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ANALYSIS COLLAGEN DENSITY ON DIABETIC AND NON-DIABETIC ACUTE WOUND MODEL: ANIMAL TRIAL USING WISTAR RATS Maryunis, Maryunis; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Tahir, Takdir; Rahayu, Ade Irma; Hasriyani, Hasriyani; Yusuf, Saldy
in process
Publisher : ETN Centre Indonesia

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Background: Neuropathy and peripheral vascular disease are two major factors that lead to diabetic wounds. Additionally, diabetic wound healing process takes a long time. Collagen is one indicator to assess wound healing. Aim: This study aimed to compare the wound healing process DM and non-DM In Wistar with acute wounds modeling that uses the density collagen as indicators. Methods: This study used a randomized design Post Test Control Group who uses Wistar as research objects. Wistar rats were divided into 2 groups: Wistar DM and Non-DM groups. The total sample were 30 individuals that consisted of 15 rats each group. Wistar DM was induced by injection of Streptozotocin (STZ) intraperitoneal single dose of 40-50 mg / kg. The wound were created by using punch biopsy of each group. The wound were followed up for 14 days. Data analysis was done using the Kolmogorov - Smirnov test with a confidence level of 95%. All data were analyzed by SPSS version 21.0 software (SPSS, Inc. Chicago, IL). Results: The density of collagen in DM group (20%) was lower than in non DM group (40%). However there were no significant difference in collagen density in both groups (p=0,375). Nevertheless, the percentage of collagen density is higher in non DM group compared with DM group (20.0%). This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. Conclusion : There is a tendency that the wound healing in non âDM group is better than in DM groups. More studies are needed in the future to confirm this findings. Key Words: Collagen Density, Acute Wound Model, DM

ANALYSIS COLLAGEN DENSITY ON DIABETIC AND NON-DIABETIC ACUTE WOUND MODEL: ANIMAL TRIAL USING WISTAR RATS Maryunis, Maryunis; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Tahir, Takdir; Rahayu, Ade Irma; Hasriyani, Hasriyani; Yusuf, Saldy
Jurnal Luka Indonesia Vol 2 No 3 Oktober 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.29

Background: Neuropathy and peripheral vascular disease are two major factors that lead to diabetic wounds. Additionally, diabetic wound healing process takes a long time. Collagen is one indicator to assess wound healing. Aim: This study aimed to compare the wound healing process DM and non-DM In Wistar with acute wounds modeling that uses the density collagen as indicators. Methods: This study used a randomized design Post Test Control Group who uses Wistar as research objects. Wistar rats were divided into 2 groups: Wistar DM and Non-DM groups. The total sample were 30 individuals that consisted of 15 rats each group. Wistar DM was induced by injection of Streptozotocin (STZ) intraperitoneal single dose of 40-50 mg / kg. The wound were created by using punch biopsy of each group. The wound were followed up for 14 days. Data analysis was done using the Kolmogorov - Smirnov test with a confidence level of 95%. All data were analyzed by SPSS version 21.0 software (SPSS, Inc. Chicago, IL). Results: The density of collagen in DM group (20%) was lower than in non DM group (40%). However there were no significant difference in collagen density in both groups (p=0,375). Nevertheless, the percentage of collagen density is higher in non DM group compared with DM group (20.0%). This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. Conclusion : There is a tendency that the wound healing in non ?DM group is better than in DM groups. More studies are needed in the future to confirm this findings. Key Words: Collagen Density, Acute Wound Model, DM

ANALYSIS COLLAGEN DENSITY ON DIABETIC AND NON-DIABETIC ACUTE WOUND MODEL: ANIMAL TRIAL USING WISTAR RATS Maryunis, Maryunis; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Tahir, Takdir; Rahayu, Ade Irma; Hasriyani, Hasriyani; Yusuf, Saldy
Jurnal Luka Indonesia Vol 2 No 3 Oktober 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.29

