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All Journal Jurnal Luka Indonesia Nusantara Hasana Journal International Journal of Science and Environment PEDAMAS (Pengabdian Kepada Masyarakat) Journal of Innovative and Creativity Advances in Healthcare Research IJF (Indonesia Jurnal Farmasi) Journal Health of Indonesian

Hasriyani Hasriyani, Hasriyani

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Author-ID : 638310

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Energy Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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ANALYSIS COLLAGEN DENSITY ON DIABETIC AND NON-DIABETIC ACUTE WOUND MODEL: ANIMAL TRIAL USING WISTAR RATS Maryunis, Maryunis; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Tahir, Takdir; Rahayu, Ade Irma; Hasriyani, Hasriyani; Yusuf, Saldy
in process
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Neuropathy and peripheral vascular disease are two major factors that lead to diabetic wounds. Additionally, diabetic wound healing process takes a long time. Collagen is one indicator to assess wound healing. Aim: This study aimed to compare the wound healing process DM and non-DM In Wistar with acute wounds modeling that uses the density collagen as indicators. Methods: This study used a randomized design Post Test Control Group who uses Wistar as research objects. Wistar rats were divided into 2 groups: Wistar DM and Non-DM groups. The total sample were 30 individuals that consisted of 15 rats each group. Wistar DM was induced by injection of Streptozotocin (STZ) intraperitoneal single dose of 40-50 mg / kg. The wound were created by using punch biopsy of each group. The wound were followed up for 14 days. Data analysis was done using the Kolmogorov - Smirnov test with a confidence level of 95%. All data were analyzed by SPSS version 21.0 software (SPSS, Inc. Chicago, IL). Results: The density of collagen in DM group (20%) was lower than in non DM group (40%). However there were no significant difference in collagen density in both groups (p=0,375). Nevertheless, the percentage of collagen density is higher in non DM group compared with DM group (20.0%). This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. Conclusion : There is a tendency that the wound healing in non âDM group is better than in DM groups. More studies are needed in the future to confirm this findings. Key Words: Collagen Density, Acute Wound Model, DM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.29

Background: Neuropathy and peripheral vascular disease are two major factors that lead to diabetic wounds. Additionally, diabetic wound healing process takes a long time. Collagen is one indicator to assess wound healing. Aim: This study aimed to compare the wound healing process DM and non-DM In Wistar with acute wounds modeling that uses the density collagen as indicators. Methods: This study used a randomized design Post Test Control Group who uses Wistar as research objects. Wistar rats were divided into 2 groups: Wistar DM and Non-DM groups. The total sample were 30 individuals that consisted of 15 rats each group. Wistar DM was induced by injection of Streptozotocin (STZ) intraperitoneal single dose of 40-50 mg / kg. The wound were created by using punch biopsy of each group. The wound were followed up for 14 days. Data analysis was done using the Kolmogorov - Smirnov test with a confidence level of 95%. All data were analyzed by SPSS version 21.0 software (SPSS, Inc. Chicago, IL). Results: The density of collagen in DM group (20%) was lower than in non DM group (40%). However there were no significant difference in collagen density in both groups (p=0,375). Nevertheless, the percentage of collagen density is higher in non DM group compared with DM group (20.0%). This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. Conclusion : There is a tendency that the wound healing in non ?DM group is better than in DM groups. More studies are needed in the future to confirm this findings. Key Words: Collagen Density, Acute Wound Model, DM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.29

Background: Neuropathy and peripheral vascular disease are two major factors that lead to diabetic wounds. Additionally, diabetic wound healing process takes a long time. Collagen is one indicator to assess wound healing. Aim: This study aimed to compare the wound healing process DM and non-DM In Wistar with acute wounds modeling that uses the density collagen as indicators. Methods: This study used a randomized design Post Test Control Group who uses Wistar as research objects. Wistar rats were divided into 2 groups: Wistar DM and Non-DM groups. The total sample were 30 individuals that consisted of 15 rats each group. Wistar DM was induced by injection of Streptozotocin (STZ) intraperitoneal single dose of 40-50 mg / kg. The wound were created by using punch biopsy of each group. The wound were followed up for 14 days. Data analysis was done using the Kolmogorov - Smirnov test with a confidence level of 95%. All data were analyzed by SPSS version 21.0 software (SPSS, Inc. Chicago, IL). Results: The density of collagen in DM group (20%) was lower than in non DM group (40%). However there were no significant difference in collagen density in both groups (p=0,375). Nevertheless, the percentage of collagen density is higher in non DM group compared with DM group (20.0%). This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. Conclusion : There is a tendency that the wound healing in non ?DM group is better than in DM groups. More studies are needed in the future to confirm this findings. Key Words: Collagen Density, Acute Wound Model, DM

