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Analisis Kandungan Calsium (Ca) Kalium (K) Pada Sedimen Danau Limboto Menggunakan Metode AAS Annisa Untuba; Ishak Isa; Wiwin Rewini Kunusa; Jafar La Kilo
Jambura Journal of Chemistry Vol 4, No 2 (2022): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i2.14768

ABSTRACT Lake Limboto is a natural resource currently owned by Gorontalo Province. Lake Limboto has played a role as a source of income for fishermen, flood prevention, irrigation water sources and tourism objects. Sediment is sediment that comes from the breakdown of rocks, or biological materials that are transported through a liquid, and solid materials (sediments) that float in, or are deposited in water. This study aims to determine the content of calcium and potassium in the sediment of Limboto lake, straw, and analysis of Ca and K in liquid organic fertilizer from straw and sediment using the AAS method. The results showed that the levels of calcium (Ca) from the three points in the sediments of the Limboto lake met the SNI standards, namely 0.20, 0.37, 0.59%. Meanwhile, the potassium (K) levels from the three points did not meet the SNI standards, namely 0.15, 0.10, 0.13%, different from those obtained from the analysis of the calcium and potassium content of the straw that met the SNI standards of 0.35% and 1.52. %. In liquid organic fertilizer the content of Ca and K from three points yields little, while the results of Ca content meet the SNI standards of 0.04, 0.05, 0.06%, the results of K levels do not meet the SNI standards, namely 0.09, 0.07, 0.08%. Keywords: Limboto Lake; Straw Sediment; Calcium; Potassium

Measuring Students' Scientific Argumentation Skills in Explaining Phenomena Related to Acid-Base Concepts Rahmawati Hilala; Lukman Abdul Rauf Laliyo*; Jafar La Kilo; Julhim S. Tangio; Erni Mohamad; Mangara Sihaloho
Jurnal Pendidikan Sains Indonesia Vol 11, No 2 (2023): APRIL 2023
Publisher : Universitas Syiah Kuala

Scientific argumentation is one of the main competencies of students in communicating chemical phenomena through the application of conceptual mastery that they have understood. The development of this ability has been postulated in the 2013 curriculum through constructivist-based learning approaches and scientific inquiry, either in the classroom or the laboratory. However, there is relatively little information on how students' scientific argumentation skills develop. This study aims to measure students' scientific argumentation skills in explaining five science phenomena related to the acid-base concept, namely: acid rain, salt crystal making, the use of antacids as ulcer medicine, the use of CaMgCO3 dolomite fertilizer, and the difference in the acidity level of HCl and H2SO4, using Rasch modeling. Each phenomenon was measured by three multiple-choice test items, which were developed to test students' ability to make claims (Q1), evidence (Q2), and justification (Q3). The data were analyzed using Rasch modeling, allowing researchers to measure the item and individual respondent levels. Respondents were 100 chemistry students in Gorontalo, who were differentiated in gender and adversity quotient. The results showed that the measurement instrument has good validity and reliability. In addition, it was found that students' abilities differed; some items responded differently regarding gender and adversity quotient. Most students tended to be weak in explaining the phenomenon of acid rain, the use of antacids for ulcer disease, the use of dolomite fertilizer, and the difference in the acidity level of HCl and H2SO4

STUDI HKSA SENYAWA ANALOG QUINOLON-4(1H)-IMINE SEBAGAI ANTIMALARIA MENGGUNAKAN PERHITUNGAN HARTHREE-FOCK Jafar La Kilo; Akram La Kilo
Jambura Journal of Chemistry Vol 4, No 1 (2022): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i1.20008

Penelitian ini bertujuan untuk melakukan studi hubungan kuantitatif struktur-aktivitas (HKSA) terhadap senyawa analog Quinolon-4(1H)-imine sebagai agen antimalaria. Pendekatan HKSA digunakan untuk menghubungkan aktivitas biologi molekul dengan deskriptor yang dihasilkan dari perhitungan menggunakan metode kimia kuantum Harthree-Fock Sebanyak 22 senyawa turunan Quinolon-4(1H)-imine digunakan sebagai bahan kajian, dengan perhitungan deskriptor elektronik dan molekul yang berpengaruh terhadap aktivitas antimalaria. Model HKSA dianalisis menggunakan metode regresi linear berganda (MLR) dan delapan model persamaan HKSA terbaik dihasilkan. Model-model tersebut kemudian divalidasi dan model terbaik dipilih berdasarkan parameter statistik yang signifikan. Rancangan senyawa usulan juga dilakukan berdasarkan model terbaik, dengan mengganti substituen pada senyawa turunan Quinolon-4(1H)-imine. Hasil penelitian ini dapat memberikan kontribusi dalam pengembangan obat antimalaria baru dengan pendekatan teoritik dan pemodelan, sehingga dapat mengurangi biaya dan waktu yang diperlukan dalam penemuan dan pengembangan obat antibiotik baru.

