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All Journal ACTA VETERINARIA INDONESIANA ARSHI Veterinary Letters Veterinary Biomedical and Clinical Journal Jurnal Veteriner dan Biomedis Current Biomedicine Genbinesia Journal of Biology
Amaq Fadholly
Division Of Pharmacology And Toxicology, School Of Veterinary Medicine And Biomedical Sciences, IPB University, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Journal : Veterinary Biomedical and Clinical Journal

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Efficacy of Shallots Infusion (Allium Cepa L.) as an Antidiarrhea in Mice (Mus Musculus) Purohita, Adwisto Saktika; Aulia Andi Mustika; Lina Noviyanti Sutardi; Fadholly, Amaq
Veterinary Biomedical and Clinical Journal Vol. 4 No. 2 (2022)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2022.004.02.2

Abstract

Shallots have been used for generations as traditional medicine, one of which is used in the treatment of diarrhea. This study determined the antidiarrheal activity of the shallot bulbs using intestinal protection and intestinal transit methods, and to determine the effective concentration that gives the best antidiarrheal effect in mice. This study used thirty mice and divided into six groups. The negative control group was given Tween 80 (1%), positive control group was given Loperamide HCl, and four various concentrations of shallot infusion treatment groups (1.25%, 2.5%, 5%, and 10 %). The treatment was given by the oral route. The parameters used in the intestinal protection method were frequency of defecation and feces consistency, while in intestinal transit method the parameters used were the percentage ratio of the marker trajectories compared to the overall length of the intestine. The results showed that the 1.25% concentration of shallot infusion indicated the best antidiarrheal activity and had a smaller ratio or stronger inhibition to intestinal peristaltic compared to all other concentrations, 2.5%, 5%, dan 10%. We concluded that shallot bulbs infusion with a concentration of 1.25% has the most effective anti-diarrheal effect. This research can be continued by measurement of other diarrheal parameters such as stool weight, as well as start and stop time of diarrhea to further clarify the anti-diarrheal potential of shallot bulb infusion.
Co-Authors Adi Sofyan Ansori, Muhammad Andriyanto Andriyanto Anggraeni, Henny Endah Anisa Rahma Aulia Andi Mustika Aurellia, Sharon Dhea Kharisma, Viol Diah Nugrahani Pristihadi Dings, Tim Godefridus Antonius Dwi Budiono Fedik Abdul Rantam Firdaus, Munira Laeli Hanum, Nur Aisah Hendri Zonathan Heryudianto Vibowo Iryanto, Anetonia Felicia Istiqmal, Kahfi Aulia Ivan Taufiq Nugraha Kukuh Amru Dhiya Rahmat Kurniasih Lina Noviyanti Sutardi Pradnya Calista Purohita, Adwisto Saktika Putri, Imelya Andira Putri, Ramadita Aisyah Rahadian Zainul Ramadhan, Maharani Kartika Rasyadan Taufiq Probojati Sajidah, Halilah Wafa’ Saragih, Mariah Mada Rahma Nauli Srihadi Agungpriyono Tacharina, Martia Rani Tekad Urip Pambudi Sujarnoko Tri Untari Turista, Dora Dayu Rahma Ullah, Md. Emdad