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All Journal Universa Medicina Jurnal Respirologi Indonesia Oto Rhino Laryngologica Indonesiana Jurnal Dharma Bhakti Ekuitas Metta : Jurnal Ilmu Multidisiplin JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA Jurnal Indonesia Sosial Sains AMMA : Jurnal Pengabdian Masyarakat
David Tjahyadi
Universitas Trisakti
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Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats Tjahyadi, David; Parwanto, Edy; Sisca, Sisca; Xavierees, Endrico; Jaya Edy, Hosea; Digambiro, Reza Aditya; Oladimeji, Ashaolu Victoria; Tjahyadi, Joey Joshua Vidova; Gabrielle, Laurentia
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.263-275

Abstract

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.
Role of sex steroid hormone on hand grip strength and cognitive function in the elderly Parwanto, Edy; Tjahyadi, David; Amalia, Husnun; Hairunisa, Nany; Edy, Hosea Jaya; Oladimeji, Ashaolu Victoria; Djebli, Noureddine
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.329-345

Abstract

The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.
Analysis of Pulmonary Function between E-Cigarette Users and Non-Smokers Aged 20–30 Years in Jakarta Digambiro, Reza Aditya; Parwanto, Edy; Tjahjadi, David; Ditriana, Ditriana
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.791

Abstract

Background: This study aimed to compare pulmonary function between e-cigarette users and non-smokers aged 20–30 years in Jakarta. Methods: A cross-sectional study was carried out between May 2023 and May 2024 at SMC Clinic Jakarta, Ibnusina Hospital Jakarta, and Naura Medika Clinic Depok. The sample consisted of 65 individuals who used e-cigarettes and 63 individuals who did not smoke. Spirometry was employed to evaluate pulmonary function by measuring forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. The data were analyzed using independent t-tests using IBM SPSS software version 25.0. Results: The study revealed substantial disparities in pulmonary function between individuals who use e-cigarettes and those who do not smoke. Individuals who use e-cigarettes had significantly reduced FEV1 at 3.02±0.50 L and FVC at 4.00±0.47 L, in comparison to non-smokers (FEV1=3.51±0.57 L; FVC=4.57±0.50 L). E-cigarette users exhibited a considerably lower FEV1/FVC ratio (74.86±5.55) compared to non-smokers (79.29±5.11), suggesting a higher occurrence of obstructive airway diseases. Conclusion: Young adults aged 20-30 years in Jakarta who use e-cigarettes experience a decrease in pulmonary function. The results emphasize the possible respiratory hazards associated with the use of e-cigarettes and emphasize the necessity for greater awareness and regulatory actions to tackle these hazards.
Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca, Sisca; Parwanto, Edy; Hartanti, Monica Dwi; Tjahyadi, David
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Abstract

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values ​​of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia
Pelayanan Kesehatan Terhadap Lansia Dalam Meningkatkan Kualitas Hidup Di Kelurahan Meruya Selatan Jakarta Sisca; Monica Dwi Hartanti; Orliando Roeslan; David; Yani Kurniawan; ML Edy Parwanto; Joey Joshua Vidova Tjahyadi
AMMA : Jurnal Pengabdian Masyarakat Vol. 3 No. 2 : Maret (2024): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Elderly people are part of the life process that cannot be avoided and will be experienced by every human being. Objective: to help the elderly community in the area of the Lukas Church of Maria Kusuma Karmel Parish, West Jakarta, Meruya Selatan Subdistrict to improve their quality of life, especially in the physical domain, through counseling activities, health services and treatment so that it is hoped that it can improve the quality of life of the elderly. Method: Health services were provided to 60-70 elderly people in South Meruya Village. The service team consists of 6 lecturers and 3 students. Blood pressure, height and weight, glucose, uric acid and cholesterol were measured. Results: High blood pressure was checked for around 37% of elderly people, 33% for cholesterol, 10% for glucose and 57% for uric acid. Conclusion: Regular health checks are an important part of comprehensive prevention and management of chronic diseases. Family and local community support can help elderly residents undergo treatment to improve their quality of life.
Tingkat Pengetahuan Kecacingan Di Desa Sukasari Pandeglang David Tjahyadi; Edy Parwanto; Haryo Ganeca Widyatama; Sisca Sisca; Reza Aditya Digambiro; Alfred Pakpahan
AMMA : Jurnal Pengabdian Masyarakat Vol. 3 No. 6 : Juli (2024): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Worm disease still a serious problem and is second health problem in Indonesia come after malnutrition. Cumulative worms in human body can cause loss of substances that are useful for growth. The Filariasis and Worm Worms Sub-Directorate of P2PL stated that the prevalence of worm diseases in Pandeglang Regency was 58.3%. Various worm larvae were found when examining soil samples taken at the homes of residents of Sukasari, Pulosari, Pandeglang villages. The aim of this community service (PKM) is to increase knowledge about worm diseases. This Community Service Method (PKM) uses the counseling or lecture method by the presenter. Before and after counseling, residents were given a questionnaire to measure their level of knowledge about worm diseases. Residents' knowledge increased after being given counseling and it is hoped that this can help the community to prevent the emergence of worm diseases in the future.
Penyuluhan dan Pelatihan Perilaku Hidup Bersih Sehat (PHBS): Mengajarkan Anak TK Hidup Sehat dan Bersih Sejak Dini Endrico Xavierees Tungka; David David; Suriyani Suriyani; Alfred Pakpahan; John Steward Castellano; Sisca Sisca
Jurnal Dharma Bhakti Ekuitas Vol. 10 No. 1 (2025): Jurnal Dharma Bhakti Ekuitas
Publisher : Universitas Ekuitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52250/dbe.v10i1.1011

