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All Journal Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Sains dan Komunitas Jurnal Kesehatan Bakti Tunas Husada SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Indonesian Journal of Medicine Jurnal Farmasi Indonesia Jurnal Ilmu Kefarmasian Indonesia Health Sciences and Pharmacy Journal Majalah Farmasetika Pharmacoscript Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat INDRA: Jurnal Pengabdian kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacy Genius Jurnal Kesehatan Bakti Tunas Husada Medical Sains : Jurnal Ilmiah Kefarmasian
Yedy Purwandi Sukmawan
Bakti Tunas Husada Health Science College
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Ilmu Kefarmasian Indonesia

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Efektifitas Rebusan Daun Babadotan dan Kombinasinya dengan Pregabalin sebagai Anti Nyeri Neuropatik serta Uji Toksisitas Akutnya Yedy Purwandi Sukmawan; Hendy Suhendy; Maritsa Nurfatwa
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1057

Abstract

Neuropathic pain is a condition that is difficult to treated and impaired quality of life. The objective of the study was to determine the anti-neuropathic pain effectivity of Ageratum conyzoides aqueous extract and the acute toxicity study. We had 7 groups (normal, negative, pregabalin, ageratum. conyzoides-I (AC-I) 50mg/kg BW, A. conyzoides-II (AC-II) 100mg/kg BW, combination of pregabalin and AC-II), combination of AC-II and naloxone). Each group contain 5 animals (mice). All groups was induced with pyridoxine 400 mg/kg BW i.p for 14 days to cause neuropathy and followed by hyperalgesia, allodynia, and wire-hang test. In the acute toxicity study, we had 1 group and contain 5 animals (rats). The results of the hyperalgesia and allodynia study showed the effect of AC-II was better than AC-I. The combination of pregabalin and AC-II was better than AC-II as monotherapy (p<0.05). However, AC II activity was abolished when combined with naloxone. In wire hang test demonstrated no difference between falling score (p: 0.053) and reaching score (0.903), that showed AC-II wasn’t impaired the motoric system. No death or toxicity symptoms were observed for 14 days in the acute toxicity study. A. conyzoides aqueous extract is potential for anti-neuropathic pain..
Antidepressant Activity of Some Fractions of The Basil Leaves [Ocimum Basilicum (L)] on The Swiss Webster Male Mice Hendy Suhendy; Muharam Priatna; Yedy Purwandi Sukmawan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (574.085 KB) | DOI: 10.35814/jifi.v16i2.533

Abstract

Objectives : Determine the antidepressant activity of some fractions of the leaves of Ocimum basilicum L Methods : The experimental methods are using Force Swimming Test and Tail Suspension Test. The experiment was divided into seven groups. Negative control group (CMC 1 %), Positive control group (fluoxetine 0,052 mg/20 g BW of mice), test I group (fraction of n-hexane 50 mg/Kg BW), test II group (fraction of ethyl acetate 50 mg/Kg BW), test III group (fraction of ethanol 50 mg/Kg BW), test IV group (combination of cyproheptadine 0,0208 mg/20 g BW of mice and fluoxetine 0,052 mg/20 g BW of mice) and test V group (combination of cyproheptadine 0,0208 mg/20 g BW of mice and fraction of ethyl acetate 50 mg/Kg BW). Result : The Force Swimming Test and Tail Suspension Test showed the same result that ethyl acetate fraction was given significant difference (p<0,05) in immobilization time reduction compared to negative control and has a better immobility reduction time than other groups. Added on cyproheptadine to fluoxetine and ethyl acetate fraction groups showed an increased in immobilization time compared to fluoxetine and ethyl acetate fraction alone. Conclusion : Ethyl acetate fraction showed better antidepressant activity than another fraction through the role of serotonin.
Co-Authors Afifah, Fitri Nur Agustin, Desi Alifiar, Ilham Anisa, Anis Billah, Tazkia Hasna Bilqis, Juwita Amanda Citra Dewi Salasanti Dianingsih, Meisye Utami Esti Deviana Esti Deviana Fauziah, Risa Nur Febrianti, Wulan Hendy Suhendy Hendy Suhendy Hendy Suhendy Hendy Suhendy Hidayati, Nurlaili Dwi Husadiani, Humaira Nursyifa I Ketut Adnyana Ilham Alifiar, Ilham Ira Rahmiyani Irma Amalia Isma, Naylatul Ismi, Sheptia Nur Jahara, Syabila Arnika Keni Idacahyati Kusmiati, Karin Kusnandar Anggadiredja Lia Amalia Maharani, Ira Maria Ulfa Maritsa Nurfatwa Meisya, Mesiya Mubarok, Samsul Muharam Priatna Nidi Halipah Nur Aulia, Iva Fadia Nur Laili Dwi Hidayati Nur Rahayuningsih, Nur Nurjahan, Nurjahan Nurjanah, Tamia Febriani Pandu Nurdiansyah Pebrianti, Setiani Putri, Nadhira Alika Putri, Suci Gandara Putri, Vicky Febriani Rahmawati Rahmawati Rani Rahmawati Ratih Aryani Rezky Fahrizal Firdaus Rojak, Rizki Ahmad Romadin, Mohammad Angga Ibnu Sarah Sahila Sidik, Hasbi Muhammad Solihah, Silfi Isyahul Sonia, Irma Sutiawan, Agus Tita Nofianti, Tita Ulfah, Nabila Maulidia Yusuf, Fitra Arif Maulana