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All Journal Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Kimia Riset Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Media Kesehatan Politeknik Kesehatan Makassar Journal of Pharmaceutical and Medicinal Sciences Jurnal Mandala Pharmacon Indonesia Jurnal farmasi UIN Alauddin Makassar Current Research on Biosciences and Biotechnology Jurnal Katalisator Borneo Journal of Pharmacy
Fitriyanti Jumaetri Sami
Departemen Analisis Farmasi dan Kimia Medisinal, Fakultas Ilmu Kesehatan, Universitas Almarisah Madani
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Anthocyanin From Rosella Petals (Hibiscus sabdariffa L.) as Anion Chemosensory Syamsu Nur; Imrawati Imrawati; Fitriyanti Jumaetri Sami; Alfat Fadri; Megawati Megawati
Jurnal Farmasi dan Ilmu Pengobatan Vol 6 No 2 (2021): JPMS Volume 6 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v6i2.132

Abstract

Rosella plants are a type of hibiscus plant and can be used as a health drink for various diseases. Rosella flowers have the potential to be used as a source of natural dyes in food. The purpose of this study is to determine the anthocyanin of rosella petals as a chemosensory anion compound. To be used as a chemosensory anion compound, testing needs to be done. The ethanol extract of rosella flower petals was extracted by sonication and the filtrate was evaporated to obtain a red extract. From the results of the extract obtained a rendition of 2.9%. Then the extract was tested as an anion chemosensory with the stages of determining the total anthocyanin content, solvatochromic test, and chemosensory test for saturated anions. The total anthocyanin content obtained was 7.648 grams / 100 grams and the chemosensor test results for saturated anions showed a significant change with the addition of KSCN from pink to clear color. Anthocyanin contained in rosella petals can be used as a chemosensor cyanide anion compound.
Isolation, identification and biochemical studies of gallic acid from Turbinaria decurrens Bory Fitriyanti Jumaetri Sami; Syamsu Nur
Current Research on Bioscences and Biotechnology Vol. 4 No. 1 (2022)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2022.4.1/X7DD09RY

Abstract

Cancer is one of the diseases that cause the biggest death in the world. The research for natural compounds derived from marine is very developed at this time, especially in algae. Brown algae have more phenolic content than other types of algae, T. decurrens Bory is one of the brown algae that had taken from the Indonesian island of Dutungan, South Sulawesi. Phenolic groups are also known to be able to inhibit the growth of cancer cells. The purpose of this study is to isolate and identify compounds using spectrophotometer instruments. The isolates obtained were tested for anticancer activity against H460 and MCF-7 cells. Extraction was carried out by maceration method, fractionation was done by chromatography column eluent n-hexane:EtOAc: MeOH by increasing polarity. The structure determination is done based on the interpretation of FT-IR, 1D-NMR 1H,13C, and ESI-LCMS spectra data and anticancer activity test used MTT bioassay. The isolate is known as gallic acid, and the isolate was tested for anticancer activity against H460 and MCF-7 cells. The result is obtained IC50 value for H460 cells 5.69 μg/ml and MCF-7 cells 4.63 μg/ml. As a positive control used cisplatin with an IC50 value of 5.81 μg/ml against H460 cells and MCF-7 cells with a value of 5.59 μg/ml. Gallic acid has a higher toxic effect compared to cisplatin. One phenolic compound has been found in T. decurrens Bory which is gallic acid. Gallic acid has a higher toxic effect than cisplatin, this compound can be used as an anticancer agent.
SINTESIS FURFURAL DARI UMBI TALAS SAFIRA (Colocasia esculenta (L.) Schott var. Antiquorum) N Nursamsiar; Fitriyanti Jumaetri Sami; Dayan El-Roy Matitawaer; L Lukman; Muhammad Aswad
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 8, No 1 (2022): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/pharmauho.v8i1.18327

Abstract

Furfural merupakan senyawa aldehid aromatik dan termasuk salah satu senyawa terpenting dalam golongan senyawa heterosiklik yang dikenal dengan nama furan. Dalam industri furfural digunakan sebagai bahan baku adiponitril, furfural alkohol, metil furan, pirrole, piridin, asam furoat, hidro furamid, tetrahidrofurfuril alkohol, dan fenol-aldehid. Penelitian ini bertujuan untuk mensintesis furfural dari umbi talas safira. Pembuatan furfural dilakukan melalui hidrolisis pentosan menggunakan katalis asam sulfat kemudian terjadi dehidrasi dan siklodehidrasi membentuk furfural. Hasil karakterisasi menunjukkan indeks bias furfural sebesar 1,6207 yang memberikan serapan pada panjang gelombang maksimum 277,43 nm, dan penentuan gugus fungsi didapatkan serapan C-H aldehid pada daerah 2852,72 cm-1, serapan C=O aldehid pada daerah 1734,01 cm-1, serapan C-O eter pada daerah 1151,34 cm-1. Furfural dapat disintesis dari umbi talas safira dengan rendamen sebesar 0,37%.
Phenolic and Flavonoid Content of Black Mulberry (Morus nigra L.) Stem and Their Evaluation Antioxidant and Cytotoxic Profile Syamsu Nur; Fitriyanti Jumaetri Sami; Marwati Marwati; Nursamsiar Nursamsiar; Alfat Fadri; Khairuddin Khairuddin
Borneo Journal of Pharmacy Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i4.3760