Atomistic Simulation of La and Mn-Doped PbBi2Nb2O9 Aurivillius Phase Akram La Kilo; Ramona Nintias R. Abas; Alberto Costanzo; Daniele Mazza; Deasy N Botutihe; Jafar La Kilo
Molekul Vol 17 No 2 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.2.6346

This study aims to determine the effect of Mn3+ and La3+ dopants on the structure of PbBi2Nb2O9 (PBN) using atomistic simulation. PBN phase geometry was optimized before the Mn3+ and La3+-doped phase. Mn3+ partially substituted octahedral Nb5+ in the perovskite layer. While La3+partially substituted Bi3+ in the bismuth layer and dodecahedral Pb2+in the perovskite layer. The concentration (x) of dopants that doped PBN was made in such a way that it produces a phase of Pb1-2xBi1.5 + 2xLa0.5Nb2-xMnxO9 (x = 0, 0.1, and 0.3) which was not charged. The simulation results showed that the optimized PBN cell parameters were in a good agreement with the experimental result. Increasing the concentration of dopants result in the Pb1-2xBi1.5+ 2xLa0.5Nb2-xMnxO9 phase (PBNM-Bi and PBNM-A) being less stable, as indicated by the increased lattice energy. PBNLM-Bi structures experiences an elongation which was showed by the cell parameters of c increase while a and b decrease. La3+prefers to occupy bismuth oxide layer rather than the dodecahedral A-site of the perovskite layer. The results of this simulation can explain the PBLNM structure of experimental results that do not pay attention to the multiplicity of doped PBN with certain dopant concentrations.

Analisis Cemaran Klorin Pada Beras Dengan Metode Volumetri Studi Kasus : Kabupaten Bone Bolango Muhammad Taupik; A. Muâ€™thi Andy Suryadi; Andi Makkulawu; Jafar La Kilo
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.18611

Rice is a staple food because it contains protein needed by the body is a source of energy. Rice that is white and shiny sometimes attracts peopleâ€™s attention. Therefore, to increase buyersâ€™ interest, many sellers add bleaching additives such as chlorine ( a chemical to kill germs) without reckoning the side effects that will be inflicted. This study examines the chlorine content in circulated rice in Bone Bolango Regency. This study used seven rice samples to be analyzed through color and precipitation tests. This research implements a mixed method in the form of qualitative as well as Iodometric and Argentometry titrations for quantitative. The results reveal that in the seven rice samples studied, there was no chlorine content due to the absence of discoloration and precipitate. It is supported by the Iodometric and Argentometric tests which show the results of chlorine levels are at 0%.

Good Laboratory Practice (GLP) in The European Union Viviane Annisa; Jafar La Kilo
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.11781

GLP (Good Laboratory Practice) regulations regulate how to work in laboratories, personnel training, standard operating procedures, software for data recording, documentation, etc. The main goal of GLP is to improve the quality of data testing so that each country can produce continuous and continuous testing of data, avoid repeated testing, and save time. The members of the OECD (Organization for Economic Co-operation and Development) are 29 countries around the world, including Asia-Pacific, America, and Europe. Adherence to the GLP can remove trade barriers between member countries. The GLP principles applied in the European Union are similar to those of the OECD, namely to improve the quality of testing valid data. This study aims to review about Good Laboratory Practice in European Union. The European Union adopted the GLP regulations in 1987. The amendments related to the GLP were carried out following the OECD in 1999. The EU regulatory regulations on GLP 'Directive 2004/9/EC' was later added 'Directive 88/320/EEC' explaining what was given to member states of the Union Europe to establish GLP inspections in each region and Mutual Acceptance of Data (MAD) requirements. Â Non-clinical testing of medicinal products in accordance with the provisions of the GLP refers to the OECD and European Union legislation consisting of 'Directive 2004/10/EC' and 'Directive 2004/9/EC'.

Kajian QSAR Berbasis Machine Learning dalam Desain Antimalaria Senyawa Turunan Quinolon-4(1H)-imine Jafar La Kilo
Jambura Journal of Chemistry Vol 5, No 1 (2023): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i1.22423

Study on antimalarial activity of 22 quinolon-4(1H)-imine derivatives by using Quantitative Structure-Activity Relationships (QSAR) has been performed. Electronic and molecular descriptors were used in Quantitative Structure-Activity Relationships (QSAR) model and it was obtained from Hartree-Fock (HF) molecular orbital calculation with 6-31G basis set. QSAR analysis has been performed by multiple linear regression (MLR) method. The best equation of QSAR model on this study is: pEC50 = -4,177 + (37,902 x qC3) + (171,282 x qC8) + (9,061 x qC10) + (125,818 x qC11) + (-149,125 x qC17) + (191,623 x qC18), with statistical parameters, n = 22; r2 = 0,732; SEE = 0,248; Fcal/Ftab = 2,443 and PRESS = 0,925. The best equation can applied to design and predict new compounds with higher antimalarial activity.

