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All Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Global Health research Jurnal Locus Penelitian dan Pengabdian Sewagati Journal of Medicine and Health Technology
Hidayah, Rizka Nurul
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Aerospace Engineering Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Case Report: Drug Related Supraventricular Tachycardia in A 58-Year-Old Male with Lung Tuberculosis Wira Putri, Atina Irani; Hidayah, Rizka Nurul
Journal of Medicine and Health Technology Vol. 2 No. 1 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i1.1937

Abstract

Background: Arrhythmia in tuberculosis is a rare and life-threatening condition. It can occur as an adverse effect of drugs included in the regiment. Case presentation: This study reported a case of arrhythmia in a 58-year-old male who experienced sudden onset of palpitations, several days after his tuberculosis regiment was changed from the fixed drug combination to a non-hepatotoxic regiment. Based on the clinical presentation, electrocardiogram, laboratory finding, echocardiogram, and analysis of the adverse effects of all given drugs, a drug was suspected as the cause of his arrhythmia. The patient survived after undergoing acute phase management for arrhythmia and discontinuation of the culprit drug. Discussion: One of the serious adverse effects of fluoroquinolone is prolonged QT intervals that could lead to deadly arrhythmia. Therefore, close monitoring of the clinical, vital, and physical is crucial, especially during the first month of therapy. Conclusion: Conscientious consideration should be made before starting therapy for tuberculosis, and acute phase management is pivotal in termination of arrhythmia.
Improving the Knowledge and Attitudes of Pulmonary Tuberculosis Prevention in the Probolinggo Community with Counseling and the Use Of Sobat-TB Haykal, Muhammad Nazhif; Eljatin, Dwinka Syafira; Putri, Atina Irani Wira; Karimah, Rumman; Fitriani, Fatimah Nur; Putra, Gumilar Fardhani Ami; Hidayah, Rizka Nurul; Fadhlina, Afia Nuzila; Fatmasari, Hindana; Widodo, Aulia Febrianti; Sakina, Sakina
Indonesian Journal of Global Health Research Vol 6 No 5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i5.3480

Abstract

Tuberculosis (TB) is a significant global health issue, particularly in Indonesia. The increasing number of TB cases and deaths highlights the need for health education to reduce the incidence of TB and support eradication efforts. Objective: This study aimed to analyze the knowledge and attitudes of the Probolinggo community toward preventing pulmonary TB through counseling and the use of the Sobat-TB. Method: An analytical observational study with a cross-sectional approach was conducted. The knowledge and attitudes of 50 voluntary respondents were measured using a validated and reliable questionnaire before and after health education interventions, which included counseling, educational videos, and an introduction to the Sobat TB app. The data were analyzed descriptively and statistically at the 95% confidence level. Results: In the Puskesmas Kanigaran area, the initial findings showed poor knowledge and attitudes toward TB prevention among respondents. Postintervention, there was a significant improvement: 46 out of 50 respondents had good knowledge, and 48 out of 50 had positive attitudes toward TB prevention. Statistical analysis confirmed a significant relationship between pre- and postintervention knowledge and attitudes (p=0.0001). Conclusions: Enhanced access to information and continuous health education using modern technology are crucial for achieving TB elimination goals.
Antiviral Activitiy of Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin and Cyclocurcumin compounds of Curcuma longa against NSP3 on SARS-CoV-2 Hidayah, Rizka Nurul; Nafisa, Belia Bima; 'Arifin, Miftah Saiful; Santosaningsih, Dewi; Muti'ah, Roihatul
Indonesian Journal of Cancer Chemoprevention Vol 13, No 3 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss3pp166-174

Abstract

SARS-CoV-2 genome encodes two large polyproteins (pp), pp1a and pp1ab which are cleaved and transformed into a mature form by a protease, non-structural protein 3 (NSP3). NSP3 is encoded by open reading frame (ORF) 1a/b. Curcuma longa (C. longa) or turmeric has been documented to have antiviral effects. The aim of this study was to assess the viral activities of C. longa against SARS-CoV-2 focusing on its potency to inhibit viral replication by targeting NSP3. PubChem databases were used to obtain the metabolic profile of C. longa. The compound's interaction with nucleocapsid was analyzed using molecular docking with Molegro Virtual Docker. Bioinformatics analysis based on rerank score presents all compounds of C. longa have higher binding affinity than the native ligand with cyclocurcumin as the lowest score (-128.38 kcal/mol). This anti-viral activity was hypothesized from the similarity of hydrogen bonds with amino acid residues Ser 128 and Asn 40 as key residues present in Ribavirin. This study reveals that C. longa is the potential to be developed as an antiviral agent through replication inhibition in SARS-CoV-2 targeting its replication mediated by NSP3.Keywords: C. longa, Non-Structural Protein 3, COVID-19.
Determinants of Smoking Behaviour Among Indonesian Elementary School Students: A Cross-Sectional Study Hidayah, Rizka Nurul; Jason, Jason; Sakina, Sakina; Syulthoni, Zain Budi; Syafira Eljatin, Dwinka
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 11 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i11.4897

