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All Journal Jurnal Kedokteran Syiah Kuala Biosaintifika: Journal of Biology & Biology Education Jurnal Ilmiah Mahasiswa Kedokteran Medisia Jurnal Respirologi Indonesia Majalah Biomorfologi (Biomorphology Journal) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh Indonesian Journal of Cancer Jurnal Natural Gema Lingkungan Kesehatan Journal of Clinical Microbiology and Infectious Diseases Folia Medica Indonesiana
Mahdani, Wilda
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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The Effect of Mangosteen Peel Extract (Garcinia mangostana Linn.) on the Production of Escherichia coli Bacterial Biofilm Causing Urinary Tract Infections Ryan Maulana Ardhana; Wiwin Retnowati; Danti Nur Indiastuti; Nurul Wiqoyah; Wilda Mahdani
Majalah Biomorfologi Vol. 36 No. 1 (2026): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v36i1.2026.48-56

Abstract

Background: Biofilm formation by Escherichia coli is a key factor contributing to chronic infections, particularly urinary tract infections and antibiotic resistance. Mangosteen peel (Garcinia mangostana Linn.) contains bioactive compounds that have potential as natural antibiofilm agents. Objective:  To examine how mangosteen peel extract at varying concentrations affected biofilm production of Escherichia coli in vitro. Materials and Methods:  This true experimental study using post-test control group design employed mangosteen peel extract concentrations of 0.15%, 0.10%, 0.05%, 0.025%, and 0.0125%. A clinical isolate of Escherichia coli from a urine specimen was used in this study. The authors conducted the test using a microtiter plate assay and biofilm development. ELISA reader was employed to measure the optical density (OD) at 492 nm. Furthermore, this study employed the Shapiro-Wilk test, the homogeneity test, and the Kruskal-Wallis test to assess the data. Results: The results indicated a decrease in OD values across all treatment groups compared to the negative control, suggesting a trend of reduced biofilm formation. The homogeneity test indicated equal variances across groups. Therefore, non-parametric Kruskal-Wallis test was used to test the hypothesis. This statistical analysis revealed that the decrease of the biofilm thickness was not statistically significant (p > 0.05). Conclusion:  Mangosteen peel extract demonstrates potential as a natural antibiofilm agent against Escherichia coli, although its effect was not statistically significant at the tested concentrations. Therefore, further studies should investigate fractionated active compounds and higher concentrations to determine optimal antibiofilm activity.
Co-Authors , Atika . Saminan Ade Oktiviyari Aderiana Masthura Agustin, Heidy Aida Fitri Atika Budi Yanti Constantia Lidwina Targanski Danti Nur Indiastuti Dedy Syahrizal Endang Mutiawati Rahayuningsih* Fadhil Malik Fauzul Husna Hijra Novia Suardi Iman Rusmana KEUMALAHAYATI, MEUTIA Maelani, Imelda Mafruzah Nanda Putri Maharani, Sekar ManikRetno Wahyunitisari Marisa Marisa Masthura, Aderiana Mirnasari Amirsyah Mirnasari Amirsyah Mohammad Fathul Qorib Muarif, Muhammad Fadjar Mudatsir MULIANA, DESI Ni Made Mertaniasih Nisrina Nurhikmah Nisyra, Mailani Novita Andayani Novita Andayani, Novita Nurul Wiqoyah Nurul Wiqoyah, Nurul Purwanta, Marijam PUTRI, FARAH DHITA ANISSA RAHMAWATI, CUT VIKA Rajuliana Rajuliana Ramadhan Willy Saputra Regita Ayu Kumuda Ridwan, Azwar Ryan Maulana Ardhana Sekar Maharani Solly Aryza Suhartono Suhartono Suryawati Suryawati Syamsul Rizal Syamsul Rizal Tjut Mariam Zanaria Wiwin Retnowati Wiwin Retnowati Yanifitri, Dewi Behtri Yunita Arliny Yusriadi, Teuku ZIKRI, MUHAMMAD SHADIQUL Zinatul Hayati Zinatul Hayati