Measuring Students' Scientific Argumentation Skills in Explaining Phenomena Related to Acid-Base Concepts Rahmawati Hilala; Lukman Abdul Rauf Laliyo*; Jafar La Kilo; Julhim S. Tangio; Erni Mohamad; Mangara Sihaloho
Jurnal Pendidikan Sains Indonesia Vol 11, No 2 (2023): APRIL 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jpsi.v11i2.27822

Scientific argumentation is one of the main competencies of students in communicating chemical phenomena through the application of conceptual mastery that they have understood. The development of this ability has been postulated in the 2013 curriculum through constructivist-based learning approaches and scientific inquiry, either in the classroom or the laboratory. However, there is relatively little information on how students' scientific argumentation skills develop. This study aims to measure students' scientific argumentation skills in explaining five science phenomena related to the acid-base concept, namely: acid rain, salt crystal making, the use of antacids as ulcer medicine, the use of CaMgCO3 dolomite fertilizer, and the difference in the acidity level of HCl and H2SO4, using Rasch modeling. Each phenomenon was measured by three multiple-choice test items, which were developed to test students' ability to make claims (Q1), evidence (Q2), and justification (Q3). The data were analyzed using Rasch modeling, allowing researchers to measure the item and individual respondent levels. Respondents were 100 chemistry students in Gorontalo, who were differentiated in gender and adversity quotient. The results showed that the measurement instrument has good validity and reliability. In addition, it was found that students' abilities differed; some items responded differently regarding gender and adversity quotient. Most students tended to be weak in explaining the phenomenon of acid rain, the use of antacids for ulcer disease, the use of dolomite fertilizer, and the difference in the acidity level of HCl and H2SO4

Studi Potensi Pirazolin Tersubstitusi 1-N dari Thiosemicarbazone sebagai Agen Antiamuba melalui Uji In Silico La Kilo, Akram; Aman, La Ode; Sabihi, Ismail; La Kilo, Jafar
Indonesian Journal of Chemical Research Vol 7 No 1 (2019): Edisi Bulan Juli (Edition For July)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2019.7-akr

This Research aims to study Quantitative Structure-Activity Relationship (QSAR) of pyrazoline analogues, designing the new potential compounds as antiamoebic and study the interactions between the new compunds and the drugs target by molecular docking approach. This research was a theoritical research using computational chemistry method. The object of research was 21 novel of 1-N-substituted pyrazoline analogues of thiosemicarbazones with their antiamoebic biological activity. The data of research was obtained from quantum chemistry calculation and statistically analysis using Multiple Linear Regression (MLR). The resulting QSAR equation was Log IC50 = 0.869 + (0.081 x TPSA) + (0.018 x HF) + (0.527 x E-HOMO) + (3.378 x E-LUMO) + (-16.938 x Glob) + (0.234 x LogP), with statistic parameters of n = 21; R2 = 0.933; SEE = 0.14558; FHitung/FTabel = 8.607; PRESS = 0.491. This equation was used as a basic for designing and predicting the new antiamoebic compounds of pyrazoline analogues. The design of new compound of two lead compounds with the Topliss resulted 5 of 18 new compounds having theoretical better activity than the lead compound. Molecular docking study indicated that all of the best compounds have ability to bind to drug target macromolecule.

Molecular Docking of Secondary Metabolite Compounds of Andrographis Paniculata Plant as Potential Covid-19 Drug Candidate Netty Ino Ishak; Akram La Kilo; Dandi Saputra Halidi; La Ode Aman; Jafar La Kilo; Weny J.A. Musa
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1845

The aim of this research was to investigate the interaction between secondary metabolite compounds and the Mpro receptor, which was the main protein in Covid-19. Ligand-receptor interactions were studied using the Molecular Docking method. The validation results indicated that the test ligand Andrographolide had a higher affinity value compared to the standard ligand, with a value of -6.6 kcal/mol compared to the standard ligand's -7.5 kcal/mol. Additionally, the compound 14-Acetyl-3,19-isopropylideneandrographolide, 5,4 dihydroxy-7,8,2',3'-tetramethoxyflavone-5-glucoside had an affinity of -7.5 kcal/mol, Andrographidin A had -7.6 kcal/mol, Andrographiside had -7.7 kcal/mol, Skullcapflavone I had 7.7 kcal/mol, 5-Hydroxy-7,8,2'-trimethoxyflavone-5-glucoside had -7.7 kcal/mol, Apigenin had 7.7 kcal/mol, 5-Hydroxy-7,8-dimethoxyflavone-5-glucoside had -7.8 kcal/mol, Neoandrographolide had -7.8 kcal/mol, Andropanoside had -7.9 kcal/mol, Wogonin-5 glucoside had -8.1 kcal/mol, 5,2',3'-Trihydroxy-7,8-dimethoxyflavone-3'-glucoside had -8.4 kcal/mol, and Bisandrographolide had -8.5 kcal/mol. From the molecular docking results, the secondary metabolite compounds from the Andrographis paniculata plant exhibited significant interactions surpassing the standard ligand N3. Active residue interactions observed included Phe140, Leu141, Asn142, Gly143, His163, Glu166, Gln189, and Thr190. Keywords: Andrographis paniculata; Covid-19 drug; Mpro receptor; molecular docking

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