Background: Neuropathy and peripheral vascular disease are two major factors that lead to diabetic wounds. Additionally, diabetic wound healing process takes a long time. Collagen is one indicator to assess wound healing. Aim: This study aimed to compare the wound healing process DM and non-DM In Wistar with acute wounds modeling that uses the density collagen as indicators. Methods: This study used a randomized design Post Test Control Group who uses Wistar as research objects. Wistar rats were divided into 2 groups: Wistar DM and Non-DM groups. The total sample were 30 individuals that consisted of 15 rats each group. Wistar DM was induced by injection of Streptozotocin (STZ) intraperitoneal single dose of 40-50 mg / kg. The wound were created by using punch biopsy of each group. The wound were followed up for 14 days. Data analysis was done using the Kolmogorov - Smirnov test with a confidence level of 95%. All data were analyzed by SPSS version 21.0 software (SPSS, Inc. Chicago, IL). Results: The density of collagen in DM group (20%) was lower than in non DM group (40%). However there were no significant difference in collagen density in both groups (p=0,375). Nevertheless, the percentage of collagen density is higher in non DM group compared with DM group (20.0%). This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. Conclusion : There is a tendency that the wound healing in non ?DM group is better than in DM groups. More studies are needed in the future to confirm this findings. Key Words: Collagen Density, Acute Wound Model, DM

UJI TOKSISITAS AKUT EKSTRAK ETANOL 70% KULIT PISANG KEPOK KUNING (Musa paradisiaca L.) TERHADAP LARVA UDANG (Artemia salina Leach) MENGGUNAKAN METODE Brine Shrimp Lethality Test (BSLT) Hasriyani, Hasriyani; Putri Rahmawati, Riana; Putri Utami, Meira
Nusantara Hasana Journal Vol. 4 No. 9 (2025): Nusantara Hasana Journal, February 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i9.1366

Yellow kepok banana is a horticultural plant native to Indonesia in Southeast Asia, which is used as an antimicrobial, antihypertensive, antiallergic, antioxidant, antianalgesic, diuretic, hypolipidemic and vasodilator. Yellow kepok banana peel is a waste of kepok banana which contains high antioxidant compounds such as phenol, catecholamide, carotene and flavonoids, polyphenols, vitamin C, and tannins. Method: Experimental research design, 180 Artemia Shrimp Larvae were divided into 5 concentration groups consisting of 10 shrimp larvae with 3 replications of concentration groups, namely 250, 500, 750, 1,000 ppm. Results: Phytochemical screening of 70% ethanol extract of yellow kepok banana peel contains active compounds of alkaloids, flavonoids, saponins, and tannins. Observations for 24 hours, at a concentration of 250 ppm there was a percentage of death of 63%, at a concentration of 500 ppm of 73%, at a concentration of 750 ppm of 87% and a concentration of 1000 ppm of 97%. The LC50 value obtained was 38.899 ppm. So the highest dose is 1,000 ppm and it can be stated that the yellow banana peel extract in this study was highly toxic to Artemia salina larvae test animals so that it can be used as an anti-cancer. Conclusion: Ethanol extract of 70% yellow banana peel has the potential for acute toxicity to Artemia Shrimp Larvae using the (BSLT) method because the LC50 value was <50 µg/ml.

AKTIVITAS BIOLARVASIDA EKSTRAK ETANOL SEREH WANGI (Cymbopogon nardus L) TERHADAP MORTALITAS LARVA AEDES AEGYPTI Putri Rahmawati, Riana; Hasriyani, Hasriyani; Nisrina Absor, Farah
Nusantara Hasana Journal Vol. 4 No. 9 (2025): Nusantara Hasana Journal, February 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i9.1370

Aedes aegypti mosquitoes are the main vector of the spread of dengue hemorrhagic fever (DHF). These mosquito controls are often carried out with synthetic insecticides, but their use can lead to resistance and negative impacts on the environment. Therefore, a more environmentally friendly control alternative is needed, one of which is with natural biolarvicides. One example of a plant that has the potential to be a biolarvicide is citronella (Cymbopogon nardus L). This study aims to determine the biolarvicide activity of citronella ethanol extract (Cymbopogon nardus L) on the mortality of Aedes aegypti larvae and determine the Lethal Concentration 50 (LC50) value. This research was carried out using experimental methods and data analysis techniques used, namely quantitative by calculating the LC valueof 50 using the probit analysis test on SPSS. The results of the average percentage of mortality of Aedes aegypti larvae in group 1 (5%) was 61.3%, group 2 (10%) was 86.6%, and group 3 (15%) was 96.6%. The LC value of 50 from citronella ethanol extract (Cymbopogon nardus L) on the mortality of Aedes aegypti larvae was 3.531%. Citronella ethanol extract (Cymbopogon nardus L) has been shown to have natural biolarvicide effectiveness as the concentration of the extract increases.

