to be understood that Indonesia has rules regarding marriage which are contained in Law Number 1 of 1974 which should be the main legal rule (lex specialist) in its implementation. Meanwhile, the rules or norms contained in international conventions conflict with Law Number 1 of 1974. Therefore there is no legal problem with the existence of Law No. 1 of 1974 is different from the Universal Declaration of Human Rights as a fundamental instrument of human rights.
Implementasi Kurikulum Merdeka Belajar Pada Mata Pelajaran Bahasa Indonesia Di 3 SMPN Kabupaten Pacitan Mukodi, Mukodi; Habiburrahman, Muhammad; Devinta , Clara; Lestari, Linda Ayu; Rahmadani , Novalia Indah; Hidayah, Khusnul; Riski Yudha , Nur; Listiani , Dina; Halimah , Nur; Kholis , Nur; Aris Aprianto , Edi; Ayu Saputri , Siska; Novla , Debby; Citra Arsetya , Jasmin; Ngainur Roqim , Walil; Keptiana, Dyah; Saputra, Iwan
Jurnal Penelitian Pendidikan Vol 16 No 2 (2024): Jurnal Penelitian Pendidikan
Publisher : LPPM Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21137/jpp.2024.16.2.9

Abstract

Penelitian ini bermula dari kegelisahan akademik dan keperhatinan yang mendalam atas tumpang tindih kurikulum yang ada dan persoalan pelaksanaan Kurikulum Merdeka Belajar yang belum terlaksana secara optimal. Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis pelaksanaan kurikulum merdeka belajar pada mata pelajaran Bahasa Indonesia SMPN 3 Pacitan, SMPN 5 Ngadirojo Satu Atap Kab. Pacitan, dan SMPN 1 Kebonagung. Jenis penelitian ini adalah deskriptif kualitatif. Objek penelitian ini adalaha SMPN 3 Pacitan, Kab. Pacitan, SMPN 5 Ngadirojo Satu Atap, dan SMPN 1 Kebonagung. Informan kuncinya adalah kepala sekolah, wakil kepala sekolah, guru dan peserta didik. Teknik pengumpulan data, berupa; observasi, wawancara mendalam, dan dokumentasi. Analisis datanya menggunakan pisau analisis Miles & Huberman dan diolah dengan alat bantu software ATLAS.ti9. Hasil riset menunjukkan bahwa; (1) SMPN 3 Pacitan; (2) SMPN 5 Ngadirojo Satu Atap Kab. Pacitan; (3) SMPN 1 Kebonagung telah melaksanakan kurikulum merdeka, khususnya pada mata Pelajaran Bahasa Indonesia secara bertahap sesuai dengan kapasitas, kemampuan, dan kearifan lokal (ciri khas) di masing-masing sekolah. Efektifitas pelaksanaan implementasi kurikulum merdeka pada mapel Bahasa Indonesia di ketiga objek riset tersebut, bertumpu pada kuatnya leadership di sekolah, sehingga aliran distribusi kebijakan bisa terselesaikan secara optimal. P5 menjadi penciri yang autentik di masing-masing sekolah tersebut. Kurikulum merdeka pada mapel Bahasa Indonesia telah diterapkan di SMPN 3 Pacitan, SMPN 5 Ngadirojo Satu Atap Kab. Pacitan, SMPN 1 Kebonagung secara efektif dan proporsional sesuai dengan ketentuan yang ditetapkan pemerintah.
Transfer of Function of Waqf Land Analysis of Law Number 41 of 2004 Thuwaiba, Thuwaiba; Habiburrahman, Muhammad; Isma Putri, Cici
Samara: Journal of Islamic Law and Family Studies Vol. 3 No. 1 (2025): June
Publisher : Samara: Journal of Islamic Law and Family Studies