Abstract

The black mulberry (Morus nigra) plant has been widely developed for its bioactivity as natural medicine. This study evaluated plant extracts' total phenolic and flavonoid content and their correlation to M. nigra stem's antioxidant activity and toxicity. Dry powder from the M. nigra stem was extracted by maceration with 96% ethanol to obtain a thick extract (TE) and fractionated using hexane (HF), ethyl acetate (EAF), and ethanol-aqueous (EF). The samples were analyzed for a compound using reagents and the determination of total phenolic and flavonoid content. The samples were evaluated for antioxidant activity using several parameters and their cytotoxic effects using the BSLT method. Identification of compounds in EAF was confirmed to contain phenolic, flavonoids, alkaloids, saponins, tannins, steroids, and terpenoids. EAF showed higher phenolic and flavonoid content than others. The evaluation of antioxidant activity showed that extracts and fractions from M. nigra stems showed the ability to reduce ions and free radicals. EF sample has activity in reducing Mo (IV) ion by TAC method of 98.82±0.53 µM/mg, indicating substantial antioxidant capacity. In addition, EAF samples showed potential activity in reducing DPPH, hydroxyl, and peroxide radicals in the β-carotene bleaching method with IC50 values of 12.13, 42.06, and 57.6 µg/mL, respectively. Similar activity was also seen in the cytotoxic effect of a robust EAF sample with an LC50 value of 16.31 µg/mL. The results show that EAF can be developed as a raw material for traditional medicine as an antioxidant and anticancer candidate with a significant flavonoid and phenolics content.
Pengaruh Jenis Pelarut Terhadap Kadar Fenolik dan Flavonoid Total Daun Kesambi (Schleichera oleosa. L) Asal kabupaten Gowa Nursamsiar Nursamsiar; Alfad Fadri; Marwati Marwati; Fitriyanti Jumaetri Sami; Nur Syam Hidayah Rahma Ismail; Henny Kasmawati
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.394

Abstract

Daun kesambi (Schleichera oleosa L.) merupakan tanaman yang banyak digunakan dalam pengobatan karena mengandung metabolit primer maupun sekunder seperti fenolik dan flavonoid. Efek farmakologi dari tanaman ini merupakan sumbangan dari adanya senyawa golongan fenolik dan flavonoid. Penarikan kandungan senyawa dari tanaman dipengaruhi oleh tingkat kepolaran pelarut berdasarkan prinsip like dissolve like. Penelitian ini dilakukan untuk mengetahui kadar flavonoid dan fenolik total pada daun kesambi dengan variasi cairan penyari. Simplisia kering daun kesambi diekstraksi menggunakan berbagai pelarut dengan metode ultrasonic assisted extraction (UAE) yang dimulai dengan n-heksan dan dilanjutkan secara berturut-turut dengan etil asetat, aseton dan metanol. Penentuan kadar fenolik dan flavonoid total dari semua ekstrak daun kesambi dilakukan secara kolorimetri dengan menggunakan reagen kimia dan absorbansinya diukur dengan menggunakan spektrofotometer UV-Visible. Hasil penelitian menunjukkan Kadar fenolik total pada ekstrak daun kesambi diperoleh hasil ekstrak aseton sebesar 355,3 ± 3,74 (mgEAG/g), ekstrak etil asetat sebanyak 158,3 ± 3,33 (mgEGA/g), ekstrak metanol 86,2 ± 1,08 (mgEAG/g) dan ekstrak n-heksan 18,5 ± 0,45 (mgEGA/g). Sementara itu, kadar flavonoid total ekstrak daun kesambi diperoleh hasil ekstrak etil asetat 166,3 ± 3,72 (mgEQ/g), ekstrak aseton 61,4 ± 2.60 (mgEQ/g), ekstrak metanol 65,7 ± 0,65 (mgEQ/g) dan ekstrak n-heksan sebesar 33,7 ± 0,83 (mgEQ/g). Kadar fenolik total tertinggi diperoleh pada ekstrak aseton dan kadar flavonoid total tertinggi diperoleh pada ekstrak etil asetat.
Korelasi Antara Kadar Total Flavonoid dan Fenolik dari Ekstrak dan Fraksi Daun Jati Putih (Gmelina Arborea Roxb.) Terhadap Aktivitas Antioksidan: Correlation Between Total Phenolic and Flavonoid Contents of Jati Putih (Gmelina arborea Roxb.) Leaves Extract and Fraction Toward Antioxidant Activity Nur, Syamsu; Sami, Fitriyanti Jumaetri; Awaluddin, Akbar; Afsari, Mutiara Indah Ayu
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.042 KB) | DOI: 10.22487/j24428744.2019.v5.i1.12034