Abstract

Counseling on clean and healthy living behavior among kindergarten children is highly urgent, considering that early childhood is a golden age in the formation of healthy living habits that will extend into adulthood. At this stage of development, children begin to absorb various information and form routines, so early healthy living behaviour education has the potential to create a sustainable healthy lifestyle. One important aspect clean and healthy living that is the main focus is the habit of washing hands properly according to the WHO six-step standard. This activity aims not only to provide direct education to kindergarten children, but also to raise awareness of teachers and parents as important figures in the process of mentoring and reinforcing healthy behaviors. The methods used in the educating are designed to be interactive and engaging for 30 children, including educational games, fun animated videos, and hands-on handwashing practice sessions under the supervision of health workers and educators. Post-activity evaluations showed that approximately 90% of children actively participated, and 80% of them were able to correctly state the six steps of handwashing. Furthermore, children demonstrated increased independence in handwashing, including using soap, rubbing palms, backs of hands, between fingers, and nails, and rinsing with clean water. This ability is a key indicator of the intervention's success. By collaboratively involving schools and families, this outreach program has proven effective in instilling a culture of clean living from an early age.Keywords: clean and healthy habits, early childhood, training   Abstrak Penyuluhan Perilaku Hidup Bersih dan Sehat (PHBS) di kalangan anak Taman Kanak-kanak (TK) memiliki urgensi yang sangat tinggi, mengingat usia dini merupakan masa emas dalam pembentukan kebiasaan hidup sehat yang akan membentang hingga masa dewasa. Pada tahap perkembangan ini, anak mulai menyerap berbagai informasi dan membentuk rutinitas, sehingga edukasi PHBS yang diberikan secara dini berpotensi menciptakan pola hidup sehat yang berkelanjutan. Salah satu aspek penting dari PHBS yang menjadi fokus utama adalah kebiasaan mencuci tangan dengan benar menurut standar enam langkah WHO. Kegiatan ini bertujuan tidak hanya untuk memberikan edukasi langsung kepada anak-anak TK, tetapi juga untuk meningkatkan kesadaran guru dan orang tua sebagai figur penting dalam proses pendampingan dan penguatan perilaku sehat. Metode yang digunakan dalam penyuluhan dirancang secara interaktif dan menarik bagi 30 anak-anak TK dan orang tua, meliputi permainan edukatif, tayangan video animasi yang menyenangkan, serta sesi praktik langsung mencuci tangan di bawah pengawasan tenaga kesehatan dan pendidik. Evaluasi pasca-kegiatan menunjukkan bahwa sekitar 90% anak aktif berpartisipasi, dan 80% di antaranya mampu menyebutkan keenam langkah mencuci tangan secara tepat. Lebih lanjut, anak-anak menunjukkan peningkatan kemandirian dalam melakukan cuci tangan, termasuk penggunaan sabun, menggosok telapak tangan, punggung tangan, sela jari, kuku, hingga membilas dengan air bersih. Kemandirian ini menjadi indikator keberhasilan utama dari intervensi. Dengan melibatkan sekolah dan keluarga secara kolaboratif, penyuluhan ini terbukti efektif dalam menanamkan budaya hidup bersih sejak dini.Kata kunci: PHBS, anak usia dini, penyuluhan
Sinonasal schwannoma in a patient with Eisenmenger syndrome Reza Aditya Digambiro; Ashri Yudhistira; David Tjahyadi; Dewi Hastuty
Oto Rhino Laryngologica Indonesiana Vol. 56 No. 1 (2026): VOLUME 56, NO. 1 JANUARY - JUNE 2026
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v56i1.765

