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All Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Global Health research Jurnal Locus Penelitian dan Pengabdian Journal of Medicine and Health Technology
Hidayah, Rizka Nurul
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Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Case Report: Drug Related Supraventricular Tachycardia in A 58-Year-Old Male with Lung Tuberculosis Wira Putri, Atina Irani; Hidayah, Rizka Nurul
Journal of Medicine and Health Technology Vol. 2 No. 1 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i1.1937

Abstract

Background: Arrhythmia in tuberculosis is a rare and life-threatening condition. It can occur as an adverse effect of drugs included in the regiment. Case presentation: This study reported a case of arrhythmia in a 58-year-old male who experienced sudden onset of palpitations, several days after his tuberculosis regiment was changed from the fixed drug combination to a non-hepatotoxic regiment. Based on the clinical presentation, electrocardiogram, laboratory finding, echocardiogram, and analysis of the adverse effects of all given drugs, a drug was suspected as the cause of his arrhythmia. The patient survived after undergoing acute phase management for arrhythmia and discontinuation of the culprit drug. Discussion: One of the serious adverse effects of fluoroquinolone is prolonged QT intervals that could lead to deadly arrhythmia. Therefore, close monitoring of the clinical, vital, and physical is crucial, especially during the first month of therapy. Conclusion: Conscientious consideration should be made before starting therapy for tuberculosis, and acute phase management is pivotal in termination of arrhythmia.
Improving the Knowledge and Attitudes of Pulmonary Tuberculosis Prevention in the Probolinggo Community with Counseling and the Use Of Sobat-TB Haykal, Muhammad Nazhif; Eljatin, Dwinka Syafira; Putri, Atina Irani Wira; Karimah, Rumman; Fitriani, Fatimah Nur; Putra, Gumilar Fardhani Ami; Hidayah, Rizka Nurul; Fadhlina, Afia Nuzila; Fatmasari, Hindana; Widodo, Aulia Febrianti; Sakina, Sakina
Indonesian Journal of Global Health Research Vol 6 No 5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i5.3480

Abstract

Tuberculosis (TB) is a significant global health issue, particularly in Indonesia. The increasing number of TB cases and deaths highlights the need for health education to reduce the incidence of TB and support eradication efforts. Objective: This study aimed to analyze the knowledge and attitudes of the Probolinggo community toward preventing pulmonary TB through counseling and the use of the Sobat-TB. Method: An analytical observational study with a cross-sectional approach was conducted. The knowledge and attitudes of 50 voluntary respondents were measured using a validated and reliable questionnaire before and after health education interventions, which included counseling, educational videos, and an introduction to the Sobat TB app. The data were analyzed descriptively and statistically at the 95% confidence level. Results: In the Puskesmas Kanigaran area, the initial findings showed poor knowledge and attitudes toward TB prevention among respondents. Postintervention, there was a significant improvement: 46 out of 50 respondents had good knowledge, and 48 out of 50 had positive attitudes toward TB prevention. Statistical analysis confirmed a significant relationship between pre- and postintervention knowledge and attitudes (p=0.0001). Conclusions: Enhanced access to information and continuous health education using modern technology are crucial for achieving TB elimination goals.
Antiviral Activitiy of Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin and Cyclocurcumin compounds of Curcuma longa against NSP3 on SARS-CoV-2 Hidayah, Rizka Nurul; Nafisa, Belia Bima; 'Arifin, Miftah Saiful; Santosaningsih, Dewi; Muti'ah, Roihatul
Indonesian Journal of Cancer Chemoprevention Vol 13, No 3 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss3pp166-174

Abstract

SARS-CoV-2 genome encodes two large polyproteins (pp), pp1a and pp1ab which are cleaved and transformed into a mature form by a protease, non-structural protein 3 (NSP3). NSP3 is encoded by open reading frame (ORF) 1a/b. Curcuma longa (C. longa) or turmeric has been documented to have antiviral effects. The aim of this study was to assess the viral activities of C. longa against SARS-CoV-2 focusing on its potency to inhibit viral replication by targeting NSP3. PubChem databases were used to obtain the metabolic profile of C. longa. The compound's interaction with nucleocapsid was analyzed using molecular docking with Molegro Virtual Docker. Bioinformatics analysis based on rerank score presents all compounds of C. longa have higher binding affinity than the native ligand with cyclocurcumin as the lowest score (-128.38 kcal/mol). This anti-viral activity was hypothesized from the similarity of hydrogen bonds with amino acid residues Ser 128 and Asn 40 as key residues present in Ribavirin. This study reveals that C. longa is the potential to be developed as an antiviral agent through replication inhibition in SARS-CoV-2 targeting its replication mediated by NSP3.Keywords: C. longa, Non-Structural Protein 3, COVID-19.
Determinants of Smoking Behaviour Among Indonesian Elementary School Students: A Cross-Sectional Study Hidayah, Rizka Nurul; Jason, Jason; Sakina, Sakina; Syulthoni, Zain Budi; Syafira Eljatin, Dwinka
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 11 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i11.4897

Abstract

Indonesia faces a critical public health challenge with one of the highest smoking rates globally, including among elementary school children. Understanding the determinants of this early smoking behavior is essential for developing effective prevention strategies. This study, Determinants of Smoking Behaviour Among Indonesian Elementary School Students: A Cross-Sectional Study, aimed to identify the factors associated with smoking behavior among elementary school students in Bojonegoro Regency, Indonesia. A cross-sectional study was conducted using secondary data from a Ministry of Health survey. The sample consisted of 1,071 students from grades 4–6 across 20 elementary schools, selected via total population sampling. Data were analyzed using Chi-square tests to examine associations between smoking status and variables such as gender, grade level, knowledge, and environmental exposure. The prevalence of ever having smoked was 8.7%, exclusively among boys. Significant risk factors (p < 0.01) included being male, higher grade level, having smoking family members, having peers who smoke, and witnessing people smoke at school—notably, teachers and community members. Surprisingly, children who knew the dangers of smoking had a higher smoking prevalence. Smoking behavior in elementary students is strongly influenced by environmental exposure and gender. Prevention requires a multi-faceted approach, including strict smoke-free policies in schools, targeted anti-smoking education for boys, and community-wide interventions to reduce children's exposure to smoking role models.
Co-Authors 'Arifin, Miftah Saiful Abdurahman Abdurrahman Adhi Dharma Wibawa, Adhi Dharma Dewi Santosaningsih Dwinka Syafira Eljatin Fadhlina, Afia Nuzila Fadli, Sonny Fatmasari, Hindana Fitriani, Fatimah Nur Haykal, Muhammad Nazhif Hedianto, Tri Imam Susilo Indriani, Ratri Dwi Indriastuti, Endah Jason, Jason Karimah, Rumman Muti'ah, Roihatul Nafisa, Belia Bima Njoto, Edwin Nugroho Parlindungan, Putra Gelar Putra, Gumilar Fardhani Ami Putri Alief Siswanto Putri, Atina Irani Wira Rangkuti, Rahmah Yasinta Ridhoi, Ahmad Sakina Sakina Sakina, Sakina Syafira Eljatin, Dwinka Syulthoni, Zain Budi Widodo, Aulia Febrianti Wira Putri, Atina Irani Yuri Pamungkas