UJI KARAKTERISTIK FISIK FORMULASI CLAY MASK EKSTRAK ETANOL DAUN UNGU (Graptophyllum pictum L.Griff) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus Choirun Nisak; Hasriyani, Hasriyani; Bintari Tri Sukoharjanti
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1534

Skin problems caused by hormones, dead skin cells, clogged pores due to excess oil, and bacterial infections such as Staphylococcus aureus are known as acne. Antibiotics can cause side effects, so natural alternatives such as purple leaf masks are used because of their content of flavonoids, saponins, and tannins with antibacterial properties. Clay masks work by absorbing oil and cleaning pores. This study aims to determine the effectiveness of purple leaf extract clay mask in inhibiting Staphylococcus aureus and its physical characteristics. Formulations include F0 (0%), F1 (20%), F2 (23%), and F3 (26%) with antibacterial testing using disc diffusion methods and physical characteristics. The best physical results are shown by F2 (23%) because the physical quality of the formula is the best. Antibacterial results showed that F3 (26%) had the largest inhibition zone (9.16 mm), followed by F2 (5.76 mm), and F1 (3.9 mm). Purple leaf clay mask shows potential as an antibacterial against Staphylococcus aureus with F2 (23%) considered the best formulation due to its good inhibitory effect and standard-compliant physical properties.

FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SERUM WAJAH EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) Abdilla Mahmud Arrafiq; Hasriyani, Hasriyani; Eko Retnowati
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1551

Free radicals accelerate skin aging and cellular damage. Kersen leaves (Muntingia calabura L.) are known to contain flavonoids, saponins, and tannins with antioxidant potential. This study aimed to formulate a facial serum using ethanolic extract of kersen leaves and evaluate its physical properties and antioxidant activity. The extract was obtained via maceration using 96% ethanol and formulated into three concentrations: 5%, 10%, and 15%. Physical evaluations included organoleptic properties, homogeneity, pH, spreadability, viscosity, and irritation tests. Antioxidant activity was assessed using the DPPH method, with IC₅₀ values as indicators. All formulations met the physical quality standards. The 5% extract formula exhibited the highest antioxidant activity with an IC₅₀ value of 72.22 μg/mL, classified as active. Irritation tests confirmed that all formulations were safe for topical use. These findings support the potential of kersen leaf extract as a natural antioxidant ingredient in cosmetic formulations.

Unveiling Pagodroma Nivea's Fossil Healing Power: A Journey Through Farmacoantarctic Chronicles And Bioactivity Studies Yuneka Saristiana; Yunita Dian Permatasari; Anita Dwi Setyarini; Hasriyani, Hasriyani; Neni Probosiwi; Fendy Prasetyawan
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.122

Research on the bioactivity of Antarctic organisms has garnered significant attention due to the continent's unique environmental conditions and the potential therapeutic value of its inhabitants. This study delves into the bioactivity of Pagodroma nivea, commonly known as the Snow Petrel, found in Antarctica, aiming to explore its medicinal potential. Despite previous research highlighting the bioactivity of various organisms in extreme environments, specific investigations into Pagodroma nivea remain scarce. Farmacoantarctic Research offers a promising avenue for exploring the therapeutic properties of Antarctic organisms, including Pagodroma nivea, traditionally used for medicinal purposes by local communities. Understanding the biochemical adaptations of organisms to Antarctica's extreme conditions is crucial, as these adaptations may yield bioactive compounds with pharmacological potential. The research not only seeks to uncover the bioactivity of Pagodroma nivea but also aims to contribute to drug development and environmental conservation efforts. In a parallel discussion, the study examines Mumijo, a traditional remedy found in various regions, including Antarctica. Chemical analysis of Mumijo extract, particularly the ester wax fraction, reveals its potential biomedical applications, including wound healing, skin diseases, and neuroprotection. The presence of glycerol-related ethers in Antarctic Mumijo suggests further avenues for exploration in neuroprotection and antimicrobial properties. By investigating the bioactivity of Antarctic organisms like Pagodroma nivea and Mumijo, this research offers insights into their therapeutic potential and underscores the importance of conservation efforts to preserve these unique ecosystems.

