Article Per Year (5 Year)
p-Index From 2021 - 2026
2.454
P-Index
This Author published in this journals
All Journal Jurnal Respirologi Indonesia Jurnal Buana Farma Eduvest - Journal of Universal Studies PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Jurnal Kesehatan dan Kedokteran Jurnal Penelitian Sains dan Kesehatan Avicenna Sinergi : Jurnal Ilmiah Multidisiplin
Daimah Wirdatus Sanaun Harahap
Unknown Affiliation
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

Published : 17 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 17 Documents
Search

 1   2 
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL PADA BUAH BIT (Beta vulgaris L.) MENGGUNAKAN METODE DPPH (2,2-DIPHENYL-1-PICRYLHYDRAZIL) Dian Sry Rejeki Nadeak; Astriani Natalia br ginting; Daimah Wirdatus Sanaun Harahap
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1637

Abstract

Oxidative stress due to the accumulation of free radicals plays a role in the development of various degenerative diseases, so that natural antioxidant sources that can be scientifically evaluated are needed. Beetroot (Beta vulgaris L.) is known to contain bioactive compounds such as betalains, flavonoids, and polyphenols that have the potential as antioxidants. This study aims to evaluate the antioxidant activity of beetroot (Beta vulgaris L.) ethanol extract in vitro using the DPPH method. Extraction was carried out by maceration method using 96% ethanol. The antioxidant activity test was carried out using DPPH solution with absorbance measurement at a wavelength of 517 nm. The extract was tested at a concentration range of 10–100 µg/mL with three replications, while quercetin was used as a positive control. Antioxidant activity was expressed as the percentage of DPPH radical inhibition and the IC₅₀ value calculated using linear regression analysis. The results showed that the beetroot ethanol extract had an IC₅₀ value of 3.35 µg/mL, while quercetin had an IC₅₀ value of 2.76 µg/mL. The yield of the extract obtained was 20.29%. These results indicate that the beetroot ethanol extract has DPPH radical scavenging activity in the in vitro test system used.
ANALISIS BIAYA TERAPI ASPIRIN DAN CLOPIDOGREL PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT ROYAL PRIMA TAHUN 2022 – 2025 Nursaima Putri Nasution; Daimah Wirdatus Sanaun Harahap; Astriani Natalia Br Ginting
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1647

Abstract

Ischemic stroke is one of the leading causes of mortality and long-term disability, imposing a substantial economic burden due to high treatment and rehabilitation costs. Antiplatelet therapies such as aspirin and clopidogrel are commonly used for secondary prevention to reduce the risk of recurrent stroke; however, differences in treatment costs require evaluation to support efficient use of healthcare resources. This study aimed to analyze and compare the total cost and cost-effectiveness of aspirin and clopidogrel therapy in patients with ischemic stroke at Royal Prima General Hospital during the period 2022-2025. This study was an observational analytic study with a retrospective design using patients’ medical record data. The analysis was conducted from the hospital perspective by calculating direct medical costs, including drug costs, hospitalization, diagnostic examinations, and medical procedures. Pharmacoeconomic evaluation was performed using the Cost-Effectiveness Analysis (CEA) approach, with cost-effectiveness assessed through the calculation of the Cost-Effectiveness Ratio (CER) based on patients’ clinical outcomes. The results demonstrated differences in total treatment costs between aspirin and clopidogrel therapy, influenced by variations in cost components and patients’ clinical characteristics. In conclusion, cost-effectiveness analysis using CEA and CER can provide a scientific basis for selecting antiplatelet therapy that is rational and cost-efficient in the management of patients with ischemic stroke.
EVALUASI PENGGUNAAN OBAT PADA PASIEN DISPEPSIA MENGGUNAKAN METODE ATC/DDD DI RUMAH SAKIT ROYAL PRIMA TAHUN 2022 Rachel Epifanes Hutabarat; Daimah Wirdatus Sanaun Harahap; Astriani Natalia Br Ginting
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1677

