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Improving Pulmonary Tuberculosis Treatment Adherence: The role of patient knowledge in Cirebon, West Java, Indonesia Marfuati, Sri; Fitriani, Hikmah; Weni, Mustika; Riawan, Firanda Putri
GHMJ (Global Health Management Journal) Vol. 7 No. 2 (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-72987

Abstract

Background: With 10 million cases around the world, pulmonary tuberculosis (TB) has been classified as a highly contagious disease and mostly affecting low and middle countries. Having the second highest incident cases in West Java of Indonesia, Cirebon becomes a challenging city in order to reduce the number of TB cases in the country. Aims: This study aims to identify the patients’ knowledge and treatment phases, and how the two factors encourage patients to comply with their medication. Methods :  This cross-sectional observational study was conducted among 91 new pulmonary tuberculosis patients at the Cirebon City Community Lung Health Centre, selected using random sampling. Not only respondent characteristics, but also data on the patients' knowledge levels, treatment phases, and medication adherence were collected using a questionnaire and medical records. To assess the relationship between these variables, the collected data was then analyzed using the Spearman Correlation test. Ethical clearance was obtained from the Health Research Ethics Commission, and informed consent was gathered from all participants. Results: This study reveals the most updated characteristics of the Tuberculosis patients at the Cirebon City Community Lung Health Center aged 15-64 years old with treatment duration ranged 1-6 months. The majority have insufficient knowledge about tuberculosis (45.1%), and 75.8% of patients adhered to their prescribed medication regimen, regardless of their knowledge level. The data indicates a significant positive correlation between knowledge level and medication adherence (p = 0.015), with 95% of patients with good knowledge adhering to treatment compared to only 34% with poor knowledge. Furthermore, there is a significant relationship between adherence and treatment duration (p = 0.002), as 85% of patients who adhered to treatment did so for more than two months. Conclusion: The study shows that patients with better knowledge of tuberculosis are more likely to stick to their medication, which also leads to longer treatment durations. Given the high incidence of TB in the region, these findings suggest the need for targeted educational programs to enhance patients' understanding of TB, thereby improving adherence to treatment protocols. Received: 20 May 2024, Reviewed: 09 June 2024, Revised: 26 August 2024, Accepted: 30 August 2024.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kersen (Muntingia calabura L.) terhadap Bakteri Escherichia coli Weni, Mustika; Marfuati, Sri; Fauzah, Shofa Nur; Affandi, Thysa Thysmelia
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 10 No 3 (2024): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v10i3.9618

