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All Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Chemical Science Jurnal Farmasi Sains dan Komunitas JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Kesehatan Prima FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Pemberdayaan Masyarakat Universitas Al Azhar Indonesia Jurnal Ilmiah Farmako Bahari Advance Sustainable Science, Engineering and Technology (ASSET) Jurnal Olahraga dan Kesehatan Indonesia (JOKI) Pharmaceutical And Biomedical Sciences Journal (PBSJ) Proceeding ISETH (International Summit on Science, Technology, and Humanity) Indonesian Journal of Pharmacy and Natural Product Indonesian Journal of Community Empowerment (IJCE) Jurnal Ilmiah Nusantara
Luhurningtyas, Fania Putri
Universitas Ngudi Waluyo
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Formulasi dan Karakterisasi Nanopartikel Ekstrak Biji Carica (Carica pubescens) dengan Variasi Konsentrasi Kitosan menggunakan Metode Gelasi Ionik Luhurningtyas, Fania Putri; Damayanti, Prashinta Nita; Astyamalia, Suzan; Kemila, Mir-a; Novitasari, Evi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39161

Abstract

Carica seeds (Carica pubescens) contain alkaloid, saponin, and flavonoid compounds, which have pharmacological activities such as antibacterial, anti-inflammatory, immunomodulatory, and antihyperlipidemic properties, but their bioavailability is low. Nanotechnology has significantly advanced in drug delivery systems because it can enhance absorption in the gastrointestinal tract, allowing entry into the bloodstream. This study aims to create and evaluate the characteristics of carica seed extract nanoparticles with varying concentrations of chitosan. The carica seed extract was obtained using the maceration method with 70% ethanol as the solvent. The Carica seed extract was then formulated into nanoparticles using the ionic gelation method with varying concentrations of chitosan: NaTPP, specifically formulas FA (0.3:1), FB (0.2:1), and FC (0.1:1). The resulting nanoparticle colloids were characterized for particle size, polydispersity index (PDI), percent transmittance (%T), and specific functional groups. The results showed that the particle sizes for formulas FA, FB, and FC were 243.7 nm, 47.96 nm, and 116.6 nm, respectively. The PDI values for formulas FA, FB, and FC were 0.378, 0.357, and 0.52, respectively. The percent transmittance for all three formulas ranged from 99.5% to 99.6%. The characterization of functional groups indicated interactions between the carica seed extract, chitosan, and NaTPP, with the presence of OH, N-H, aliphatic CH, P=O, and PO3 groups. These interactions were observed based on the shift in wavenumbers in the FTIR results for each sample. All carica seed nanoparticle formulas showed particle sizes within the nanometer range (<1000 nm), polydispersity indices less than 1, percent transmittance close to 100%, and specific functional groups indicating interactions between the extract and the coating polymer. Formula FB was the optimal formula, with the smallest nanoparticle size (<100 nm), a PDI value of <0.5, and a percent transmittance of >99%.
In Vivo Antihypercholesterolemic Effects of Caricapubescens Seeds Hypercholesterolemic-induced Rats Luhurningtyas, Fania Putri; Aprilliana, Melati; Alifa, Gea Ros
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1428

Abstract

Background: Carica is a typical plant originating from the Dieng Plateau. Carica processed products leave waste in the form of Carica seeds which have not been utilized. Based on the previous study, Carica seeds contain tannin, flavonoids, and alkaloids, so in this study, Carica seeds extract was used in the antihyperlipidemic study. Objective: To analyze the reduction of total cholesterol and secondary metabolites in the ethanol extract of Carica seeds using thin-layer chromatography.Method:Extraction was carried out by the maceration method using 96% ethanol. Antihypercholesterolemic study used 6 groups of rats Wistar strains consisting of normal group, positive control, negative control, treatment 1 (200 mg / KgBB), treatment 2 (400 mg / KgBB), treatment 3 (600 mg / KgBB). Total cholesterol level tests were carried out by using a biosystem with diasysic reagents. Statistical tests were carried out with one way ANOVA followed by LSD post hoc tests.Result: Carica seed extract has flavonoids and alkaloids. The percentage decrease in cholesterol levels in treatments 1, 2 and 3 was 15% ± 11,619, 24% ± 8,813 and 21% ± 19,471 with a significance value in the one way ANOVA test was 0,000. Conclusion: The dosage variations of Carica seed extract Affects comparable to simvastatin in reducing total cholesterol levels.
Fractionation of metabolite compound from Medinilla speciosa and their antioxidant activities using ABTS.+ radical cation assay Vifta, Rissa Laila; Luhurningtyas, Fania Putri
Advance Sustainable Science, Engineering and Technology Vol 1, No 1 (2019): May-October
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v1i1.4878

Abstract

Phenolic compounds are one of the main parts in secondary metabolites. Parijoto fruit is a family of Melastomataceae which contains flavonoids as phenolic compounds which are known to have antioxidant potential. Flavonoids have an-OH groups that play an active role as free radical scavengers. The study was conducted as initial screening in testing the antioxidant activity of extracts and fractions of the Parijoto fruit (Medinilla speciosa). The study began with the phytochemical screening process using the Thin Layer Chromatography method to ensure the presence of flavonoid content in extracts and fractions of parijoto fruit, then proceed with the measurement of antioxidant power. Testing the antioxidant activity using the ABTS method (2,2 azinobis (3-ethylbenzothiazolin) -6-sulfonic acid) which is specific, simple and easy to apply. Parijoto fruit extracts and fractions were made in a series of concentrations, measured antioxidant activity, and each IC50 value was determined. Phytochemical screening test results showed the presence of flavonoids in extracts and fractions of parijoto fruit. The results of measurements of antioxidant power in extracts and fractions of parijoto fruit gave IC50 values of 6,520 ppm in ethanol extracts with very strong antioxidant categories. The n-hexane fraction produced an IC50 value of 118,424 ppm with a moderate antioxidant category, while the IC50 value of ethyl acetate and ethanol fractions was 4,246 ppm and 3,874 ppm, respectively, with a very strong antioxidant category. The activity and value of IC50 produced by extracts and fractions of Parijoto fruits showed potential as a candidate of antioxidant.Keywords: ABTS, Antioxidant, Flavonoids, Medinilla speciosa, Phenolic
Co-Authors Aini, Zhahiria Nur Alifa, Gea Ros Amaliasari, Tesalonika Dinda Andi Pradana Aprilliana R, Melati Astyamalia, Suzan Deny Saputra Dewi, Faradilla Afri Nirmala Dian Oktianti Dyah Kartika Wening Erma Widhihastuti Februani, Riska Firman Wahyu Ardiyansah Galih Y, Yunita Hasani, Nova Jatmiko Susilo Kemila, Mir-a Mahardika Adhi Candra Melati Aprilliana Ramadhani, Melati Aprilliana Niken Dyaharesti Nova Hasani Furdiyanti Novitasari, Evi Nur Syarohmawati Prashinta Nita Damayanti Prayasanti, Dewi Rahayu, Restu Tutut Ranu Putra Adi Surya Ratna Sari Richa Yuswantina Septi Fitri Eka M Setiawan, Fredy Eko Siti Khusnul Khotimah Siti Khusnul Khotimah, Siti Khusnul Sofia, Arikatus Vifta, Rissa vifta, rissa laila Yulianti Yulianti Yunita Galih Y Yurike Tatengkeng