Abstract

Indonesia faces a critical public health challenge with one of the highest smoking rates globally, including among elementary school children. Understanding the determinants of this early smoking behavior is essential for developing effective prevention strategies. This study, Determinants of Smoking Behaviour Among Indonesian Elementary School Students: A Cross-Sectional Study, aimed to identify the factors associated with smoking behavior among elementary school students in Bojonegoro Regency, Indonesia. A cross-sectional study was conducted using secondary data from a Ministry of Health survey. The sample consisted of 1,071 students from grades 4–6 across 20 elementary schools, selected via total population sampling. Data were analyzed using Chi-square tests to examine associations between smoking status and variables such as gender, grade level, knowledge, and environmental exposure. The prevalence of ever having smoked was 8.7%, exclusively among boys. Significant risk factors (p < 0.01) included being male, higher grade level, having smoking family members, having peers who smoke, and witnessing people smoke at school—notably, teachers and community members. Surprisingly, children who knew the dangers of smoking had a higher smoking prevalence. Smoking behavior in elementary students is strongly influenced by environmental exposure and gender. Prevention requires a multi-faceted approach, including strict smoke-free policies in schools, targeted anti-smoking education for boys, and community-wide interventions to reduce children's exposure to smoking role models.
Aplikasi Media Pembelajaran Tiga Dimensi tentang Penyakit Akibat Rokok Pada Siswa Sekolah Dasar Hidayah, Rizka Nurul; Putra, Gumilar Fardhani Ami; Syulthoni, Zain Budi; Furaidah, Erna; Rangkuti, Rahmah Yasinta; Ridhoi, Ahmad; Fitriani, Fatimah Nur; Indriastuti, Endah; Karimah, Rumman
Sewagati Vol 9 No 6 (2025)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v9i6.9109

Abstract

Rokok sebagai salah satu penyebab utama berbagai penyakit serius, termasuk penyakit jantung, kanker paru-paru, dan gangguan pernapasan menyebarkan dampak tanpa memandang usia. Anak-anak, terutama siswa sekolah dasar, sangat rentan terhadap dampak negatif dari paparan asap rokok. Namun, metode pembelajaran yang digunakan saat ini sering kali kurang efektif dalam menyampaikan informasi yang kompleks dan penting ini. Oleh karena itu, diperlukan pendekatan inovatif untuk meningkatkan literasi kesehatan siswa tentang bahaya rokok. Solusi yang ditawarkan adalah pengembangan media pembelajaran tiga dimensi yang interaktif dan menarik untuk mengedukasi siswa tentang bahaya rokok melalui visualisasi penyakit akibat merokok. Metode pembelajaran diaplikasikan dengan membentuk kelompok kecil agar komunkasi lebih efektif dan diskusi berjalan terbuka serta fokus siswa dapat tersalurkan dengan optimal. Pengetahuan siswa diukur dengan pre-test dan posttest pada sebelum dan setelah materi. Hasil pelaksanaan menggambarkan media ini memberikan pengalaman belajar yang lebih mendalam dan interaktif, sehingga siswa dapat memahami materi secara komprehensif melalui audio, visual dan kinestetik.
Peningkatan Deteksi Dini Kanker Serviks melalui Skrining HPV DNA kepada Masyarakat di Institut Teknologi Sepuluh Nopember Karimah, Rumman; Indriastuti, Endah; Eljatin, Dwinka Syafira; Soraya, Fira; Fitriani, Fatimah Nur; Haykal, Muhammad Nazhif; Hidayah, Rizka Nurul; Sari, Desiana Widityaning; Rangkuti, Rahmah Yasinta; Nurhayati, Lely; Syulthoni, Zain Budi; Fadli, Sonny
Sewagati Vol 9 No 6 (2025)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v9i6.9141