Abstract

Permasalahan penyakit infeksi dan penyakit tropik masih menjadi permasalahan yang sangat penting karena angkakesakitan dan kemartian yang cukup tinggi. Escherichia coli adalah salah satu bakteri yang dapat menyebabkaninfeksi. Resistensi Escherichia coli sering dilaporkan terjadi, salah satunya Antimicrobial Resistant in Indonesiatelah melaporkan Escherichia coli resisten terhadap beberapa jenis antibiotik, oleh sebab itu dibutuhkan alternatiflain untuk menghambat pertumbuhan bakteri Escherichia coli. Daun kersen mengandung senyawa flavonoid,tannin, saponin yang diketahui berkhasiat sebagai antibakteri. Tujuan: Mengetahui aktivitas antibakteri ekstraketanol daun kersen (Muntingia calabura L.) terhadap bakteri Escherichia coli. Metode: Penelitian ini merupakanpenelitian eksperimental dengan rancangan penelitian post-test only control grup design. Penelitian inimenggunakan 7 kelompok, 2 kelompok kontrol dan 5 kelompok perlakuan. Kelompok perlakuan terdiri dariekstrak etanol dari daun kersen konsentrasi 2%, 10%, 20%, 40%, 60%. Kelompok kontrol yaitu kontrol positif(K(+)) dengan cotrimoxazole dan kontrol negatif ((K(-)) yaitu Dimethyl Sulfoxide (DMSO) 10%. Data diujimenggunakan uji One-way Anova. Hasil: Rata-rata zona hambat terbesar pada konsentrasi 60% yaitu 10,5 mm,sedangkan rata-rata zona hambat terkecil pada konsentrasi 10% yaitu 6 mm, konsentrasi 2% tidak didapatkanadanya zona hambat Kesimpulan: Terdapat perbedaan yang bermakna pada setiap konsentrasi ekstrak etanol daunkersen terhadap bakteri Escherichia coli dan Kadar hambat minimum dari ekstrak etanol daun kersen terhadapbakteri Escherichia coli ada pada konsentrasi 10% dengan rata-rata zona hambat 6 mmKata Kunci: Ekstrak Daun Kersen, Escherichia coli, Aktivitas AntibakteriABSTRACTThe problem of infectious diseases and tropical diseases is still a very important problem because the morbidityand mortality rates are quite high. Escherichia coli is a bacteria that can cause infection. Escherichia coliresistance is often reported, one of which is Antimicrobial Resistance in Indonesia which has reported thatEscherichia coli is resistant to several types of antibiotics, therefore other alternatives are needed to inhibit thegrowth of Escherichia coli bacteria. Cherry leaves contain flavonoid compounds, tannins, saponins which areknown to have antibacterial properties. Objective: To determine the antibacterial activity of ethanol extract ofcherry leaves (Muntingia calabura L.) against Escherichia coli bacteria. Methods: This research is anexperimental study with a post-test only control group design. This study used 7 groups, 2 control groups and 5treatment groups. The treatment group consisted of ethanol extract from cherry leaves at concentrations of 2%,10%, 20%, 40%, 60%. The control group was the positive control (K(+)) with cotrimoxazole and the negativecontrol (K(-)) namely Dimethyl Sulfoxide (DMSO) 10%. Data were tested using the One-way Anova. Results:Obtained the largest average inhibition zone at a concentration of 60%, namely 10,5 mm, while the smallestaverage inhibition zone at a concentration of 10%, namely 6 mm, concentrations of 2% found no inhibition zoneConclusion: There is a significant difference in each concentration of the ethanol extract of cherry leaves againstEscherichia coli bacteria and the minimum inhibition level of the ethanol extract of cherry leaves againstEscherichia coli bacteria is at a concentration of 10 % with an average inhibition zone of 6 mm
Antibacterial Activity of Ethyl Acetat Fraction of Basil Leave (Ocimum Basilicum L) Toward Escherichia Coli Growth Marfuati, Sri; Weni, Mustika; Putri, Inayati Diana
Indonesian Journal of Applied Research (IJAR) Vol. 5 No. 1 (2024): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v5i1.433

Abstract

Antibiotic resistance to Escherichia coli is commonly found. Several studies have found that basil leaves contain chemical compounds: flavonoids, alkaloids, tannins, and saponins, which act as antibacterials. This research aimed to determine the inhibitory power of the ethyl acetate fraction of basil leaves (Ocimum basilicum L) on the growth of Escherichia coli. This study used a post-test-only control group design. This study contained five groups: one positive control group, one negative control group, and three treatment groups. The treatment group consisted of the ethyl acetate fraction of basil leaves at 12.5% μ, 25% μ, and 50% μ. The control group was a positive control K(+) with co-trimoxazole and a negative control K(-) with 10% Dimethyl Sulfoxide (DMSO). Kruskal walls test was chosen, followed by the Mann-Whitney difference test. In the Kruskal Walls test, a significant difference was found (p-value < 0.050) for basil leaf ethyl acetate fraction treatment. The largest average was obtained, namely the ethyl acetate fraction with a concentration of 12.5%. The Mann-Whitney test was carried out to determine fundamental differences between groups. The results of ethyl acetate fraction showed that the Minimum inhibitory concentration (MIC) for Escherichia coli was 12.5%.
UJI AKTIVITAS ANTIBAKTERI FRAKSI ETIL ASETAT DAUN KEMANGI (Ocimum basilicum L) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli Putri, Inayati Diana; Marfuati, Sri; Weni, Mustika
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 3 No 2 (2024): Indonesian Journal of Biomedicine and Health Science
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v3i2.10523