Morphological Analysis of Ciplukan Plant (Physalis angulata L.) Pollen for Macroscopic Identification Prasetyawan, Fendy; Saristiana, Yuneka; Akhmal Muslikh, Faisal; Hasriyani, Hasriyani; Dian Permatasari, Yunita
International Journal of Science and Environment (IJSE) Vol. 4 No. 1 (2024): February 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijse.v4i1.63

This research addresses the prevalence of arthritis in Indonesia, focusing on traditional medicinal plants like Ciplukan due to the side effects of synthetic treatments. Arthritis, affecting 23.6-31.3% of the population, with Osteoarthritis (50-60% in the elderly) being the most common, necessitates alternative, less toxic remedies. Traditional medicine, relying on plant-derived remedies, is explored for its accessibility, affordability, and lower side effects. The study delves into Ciplukan, known for its anti-arthritis properties, conducting in vitro tests on its methanol extract. Results reveal anti-arthritis activity attributed to steroids, flavonoids, and alkaloids. The methodology involves macroscopic and microscopic examinations of Ciplukan plants, verifying authenticity and confirming the accuracy of plant samples. Organoleptic assessments highlight distinctive features, contributing to the plant's identification. Microscopic examination reveals the presence of stomata and palisade cells in the upper epidermis, aligning with literature data. The vascular system analysis emphasizes the efficiency of resource transport and adaptation to environmental changes. In conclusion, the study provides a comprehensive understanding of Ciplukan's characteristics, supporting its potential in arthritis treatment. The findings contribute to the utilization of traditional medicine in healthcare, emphasizing the importance of plant-based remedies with fewer side effects.

UJI TOKSISITAS AKUT EKSTRAK ETANOL 70% KULIT PISANG KEPOK KUNING (Musa paradisiaca L.) TERHADAP LARVA UDANG (Artemia salina Leach) MENGGUNAKAN METODE Brine Shrimp Lethality Test (BSLT) Hasriyani, Hasriyani; Putri Rahmawati, Riana; Putri Utami, Meira
Nusantara Hasana Journal Vol. 4 No. 9 (2025): Nusantara Hasana Journal, February 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i9.1366

Yellow kepok banana is a horticultural plant native to Indonesia in Southeast Asia, which is used as an antimicrobial, antihypertensive, antiallergic, antioxidant, antianalgesic, diuretic, hypolipidemic and vasodilator. Yellow kepok banana peel is a waste of kepok banana which contains high antioxidant compounds such as phenol, catecholamide, carotene and flavonoids, polyphenols, vitamin C, and tannins. Method: Experimental research design, 180 Artemia Shrimp Larvae were divided into 5 concentration groups consisting of 10 shrimp larvae with 3 replications of concentration groups, namely 250, 500, 750, 1,000 ppm. Results: Phytochemical screening of 70% ethanol extract of yellow kepok banana peel contains active compounds of alkaloids, flavonoids, saponins, and tannins. Observations for 24 hours, at a concentration of 250 ppm there was a percentage of death of 63%, at a concentration of 500 ppm of 73%, at a concentration of 750 ppm of 87% and a concentration of 1000 ppm of 97%. The LC50 value obtained was 38.899 ppm. So the highest dose is 1,000 ppm and it can be stated that the yellow banana peel extract in this study was highly toxic to Artemia salina larvae test animals so that it can be used as an anti-cancer. Conclusion: Ethanol extract of 70% yellow banana peel has the potential for acute toxicity to Artemia Shrimp Larvae using the (BSLT) method because the LC50 value was <50 µg/ml.

