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All Journal Chemistry Indonesian Journal of Chemical Research Fullerene Journal of Chemistry Jurnal Ilmu Kesehatan Community Empowerment Jurnal ABDIMAS (Pengabdian kepada Masyarakat) UBJ Sasambo Journal of Pharmacy Pharmademica: Jurnal Kefarmasian dan Gizi SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Borobudur Pharmacy Review Journal of Pharmaceutical and Sciences. Analit: Analytical And Environmental Chemistry
Wardani, Arief Kusuma
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Studi in silico senyawa golongan flavonoid dari ranting dan akar dadap serep (Erythrina subumbrans) sebagai antipiretik Montero, Mahkota Alda Mora; Wardani, Arief Kusuma
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 1 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i1.483

Abstract

Studies in silico offer an exciting world where researchers use the power of computing to explore a variety of scientific phenomena. In silico allows researchers to virtually test thousands of potential compounds, including natural ingredients, interacting with biological targets. This can speed up drug discovery and reduce reliance on expensive laboratory trials. Erythrina subumbrans is a plant in the Papilonaceae family that has been phytochemically tested to contain flavonoids suspected of having antipyretic effects. The study aims to identify the most potentially antipyretic compounds among the eight flavonoid groups of the branches and roots of Dadap Serep (Erythrina subumbrans). The study uses the molecular docking method. Tests were conducted against eight flavonoids of the branches and roots of the Dadap serep, namely pinocembrin, 3,6,4’-trichydroxyflavone, 3,6-dihydroxylflavon, lupalbigenin, erysubin F, genistein, 5-hydroxyphoronone, and abyssinone V, as well as positive controls of paracetamol against target proteins with PDB code 1CX2. The data analysis compared the total binding energy and hydrogen binding scores on the emerging amino acid residues. The test results showed that the three most potentially antipyretic compounds were lupalbigenin, erysubin F, and abyssinone V, with consecutive total bending energy scores of -126.3 kcal/mol, -113.1 kcal/mol, and -111.8 kcal/mol.
Validation of Medicinal Chemicals Analysis Methods in Pegel Linu and Rheumatic Herbs using the TLC-UV-Visible Spectrophotometry method Haresmita, Perdana Priya; Wardani, Arief Kusuma; Ramadhani, Diva Laila; Bayuaji, Dwibara; Azri, Anna Sa'dia; Putri, Nindya Yunia; Nadia, Mayla Eka
Analit : Analytical and Environmental Chemistry Vol. 8, No. 02 October (2023) Analit: Analytical and Enviromental Chemistry
Publisher : Jurusan Kimia FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/aec.v8i2.2023.p63-74

Abstract

Jamu is a traditional Indonesian medicine. Herbal medicine for rheumatism and “pegal linu” is one of the most widely consumed types of traditional medicinal products by the public, so it is a type of traditional medicinal preparation that is prone to the addition of chemical drugs (BKO). All types of traditional medicines are prohibited from containing isolated or synthetic chemicals with medicinal properties. Samples of rheumatism and “pegal linu” jamu were purchased from Grobogan, Central Java, and Gunungkidul, Yogyakarta. Two samples were purchased from Grobogan, while four samples were purchased from Gunungkidul. The standards used were mefenamic acid, phenylbutazone, and diclofenac sodium. Qualitative analysis was carried out using thin-layer chromatography and quantitative analysis using UV-visible spectrophotometry. Validation of the analytical method is carried out by setting four parameters: linearity, precision, limit of detection, and limit of quantitation. Information about the content of BKO in traditional medicines circulating in the Grobogan and Gunungkidul areas, as well as references to valid analytical methods, will greatly assist the government and academics in educating the public about the dangers of long-term consumption of traditional medicine with BKO. The results showed that three of the six samples contained BKO, and the analytical method was valid.
Enhancing the value-added of traditional herbal medicine through instant product diversification and KUBE Strengthening Wardani, Arief Kusuma; Apriyanto, Nugraha Dimas; Aji, Adiwira Wahyu; Azizah, Bilqis Rahil; Firdausa, Clara Adinda; Niamah, Nailiz Zulfiatin
Community Empowerment Vol 10 No 12 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.11203

Abstract

The traditional 'jamu gendong' (herbal medicine) business in Trasan Hamlet, Magelang, faces challenges due to low productivity and an extremely short product shelf life (only one day), which limits the welfare of its practitioners. This community service program aims to transform this traditional business through product innovation and digital market expansion. The methodology employed a participatory approach involving institutional strengthening, product diversification, and digital literacy. The results demonstrated the successful formation of the "Trajaya" Joint Business Group (KUBE) as a collective platform for vendors. The implemented technological innovation successfully converted liquid jamu into an instant powder format, which possesses a longer shelf life and higher market value. Furthermore, the integration of digital marketing through Shopee has opened national market access for these local products. The transformation from a conventional business model to one based on product innovation and digitalization has proven effective in increasing competitiveness and providing sustainable solutions for the income growth.
Pengaruh Variasi Minyak Kelapa Terhadap Karakteristik Fisik Sabun Padat Minyak Atsiri Sereh Wangi Listiyani, Oktavia; Wardani, Arief Kusuma; Yuliastuti, Fitriana; Hadi, Ismanurrahman
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 5 No. 1 (2026): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v5i1.164

