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All Journal Chemistry Indonesian Journal of Chemical Research Fullerene Journal of Chemistry Jurnal Ilmu Kesehatan Community Empowerment Jurnal ABDIMAS (Pengabdian kepada Masyarakat) UBJ Sasambo Journal of Pharmacy Borobudur Pharmacy Review Journal of Pharmaceutical and Sciences. Analit: Analytical And Environmental Chemistry
Wardani, Arief Kusuma
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Studi in silico senyawa golongan flavonoid dari ranting dan akar dadap serep (Erythrina subumbrans) sebagai antipiretik Montero, Mahkota Alda Mora; Wardani, Arief Kusuma
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 1 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i1.483

Abstract

Studies in silico offer an exciting world where researchers use the power of computing to explore a variety of scientific phenomena. In silico allows researchers to virtually test thousands of potential compounds, including natural ingredients, interacting with biological targets. This can speed up drug discovery and reduce reliance on expensive laboratory trials. Erythrina subumbrans is a plant in the Papilonaceae family that has been phytochemically tested to contain flavonoids suspected of having antipyretic effects. The study aims to identify the most potentially antipyretic compounds among the eight flavonoid groups of the branches and roots of Dadap Serep (Erythrina subumbrans). The study uses the molecular docking method. Tests were conducted against eight flavonoids of the branches and roots of the Dadap serep, namely pinocembrin, 3,6,4’-trichydroxyflavone, 3,6-dihydroxylflavon, lupalbigenin, erysubin F, genistein, 5-hydroxyphoronone, and abyssinone V, as well as positive controls of paracetamol against target proteins with PDB code 1CX2. The data analysis compared the total binding energy and hydrogen binding scores on the emerging amino acid residues. The test results showed that the three most potentially antipyretic compounds were lupalbigenin, erysubin F, and abyssinone V, with consecutive total bending energy scores of -126.3 kcal/mol, -113.1 kcal/mol, and -111.8 kcal/mol.
Validation of Medicinal Chemicals Analysis Methods in Pegel Linu and Rheumatic Herbs using the TLC-UV-Visible Spectrophotometry method Haresmita, Perdana Priya; Wardani, Arief Kusuma; Ramadhani, Diva Laila; Bayuaji, Dwibara; Azri, Anna Sa'dia; Putri, Nindya Yunia; Nadia, Mayla Eka
Analit : Analytical and Environmental Chemistry Vol. 8, No. 02 October (2023) Analit: Analytical and Enviromental Chemistry
Publisher : Jurusan Kimia FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/aec.v8i2.2023.p63-74

Abstract

Jamu is a traditional Indonesian medicine. Herbal medicine for rheumatism and “pegal linu” is one of the most widely consumed types of traditional medicinal products by the public, so it is a type of traditional medicinal preparation that is prone to the addition of chemical drugs (BKO). All types of traditional medicines are prohibited from containing isolated or synthetic chemicals with medicinal properties. Samples of rheumatism and “pegal linu” jamu were purchased from Grobogan, Central Java, and Gunungkidul, Yogyakarta. Two samples were purchased from Grobogan, while four samples were purchased from Gunungkidul. The standards used were mefenamic acid, phenylbutazone, and diclofenac sodium. Qualitative analysis was carried out using thin-layer chromatography and quantitative analysis using UV-visible spectrophotometry. Validation of the analytical method is carried out by setting four parameters: linearity, precision, limit of detection, and limit of quantitation. Information about the content of BKO in traditional medicines circulating in the Grobogan and Gunungkidul areas, as well as references to valid analytical methods, will greatly assist the government and academics in educating the public about the dangers of long-term consumption of traditional medicine with BKO. The results showed that three of the six samples contained BKO, and the analytical method was valid.
Co-Authors Afifah, Riza Nur Agusta, Herma Fanani Alda, Mahkota Amanda, Shalma Risqi Azri, Anna Sa'dia AzZahra, Anindya Shafira Bayuaji, Dwibara Ellsya Angeline Rawar Hadi, Ismanurrahman Hasani, Rofi Abul Hidayatullah, Farizqi Ramadhan Lestari, May Synta Listiyani, Oktavia Montero, Mahkota Alda Mora Nadia, Mayla Eka Nisa Fitriyani, Nisa Nofitriana, Risma Perdana Priya Haresmita, Perdana Priya Permatasari, Lina Permatasari, Sukma Putri Pradani, Missya Putri Kurnia Putri, Nindya Yunia Ramadhani, Diva Laila Tiara Mega Kusuma Vaira, Tischa Yusriyyah, Aanisah