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This article was written based on the discovery that there was waqf land that was originally built as a prayer room. The waqf land was located on a hill. However, the prayer room that had been built was demolished by the waqf's grandson and moved to another location. A house was built on the site of the demolished prayer room. The author used qualitative research methods, employing descriptive methods. The data collection tools were observation, interviews, and documentation. Since this study analyzed the transfer of waqf land functions based on Law No. 41 of 2004, the author used a normative legal and empirical legal approach in this paper. From the research findings, it can be concluded that first, the views of the surrounding community regarding the conversion of waqf land indicate that some members of the community are unaware of the laws governing waqf land. This suggests that the community's understanding of waqf land is still limited, as evidenced by some members of the community converting the function of waqf land. Second, the waqf land was originally built as a mosque. The location of the endowment land is on a hill, but the mosque that had been built was demolished by the endower's grandchild and relocated to another place. The site of the demolished mosque was then built into a house by the endower's grandchild. Third, an analysis of Law No. 41 of 2004 on the conversion of the function of waqf land states that waqf land that has been donated as waqf is prohibited from being changed in status or transferred in any form except through an exchange intended for public interest in accordance with the general spatial plan outlined in Law No. 41 of 2004 on Waqf, Articles 1 and 2.
Nikah Fasid dan Implikasinya terhadap Iddah Perspektif Madzhab Syafi’i Habiburrahman, Muhammad; Sa’adah, Ummu
Comprehensive Journal of Islamic Studies Vol. 2 No. 2 Mei (2025): Comprehensive Journal of Islamic Studies (STAIZA)
Publisher : Tim Jurnal STAI KH. Zainuddin Ponpes Mojosari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63829/js.v2i2mei.38

Abstract

This research aims to understand nikah fasid (invalid marriage) and its implications for iddah (waiting period) from the perspective of the Shafi’i school of thought. When a marriage is declared fasid or invalid, it leads to various legal consequences, including issues related to the status of children, mahram relationships, and one significant aspect—iddah. Iddah is a mandatory waiting period during which a woman is prohibited from remarrying, intended to confirm the emptiness of the womb, as an act of devotion, or as mourning for the deceased husband. Iddah is a prescribed obligation following a valid marriage. In the case of a fasid marriage, the implications differ, and this issue is often overlooked. This study uses a qualitative method with a library research approach and employs descriptive-analytical analysis. The primary data sources are Shafi’i fiqh books, while general fiqh books serve as secondary sources. The findings show that an invalid marriage has no legal effect if no sexual intercourse has occurred. However, if intercourse has taken place within the fasid marriage, iddah becomes obligatory for the woman.
Economic Neglect as Domestic Violence: Analysis of Divorce Decisions from Fatima Mernissi's Islamic Feminist Perspective Susantin, Jamiliya; Rijal, Syamsul; Jannah, Sofiatul; Himsyah, Fatroyah Asr; Habiburrahman, Muhammad
Nurani Vol 25 No 2 (2025): Nurani: jurnal kajian syari'ah dan masyarakat
Publisher : Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/nurani.v25i2.30116

Abstract

This study explores economic neglect as a dimension of domestic violence within Indonesian divorce cases, analyzed through the lens of Fatima Mernissi’s Islamic feminist framework. Mernissi’s framework is particularly relevant in Muslim-majority contexts, as it critically challenges patriarchal interpretations of Islamic legal norms that continue to shape family law adjudication. Using a qualitative design that integrates juridical-normative and socio-legal approaches, the study analyzes 16 divorce decisions issued by five Religious Courts in Indonesia between 2016 and 2025. The findings reveal that economic neglect never occurs in isolation: 100% of cases intersect with other forms of violence, including psychological, physical, and social abuse. Three patterns of economic neglect are identified: total neglect (37.5%), partial neglect (43.75%), and neglect accompanied by economic exploitation (18.75%). However, only 18.75% of the cases culminated in the imposition of full economic sanctions, reflecting the limited enforcement of women’s economic entitlements. Significant regional disparities were also found, with courts in East Java demonstrating greater consistency than those in other regions. The study proposes legal reforms, including explicit recognition of economic neglect as an autonomous form of domestic violence in Article 9 of the Act of the Republic of Indonesia Number 23 of 2004 concerning the Domestic Violence Elimination Law (UU PKDRT) and reformulation of Articles 80 and 84 of the Compilation of Islamic Law (KHI). These reforms are intended to reinforce enforceable post-divorce economic responsibilities, advance substantive justice, and foster greater consistency in judicial practice at the national level.
Random forest-based QSAR modeling for predicting the potency of neprilysin inhibitors using Mordred molecular descriptors Albar, Nizam; Rampengan, Derren DCH.; Azhari, Saiful; Mahmudi, Mahmudi; Fahdhienie, Farrah; Susilawati, Anggi; Habiburrahman, Muhammad
Narra X Vol. 4 No. 1 (2026): April 2026 (In Press)
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v4i1.242