Abstract

Dyspepsia is a common non-communicable disease that requires pharmacotherapy management according to clinical guidelines. Evaluation of drug use can be conducted using the ATC/DDD (Anatomical Therapeutic Chemical/Defined Daily Dose) and DU90% (Drug Utilization 90%) methods to describe prescribing patterns in healthcare facilities. This study aimed to evaluate drug use in dyspepsia patients at Royal Prima Hospital Medan in 2022 using a retrospective descriptive design using medical records of 180 patients from January–December 2022. Drugs were classified based on the WHO 2023 ATC system and analyzed using DDD calculations and the DU90% method. The results showed that four drugs included in the DU90% segment were omeprazole (tablets and injections) and ranitidine (tablets and injections), with a total contribution of 90.4% of the total DDD. The pattern of drug use is dominated by proton pump inhibitors and H₂ receptor antagonists, which are the main therapies in the management of dyspepsia based on the 2022 National Consensus on the Management of Dyspepsia and Helicobacter pylori Infection, so that the distribution of drug use obtained in this study shows compliance with national therapy recommendations.
EFEKTIVITAS DAN BIAYA SEFALOSPORIN PADA PASIEN SIROSIS HEPATIS DENGAN RISIKO SPONTANEOUS BACTERIAL PERITONITIS DI RUMAH SAKIT ROYAL PRIMA PADA TAHUN 2022-2025 Grace Kristin Sonayania Dakhi; Daimah Wirdatus Sanaun Harahap; Astriani Natalia Br Ginting
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1694

Abstract

Hepatic cirrhosis is a chronic liver disease often accompanied by serious complications, one of which is spontaneous bacterial peritonitis (SBP), which plays a significant role in increasing morbidity and mortality. Third-generation cephalosporin antibiotics, such as cefotaxime and ceftriaxone, are widely used as first-line therapy in patients with hepatic cirrhosis at risk of SBP. However, the increasing incidence of bacterial resistance and the high cost of treatment require an evaluation of the clinical effectiveness and cost-efficiency of the therapy provided. This study aims to assess the effectiveness and cost of using cephalosporin antibiotics in patients with hepatic cirrhosis at risk of SBP at Royal Prima Hospital Medan during the period 2022–2025. This study uses a pharmacoeconomic approach in the form of Cost-Effectiveness Analysis (CEA) to assess the cost-effectiveness of cephalosporins based on the relationship between treatment costs and patient clinical outcomes. Cost-effectiveness is assessed through the calculation of the Cost-Effectiveness Ratio (CER). The results show that the characteristics of patients are predominantly male and in the adult to elderly age group. This finding is in line with the epidemiological characteristics of liver cirrhosis which is more common in men, especially due to long-term risk factors such as chronic liver disease and alcohol consumption. The study shows that the analysis of the Cost-Effectiveness Ratio (CER) and Cost-Effectiveness Analysis (CEA) values has a positive and significant effect on total medical costs, which indicates that increasing costs per unit of clinical outcomes will have a direct impact on increasing total treatment costs.
Evaluasi Penggunaan Obat Diare pada Pasien Balita di Instalasi Rawat Inap Rumah Sakit Royal Prima Tahun 2022 – 2025 gusti nurmawan panjaitan; Daimah Wirdatus Sanaun Harahap; Astriani Natalia Br Ginting
Jurnal Penelitian Sains dan Kesehatan Avicenna Vol 5 No 2 (2026): Jurnal Penelitian Sains dan Kesehatan Avicenna
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat (LPPM), Institut Teknologi Dan Kesehatan (ITK) Avicenna