Abstract

This experiment aims to determine the correlation of total phenolic and flavonoid content of jati putih leaves fraction (Gmelina arborea Roxb.) towards Antioxidant activity . Sample was extracted by maceration method using ethanol 70% to obtain the ethanol extract (EE), followed by liquid-liquid extraction method to obtain fraction of ethyl acetate (EA) and n-Hexane (EH). The phytochemical screening and determination of total phenolic and flavonoid content were done by colorimetric method. Antioxidant activity were done by DPPH, FRAP and ABTS methods. Phytochemical screening showed positive results for flavonoids, phenolic and saponins. The largest total phenolic content was found on EA (11,59 µg/ml ± 0,3 %b/b EAG) and the largest total flavonoid content was on EA (3,88 µg/ml ± 0,02 %b/b EK). The total phenolic and flavonoid content of Jati putih leaves has a correlation with antioxidant activity. The coefficient correlation of activity on reducingDPPH radical was 56,7% (total of phenolic content) and 57,8% (total of flavonoid content) and on iron reduction power in FRAP method was 99,9% (total of phenolics and flavonoids content). The relationship with the activity in reducing radical ABTS obtained coefficient correlation of 57,0% and 58,1% for total phenolic and flavonoids contents, respectively.
TOTAL FLAVONOID LEVELS AND ANTIOXIDANT ACTIVITY OF KERSEN LEAF EXTRACT (muntingia calabura L.) L A, Hamdayani; Fitriyanti Jumaetri Sami; Yuri Pratiwi Utami
JURNAL KATALISATOR Vol. 9 No. 1 (2024): Jurnal Katalisator Volume 9 No.1, April 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i1.2831

Abstract

Kersen leaves (Muntingia calabura L.) are plants that contain many secondary metabolites, one of which is flavonoids that can act as antioxidants. This study aims to determine the total content of flavonoids which also have the potential as antioxidants in cherry leaves using the DPPH method (2,2-diphenyl-1-picrylhidrazyl) with various filters, namely 70% ethanol, ethyl acetate and n-hexan. Testing of total flavonoid content was carried out using AlCl3 reagent and measured using spectrophotometry at a wavelength of 422 nm. Antioxidant activity testing was measured at an absorption wavelength of 516 nm. The results showed the total flavonoid content of 70% ethanol filter leaf extract as much as 8.13 (mgQE/g), ethyl acetate as much as 8.32 (mgQE/g) and n-hexan as much as 18.96 (mgQE/g). antioxidant activity of cherry leaves using DPPH method (2,2-diphenyl-1-picrylhidrazyl) with filter variations. 70% ethanol extract of cherry leaves has an IC50 value of 7.56 μg/mL, ethyl acetate extract with an IC50 value of 36.05 μg/mL, and n-hexan extract with an IC50 value of 21.33 μg/mL. From the results obtained it can be concluded that the highest antioxidant activity is contained in 70% ethanol extract of 7.56 μg/mL.
Co-Authors Afsari, Mutiara Indah Ayu Alfad Fadri Alfat Fadri Alfat Fadri Alimuddin Ali Amriani Sapra Awaluddin, Akbar Budi Sutrisno Dayan El-Roy Matitawaer Firdaus, Firdaus Imrawati Imrawati Jalifah Latip Kasmawati, Henny Khairuddin Khairuddin L A, Hamdayani Libertin Libertin Marwati Marwati Megawati Megawati Muhammad Aswad Naimah Ramli Nunuk Hariani Soekamto Nur Syam Hidayah Rahma Ismail Nursamsiar Nursamsiar Rabiatul Adhawiyah Radhia Riski Sahibuddin A Gani Sitti Rahimah Sukriani Kursia Sukriani Kursia Syamsu Nur Syamsu Nur, Syamsu Syatriani Syatriani Trito Reski Sidupa Yuri Pratiwi Utami