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All Journal Jurnal Surya Medika Indonesia Berdaya Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Pharmaceutical Care and Sciences SENTRI: Jurnal Riset Ilmiah Sains Medisina Jurnal Katalisator
Mukti, Yusuf Anggoro
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FORMULATION ANTIAGING CREAM MELASTOMA MALABATCHRICUM EXTRACT WITH POLYOXYETHYLENE MONOSTEARATE AND STEARIC ACID Mukti, Yusuf Anggoro; Gunawan Pamudji Widodo; Teuku Nanda Saifullah Sulaiman
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3045

Abstract

Karamunting fruit (Melastoma malabathricum L.) contains flavonoids, triterpenoids and tannins. The purpose of this study was to make anti-aging cream preparations using caramunting fruit extract with a combination of PEG 40 stearic acid and stearic acid to obtain optimum physical quality. Extract with 96% ethanol filter in the form of extracts used for cream preparations using a base of PEG 40 stearic and stearic acid, so that 8 formulas were obtained, then optimized based on the physical quality parameters of viscosity, spreadability, adhesion and pH, then optimization of the formula to determine the formula optimum using the Simplex Lattice Design method. The conclusion obtained based on this research is the optimum combination of PEG 40 stearic and stearic acid in the cream of caramunting fruit extract using the Simplex Lattice Design method, namely PEG 40 Stearate 4.76% and stearic acid 15.74%. The physical quality stability did not change during one month of storage and the cream did not cause irritation. Formula I had a better and almost equal effect on the collagen test while formula V had a better effect on the elasticity test and the moisture test.
E Evaluasi Penggunaan Antibiotik Pada Pasien Ulkus Diabetikum Rawat Jalan Di RSUD Ulin Banjarmasin Sindi Kornelia; Mukti, Yusuf Anggoro; Aryzki, Saftia; Salwati, Salwati
Jurnal Pelayanan Kefarmasian dan Sains Vol 5 No 2 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v5i2.725

Abstract

Background: Diabetic ulcer is a complication in patients with diabetes mellitus characterized by chronic wounds on the foot that are difficult to heal, due to nerve damage and impaired blood flow. Drug resistance, especially to antibiotics occurs due to improper use and increases the risk of amputation to be a significant problem  in treatment of diabetic ulcer. Objective: This study aims to evaluate the use of antibiotics in outpatients with diabetic ulcer at Ulin Banjarmasin Hospital in 2023. Methods: This research method is descriptive observational quantitatively and qualitatively, taken retrospectively from medical record data, the population and sample are outpatients with diabetic ulcer at Ulin Hospital, totaling 100 samples. Results: Based on the result of the study on 100 samples evaluations of the ATC/DDD method with a total antibiotic use of 978,66 DDD/patients days, the highest antibiotic was Cefixim (41,429%)and the lowest antibiotic was Metrodinazole (20,417%). Antibiotic included in the 90% segments are Cotrimoxazole (36,13%), Cefixim (34,75%), and Ciprofloxacin (11,18%), while the 10% segments is Clindamycin (9,54%) and Metrodinazole (8,41%. Evaluation of the Gyssens method obtained category 0 as many as 40 patients, category I as many as 33 patients, and category IVA as many as 27 patients. The result of the chi square of the Fisher’s Exact Test analysis of the Gyssens category with sig. value of 0.000<0.05 and the use of antibiotic Cefixim, Clindamycin, Ciprofloxacin, Cotrimoxazole, and Metrodinazole with a sig. value of 0.000<0.05. Conclusion: Based on the results of quantitave and qualitative evalution of antibiotic use, it was concluded that the quantity of antibiotic use exceeding WHO standars has potential to cause resistance, and the quality of antibiotic use in outpatient diabetic ulcer at Ulin Hospital in 2023.
Co-Authors Adhea Martin, Muhammad Alfisyah, Nur Andrian, Ine Aryzki, Saftia Bella Aprilia Punlin Dewi Susanti Atmaja Fatimah Azzahra Fatmalika, Tria Gunawan Pamudji Widodo Khairunisa, Aisya Fitri Kurniawati, Darini Melviani, Melviani Mia Audina, Mia Miftahul Jannah Oktavia, Nadia Putri, Juliance Yolanda Rabiatul Adawiyah Raema, Misa Rahmah, Mulia Ramadina, Najwa Rina Saputri Sagita, Ririn Salwati, Salwati Setia Budi Sindi Kornelia Syamsu, Erlina Teuku Nanda Saifullah Sulaiman Yuwindry, Iwan