Abstract

Sabun padat merupakan produk pembersih yang semakin diminati karena efektif dan ekonomis. Salah satu bahan alami potensial dalam pengembangan sabun padat adalah minyak atsiri sereh wangi sebagai antibakteri, serta minyak kelapa yang berperan dalam pembentukan busa sabun. Penelitian ini bertujuan untuk mengevaluasi pengaruh variasi konsentrasi minyak kelapa terhadap karakteristik fisik sabun padat berbahan aktif minyak atsiri sereh wangi. Penelitian dilakukan secara eksperimental dengan tiga formula berbeda (F1: 18%, F2: 16%, F3: 14% minyak kelapa) dan konsentrasi minyak atsiri tetap 2%. Evaluasi dilakukan terhadap parameter organoleptik, pH, tinggi busa, dan stabilitas busa selama penyimpanan empat minggu. Hasil menunjukkan bahwa F1 memiliki kestabilan bentuk dan warna terbaik, sementara F3 menghasilkan tinggi dan stabilitas busa paling konsisten. Seluruh formula berada dalam rentang pH sesuai SNI 3532:2021. Kesimpulannya, variasi konsentrasi minyak kelapa memengaruhi karakteristik fisik sabun, dan formulasi F1 dinilai paling optimal dalam mendukung pembentukan dan kestabilan busa.
Formulasi Nanoenkapsulasi Ekstrak Kacang Gude (Cajanus cajan L. (Huth.)) sebagai Antidiabetes Ginaris, Rifkarosita Putri; Aryadi, Anggi; Afifa, Nadya; Wardani, Arief Kusuma; Indrayati, Lyna L.; Santoso, Blegoh Iwan
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.126

Abstract

Pigeon pea (Cajanus cajan L. (Huth.)) contains flavonoids that exhibit potential antidiabetic activity through the inhibition of the α-glucosidase enzyme. The main limitation in the application of flavonoid compounds is their low solubility and stability. Nanoencapsulation using chitosan–TPP via a simple ionic gelation method can enhance the stability and bioactivity of active compounds. This study aimed to develop a nanoencapsulation formulation of pigeon pea extract and to evaluate its physical characteristics, stability, and α-glucosidase inhibitory activity. The research was conducted using variations in nanoencapsulation extract concentrations: F1 (0.2%), F2 (0.4%), and F3 (1%). Physical characterization included particle size, polydispersity index (PDI), and zeta potential, along with a freeze–thaw stability test for five cycles. Antidiabetic activity was assessed by measuring α-glucosidase inhibition and determining the IC₅₀ value. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test (p < 0.05). The results showed that particle size decreased from 290.40 nm (F1) to 198.30 nm (F3), with polydispersity index values below 0.3 for F2 and F3. The zeta potential ranged from −28.10 to −36.10 mV. F3 demonstrated the highest stability and the strongest antidiabetic activity with an IC₅₀ value of 68 ppm (p < 0.05). In conclusion, the nanoencapsulation formulation of pigeon pea extract produced small-sized, stable particles with effective α-glucosidase inhibitory activity. The optimal formulation was F3, which shows potential for further development as a natural-based antidiabetic nanoencapsulation system.
Co-Authors Afifa, Nadya Afifah, Riza Nur Agusta, Herma Fanani Aji, Adiwira Wahyu Alda, Mahkota Amanda, Shalma Risqi Apriyanto, Nugraha Dimas Aryadi, Anggi Azizah, Bilqis Rahil Azri, Anna Sa'dia AzZahra, Anindya Shafira Bayuaji, Dwibara Ellsya Angeline Rawar Firdausa, Clara Adinda Fitriana Yuliastuti Hadi, Ismanurrahman Hasani, Rofi Abul Hidayatullah, Farizqi Ramadhan Indrayati, Lyna L. Lestari, May Synta Listiyani, Oktavia Montero, Mahkota Alda Mora Nadia, Mayla Eka Niamah, Nailiz Zulfiatin Nisa Fitriyani, Nisa Nofitriana, Risma Perdana Priya Haresmita, Perdana Priya Permatasari, Lina Permatasari, Sukma Putri Pradani, Missya Putri Kurnia Putri, Nindya Yunia Ramadhani, Diva Laila Rifkarosita Putri Ginaris Santoso, Blegoh Iwan Tiara Mega Kusuma Vaira, Tischa Yusriyyah, Aanisah