Abstract

Background: Sinonasal schwannoma is a rare tumor of the nasal cavity and paranasal sinuses, often presenting with recurrent epistaxis and nasal obstruction. Eisenmenger syndrome is a life-threatening cardiopulmonary condition resulting from uncorrected congenital heart disease. Purpose: To report a rare case of sinonasal schwannoma in a patient with Eisenmenger syndrome, and to explore therapeutic considerations. Case report: A 23-year-old male presented with recurrent nasal bleeding and progressive dyspnea. Imaging revealed a lobulated mass in the right nasal cavity. Histopathological evaluation confirmed sinonasal schwannoma. The patient also had an unrepaired secundum atrial septal defect with Eisenmenger physiology, rendering surgical excision high-risk. Clinical question: In patients with sinonasal schwannoma and Eisenmenger syndrome, when is surgical excision appropriate? Can conservative therapy provide adequate control in high-risk cases? Method: A literature search was conducted on PubMed, Medline, and Google Scholar using relevant keywords. Articles were selected based on the last 10 years of publication and full-text availability. Result: No studies specifically addressed this dual pathology. However, available literature emphasized the need for individualized management, with surgery being curative in healthy patients, and conservative observation preferred in high-risk cardiac cases. Conclusion: While surgical excision remains the “In patients with sinonasal hemangiopericytoma (HPC), conservative management may be justified in patients with Eisenmenger syndrome due to the prohibitive cardiopulmonary risks.
Hubungan Intensitas Penggunaan Media Sosial Dengan Eating Disorder Pada Remaja SMA Sahat Elia Carlos Siahaan; David Tjahyadi
Metta : Jurnal Ilmu Multidisiplin Vol. 6 No. 1 (2026)
Publisher : Jayapangus Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37329/metta.v6i1.5274

Abstract

Adolescence is a developmental stage highly susceptibel to psychososcial pressures, which contributes to an increased risk of eating disorders amidst the dominance of social media use. Although previous studies have shown contradictory result this, study aims to provide empirical clarification regarding the relationship between social media use intensity and eating disorder risk in adolescents. Utilizing a cross-sectional design, thos study involved 118 students at Regina Pacis Bogor High School selected through simple random sampling. Data were collected using the Social Networking Time Use Scale (SONTUS) and the Eating Attitude Test-26 (EAT-26) instruments, followed by Chi-square analysis. The findings indicated that the majority of respondents had a moderate instensity of social media use (58,5%) and were not at risk for eating disorders (84,7%). Statistical testing yielded a p-value of 0.721 (p>0,05), confirming the absence of significant contribution to adolescent mental healtth literature by demonstrating that social media use intensity is not the sole determinant in the development of eating disorders, rather othe multiaxial factors warrant further exploration.
Hubungan Keterampilan Koping dan Empati Terhadap Kesehatan Mental Remaja di SMA Tiara Alya Fauziyah; David Tjahyadi
Metta : Jurnal Ilmu Multidisiplin Vol. 6 No. 1 (2026)
Publisher : Jayapangus Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37329/metta.v6i1.5275

Abstract

Adolescence is a vulnerable developmental period marked by increased risk of mental health problems. Coping skills and empathy are important psychological factors that may influence adolescent mental well-being. This study examined the relationships among coping skills, empathy, and mental health among high school students using a cross-sectional quantitative design with 152 participants. Data were collected using the Brief COPE, Basic Empathy Scale (BES), and Self-Reporting Questionnaire-20 (SRQ-20), and analyzed using Pearson correlation. Findings indicated that adaptive coping skills were significantly associated with fewer symptoms of emotional mental disorders. In contrast, empathy showed a significant positive correlation with mental disorder symptoms. This paradoxical finding suggests that while empathy is socially beneficial, high levels of empathy may increase psychological vulnerability when not accompanied by adequate emotional regulation. These results highlight the importance of strengthening adaptive coping strategies while simultaneously fostering balanced empathy supported by emotional regulation skills in adolescent mental health interventions.
Co-Authors Alfred Pakpahan Alfred Pakpahan Ashri Yudhistira Dewi Hastuty Ditriana, Ditriana Djebli, Noureddine Edy Parwanto Endrico Xavierees Tungka Flavius Vania Gabrielle, Laurentia Hairunisa, Nany Hanslavina Arkerman, Hanslavina Haryo Ganeca Widyatama Haryo Ganeca Widyatama Hosea Jaya Edy Husnun Amalia Joey Joshua Vidova Tjahyadi John Steward Castellano ML Eddy Parwanto ML Edy Parwanto ML Edy Parwanto Monica Dwi Hartanti Monica Dwi Hartanti, Monica Dwi MZ Onibala, MZ Oladimeji, Ashaolu Victoria Orliando Roeslan Parwanto, Edy Putri Suspita Faizal Reza Aditya Digambiro Reza Aditya Digambiro Sahat Elia Carlos Siahaan Sisca Sisca Sisca Sisca Sisca Sisca Sisca Sisca Sisca, Sisca Suriyani Suweino Suweino Tiara Alya Fauziyah Tjahyadi, Joey Joshua Vidova Widyatama, Haryo Ganeca Xavierees, Endrico Yani Kurniawan