Abstract

Latar Belakang : Escherichia coli merupakan bakteri penyebab diare. Banyak yang melaporkan terjadinya resistensi antibiotik terhadap Escherichia coli. Oleh karena itu dibutuhkan alternatif pengobatan. Beberapa penelitian mengatakan Daun Kemangi mengandung zat metabolit sekunder seperti alkaloid, flavonoid, saponin dan tanin yang berfungsi sebagai antibakteri. Tujuan : Mengetahui Daya Hambat Fraksi Etil Asetat Daun Kemangi (Ocimum basilicum L) Terhadap Pertumbuhan Escherichia coli. Metode : Penelitian ini adalah penelitian eksperimental laboratorium dengan rancangan penelitian post-test only control grup design. Penelitian ini menggunakan 5 kelompok, yaitu 2 kelompok kontrol dan 3 kelompok perlakuan. Kelompok perlakuan terdiri dari fraksi etil asetat dari daun kemangi konsentrasi 12,5%, 25% , 50% . Kelompok kontrol yaitu kontrol positif (K(+)) dengan cotrimoxazole dan kontrol negatif (K(-)) yaitu Dimetil Sulfoksida (DMSO) 10%. Data diuji menggunakan uji Kruskal wallis dan dilanjutkan dengan uji beda Mann Whitney Hasil : Pada uji Kruskal walls terdapat perbedaan yang signifikan (p-value < 0,050), terhadap pemberian perlakuan fraksi etil asetat daun kemangi. Didapat rerata terbesar yaitu pada fraksi etil asetat konsentrasi 12,5% 28960000000. Dilanjutkan dengan uji Mann whitney untuk mengetahui perbedaan antar kelompok, didapatkan perbedaan daya hambat pada masing-masing konsentrasi Kesimpulan : Kadar hambat minimum dari fraksi etil asetat daun kemangi terhadap pertumbuhan Escherichia coli konsentrasi 12,5% dengan nilai TPC sebesar 28960000000, dan terdapat perbedaan yang bermakna setiap konsentrasi fraksi etil asetat daun kemangi terhadap pertumbuhan Escherichia coli Kata Kunci : Daun Kemangi, Fraksi, Escherichia coli
CORRELATION BETWEEN BODY MASS INDEX WITH BLOOD PRESSURE SYSTOLIC AND DIASTOLIC STUDY IN FACULTY OF MEDICINE UNIVERSITAS SWADAYA GUNUNG JATI Kati Sriwiyati; Muhamad Akbar Namusy; Mustika Weni
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 1 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i1.41214

Abstract

Background: An increase in body mass index significantly excess fat in the body. It can affect blood pressure through sympathetic nerve pathways, renin-angiostensin and inflammation. Fat deposits on blood vessel walls cause atherosclerosis, narrowing, increasing blood pressure, and increasing heart work. So that BMI can be a contributing factor to cardiovascular disease. Objective: Knowing the correlation between body mass index and blood pressure in medical students of Universitas Swadaya Gunung Jati (UGJ) Methods: This research is an analytic observational study with a Cross Sectional design. The correlation analysis method uses the Spearman rank correlation test. The measuring instruments used include weight scales, microtoice, and digital tension. Respondents totaled 262 preclinic students from the Faculty of Medicine UGJ. Results: Based on the spearman rank correlation test, a significant correlation was found between body mass index with systolic and diastolic blood pressure. The p-value for both is (p=0.000), indicating a correlation. The strength of the correlation was weak positive with values of (r=0.375) for systolic blood pressure and (r=0.337) for diastolic blood pressure. That is, higher the BMI of a person, the higher the blood pressure. Conclusion: There is a significant correlation with weak positive strength between body mass index with systolic and diastolic blood pressure in Medical Students. Keywords: Body Mass Index, Blood Pressure, Faculty od Medicine, Hypertension, Obesity
HUBUNGAN POLA ASUH DAN PEMBERIAN MAKAN DENGAN STUNTING DI PUSKESMAS NELAYAN CIREBON Rahadian, Zulfikar; Afandi, Thysa Thysmelia; Weni, Mustika
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 10 No. 1 (2026): APRIL 2026
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v10i1.55562