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69677/avicenna.v5i2.304

Abstract

balita di Indonesia. Evaluasi penggunaan obat secara berkala sangat diperlukan untuk menjamin ketepatan terapi dan mencegah risiko efek samping serta resistensi obat pada pasien pediatrik. Tujuan: Penelitian ini bertujuan untuk mengevaluasi ketepatan penggunaan obat pada pasien balita dengan diare di Instalasi Rawat Inap Rumah Sakit Royal Prima tahun 2022-2025. Metode: Data diambil dari rekam medis pasien balita dengan diagnosa diare yang menjalani rawat inap selama periode 2022–2025. Teknik pengambilan sampel menggunakan purposive sampling. Analisis data dilakukan secara univariat untuk melihat distribusi frekuensi karakteristik pasien dan ketepatan penggunaan obat berdasarkan parameter tepat pasien, tepat indikasi, tepat obat, dan tepat dosis mengacu pada Pedoman Pengendalian Penyakit Diare. Hasil: Hasil penelitian menunjukkan bahwa mayoritas pasien diare balita berjenis kelamin laki-laki, yaitu sebanyak 59%. Sebagian besar pasien berada pada rentang usia 1–5 tahun (76%). Terapi farmakologis yang paling banyak digunakan adalah probiotik (51%) dan zinc (43%). Evaluasi ketepatan penggunaan obat menunjukkan hasil tepat indikasi (100%), tepat obat (100%), tepat pasien (100%), tepat rute pemberian obat (45%), serta ketepatan peresepan berdasarkan panduan Lintas Diare dari Kementerian Kesehatan Republik Indonesia sebesar 100%. Kesimpulan: penggunaan obat diare pada pasien balita di Instalasi Rawat Inap Rumah Sakit Royal Prima tahun 2022-2025 secara umum telah sesuai dengan pedoman pengobatan yang berlaku. Namun, masih diperlukan peningkatan dalam aspek ketepatan rute pemberian obat guna mendukung penerapan penggunaan obat yang lebih rasional dan optimal.
Analisis Potensi Interaksi Obat Golongan Proton Pump Inhibitor Pada Pasien Rawat Jalan di Rumah Sakit Royal Prima Tahun 2022 Sri Cinta Aulia; Daimah Wirdatus Sanaun Harahap; Astriani Natalia Br Ginting
Jurnal Penelitian Sains dan Kesehatan Avicenna Vol 5 No 2 (2026): Jurnal Penelitian Sains dan Kesehatan Avicenna
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat (LPPM), Institut Teknologi Dan Kesehatan (ITK) Avicenna