Abstract

Kanker serviks merupakan penyebab kematian paling sering kedua akibat kanker pada wanita di Indonesia, dengan sebagian besar kasus berhubungan dengan infeksi persisten Human Papillomavirus (HPV) risiko tinggi. Deteksi dini melalui skrining berbasis HPV Deoxyribonucleic Acid (DNA) direkomendasikan sebagai metode paling sensitif untuk mencegah progresi lesi prakanker menjadi kanker invasif.Kegiatan pengabdian masyarakat ini bertujuan meningkatkan cakupan deteksi dini kanker serviks di lingkungan Institut Teknologi Sepuluh Nopember (ITS) melalui program skrining HPV DNA. Kegiatan melibatkan peserta perempuan diatas 30 tahun dan mencakup edukasi kesehatan reproduksi wanita, pemeriksaan HPV DNA secara gratis, serta survei kepuasan layanan. Hasil skrining HPV DNA menunjukkan bahwa 75 peserta (97%) memiliki hasil negatif untuk HPV risiko tinggi (High Risk-HPV atau HR-HPV) dan 2 peserta (3%) memiliki hasil positif untuk HR-HPV. Selain itu, survei kepuasan menunjukkan sebagian besar peserta menilai proses layanan sangat baik, terutama pada keramahan petugas (96% tingkat tertinggi), manfaat pemeriksaan (88%), serta kejelasan prosedur dan hasil pemeriksaan. Peserta juga memberikan masukan agar kegiatan serupa dilakukan secara rutin dan diperluas untuk skrining penyakit lain yang dapat dicegah. Program ini menunjukkan bahwa skrining HPV DNA dapat diterima dengan baik, meningkatkan literasi kesehatan, dan berpotensi menjadi model implementasi deteksi dini berkelanjutan di institusi pendidikan.
Program Skrining Prostate-Specific Antigen sebagai Upaya Deteksi Dini Kanker Prostat di Lingkungan Institut Teknologi Sepuluh Nopember Tahun 2025 Karimah, Rumman; Indriastuti, Endah; Eljatin, Dwinka Syafira; Soraya, Fira; Fitriani, Fatimah Nur; Haykal, Muhammad Nazhif; Hidayah, Rizka Nurul; Sari, Desiana Widityaning; Rangkuti, Rahmah Yasinta; Nurhayati, Lely; Syulthoni, Zain Budi; Fadli, Sonny
Sewagati Vol 9 No 6 (2025)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v9i6.9145

Abstract

Kanker prostat merupakan salah satu kanker penyebab utama mortalitas pada pria, dan deteksi dini melalui pemeriksaan prostate-specific antigen (PSA) berperan penting dalam mencegah keterlambatan diagnosis. Program skrining ini diselenggarakan sebagai bagian dari kegiatan pengabdian masyarakat untuk meningkatkan kesadaran dan akses deteksi dini pada kelompok pria berisiko khususnya untuk civitas akademika ITS dan masyarakat sekitar. Kegiatan meliputi edukasi mengenai pengetahuan umum, faktor risiko, dan gejala kanker prostat, kemudian diikuti pemeriksaan PSA secara gratis. Hasil skrining menunjukkan bahwa 75% peserta memiliki kadar PSA normal (<4,0 μg/L), sementara 25% peserta memiliki kadar PSA tidak normal (4,0 μg/L). Nilai PSA tinggi memiliki beberapa kemungkinan, di antaranya prostatitis, benign prostatic hyperplasia, pasca-ejakulasi/ digital rectal examination yang dilakukan dalam 48-72 jam sebelum pemeriksaan, aktivitas fisik berat sebelum pemeriksaan, atau kanker prostat. Peserta dengan PSA normal direkomendasikan melakukan pemeriksaan ulang setiap 1–2 tahun, sedangkan peserta dengan PSA tinggi disarankan berkonsultasi ke dokter spesialis urologi untuk evaluasi lanjutan. Program ini menegaskan pentingnya skrining PSA berbasis komunitas sebagai strategi efektif untuk meningkatkan deteksi dini dan mempercepat penatalaksanaan pada kasus berisiko tinggi untuk dampak jangka panjang terhadap kesehatan masyarakat. Kegiatan ini juga berhasil memperoleh penghargaan rekor MURI untuk skrining PSA dengan jumlah peserta terbanyak, yaitu 420 peserta.
Co-Authors 'Arifin, Miftah Saiful Abdurahman Abdurrahman Adhi Dharma Wibawa, Adhi Dharma Dewi Santosaningsih Dwinka Syafira Eljatin Fadhlina, Afia Nuzila Fadli, Sonny Fatmasari, Hindana Fira Soraya, Fira Fitriani, Fatimah Nur Furaidah, Erna Haykal, Muhammad Nazhif Hedianto, Tri Imam Susilo Indriani, Ratri Dwi Indriastuti, Endah Jason, Jason Karimah, Rumman Muti'ah, Roihatul Nafisa, Belia Bima Njoto, Edwin Nugroho Nurhayati, Lely Parlindungan, Putra Gelar Putra, Gumilar Fardhani Ami Putri Alief Siswanto Putri, Atina Irani Wira Rangkuti, Rahmah Yasinta Ridhoi, Ahmad Sakina Sakina Sakina, Sakina Sari, Desiana Widityaning Syafira Eljatin, Dwinka Syulthoni, Zain Budi Widodo, Aulia Febrianti Wira Putri, Atina Irani Yuri Pamungkas