Abstract

Stunting merupakan masalah gizi kronis pada balita yang berdampak jangka panjang terhadap pertumbuhan fisik, perkembangan kognitif, serta kualitas sumber daya manusia. Prevalensi stunting di Indonesia masih relatif tinggi, termasuk di wilayah kerja Puskesmas Nelayan Kota Cirebon. Berbagai faktor berperan dalam terjadinya stunting, di antaranya pola asuh dan praktik pemberian makan yang tidak optimal. Penelitian ini bertujuan untuk mengetahui hubungan antara pola asuh dan pemberian makan dengan kejadian stunting pada balita di wilayah kerja Puskesmas Nelayan Kota Cirebon. Penelitian ini merupakan penelitian observasional analitik dengan desain cross-sectional. Populasi penelitian adalah ibu yang memiliki balita di wilayah kerja Puskesmas Nelayan Kota Cirebon, dengan jumlah sampel sebanyak 81 responden yang dipilih menggunakan teknik purposive sampling. Variabel independen dalam penelitian ini adalah pola asuh dan pemberian makan, sedangkan variabel dependen adalah kejadian stunting. Data dikumpulkan menggunakan kuesioner pola asuh dan pemberian makan, serta data status stunting yang diperoleh dari catatan antropometri balita. Data dianalisis secara univariat, bivariat menggunakan uji chi-square dan Spearman, serta multivariat dengan regresi logistik. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara pemberian makan dengan kejadian stunting (p = 0,000; r = -0,663) serta antara pola asuh dengan kejadian stunting (p = 0,001). Analisis multivariat menunjukkan bahwa pemberian makan memiliki pengaruh yang lebih dominan terhadap kejadian stunting dibandingkan pola asuh. Simpulan penelitian ini adalah terdapat hubungan bermakna antara pola asuh dan pemberian makan dengan kejadian stunting pada balita di wilayah kerja Puskesmas Nelayan Kota Cirebon, dengan pemberian makan sebagai faktor yang paling berpengaruh.
Potential of Kersen Leaf Extract (Muntingia calabura L) and Basil Leaf Extract (Ocimum basilicum L.) as Natural Antibacterial Candidates against Salmonella typhi Mustika Weni; Sri Marfuati; Hikmah Fitriani
Indonesian Journal of Applied Research (IJAR) Vol. 6 No. 3 (2025): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v6i3.771

Abstract

Salmonella typhi remains a global health issue with rising antibiotic resistance, necessitating alternative natural therapies. Kersen (Muntingia calabura L.) and basil (Ocimum basilicum L.) leaves contain bioactive compounds with antibacterial potential. The purpose of this research was to examine the antibacterial activity of kersen and basil leaf ethanol extracts against Salmonella typhi at various concentrations. The research applied an experimental Post-Test Only Control Group Design. Antibacterial activity assessment was performed using the well diffusion method with varying extract concentrations of 20%, 35%, 45%, 50%, and 75%. Data analysis was performed using the Shapiro–Wilk test was used to examine data normality, while group differences were evaluated with the Kruskal–Wallis non-parametric test. Kersen extract contained saponins, tannins, alkaloids, flavonoids; basil extract contained phenolics, saponins, tannins, alkaloids, steroids, flavonoids. Both showed concentration-dependent inhibition. At 75%, inhibition zones reached 13.15 mm (strong), while the lowest were 4.70 mm (kersen, weak) and 7.30 mm (basil, moderate). Negative control showed no activity. Statistical test p=0.005 confirmed significant differences between groups. Ethanol extracts of kersen and basil leaves possess significant antibacterial activity against S. typhi, supporting their potential as natural phytotherapeutics for typhoid.
The Antibacterial Activity Test using Ethyl Acetate Fraction from Kersen Leaves (Muntingia calabura L.) against the Staphylococcus aureus Mutiara Fadilah; Mustika Weni; Sri Marfuati
GHMJ (Global Health Management Journal) Vol. 9 No. 1 (2026)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-911232