Abstract

Neprilysin (NEP) is a zinc-dependent metallopeptidase, considered a key therapeutic target in heart failure management. Efficient identification of potent NEP inhibitors remains a challenge in drug discovery. The aim of this study was to develop a quantitative structure–activity relationship (QSAR) model using 2D Mordred molecular descriptors and Random Forest algorithms to predict the inhibitory potency (pIC50) of drug candidates. A curated dataset of compounds with experimentally determined IC₅₀ values (in nM) against NEP was preprocessed and converted to pIC50. Mordred was used to calculate 2D molecular descriptors, and descriptors with missing values were excluded. The dataset was split into training, internal validation, and external test sets. A Random Forest regression model was trained using 500 estimators, and model performance was evaluated using R2, root mean square error (RMSE), mean absolute error (MAE), and concordance correlation coefficient (CCC), while a binary classification model was also constructed. Feature importance, residual analysis, and chemical space visualization were conducted to assess model interpretability and reliability. The regression model demonstrated moderate to strong predictive performance, with R2 of 0.286, RMSE of 0.949, MAE of 0.723, and CCC of 0.532 in the internal validation. External validation showed improved generalization, with R2=0.659, RMSE=0.858, MAE=0.630, and CCC=0.763. Binary classification revealed an accuracy of 0.953, precision of 1.000, recall of 0.943, and an F1-score of 0.971, indicating strong discriminative ability in classifying inhibitory versus non-inhibitory compounds. Top contributing descriptors included ATSC2p (feature importance=0.0505), GATS2p (0.0408), and SaasC (0.0317). Principal component analysis (PCA) and Williams plots confirmed that test compounds lie within the model’s applicability domain, with no major outliers in leverage or residual distribution. The developed Random Forest-based QSAR model demonstrates strong predictive power and interpretability for identifying NEP inhibitors. This study provides a valuable tool for virtual screening and highlights the relevance of 2D structural features in governing NEP inhibitory activity. It is the first dedicated QSAR analysis of neprilysin inhibition using Mordred descriptors with rigorous internal and external validation.
Co-Authors Agung Prayudha Hidayat Ahmad Faqihi, Ahmad Aini Shalihah Albar, Nizam Anggi Susilawati Ardhinata , Niken Aris Aprianto , Edi Ayu Saputri , Siska Azhari, Saiful Barokah, Wuliddah Tamsil Citra Arsetya , Jasmin Devinta , Clara Dwi Pratama, Nanda Faqihhudin, Muhammad Raka Farrah Fahdhienie Fatroyah Asr Himsyah, Fatroyah Asr Halimah , Nur Heryudianto Vibowo Hidayah, Agus Sofian Eka Isma Putri, Cici Jamiliya Susantin Jannah, Sofiatul Keptiana, Dyah Khairunnisa Dwinalida kholis , Nur Khusnul Hidayah Lestari, Linda Ayu Listiani , Dina Lubis, Yani Mahmudi Mahmudi Maskur, Moh. Mukodi . Nerol, Ivan De Ngainur Roqim , Walil Novla , Debby Putra , Fibrian Khotmul Aula Rahadiani, Nur Rahmadani , Novalia Indah Rahmah, Ulfa Maulidiyah Rampengan, Derren DCH. Ridwan Siskandar Riski Yudha , Nur Saepullah Saparudin Saparudin Saputra, Iwan Saudah Sa’adah, Ummu Sesar Husen Santosa Siregar, Aulia Sabrina Supiarmo, M. Gunawan Sutopo, Stefanus Suwanda, Bayu Suriaatmaja Syamsul Rijal Tanjung, Nur Rahmaida Thuwaiba, Thuwaiba Widiyanto, Gayu Zainuddin, Zainuddin