SOSIALISASI DAN PENINGKATAN AKSES KEADILAN MELALUI POS BANTUAN HUKUM BERDASARKAN PERMA NO.1 TAHUN 2014 DI KECAMATAN ANGGERAJA, KABUPATEN ENREKANG Hidayat, Asrul; Fatimah, Fatimah; Hasriyani, Hasriyani; Salim, Jumiah
PEDAMAS (PENGABDIAN KEPADA MASYARAKAT) Vol. 3 No. 05 (2025): SEPTEMBER 2025
Publisher : MEDIA INOVASI PENDIDIKAN DAN PUBLIKASI

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Peraturan Mahkamah Agung Republik Indonesia Nomor 1 Tahun 2014 mengatur pedoman pemberian layanan hukum bagi masyarakat tidak mampu di pengadilan, yang mencakup pemberian layanan informasi, konsultasi, dan penyediaan Pos Bantuan Hukum (Posbakum), sidang di luar pengadilan (keliling), Prodeo (bebas biaya perkara), secara cuma-cuma. Namun, di lapangan masih banyak masyarakat tidak mampu yang belum mengetahui keberadaan dan tata cara memperoleh layanan tersebut. Kegiatan pengabdian ini bertujuan untuk mendukung implementasi PERMA Nomor 1 Tahun 2014 dengan memberikan sosialisasi dan pendampingan hukum kepada masyarakat tidak mampu, khususnya terkait prosedur, syarat administratif, dan manfaat layanan Posbakum. Kegiatan ini di laksanakan pada 18 juli 2025. Hasil pelaksanaan menunjukkan bahwa kurangnya pemahaman hukum dan minimnya informasi menjadi kendala utama masyarakat dalam mengakses layanan hukum. Melalui sosialisasi dan pendampingan yang tepat, masyarakat menjadi lebih memahami hak-haknya di pengadilan serta mampu memanfaatkan layanan hukum gratis sesuai ketentuan dalam PERMA Nomor 1 Tahun 2014.

Pengembangan dan Evaluasi Floating Oral In Situ Gel Aspirin Berbasis Matriks Sodium Alginat–HPMC sebagai Gastroretentive Drug Delivery System Sari, Fatika; Hasriyani, Hasriyani; Besan, Emma Jayanti
Journal of Innovative and Creativity Vol. 6 No. 2 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

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Aspirin memiliki waktu tinggal lambung yang singkat dan risiko iritasi gastrointestinal, sehingga diperlukan sistem penghantaran obat yang mampu memperpanjang retensi dan mengendalikan pelepasan. Floating oral in situ gel berbasis sodium alginat–HPMC dikembangkan untuk menghasilkan gel yang terbentuk spontan di lingkungan lambung, mengapung stabil, serta melepaskan obat secara bertahap. Penelitian ini bertujuan merumuskan dan mengevaluasi tiga formula floating in situ gel aspirin dengan variasi rasio sodium alginat–HPMC, serta menentukan formula optimum berdasarkan viskositas, gelasi, daya apung, dan profil pelepasan obat. Penelitian dilakukan secara eksperimental laboratorium melalui tahap preformulasi, desain dan formulasi tiga sediaan floating oral in situ gel aspirin berbasis matriks sodium alginat dan HPMC (F1: 1% dan 0,3%; F2: 1,5% dan 0,5%; dan F3: 2% dan 0,7%) , serta evaluasi pH, organoleptis, viskositas, floating lag time, total floating time, dan uji pelepasan dengan disolusi USP II. Hasil menunjukkan seluruh formula homogen, berwarna putih kekuningan, dan berbau khas aspirin. Nilai pH berada pada rentang 6,21–6,52. Viskositas meningkat seiring kenaikan konsentrasi polimer, yaitu 126,9 cP (F1), 171,0 cP (F2), dan 263,7 cP (F3). Seluruh formula memenuhi kriteria floating dengan FLT <1 menit dan TFT >12 jam. Profil pelepasan menunjukkan pola sustained release dengan urutan F1 > F2 > F3; pada jam ke-6 pelepasan masing-masing sebesar 68,92%, 56,23%, dan 47,47%. Variasi konsentrasi sodium alginat–HPMC memengaruhi karakteristik fisik, kemampuan mengapung, dan laju pelepasan aspirin. Formula F2 merupakan formula optimum karena memberikan keseimbangan terbaik antara viskositas, stabilitas floating, dan pelepasan obat terkontrol.

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