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69677/avicenna.v5i2.305

Abstract

Latar Belakang: Penggunaan obat golongan Proton Pump Inhibitor (PPI) pada pasien rawat jalan sering disertai dengan pemberian obat lain, sehingga berpotensi menimbulkan interaksi obat. Interaksi obat dapat mempengaruhi efektivitas terapi dan meningkatkan risiko terjadinya efek samping. Tujuan: Penelitian ini bertujuan untuk menganalisis potensi interaksi obat golongan Proton Pump Inhibitor pada pasien rawat jalan di Rumah Sakit Royal Prima Medan tahun 2022. Metode: Penelitian ini menggunakan desain observasional retrospektif dengan sumber data berupa rekam medis pasien rawat jalan yang menerima terapi PPI. Analisis data dilakukan secara deskriptif untuk menggambarkan karakteristik pasien, jenis PPI yang digunakan, potensi interaksi obat, tingkat keparahan, serta mekanisme interaksi. Hasil: Hasil penelitian menunjukkan bahwa dari 242 pasien, terdapat 75 kasus potensi interaksi obat (30,99%) yang seluruhnya termasuk dalam kategori keparahan moderat. Mekanisme interaksi yang paling banyak ditemukan adalah farmakokinetik (98,67%). Kombinasi obat yang paling sering berpotensi menimbulkan interaksi adalah lansoprazole dengan sukralfat. Kesimpulan: Kesimpulan dari penelitian ini menunjukkan bahwa potensi interaksi obat golongan PPI pada pasien rawat jalan masih cukup tinggi. Oleh karena itu, diperlukan peran aktif apoteker dalam pemantauan terapi serta pengaturan waktu pemberian obat guna meningkatkan keamanan dan efektivitas pengobatan.
Uji Aktivitas Antibakteri Ekstrak Daun Sirsak (Annona muricata L.) terhadap Pseudomonas aeruginosa secara In Vitro Lulu Pratiwi; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Sinergi : Jurnal Ilmiah Multidisiplin Vol. 2 No. 1 (2026): Sinergi: Jurnal Ilmiah Multidisiplin
Publisher : PT. AHLAL PUBLISHER NUSANTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bacterial infection in chronic wounds, particularly diabetic foot ulcers in patients with diabetes mellitus, remains a serious health problem due to their susceptibility to pathogenic bacteria such as Pseudomonas aeruginosa. Soursop leaves (Annona muricata L.) are rich in bioactive compounds with potential antibacterial properties, and several previous studies have reported their antibacterial activity. Therefore, this study aimed to evaluate the antibacterial activity of soursop leaf extract against these two bacteria in vitro using the disc diffusion method, with inhibition zone diameter as an indicator. This experimental study focused on assessing the interaction of 96% ethanolic soursop leaf extract obtained by maceration against Pseudomonas aeruginosa at various concentrations. The results demonstrated concentration-dependent antibacterial activity, in which increasing extract concentration led to larger inhibition zones. However, the antibacterial effect of the extract was lower than that of the positive control (gentamicin), which may be attributed to the use of crude secondary metabolites and the limitation of the disc diffusion method as a preliminary screening tool with restricted quantitative accuracy. Keywords: soursop leaves (annona muricata L.), antibacterial activity, pseudomonas aeruginosa, disc diffusion method, ethanol extract   Abstrak Infeksi bakteri pada luka kronik, terutama ulkus diabetikum pada penderita diabetes melitus, tetap menjadi masalah kesehatan serius karena kerentanan terhadap bakteri patogen seperti Pseudomonas aeruginosa. Daun sirsak (Annona muricata L.) kaya akan senyawa bioaktif yang berpotensi sebagai antibakteri alami, dan beberapa studi sebelumnya telah menunjukkan aktivitasnya. Oleh karena itu, penelitian ini bertujuan menguji aktivitas antibakteri ekstrak daun sirsak terhadap kedua bakteri tersebut secara in vitro menggunakan metode difusi cakram, dengan mengukur zona hambat sebagai indikator. Penelitian ini bersifat eksperimental, fokus pada pengujian interaksi ekstrak etanol 96% daun sirsak yang diperoleh melalui maserasi terhadap Pseudomonas aeruginosa dengan variasi konsentrasi. Hasilnya menunjukkan aktivitas antibakteri yang bergantung pada konsentrasi, di mana peningkatan konsentrasi ekstrak meningkatkan diameter zona hambat. Namun, daya hambat ekstrak ini masih lebih rendah dibandingkan kontrol positif gentamisin, hal ini dikarenakan ekstrak daun sirsak (Annona Muricata L.) masi merupakan metabolit sekunder, dan metode difusi cakram hanya cocok sebagai skrining awal dengan keterbatasan dalam akurasi. Kata kunci: daun sirsak (annona muricata l.), aktivitas antibakteri, pseudomonas aeruginosa, metode difusi cakram, ekstrak etanol
Co-Authors Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia br ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Br Sembiring, Novitaria Cinta Alya Diah Handayani Dian Sry Rejeki Nadeak Grace Kristin Sonayania Dakhi gusti nurmawan panjaitan Iksen, Iksen Kasta Gurning Lulu Pratiwi Lumban Gaol, Irma Yohana Muhammad Yunus Ningsih, Wulan Seppia Nursaima Putri Nasution Rachel Epifanes Hutabarat Raden Rara Diah Handayani Rara Widiya Marisha Retnosari Andrajati Retnosari Andrajati Roy Indrianto Bangar S Santi Purna Sari Sihotang, Nurhanifah Siti Mahzura Sri Cinta Aulia Syahputra, Hariyadi Dharmawan Vera Estefania Kaban