AKTIVITAS BIOLARVASIDA EKSTRAK ETANOL SEREH WANGI (Cymbopogon nardus L) TERHADAP MORTALITAS LARVA AEDES AEGYPTI Putri Rahmawati, Riana; Hasriyani, Hasriyani; Nisrina Absor, Farah
Nusantara Hasana Journal Vol. 4 No. 9 (2025): Nusantara Hasana Journal, February 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i9.1370

Aedes aegypti mosquitoes are the main vector of the spread of dengue hemorrhagic fever (DHF). These mosquito controls are often carried out with synthetic insecticides, but their use can lead to resistance and negative impacts on the environment. Therefore, a more environmentally friendly control alternative is needed, one of which is with natural biolarvicides. One example of a plant that has the potential to be a biolarvicide is citronella (Cymbopogon nardus L). This study aims to determine the biolarvicide activity of citronella ethanol extract (Cymbopogon nardus L) on the mortality of Aedes aegypti larvae and determine the Lethal Concentration 50 (LC50) value. This research was carried out using experimental methods and data analysis techniques used, namely quantitative by calculating the LC valueof 50 using the probit analysis test on SPSS. The results of the average percentage of mortality of Aedes aegypti larvae in group 1 (5%) was 61.3%, group 2 (10%) was 86.6%, and group 3 (15%) was 96.6%. The LC value of 50 from citronella ethanol extract (Cymbopogon nardus L) on the mortality of Aedes aegypti larvae was 3.531%. Citronella ethanol extract (Cymbopogon nardus L) has been shown to have natural biolarvicide effectiveness as the concentration of the extract increases.

UJI KARAKTERISTIK FISIK FORMULASI CLAY MASK EKSTRAK ETANOL DAUN UNGU (Graptophyllum pictum L.Griff) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus Choirun Nisak; Hasriyani, Hasriyani; Bintari Tri Sukoharjanti
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1534

Skin problems caused by hormones, dead skin cells, clogged pores due to excess oil, and bacterial infections such as Staphylococcus aureus are known as acne. Antibiotics can cause side effects, so natural alternatives such as purple leaf masks are used because of their content of flavonoids, saponins, and tannins with antibacterial properties. Clay masks work by absorbing oil and cleaning pores. This study aims to determine the effectiveness of purple leaf extract clay mask in inhibiting Staphylococcus aureus and its physical characteristics. Formulations include F0 (0%), F1 (20%), F2 (23%), and F3 (26%) with antibacterial testing using disc diffusion methods and physical characteristics. The best physical results are shown by F2 (23%) because the physical quality of the formula is the best. Antibacterial results showed that F3 (26%) had the largest inhibition zone (9.16 mm), followed by F2 (5.76 mm), and F1 (3.9 mm). Purple leaf clay mask shows potential as an antibacterial against Staphylococcus aureus with F2 (23%) considered the best formulation due to its good inhibitory effect and standard-compliant physical properties.

FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SERUM WAJAH EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) Abdilla Mahmud Arrafiq; Hasriyani, Hasriyani; Eko Retnowati
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1551

Free radicals accelerate skin aging and cellular damage. Kersen leaves (Muntingia calabura L.) are known to contain flavonoids, saponins, and tannins with antioxidant potential. This study aimed to formulate a facial serum using ethanolic extract of kersen leaves and evaluate its physical properties and antioxidant activity. The extract was obtained via maceration using 96% ethanol and formulated into three concentrations: 5%, 10%, and 15%. Physical evaluations included organoleptic properties, homogeneity, pH, spreadability, viscosity, and irritation tests. Antioxidant activity was assessed using the DPPH method, with IC₅₀ values as indicators. All formulations met the physical quality standards. The 5% extract formula exhibited the highest antioxidant activity with an IC₅₀ value of 72.22 μg/mL, classified as active. Irritation tests confirmed that all formulations were safe for topical use. These findings support the potential of kersen leaf extract as a natural antioxidant ingredient in cosmetic formulations.