Abstract

Background: Staphylococcus aureus is a common cause of skin and soft tissue infections (pyoderma) and has developed resistance to multiple antibiotics. Kersen (Muntingia calabura L.) leaves contain bioactive compounds such as flavonoids, triterpenoids, steroids, tannins, and saponins, which have been reported to possess antibacterial properties. Aim: This study aimed to evaluate the in vitro antibacterial activity of the ethyl acetate fraction of M. calabura leaves against S. aureus. Methods: An experimental study with a post-test-only control group design was conducted. Phytochemical screening was performed to identify the secondary metabolites present in the fraction. Antibacterial testing was done using the well diffusion method on Mueller-Hinton Agar (MHA). Five treatment groups (ethyl acetate fractions at concentrations of 100%, 60%, 20%, 10%, and 1%) were compared to a negative control (10% DMSO) and a positive control (doxycycline). Inhibition zones were measured manually in millimeters and analyzed using one-way ANOVA (p < 0.05). Results: The ethyl acetate fraction demonstrated a concentration-dependent antibacterial effect. Mean ± SD inhibition zones were 17.20 ± 1.92 mm (100%), 12.94 ± 1.13 mm (60%), 7.99 ± 0.70 mm (20%), 7.34 ± 0.35 mm (10%), and 6.71 ± 0.85 mm (1%). The positive control showed a significantly higher inhibition zone (33.82 ± 1.62 mm), while the negative control showed no inhibition. Phytochemical screening of the kersen leaf ethyl acetate fraction includes tannins, saponins, steroids, triterpenoids, and phenolics. Conclusion: The ethyl acetate fraction of M. calabura leaves exhibited antibacterial activity against S. aureus. These findings support its potential development as a plant-based antibacterial agent, although further in vivo studies are needed.
DESCRIPTION OF EATING BEHAVIOR AND BODY MASS INDEX IN ADOLESCENTS Mustika Weni; Briantoro Rekso Janitro; Edy Riyanto
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.54446

Abstract

Background: Adolescence is a crucial phase of growth and development characterized by biological, psychological, and social changes. Eating patterns during this period play an important role in determining nutritional status, including the risk of underweight or overweight. Unhealthy eating behaviors may affect nutritional status and increase the risk of chronic diseases later in life. Aim: This study aimed to describe eating behavior and body mass index (BMI) among adolescents. Methods: This cross-sectional descriptive study was conducted from May to July 2025 at the Faculty of Medicine, Universitas Swadaya Gunung Jati. A total of 64 first-year medical students were selected using simple random sampling. Data were collected using the Eating Behavior Patterns Questionnaire (EBPQ) and BMI was assessed based on height and weight measurements. Results: Most respondents had poor eating behavior (60.94%) and were categorized as overweight (67.19%). The majority of respondents were 19 years old (51.56%) and female (59.38%). Conclusion: The findings indicate a high proportion of adolescents with poor eating behaviors and overweight status. This highlights the need for education on healthy eating patterns and regular monitoring of nutritional status among adolescents to prevent long-term health impacts.
Meningkatkan Kemampuan Menghitung dengan Media Papan Hitung pada Siswa Kelas 2 SD Negeri Petir 2 Kota Tangerang Weni, Mustika; Widiani, Uci; Zuliani, Rizki
MASALIQ Vol 3 No 5 (2023): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v3i5.1356

Abstract

This study aims to develop a counting board learning media for grade 2 elementary schools. The research was conducted based on the basic facts in the field, it is known that the understanding of distribution is still low and there is a lack of supporting media for distribution. The type of research used is research that takes place in 3 stages. The research subjects were students of SD Negeri Petir 2 Tangerang City. The data collection technique used was a questionnaire which was assessed by giving questionnaires to students after using the counting board media. The results of this development research indicate that the developed learning media meets the good and feasible criteria so that it can be tested on grade 2 elementary school students. Based on the results of the total research sample, 90% of students received and felt the benefits of the division counting board learning media. The main benefit that students get is the division of the counting board which simplifies and speeds up the process of dividing arithmetic.