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All Journal Indonesian Journal of Medicine MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Kedokteran Universitas Palangka Raya Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Smart Society Empowerment Journal
Adhiputri, Artrien
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Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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The Effect of Curcuma longa Extract on Interleukin 6, Procalcitonin, Microbial Count, and Histopathology of the Lungs in a Rat Model Infected with Streptococcus pneumoniae Prasetyo, Yudhi; Reviono, Reviono; Hikmayani, Nur Hafidha; Adhiputri, Artrien; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.460

Abstract

Background: Streptococcus pneumoniae causes 95% of cases of community-acquired pneumonia (CAP). Interleukin 6, procalcitonin, microbial count, and lung histopathology can help in determining indicators of inflammatory processes and prognosis. Curcumin, which acts as an anti-inflammatory and anti-microbial, can be used as an adjunctive therapy in infectious diseases. Methods: This was a laboratory experimental study. A sample of 30 white rats (Rattus norvegicus) infected with Streptococcus pneumoniae was carried out in the experimental animal laboratory at the Faculty of Medicine, Universitas Sebelas Maret in November 2022 with incidental sampling. The control group received 1cc of aquadest, the first treatment group received 30 mg/200 g of curcuma longa extract, the second treatment group received 50 mg/200 g of Curcuma longa extract, the third treatment group received 30 mg/200 g of Curcuma longa extract and 30 mg/200 g of amoxicillin, and the fourth treatment group received 30 mg/200 g of amoxicillin. Interleukin 6 and procalcitonin were measured on the third and twelfth days after the rats were infected with Streptococcus pneumoniae. The microbial count and histopathology of the lungs were assessed after the twelfth day. Results: There was a significant difference (P<0.05) in the decrease in levels of interleukin 6, procalcitonin, and microbial count in the treatment group compared to the control group. There was no significant difference (P>0.05) in the improvement in the histopathology of the lungs in the treatment group compared to the control group. Conclusion: Curcuma longa extract can significantly reduce levels of interleukin 6, procalcitonin, and microbial count, but not significantly improve the histopathology of the lung.
Does the SOFA Score Have the Ability to Predict Length of Stay and Mortality as well as Other Scorings? Adhiputri, Artrien; Hapsari, Brigitta Devi Anindita; Reviono, Reviono; Alfarizi, Aditya; Damayanti, Raninditya
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i1.637

Abstract

Background: In the intensive care unit (ICU), critically sick pneumonia has a high mortality rate, so forecasting the prognosis is crucial for making decisions. Early detection of clinical deterioration and the implementation of early intervention and care can be achieved through the use of scoring systems. The Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring system is a better system in predicting mortality in critically ill patients. However, in this study, we aim to observed  the use of the Sequential Organ Failure Assessment (SOFA) score as a predictor of mortality and length of stay (LOS). Methods: From April to August 2023, we treated 125 critically sick pneumonia patients in the ICU as part of a prospective observational research. An integrated ICU mortality calculator was used to assess the performance of the APACHE II, Simplified Acute Physiology Score II (SAPS II), and SOFA scores. Descriptive statistics will be used for data analysis, and the Fisher exact test and Chi-square test will be used for testing. logistic regression and linear regression methods are used in multivariate analysis. If the p-value is less than 0.05, it will be statistically significant. Results: APACHE II, SAPS II, and SOFA scores were significant in predicting the outcome of critically ill pneumonia patients (cut-off of ≥14.5, ≥34.5, and ≥3.5, respectively). The Spearman rank correlation for LOS shows that APACHE II, SOFA, and SAPS II scores have a very weak relationship with the p-values are 0.121, 0.766, and 0.436, respectively. Conclusion: The SOFA score is a good mortality predictor in critically ill pneumonia patients yet is simpler and easier to use in all settings in the hospital.
Peningkatan Pengetahuan mengenai Upaya Berhenti Merokok pada Kader dan Tenaga Kesehatan Anindita Hapsari, Brigitta Devi; Adhiputri, Artrien; Suryawati, Betty; Reviono, Reviono; Sutanto, Yusup Subagio; Harsini, Harsini; Marwoto, Marwoto
Smart Society Empowerment Journal Vol 3, No 3 (2023): November
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i3.79224

Abstract

Pendahuluan: Perokok adalah seseorang yang menghisap rokok ≥ 100 batang selama hidupnya dan saat ini masih merokok atau sudah berhenti merokok kurang dari 1 tahun. Asap rokok memiliki efek negatif terhadap kesehatan karena mengandung lebih dari 4.000 senyawa kimia, 400 zat berbahaya, dan 43 zat karsinogenik. Rokok mengandung nikotin yang bersifat adiksi menyebabkan ketergantungan sehingga diperlukan upaya lebih lanjut agar dapat berhenti merokok. Upaya berhenti merokok berlangsung baik apabila didukung kemampuan tenaga kesahatan yang memadai. Penelitian ini bertujuan meningkatkan kemampuan tenaga kesehatan dalam program berhenti merokok serta meningkatkan pengetahuan masyarakat mengenai bahaya rokok.Metode: Kegiatan pengabdian kepada masyarakat ini bekerjasama dengan Puskesmas Purwodiningratan Kota Surakarta. Metode yang digunakan adalah memberikan penyuluhan kepada kader juga kepada tenaga kesehatan di wilayah Puskesmas tersebut tentang upaya berhenti merokok. Evaluasi kegiatan dilakukan penilaian pre dan post test yang bertujuan mengetahui tingkat pengetahuan kader dan tenaga kesehatan mengenai upaya berhenti merokok.Hasil dan Pembahasan: Jumlah peserta kegiatan adalah sebanyak 26 kader dan 16 tenaga kesehatan. Hasil evaluasi menunjukkan bahwa kader dan tenaga kesehatan sudah mempunyai pengetahuan yang cukup tentang upaya berhenti merokok, tetapi dalam beberapa hal masih perlu ditingkatkan, terutama mengenai metode dan pendampingan perokok dalam melakukan upaya berhenti merokok. Didapatkan peningkatan nilai post-test menunjukkan peningkatan pengetahuan dari kader dan tenaga kesehatan setelah diberikan paparan tentang materi tersebut. Peningkatan tingkat pemahaman kader kesehatan sebesar 22% dan tenaga kesehatan sebesar 53%.Kesimpulan: Terjadi peningkatan pengetahuan tentang upaya berhenti merokok pada kader dan tenaga kesehatan Puskesmas Purwodiningratan.
Co-Authors Akhmad Syaikhu Alfarizi, Aditya Ana Rima Setijadi Anindita Hapsari, Brigitta Devi Apriningsih, Hendrastutik Atmojo, Anang Purwoko Damayanti, Raninditya Fahlevie, Fahlevie Hapsari, Brigitta Anindita Devi Hapsari, Brigitta DA. Hapsari, Brigitta Devi Anindita Harsini Harsini Hermansah, Muhamad Lukman Jatu Aphridasari Lilik Lestari marwoto marwoto Melita , Melita Mochammad Imron Awalludin Nadiya Aliyah Roselyn Nur Hafidha Hikmayani Pratiwi, Atmasari Putro, Prasetyo Sarwono Rahardjo, A. Farih Rahayu, Nur Indah Renata, Felicia Reviono Reviono Reviono Roxanne, Olivia Geraldine Siregar, Sihsusetyaningtyas Tiominar Siti Munawaroh Soewondo, Widiastuti SURYAWATI, BETTY Sutanto, Yusup S. Suyatmi Suyatmi Vagheggini, Guido Windu Prasetyo, Windu Yanuar Yudhi Prasetyo, Yudhi Yusup Subagio Sutanto