Formulation and Physical Quality Testing of Cleansing Balm from Centella Asiatica (L.) URB. Extract with Castor Oil (Ricinus Communis L.) as a Makeup Remover Pramesty, Sevty Ardhia; Hasriyani, Hasriyani; Sukoharjanti, Bintari Tri
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.597

Purpose: This study aimed to formulate and evaluate the physical quality of cleansing balm containing 3% Centella asiatica (L.). Urb. Extract with castor oil (Ricinus communis L.) at varying concentrations (30%, 35%, and 40%) to determine the optimal formulation as an effective and safe makeup remover. Research Method: An experimental laboratory design was conducted at the Cendekia Utama Kudus Institute of Health Technology. The Centella asiatica extract was obtained from UPT Lab Herbal Materia Medica Batu, East Java. Physical quality tests included organoleptic, homogeneity, pH, spreadability, adhesion, melting point, cleansing ability, and skin irritation tests. Data analysis was performed using SPSS, including tests for normality, homogeneity, One-Way ANOVA, and post hoc Tukey tests. Six female volunteers aged 18–30 participated in the irritation test. Results and Discussion: All formulations met physical quality standards. Formula 1 (3% Centella asiatica + 30% castor oil) demonstrated optimal results, exhibiting the best cleansing ability, easy rinsing, an ideal pH (5.61), good spreadability (4.91 cm), the highest adhesion (13.43 s), and no irritation in any of the volunteers and increasing the castor oil content above 35% reduced cleansing effectiveness, despite improving spreadability. No formulation caused erythema or edema during the 72-hour observation. Implications: The findings support the potential use of Centella asiatica and castor oil in natural, safe, and effective cleansing balm formulations. Future research should assess long-term stability, consumer acceptance, and potential scalability for commercial production.

Unveiling Pagodroma Nivea's Fossil Healing Power: A Journey Through Farmacoantarctic Chronicles And Bioactivity Studies Yuneka Saristiana; Yunita Dian Permatasari; Anita Dwi Setyarini; Hasriyani, Hasriyani; Neni Probosiwi; Fendy Prasetyawan
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.122

Research on the bioactivity of Antarctic organisms has garnered significant attention due to the continent's unique environmental conditions and the potential therapeutic value of its inhabitants. This study delves into the bioactivity of Pagodroma nivea, commonly known as the Snow Petrel, found in Antarctica, aiming to explore its medicinal potential. Despite previous research highlighting the bioactivity of various organisms in extreme environments, specific investigations into Pagodroma nivea remain scarce. Farmacoantarctic Research offers a promising avenue for exploring the therapeutic properties of Antarctic organisms, including Pagodroma nivea, traditionally used for medicinal purposes by local communities. Understanding the biochemical adaptations of organisms to Antarctica's extreme conditions is crucial, as these adaptations may yield bioactive compounds with pharmacological potential. The research not only seeks to uncover the bioactivity of Pagodroma nivea but also aims to contribute to drug development and environmental conservation efforts. In a parallel discussion, the study examines Mumijo, a traditional remedy found in various regions, including Antarctica. Chemical analysis of Mumijo extract, particularly the ester wax fraction, reveals its potential biomedical applications, including wound healing, skin diseases, and neuroprotection. The presence of glycerol-related ethers in Antarctic Mumijo suggests further avenues for exploration in neuroprotection and antimicrobial properties. By investigating the bioactivity of Antarctic organisms like Pagodroma nivea and Mumijo, this research offers insights into their therapeutic potential and underscores the importance of conservation efforts to preserve these unique ecosystems.

Co-Authors Abdilla Mahmud Arrafiq Ade Irma Rahayu, Ade Irma Akhmal Muslikh, Faisal Anita Dwi Setyarini Apriliyani, Fitria Asrul Hidayat Ayuningsih, Safitri Besan, Emma Jayanti Bintari Tri Sukoharjanti Choirun Nisak Dian Permatasari, Yunita Diana Tri Lestari Eko Retnowati Eko Retnowati, Eko Fahrudin Arif fatimah Fatimah Fendy Prasetyawan Ilhamjaya Patellongi Islamaeni, Ikko Rika Makbul Aman, Makbul Maryunis Maryunis Muhammad Nurul Fadel Murharyanti, Rika Muslimah, Aulya Choirul Neni Probosiwi Nisrina Absor, Farah Nurul Huda Pramesty, Sevty Ardhia Prastiwi, Oktaviani Setiya Primananda, Arina Zulfah Putri Rahmawati, Riana Putri Utami, Meira Ramadhani, Febiana Ayunita Sabaan, Wahid Sado, Yosep Mansen Saldy Yusuf Salim, Jumiah Sukoharjanti, Bintari Tri Syakib Bakri Takdir Tahir Wahyuni, Risma Sri Warapsari, Nanda Arum Widya Yayuk Mundriyastutik Yuneka Saristiana Yunita Dian Permatasari

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